公开(公告)号：US20070224293A1

公开(公告)日：2007-09-27

申请号：US11641319

申请日：2006-12-18

申请人： John Hughes ,  Jerald Darlington ,  Panayiotis Constantinides

发明人： John Hughes ,  Jerald Darlington ,  Panayiotis Constantinides

IPC分类号： A61K33/12 ,  A61K33/06

CPC分类号： C09C1/42 ,  A01N59/00 ,  A01N59/06 ,  C01P2004/20 ,  C01P2004/61

摘要： Layered phyllosilicates are useful for adsorbing and/or binding to and, thereby, inactivating viruses. Accordingly, provided herein is a method of inhibiting transfer of a virus to a surface comprising contacting the surface with a composition comprising a layered phyllosilicate material in an amount sufficient for inhibiting the transfer of the virus thereto. Also provided are methods of inactivating a virus on a surface comprising contacting the surface with a composition comprising a layered phyllosilicate material in an amount sufficient to inactivate said virus.

摘要翻译： 层状页硅酸盐可用于吸附和/或结合病毒，从而灭活病毒。 因此，本文提供了一种抑制病毒转移到表面的方法，包括使表面与包含层状页硅酸盐材料的组合物接触，所述组合物的量足以抑制病毒转移到其上。 还提供了使表面灭活病毒的方法，包括使表面与含有足以灭活所述病毒的量的层状页硅酸盐材料的组合物接触。

公开(公告)号：US20070041499A1

公开(公告)日：2007-02-22

申请号：US11459152

申请日：2006-07-21

申请人： Weiguo Lu ,  Gustavo Olivera ,  Jeffrey Kapatoes ,  Kenneth Ruchala ,  Eric Schnarr ,  John Hughes ,  Thomas Mackie ,  Paul Reckwerdt

发明人： Weiguo Lu ,  Gustavo Olivera ,  Jeffrey Kapatoes ,  Kenneth Ruchala ,  Eric Schnarr ,  John Hughes ,  Thomas Mackie ,  Paul Reckwerdt

IPC分类号： A61N5/10

CPC分类号： A61N5/103 ,  A61N5/1042 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1075

摘要： System and method of evaluating quality assurance criteria related to the delivery of a radiation therapy treatment plan. The method includes the acts of acquiring image data of a patient, generating a treatment plan for the patient based at least in part on the image data, the treatment plan including a calculated radiation dose to be delivered to the patient, acquiring an on-line image of the patient in substantially a treatment position, delivering at least a portion of the calculated radiation dose to the patient, monitoring quality assurance criteria related to the delivery of the treatment plan, calculating the radiation dose received by the patient, and determining whether delivery of the treatment plan occurred as intended based on the quality assurance criteria and the radiation dose received by the patient.

摘要翻译： 评估与放射治疗计划相关的质量保证标准的系统和方法。 该方法包括获取患者的图像数据的动作，至少部分地基于图像数据生成针对患者的治疗计划，治疗计划包括计算出的要递送给患者的辐射剂量，获取在线 将患者的图像基本上处于治疗位置，将计算的辐射剂量的至少一部分递送给患者，监测与治疗计划的递送相关的质量保证标准，计算患者接收的辐射剂量，以及确定是否递送 的治疗计划根据质量保证标准和患者接受的放射剂量进行预期的发生。

公开(公告)号：US20060291130A1

公开(公告)日：2006-12-28

申请号：US10482193

申请日：2002-07-05

申请人： John Hughes ,  Lindsey Gaunt

发明人： John Hughes ,  Lindsey Gaunt

IPC分类号： H05F3/00

CPC分类号： B05B5/043 ,  B05B5/047 ,  B05B5/0531 ,  B05B5/1691 ,  B05B11/3057

摘要： A method of imparting a charge to droplets of a liquid which is dispensed from a trigger actuated spray device in which charge is generated by the triboelectric rubbing together of two materials and one polarity of charge is transferred to the liquid at the point of atomisation. Apparatus for imparting a charge to droplets of a liquid which is dispensed from a trigger actuated spray device includes means for generating triboelectric charge by actuation of the trigger.

摘要翻译： 对从触发器驱动的喷射装置分配的液体的液滴赋予电荷的方法，其中通过两种材料的摩擦电摩擦和电荷的一个极性产生电荷，其在雾化点处被转移到液体中。 用于对从触发器驱动的喷射装置分配的液体的液滴赋予电荷的装置包括用于通过触发器的致动产生摩擦电荷的装置。

公开(公告)号：US20060250180A1

公开(公告)日：2006-11-09

申请号：US10557346

申请日：2004-05-14

申请人： John Hughes

发明人： John Hughes

IPC分类号： H04B1/10

CPC分类号： H03F3/45991 ,  H03F2200/294 ,  H03F2200/372 ,  H03H11/0444 ,  H03H11/08

摘要： A transconcuctor circuit, such a gyrator filter, comprises an arrangement of balanced class AB transconductors, capacitors and floating MOS resistors formed by MOS transistors operating in their triode region. Tuning of the filter is effected by varying a common supply rail voltage (Vdda). In order to enable the resistance values of the MOS resistors to track changes in the transconductance values (−G) of the transconductors, a circuit provides the condition R=1/G. The circuit includes a means (102) for producing a voltage (Vcm−ΔV) offset from the common mode voltage (Vcm) of the class AB transconductors. The offset voltage is supplied to a parallel arrangement of a class AB transconductor (108) having a transconductance (−G) and the source-drain path of a MOS transistor (110) emulating a MOS resistor. The current output I=ΔV(G−1/R) of the parallel arrangement is integrated and supplied as a control voltage (cntrl) to the gate electrode of the MOS transistor (110). By loop action the control voltage is adjusted so that the loop stabilises with I=0 which occurs when R=1/G, this control voltage being supplied also to the floating MOS resistors.

摘要翻译： 诸如转子滤波器的转导电路包括平衡AB类跨导体，电容器和由其三极管区域中工作的MOS晶体管形成的浮动MOS电阻器的布置。 滤波器的调谐通过改变共同的电源轨电压（V MAX）来实现。 为了使MOS电阻器的电阻值能够跟踪跨导体的跨导值（-G）的变化，电路提供条件R = 1 / G。 该电路包括用于产生从AB类跨导体的共模电压（V SUB cm）偏移的电压（V subcm-DeltaV）的装置（102）。 偏移电压被提供给具有跨导（-G）的AB类跨导体（108）和模拟MOS电阻的MOS晶体管（110）的源极 - 漏极路径的并联布置。 并联装置的电流输出I = DeltaV（G-1 / R）被积分并作为控制电压（cntr1）提供给MOS晶体管（110）的栅电极。 通过循环动作，调节控制电压，使得当R = 1 / G时，I = 0发生环路稳定，该控制电压也提供给浮动MOS电阻。

公开(公告)号：US20060221248A1

公开(公告)日：2006-10-05

申请号：US11092376

申请日：2005-03-29

申请人： Morgan McGuire ,  Wojciech Matusik ,  Hanspeter Pfister ,  John Hughes ,  Fredo Durand

发明人： Morgan McGuire ,  Wojciech Matusik ,  Hanspeter Pfister ,  John Hughes ,  Fredo Durand

IPC分类号： H04N9/74

CPC分类号： H04N5/272

摘要： A method and system extracts a matte from images acquired of a scene. A foreground image focused at a foreground in a scene, a background image focused at a background in the scene, and a pinhole image focused on the entire scene are acquired. These three images can be acquired sequentially by a single camera, or simultaneous by three cameras. In the later case, foreground, background and pinhole sequences of images can be acquired. The pinhole image is compared to the foreground image and the background image to extract a matte representing the scene. The comparison classifies pixels in the images as foreground, background, or unknown pixels. An optimizer minimizes an error function in the form of Fourier image equations using a gradient descent method. The error function expresses pixel intensity differences.

摘要翻译： 方法和系统从场景获取的图像中提取哑光。 获取聚焦在场景中的前景的前景图像，聚焦在场景背景中的背景图像以及聚焦在整个场景上的针孔图像。 这三个图像可以由单个相机顺序获取，或者由三个相机同时获取。 在后一种情况下，可以获取图像的前景，背景和针孔序列。 将针孔图像与前景图像和背景图像进行比较，以提取表示场景的哑光。 比较将图像中的像素分类为前景，背景或未知像素。 优化器使用梯度下降法将傅里叶图像方程式的误差函数最小化。 误差函数表示像素强度差异。

公开(公告)号：US20060184928A1

公开(公告)日：2006-08-17

申请号：US11311911

申请日：2005-12-19

申请人： John Hughes

发明人： John Hughes

IPC分类号： G06F9/44

CPC分类号： G06F8/65 ,  G06F8/20

摘要： This invention relates to methods and a system for supporting software. In one embodiment, a method for providing an updated version of a software program includes receiving an indication of a fault in a software program, distributing the faulty software program to a distributed community of programmers, receiving updated versions of the faulty software program from a subset of the distributed community of programmers, and determining a preferred updated software program from the received updated versions of the software program. In another embodiment, a system for providing an updated version of a software program includes a communication server for communicating faulty software programs and updates of the programs to and from the distributed community of programmers, a component storage module for storing the faulty software program, and a software testing module for determining a preferred updated version of the faulty software program.

摘要翻译： 本发明涉及用于支持软件的方法和系统。 在一个实施例中，用于提供软件程序的更新版本的方法包括接收软件程序中的故障指示，将故障软件程序分发给分布式程序员社区，从子集接收故障软件程序的更新版本 的程序员的分布式社区，以及从所接收的软件程序的更新版本确定优选的更新的软件程序。 在另一个实施例中，用于提供软件程序的更新版本的系统包括通信服务器，用于将错误的软件程序传送到程序员的分布式社区和/或从程序员的分布式社区更新程序，用于存储故障软件程序的组件存储模块，以及 用于确定故障软件程序的优选更新版本的软件测试模块。

公开(公告)号：US20050201516A1

公开(公告)日：2005-09-15

申请号：US10506866

申请日：2003-03-06

申请人： Kenneth Ruchala ,  Gustavo Olivera ,  Jeffrey Kapatoes ,  Paul Reckwerdt ,  Weiguo Lu ,  John Hughes

发明人： Kenneth Ruchala ,  Gustavo Olivera ,  Jeffrey Kapatoes ,  Paul Reckwerdt ,  Weiguo Lu ,  John Hughes

IPC分类号： A61N20060101 ,  A61N1/00 ,  A61N5/10 ,  G06T1/00

CPC分类号： A61N5/103 ,  A61N5/1038 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1069 ,  A61N2005/1061 ,  G06F19/00

摘要： The present invention provides a novel method of contoured-anatomy dose repositioning (CADR) as a means to automatically reposition a patient to better recover the planned dose distribution without reoptimize the treatment plan. Specifically, CADR utilizes planning CT images, the planned dose distribution, and on-line images for repositioning dose distribution on a given day. Contours are also placed upon the images using manual, automatic, template-based, or other techniques. CADR then optimizes the rigid-body repositioning of the patient so that the daily dose distribution closely matches the planned dose distribution. The present invention also provides a method of multiple-margin optimization with daily selection (MMODS) to improve radiation delivery without reoptimization. During the initial optimization procedure, plans are optimized for several margins of various contours (e.g., tight, medium, loose, etc.), or with different objectives (e.g., aggressive treatment, sensitive structure sparing, etc.). Similarly, if multiple patient image sets are available, plans can be optimized for the different anatomical layouts, either using current information, or accumulated information regarding the superposition of organ locations in the combination of images. A user can then choose in real time from a variety of optimized plans, generally with different margins, during the treatment process, and thereby compensate for a recognized change in size or position of the tumor or neighboring tissue.

摘要翻译： 本发明提供了一种轮廓解剖学剂量重新定位（CADR）的新方法，作为自动重新定位患者的手段，以更好地恢复计划的剂量分布，而不重新优化治疗计划。 具体来说，CADR利用计划的CT图像，计划的剂量分布和在线图像在给定的一天重新定位剂量分布。 使用手动，自动，基于模板或其他技术的轮廓也被放置在图像上。 然后，CADR优化患者的刚体重新定位，使得日剂量分布与计划的剂量分布密切相关。 本发明还提供了一种利用日常选择（MMODS）进行多边距优化的方法，以改善辐射递送而不重新优化。 在初始优化过程中，针对各种轮廓（例如紧密，中等，松散等）或不同目标（例如，积极的治疗，敏感的结构节省等）的几个边缘优化了计划。 类似地，如果多个患者图像组可用，则针对不同的解剖结构布局可以优化计划，使用当前信息或关于图像组合中器官位置的叠加的累积信息。 然后，用户可以在处理过程中从各种优化的计划（通常具有不同的边缘）实时地选择，从而补偿肿瘤或相邻组织的大小或位置的公认变化。

公开(公告)号：US20050039677A1

公开(公告)日：2005-02-24

申请号：US10496362

申请日：2002-11-27

申请人： John Hughes ,  Karen Baxter ,  Malcolm Mckechnie

发明人： John Hughes ,  Karen Baxter ,  Malcolm Mckechnie

IPC分类号： A47L13/40 ,  B03C3/28 ,  B08B6/00 ,  B05C5/02 ,  B05B5/025

CPC分类号： B08B6/00 ,  A47L13/40 ,  B03C3/28

摘要： A powder charging and delivery device which comprises a receptacle having a neck portion, the receptacle containing particles of a material which can be electrostatically charged and the receptacle having a reticulated, open pore, foam material disposed within the neck thereof, whereby as the particles are dispensed from the container they travel through the pores of the reticulated foam material and thereby become electrostatically charged.

摘要翻译： 一种粉末装料和输送装置，其包括具有颈部的容器，所述容器包含可被静电充电的材料的颗粒，并且所述容器具有设置在其颈部内的网状开孔，泡沫材料， 从容器中分配，它们穿过网状泡沫材料的孔隙，从而变得静电。

公开(公告)号：US6142925A

公开(公告)日：2000-11-07

申请号：US233977

申请日：1999-01-20

申请人： Ramon Alfredo Carvalho Siochi ,  John Hughes

发明人： Ramon Alfredo Carvalho Siochi ,  John Hughes

IPC分类号： A61N5/10 ,  A61N5/00

CPC分类号： A61N5/103

摘要： Method and system aspects for increasing resolution of a radiotherapy system to achieve virtual fractional monitor unit radiation delivery are described. Included in a method aspect, and system for achieving same, is identification of a desired treatment dose, the desired treatment dose exceeding a resolution of a radiation treatment device. Further included is the development of a schedule of treatment sessions for delivering the desired treatment dose by the radiation treatment device that produces a combined treatment dose equaling the desired treatment dose without exceeding the resolution within each treatment session.

摘要翻译： 描述了用于增加放射治疗系统的分辨率以实现虚拟分数监视器单元辐射传递的方法和系统方面。 包括在方法方面以及用于实现其的系统是鉴定所需治疗剂量，所需治疗剂量超过放射治疗装置的分辨率。 进一步包括制定治疗阶段的时间表，以通过辐射治疗装置递送期望的治疗剂量，其产生等于所需治疗剂量的组合治疗剂量，而不超过每个治疗期间的分辨率。

公开(公告)号：US5884698A

公开(公告)日：1999-03-23

申请号：US765383

申请日：1997-04-07

申请人： John Hughes ,  Michael Robert Konopczynski

发明人： John Hughes ,  Michael Robert Konopczynski

IPC分类号： E21B7/06 ,  E21B7/08

CPC分类号： E21B7/061

摘要： The whipstock assembly comprises an assembly casing (9) with preformed windows connected to production casing (7); a landing tube (21) is located within assembly casing (9) for receiving whipstock shaft; a key is located within tube (21) for cooperation with J-slot on whipstock shaft. The whipstock consists of upper (49) and lower (55) portion which are fixed against relative rotation by splines. The assembly casing (9) with landing tube (21) is positioned in the borehole using a gyro survey tool for correct orientation of the windows. After a first side hole has been drilled, upper portion (49) is raised and rotated to place wedge surface (51) for drilling a second side hole. Tube (21) is initially closed by a cap containing a marking fluid; after the cap has been drilled out the marking fluid indicates the removal of the cap. In a second embodiment two vertically spaced side holes are drilled.

摘要翻译： PCT No.PCT / EP95 / 02252 Sec。 371日期1997年4月7日 102（e）日期1997年4月7日PCT Filed 1995年6月8日PCT公布。 公开号WO95 / 33910PC。 日期1995年12月14日造斜器组件包括具有连接到生产套管（7）的预成型窗口的组装壳体（9）。 一个着陆管（21）位于组件壳体（9）内，用于接收斜齿轮轴; 一个钥匙位于管（21）内，用于与造斜轴上的J形槽配合。 造斜器由上（49）和下（55）部分组成，通过花键固定抵抗相对旋转。 具有着陆管（21）的组装壳体（9）使用陀螺仪测量工具定位在钻孔中，用于正确定向窗户。 在钻出第一侧孔之后，将上部（49）升高并旋转以放置用于钻出第二侧孔的楔形表面（51）。 管（21）最初由包含标记液的盖封闭; 在已经钻出盖子之后，标记液体指示盖子的移除。 在第二实施例中，钻出两个垂直间隔开的侧孔。