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51.发明申请Compositions Comprising Cationic Microparticles And Hcv B1e2 Dna And Methods Of Use Thereof 审中-公开包含阳离子微粒和Hcv B1e2 Dna的组合物及其使用方法公开(公告)号：US20070264285A1
公开(公告)日：2007-11-15
申请号：US10554625
申请日：2004-04-23
申请人： Derek O'Hagan , Michael Houghton , Manmohan Singh
发明人： Derek O'Hagan , Michael Houghton , Manmohan Singh
CPC分类号： A61K31/7088 , A61K9/0019 , A61K9/1617 , A61K9/1647 , A61K39/12 , A61K39/29 , A61K39/39 , A61K47/6927 , A61K48/00 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
摘要： Immunogenic HCV E1E2809 DNA compositions and methods of using the same are described. The compositions comprise HCV EIE2809 DNA adsorbed to cationic microparticles, such as poly(lactide-co-glycolide) (PLG) microparticles.
摘要翻译： 描述了免疫原性HCV E1E2 809 DNA组合物及其使用方法。 组合物包含吸附在阳离子微粒（如聚（丙交酯 - 共 - 乙交酯）（PLG））微粒上的HCV EIE2 809NN。
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52.发明授权Microparticles with adsorbent surfaces, methods of making same, and uses thereof 失效具有吸附剂表面的微粒，其制备方法及其用途公开(公告)号：US06884435B1
公开(公告)日：2005-04-26
申请号：US09581772
申请日：1999-07-29
申请人： Derek O'Hagan , Manmohan Singh , Gary Ott
发明人： Derek O'Hagan , Manmohan Singh , Gary Ott
IPC分类号： A61K9/00 , A61K9/16 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/39 , A61K9/14 , A61K31/70 , C07H21/00 , C12N15/00
CPC分类号： A61K39/245 , A61K9/1647 , A61K9/167 , A61K39/12 , A61K39/21 , A61K39/39 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , C12N2740/16111 , C12N2740/16134 , C12N2740/16234 , C12N2770/24211 , C12N2770/24234
摘要： The present invention is directed to microparticles, to microparticle compositions containing the same, to methods of forming the same, and to uses for the same, including use for a vaccine, for raising an immune response, for treatment of a disease and for diagnosis of a disease. The microparticles comprise a biodegradable polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, or a polycyanoacrylate, and a detergent selected from a cationic detergent and an anionic detergent. The microparticles further comprise an antigen adsorbed on the surface of the microparticle.
摘要翻译： 本发明涉及微粒，含有该微粒的微粒组合物，其形成方法及其用途，包括用于疫苗的用途，用于提高免疫应答，治疗疾病和诊断疾病 疾病。 微粒包括可生物降解的聚合物，例如聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐或聚氰基丙烯酸酯，以及选自阳离子洗涤剂和阴离子洗涤剂的洗涤剂。 微粒还包含吸附在微粒表面上的抗原。
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公开(公告)号：US09517263B2
公开(公告)日：2016-12-13
申请号：US13377511
申请日：2010-06-10
IPC分类号： A61K39/02 , C07D471/00 , A61K39/39 , A61K39/00 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译： 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
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公开(公告)号：US20120263753A1
公开(公告)日：2012-10-18
申请号：US13377511
申请日：2010-06-10
CPC分类号： A61K39/39 , A61K2039/55511 , A61K2039/6093
摘要： The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
摘要翻译： 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
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公开(公告)号：US20110038900A1
公开(公告)日：2011-02-17
申请号：US12990110
申请日：2009-04-28
CPC分类号： A61K39/095 , A61K2039/55555 , A61K2039/62 , C08J3/14 , C08J2300/16 , C08J2367/04
摘要： In various aspects of the present invention, nanoparticle compositions are provided which comprise (a) nanoparticles comprising at least one biodegradable polymer and (b) at least one pharmaceutical associated with the nanoparticles. In other aspects of the present invention, methods of forming nanoparticles compositions are provided, which comprise contacting a first liquid that comprises one or more biodegradable polymers dissolved in a first solvent with a second liquid that comprises a second solvent which is miscible with the first solvent while being a non-solvent for the one or more biodegradable polymers, such that nanoparticles are formed.
摘要翻译： 在本发明的各个方面，提供纳米颗粒组合物，其包含（a）包含至少一种生物可降解聚合物的纳米颗粒和（b）至少一种与纳米颗粒相关的药物。 在本发明的其他方面，提供了形成纳米颗粒组合物的方法，其包括将包含溶解在第一溶剂中的一种或多种可生物降解的聚合物的第一液体与包含与第一溶剂混溶的第二溶剂的第二液体接触 同时作为一种或多种可生物降解的聚合物的非溶剂，使得形成纳米颗粒。
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公开(公告)号：US20090035326A1
公开(公告)日：2009-02-05
申请号：US12092379
申请日：2006-11-01
申请人： Mario Contorni , Manmohan Singh , Derek O'Hagan
发明人： Mario Contorni , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K39/385 , A61K47/04 , A61P31/04 , A61P31/16
CPC分类号： A61K39/02 , A61K39/095 , A61K2039/55505
摘要： Calcium phosphate is used as an adjuvant, with a high degree of antigen adsorption to the adjuvant. The invention is particularly useful for adjuvanting conjugated capsular saccharide antigens. Buffers, such as phosphate or histidine buffers, can advantageously be used in combination with the calcium phosphate, and compositions may have a pH in the range of 5.5 to 7.5.
摘要翻译： 使用磷酸钙作为佐剂，对佐剂具有高度的抗原吸附。 本发明特别可用于佐剂结合的荚膜糖抗原。 缓冲剂，例如磷酸盐或组氨酸缓冲液，可以有利地与磷酸钙组合使用，组合物的pH可以在5.5-7.5的范围内。
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公开(公告)号：US20050123599A1
公开(公告)日：2005-06-09
申请号：US11042745
申请日：2005-01-25
申请人： Gary Ott , Manmohan Singh , Derek O'Hagan
发明人： Gary Ott , Manmohan Singh , Derek O'Hagan
IPC分类号： A61K9/00 , A61K9/107 , A61K47/26 , C07H15/24 , A61K48/00 , A61K9/127 , A61K39/12 , A61K39/145 , A61K39/21
CPC分类号： A61K9/0019 , A61K9/107 , A61K47/26 , C07H15/24
摘要： The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant composition is provided that comprises: (a) water; (b) a metabolizable oil comprising at least one branched or unbranched long-chain hydrocarbon moiety; (c) a steroid; and (d) a saponin.
摘要翻译： 本发明涉及靶向免疫细胞和/或体液臂的新型佐剂组合物。 根据本发明的一个实施方案，提供了一种水包油佐剂组合物，其包含：（a）水; （b）包含至少一个支链或非支链长链烃部分的可代谢油; （c）类固醇; 和（d）皂苷。
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公开(公告)号：US11291635B2
公开(公告)日：2022-04-05
申请号：US13808089
申请日：2011-07-06
申请人： Andrew Geall , Christian Mandi , Derek O'Hagan , Manmohan Singh
发明人： Andrew Geall , Christian Mandi , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/50 , A61K39/155 , A61K39/245 , C12N15/86 , C12N15/88 , A61K39/12 , A61K9/127 , A61K9/00 , A61K39/00
摘要： Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
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公开(公告)号：US20140220083A1
公开(公告)日：2014-08-07
申请号：US14130886
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
摘要翻译： 本发明一般涉及含有高浓度阳离子脂质并具有确定的油脂比例的阳离子水包油乳剂。 阳离子脂质可以与带负电荷的分子相互作用，从而将分子固定在乳液颗粒上。 本文所述的阳离子乳液可用于将带负电荷的分子（例如核酸分子）递送至细胞，以及配制基于核酸的疫苗。
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公开(公告)号：US20140212498A1
公开(公告)日：2014-07-31
申请号：US14130880
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K31/713
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
摘要翻译： 本发明一般涉及可用于递送核酸分子（例如RNA分子）的阳离子水包油乳液。 乳剂颗粒包含油芯和阳离子脂质。 乳剂颗粒的平均直径为约80nm至约180nm，乳液的N / P比至少为1.1:1。
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