摘要:
The present invention relates to a cannulated orthopedic screw having a torque driving head with a spherical wall for multiaxial use, a rounded fluted insertion tip and a threaded portion including a cancellous thread contiguous with a non-threaded portion. The threaded portion has a major diameter defined by a spiraling cancellous type thread and a minor diameter. The screw includes a multilobe torque driving recess.
摘要:
A support and a method for fluidic assembly are provided. The support has a surface having binding sites adapted to receive micro-components of a type that are applied to the surface using a fluid; and energy absorbing heat producers at selected binding site. Each energy absorbing heat producer is adapted to receive energy and to transduce a portion of the received energy to heat the fluid proximate to the selected binding sites; so that when the micro-components are applied using a fluid that increases viscosity when heated, the heat generated by the energy absorbing heat producers increases the viscosity of the fluid proximate to the selected binding sites to prevent the micro-components from attaching to the selected binding sites.
摘要:
A method of transferring organic material from a donor element to a substrate includes providing a radiation source; and selecting the power of the radiation applied to the donor element by the radiation source to cause the transfer of organic material to the substrate wherein the time that one or more positions of the donor element receives radiation is greater than 1 millisecond.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
The invention provides a process for selecting and ordering one or more sets of linguistic objects. The invention orders a current list of items for selection that comprises a first list of one or more items of a first language and a second list of one or more items of a second language, the current list of items being displayed in an order based on the first language having a priority over the second language. In response to a user selection of one item from the second list, the invention changes a priority for ordering a subsequent list of items to order the subsequent list of items based on the second language having a priority over the first language.
摘要:
The invention concerns user entry of information into a system with an input device. A scheme is provided in which an entire word that a user wants to enter is predicted after the user enters a specific symbol, such as a space character. If the user presses an ambiguous key thereafter, rather than accept the prediction, the selection list is reordered. For example, a user enters the phrase “Lets run to school. Better yet, lets drive to “.””” After the user presses the space, after first entering the second occurrence of the word “to,” the system predicts that the user is going to enter the word “school” based on the context in which the user has entered that word in the past. Should the user enter an ambiguous key after the space, then a word list which contains the word “school” is reordered and other options are made available to the user. The invention can also make predictions on context, such as the person to whom the message is sent, the person writing the message, the day of the week, the time of the week, etc. Other embodiments of the invention contemplate anticipation of user actions, as well as words, such as a user action in connection with menu items, or a user action in connection with form filling.
摘要:
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要:
This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered carbocyclo ring; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译:本发明描述了式III的新型吡唑化合物:其中环D是选自芳基,杂芳基,杂环基或碳环基的5-7元单环或8-10元双环; R x和R y与它们的插入原子一起形成稠合的,不饱和的或部分不饱和的5-8元碳环; 和R 2和R 2'如说明书中所述。 这些化合物可用作蛋白激酶抑制剂,特别是作为用于治疗诸如癌症,糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
摘要:
This invention describes novel pyrazole compounds of formula IIa: wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译:本发明描述了式IIa的新型吡唑化合物:其中R 1是T环D,其中环D是5-7元单环或选自芳基,杂芳基,杂环基或碳环基的8-10元双环; R x和R y与它们的插入原子一起形成具有0-3个杂原子的稠合的,不饱和的或部分不饱和的5-7元环; R 2和R 2如说明书中所述。 这些化合物可用作蛋白激酶抑制剂,特别是作为Aurora-2和GSK-3的抑制剂用于治疗诸如癌症,糖尿病和阿尔茨海默病的疾病。