公开(公告)号：US07632302B2

公开(公告)日：2009-12-15

申请号：US11559455

申请日：2006-11-14

申请人： Daniel J. Vreeman ,  Joshua Evans Berman ,  Richard Kusleika ,  Steve Gene Zaver ,  Lixiao Wang

发明人： Daniel J. Vreeman ,  Joshua Evans Berman ,  Richard Kusleika ,  Steve Gene Zaver ,  Lixiao Wang

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2/915 ,  A61F2/962 ,  A61F2002/821 ,  A61F2002/91508 ,  A61F2002/91525 ,  A61F2002/91541 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2250/0048

摘要： A renal stent includes a balloon expandable segment intended for deployment in the renal vessel and a self expanding segment intended for deployment in the aortic segment. One or both of the balloon expandable and self expanding segments can be deployed in the ostial region of the renal vessel, typically the renal artery. The balloon expandable segment provides superior radial strength for maintaining dilated diameter of the renal vessel. The self expanding segment expands to conform to the flared ostial and aortic regions of the vessel. The self expanding segment can be balloon dilated to enhance conformance of the self expanding stented segment to the ostial and aortic regions.

摘要翻译： 肾支架包括用于部署在肾容器中的球囊可扩张部分和用于部署在主动脉部分中的自扩张部分。 球囊扩张和自扩张部分中的一个或两个可以部署在肾血管的口部区域，通常是肾动脉。 球囊可扩张部分提供优越的径向强度以保持肾血管的扩张直径。 自扩张部分扩张以符合血管的扩张的口腔和主动脉瓣区域。 自膨胀部分可以球囊扩张，以增强自扩张支架段与口腔和主动脉区域的一致性。

公开(公告)号：US07575568B2

公开(公告)日：2009-08-18

申请号：US10732983

申请日：2003-12-10

申请人： Thomas J. Holman ,  Daniel K. Tomaschko ,  Leo M. Klisch ,  Richard Olson ,  Joseph M Lyver ,  Richard Dunn ,  David Griswold ,  Nie Tang ,  Lixiao Wang

发明人： Thomas J. Holman ,  Daniel K. Tomaschko ,  Leo M. Klisch ,  Richard Olson ,  Joseph M Lyver ,  Richard Dunn ,  David Griswold ,  Nie Tang ,  Lixiao Wang

IPC分类号： A61M29/00

CPC分类号： A61M25/1034 ,  A61M25/0069 ,  A61M25/104 ,  A61M2025/1093

摘要： The present invention is directed to distal tip designs for catheter, wherein distal tip material is positioned about an inner shaft. The distal tip material may also be used as a tie layer for thermally bonding two incompatible materials together, such as a waist portion of a balloon to the inner shaft.

摘要翻译： 本发明涉及用于导管的远侧末端设计，其中远侧末端材料围绕内部轴定位。 远侧末端材料也可以用作将两个不相容材料（例如球囊的腰部部分）一起热粘合到内轴的连接层。

公开(公告)号：US07541077B2

公开(公告)日：2009-06-02

申请号：US11929208

申请日：2007-10-30

申请人： Victor Schoenle ,  Daniel James Horn ,  Yiqun Wang ,  Lixiao Wang

发明人： Victor Schoenle ,  Daniel James Horn ,  Yiqun Wang ,  Lixiao Wang

IPC分类号： B32B1/08 ,  F16L11/04 ,  F16L11/20 ,  A61M29/02 ,  A61M39/00

CPC分类号： A61M25/1036 ,  A61M25/0045 ,  A61M25/10 ,  A61M25/1006 ,  A61M2025/018 ,  Y10T29/49826 ,  Y10T29/49863 ,  Y10T29/49865 ,  Y10T428/13 ,  Y10T428/1334 ,  Y10T428/1345 ,  Y10T428/1352 ,  Y10T428/139 ,  Y10T428/1393

摘要： Medical device components, such as tube-shaped catheter components, are disclosed. In some embodiments, a medical device component includes a region that includes a polyamide having a post buckle fracture tensile strength of at least about 6500 psi.

摘要翻译： 公开了医疗装置部件，例如管状导管部件。 在一些实施例中，医疗装置部件包括包括具有至少约6500psi的后扣环断裂拉伸强度的聚酰胺的区域。

公开(公告)号：US20080175887A1

公开(公告)日：2008-07-24

申请号：US11942459

申请日：2007-11-19

申请人： Lixiao Wang

发明人： Lixiao Wang

IPC分类号： A61K9/12 ,  A61K31/436 ,  A61P11/00 ,  A61M15/00 ,  A61F2/82 ,  A61M25/10 ,  A61M11/00 ,  A61K31/337

CPC分类号： A61L29/16 ,  A61K31/337 ,  A61K31/436 ,  A61K45/06 ,  A61L29/08 ,  A61L29/085 ,  A61L29/18 ,  A61L31/16 ,  A61L31/18 ,  A61L2300/216 ,  A61L2300/416 ,  A61L2300/428 ,  A61L2300/608 ,  A61L2300/802 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  A61M2210/1025 ,  A61K2300/00

摘要： Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues).

摘要翻译： 本发明的实施方案提供了一种治疗呼吸系统疾病如哮喘，慢性阻塞性肺病和慢性鼻窦炎的方法，包括囊性纤维化，间质性纤维化，慢性支气管炎，肺气肿，支气管肺发育不良和瘤形成。 该方法包括施用抗炎和抗增殖药物（雷帕霉素或紫杉醇及其类似物），优选口服，鼻或肺给药。

公开(公告)号：US07279002B2

公开(公告)日：2007-10-09

申请号：US10423598

申请日：2003-04-25

申请人： William J. Shaw ,  Eric B. Stenzel ,  Lixiao Wang

发明人： William J. Shaw ,  Eric B. Stenzel ,  Lixiao Wang

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61B17/320725 ,  A61B17/22 ,  A61B2017/00831 ,  A61B2017/22051 ,  A61F2/958 ,  A61F2250/0028 ,  A61L29/126 ,  A61M25/10

摘要： A stent or sheath having one or more cutting blades may be constructed for implantation in the body. A balloon having one or more cutting blades may be used with a stent or a sheath.

摘要翻译： 具有一个或多个切割刀片的支架或护套可被构造用于植入体内。 具有一个或多个切割刀片的气囊可以与支架或护套一起使用。

公开(公告)号：US20060259120A1

公开(公告)日：2006-11-16

申请号：US11433328

申请日：2006-05-12

申请人： Khamla Vongphakdy ,  Huisun Wang ,  Adel Hashw ,  Lixiao Wang

发明人： Khamla Vongphakdy ,  Huisun Wang ,  Adel Hashw ,  Lixiao Wang

IPC分类号： A61F2/06

CPC分类号： A61M25/09 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/9505 ,  A61F2002/9583 ,  A61F2002/9665 ,  Y10T29/49938

摘要： A medical implant delivery system maintains an orientation between a guidewire lumen of an inner member of the system and a rapid-exchange port in an outer member. The medical device is disposed intermediate the inner and outer members and in friction or pressure-fit contact with the outer member. Once the guidewire lumen of the inner member and the rapid exchange port of the outer member are oriented, the friction or pressure-fit operates to maintain the orientation until deployment of the medical implant. Orientation is further maintained by a telescoping coupling of the guide wire lumen with the rapid exchange port.

公开(公告)号：US07101597B2

公开(公告)日：2006-09-05

申请号：US10012872

申请日：2001-12-12

申请人： Lixiao Wang ,  Jianhua Chen

发明人： Lixiao Wang ,  Jianhua Chen

IPC分类号： B29D22/02 ,  B29D23/00

CPC分类号： A61M25/0009 ,  A61F2/958 ,  A61L29/049 ,  A61L29/14 ,  A61M25/1029 ,  A61M2025/1084 ,  Y10T428/1334 ,  Y10T428/1341 ,  Y10T428/1352 ,  Y10T428/1372 ,  Y10T428/139

摘要： A medical device, at least a portion of which is composed of a polymeric material in which the polymeric material is a melt blend product of at least two different thermoplastic polymers, one of the thermoplastic polymers being a thermoplastic liquid crystal polymer (LCP) having a melting point of less than 250° C. The portion of the device made from the melt blend may be a catheter body segment or a balloon for a catheter. The LCP blends suitably also include a non-LCP base polymer having a melting point in the range of about 140° C. to about 265° C.

公开(公告)号：US20060161240A1

公开(公告)日：2006-07-20

申请号：US11356368

申请日：2006-02-16

申请人： Lixiao Wang

发明人： Lixiao Wang

IPC分类号： A61F2/06

CPC分类号： A61F2/958 ,  A61F2002/9583 ,  A61F2250/0039 ,  A61M25/1002 ,  A61M29/02 ,  A61M2025/1059

摘要： A catheter having a catheter shaft and a medical balloon mounted thereon. The medical balloon having a non-inflated state and being inflatable to an inflated state. The medical balloon having a stent mounting region, with a stent being disposed about at least a portion of the stent mounting region. The stent mounting region having a middle portion, a first end portion adjacent to the middle portion and a second end portion adjacent to the middle portion. The middle portion having a middle portion diameter, the first end portion having a first end portion diameter, the second end portion having a second end portion diameter. In the non-inflated state the middle portion diameter being different from the first end portion diameter and the second end portion diameter, in the inflated state the middle portion diameter being substantially the same as the fist end portion diameter and the second end portion diameter.

公开(公告)号：US20060151921A1

公开(公告)日：2006-07-13

申请号：US11356522

申请日：2006-02-17

申请人： Lixiao Wang ,  John Chen ,  Jeffrey Lindquist ,  Nao Lee ,  Douglas Devens

发明人： Lixiao Wang ,  John Chen ,  Jeffrey Lindquist ,  Nao Lee ,  Douglas Devens

IPC分类号： H05B6/00

CPC分类号： A61L31/06 ,  A61L31/125 ,  A61M25/1029 ,  B29C48/022 ,  B29C48/09 ,  B29C48/832 ,  B29C48/86 ,  B29C48/865 ,  B29C48/919 ,  B29L2031/7542 ,  Y10T428/1086

摘要： A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.

摘要翻译： 一种用于形成医疗装置气囊的管形型坯。 型坯由聚合物材料形成，例如热塑性弹性体。 型坯的断裂伸长率不大于本体聚合材料的伸长率的80％。 通过改变挤出条件来控制型坯的伸长率。 从型坯制备的气球比从相同材料的常规型坯制备的气球提供更高的壁强度和/或更高的充气耐久性。

公开(公告)号：US07056466B2

公开(公告)日：2006-06-06

申请号：US10212926

申请日：2002-08-06

申请人： Lixiao Wang ,  Jan Weber

发明人： Lixiao Wang ,  Jan Weber

IPC分类号： B29C35/08

CPC分类号： B29C49/78 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/1036 ,  B29C33/06 ,  B29C45/14655 ,  B29C47/0026 ,  B29C47/003 ,  B29C47/0071 ,  B29C47/86 ,  B29C47/862 ,  B29C47/8805 ,  B29C47/8835 ,  B29C47/90 ,  B29C47/903 ,  B29C47/907 ,  B29C47/908 ,  B29C49/0042 ,  B29C49/783 ,  B29C2035/0855 ,  B29C2049/0089 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  H05B6/80

摘要： An apparatus and method for molding balloon catheters is disclosed. The balloon may be molded by providing a polymeric tube within a mold having an interior cavity in the shape of the desired balloon. Microwave energy, which may be generated by a gyrotron, may then be directed toward the mold, to heat the polymeric material without heating the mold. Once heated, pressurized fluid may be injected into the tube to blow the polymeric material against the interior cavity whereupon the material can cool to form the balloon or can be further heatset by additional microwave energy and be cooled to form the balloon. In accordance with one embodiment, microwave energy can also be used without a mold to form a medical device.