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公开(公告)号：US20120114673A1
公开(公告)日：2012-05-10
申请号：US13357913
申请日：2012-01-25
申请人： Mark S. Dennis , William Mallet , Paul Polakis
发明人： Mark S. Dennis , William Mallet , Paul Polakis
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： A61K47/6803 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
摘要： The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于诊断和治疗哺乳动物肿瘤的物质的抗体药物共轭组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20120045448A1
公开(公告)日：2012-02-23
申请号：US13030885
申请日：2011-02-18
申请人： Mark Reynolds , Paul Polakis
发明人： Mark Reynolds , Paul Polakis
IPC分类号： A61K39/395 , A61K31/165 , C12N5/02 , C07C233/57 , A61P35/00 , A61K31/5375 , C07D265/30
CPC分类号： C07C233/58 , A61K31/00 , A61K31/16 , A61K31/175 , A61K31/513 , A61K31/66 , C07C233/59 , C07C233/60 , C07C2601/14 , C07C2602/08 , C07D239/22 , C07D295/096 , C07D295/135 , C07D307/58
摘要： Compounds of the disclosure provide compositions, which are effective for prophylaxis and treatment of diseases or disorders, such as cell-proliferation, angiogenesis, or apoptosis mediated diseases. The disclosure encompasses compounds, analogs, prodrugs, metabolites, and pharmaceutically acceptable salts thereof, pharmaceutical compositions, and methods for prophylaxis and treatment of diseases and other maladies or conditions involving cancer, tumors, and like conditions. The disclosure also provides therapeutic methods including the administration of an effective amount of a compound of the disclosure.
摘要翻译： 本公开的化合物提供对预防和治疗诸如细胞增殖，血管生成或细胞凋亡介导的疾病等疾病或病症有效的组合物。 本公开包括其化合物，类似物，前药，代谢产物及其药学上可接受的盐，药物组合物和预防和治疗涉及癌症，肿瘤等病症和其它疾病或病症的方法。 本公开还提供治疗方法，包括施用有效量的本发明化合物。
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公开(公告)号：US08084200B2
公开(公告)日：2011-12-27
申请号：US12402434
申请日：2009-03-11
申请人： Avi J. Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin L. Gurney , Paul Polakis , Andrew Polson , William I. Wood , Thomas D. Wu , Zemin Zhang
发明人： Avi J. Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin L. Gurney , Paul Polakis , Andrew Polson , William I. Wood , Thomas D. Wu , Zemin Zhang
IPC分类号： C12Q1/68
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US07994135B2
公开(公告)日：2011-08-09
申请号：US11833954
申请日：2007-08-03
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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公开(公告)号：US20110177103A1
公开(公告)日：2011-07-21
申请号：US13045722
申请日：2011-03-11
申请人： Mark S. Dennis , William Mallet , Paul Polakis
发明人： Mark S. Dennis , William Mallet , Paul Polakis
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： A61K47/48569 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6803 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090081660A1
公开(公告)日：2009-03-26
申请号：US12079586
申请日：2008-03-26
申请人： Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth J. Hillan , Hartmut Koeppen , Heidi S. Phillips , Paul Polakis , Susan D. Spencer , Victoria Smith , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
发明人： Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth J. Hillan , Hartmut Koeppen , Heidi S. Phillips , Paul Polakis , Susan D. Spencer , Victoria Smith , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090075279A1
公开(公告)日：2009-03-19
申请号：US12156180
申请日：2008-05-29
申请人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Wang
发明人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Wang
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/30 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20090017473A1
公开(公告)日：2009-01-15
申请号：US12156218
申请日：2008-05-29
申请人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
发明人： Gretchen Frantz , Kenneth J. Hillan , Heidi Phillips , Paul Polakis , Susan D. Spencer , P. Mickey Williams , Thomas D. Wu , Zemin Zhang
IPC分类号： G01N33/574
CPC分类号： C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K16/18 , C07K16/30 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20080254024A1
公开(公告)日：2008-10-16
申请号：US11831787
申请日：2007-07-31
申请人： Weiguang Mao , Paul Polakis
发明人： Weiguang Mao , Paul Polakis
IPC分类号： A61K39/395 , C07K16/28 , C07H21/00 , C12N15/00 , G01N33/574 , C12N5/00 , C12N1/21 , C12P21/04
CPC分类号： C07K7/08 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K2039/505 , C07K7/06 , C07K16/2866 , C07K2317/77 , C07K2317/92
摘要： The invention provides anti-EphB2 antibodies, immunoconjugates, and compositions comprising and methods of using these antibodies and immunoconjugates.
摘要翻译： 本发明提供抗EphB2抗体，免疫缀合物和包含使用这些抗体和免疫缀合物的组合物。
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公开(公告)号：US20080226657A1
公开(公告)日：2008-09-18
申请号：US11833964
申请日：2007-08-03
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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