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    Poly(ester amide) block copolymers
    52.
    发明授权
    Poly(ester amide) block copolymers 有权
    聚（酯酰胺）嵌段共聚物

    公开(公告)号：US07419504B2

    公开(公告)日：2008-09-02

    申请号：US11023837

    申请日：2004-12-27

    申请人： Syed Faiyaz Ahmed Hossainy

    发明人： Syed Faiyaz Ahmed Hossainy

    IPC分类号： A61K9/16 ,  A61K47/48 ,  C08G69/44 ,  A61L31/16 ,  A61L31/10

    CPC分类号： C08G69/44 ,  A61K47/593 ,  A61K47/595 ,  A61K47/64 ,  A61L27/34 ,  A61L31/10 ,  C08L77/12

    摘要： Provided herein is a copolymer that includes a soft block (A) that contains poly(ester amide) (PEA) and a hard block (B). The copolymer can be any of AB, ABA or BAB type block copolymers. By varying the relative amount of the PEA block and the hard block, one can obtain a copolymer with a Tg for mechanical integrity in drug-delivery stent applications. The copolymer can be used alone or optionally in combination with a biobeneficial material and/or a biocompatible polymer to form an implantable device or a coating on an implantable device. When the copolymer is used in combination with a biobeneficial material, the copolymer and the biobeneficial material can be co-deposited or applied in sequence during the coating process. A coating formed of the copolymer may also include a bioactive agent. The implantable device can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, and/or tumor obstruction.

    摘要翻译： 本文提供了包含含有聚（酯酰胺）（PEA）和硬嵌段（B）的软嵌段（A）的共聚物。 共聚物可以是AB，ABA或BAB型嵌段共聚物中的任一种。 通过改变PEA嵌段和硬嵌段的相对量，可以获得在药物递送支架应用中机械完整性的具有Tα的共聚物。 共聚物可以单独使用或任选地与生物有益材料和/或生物相容性聚合物组合使用以在可植入装置上形成可植入装置或涂层。 当共聚物与生物有益材料组合使用时，共聚物和生物有益材料可以在涂覆过程中按顺序共沉积或应用。 由共聚物形成的涂层也可以包括生物活性剂。 可植入装置可以植入患者体内以治疗，预防或改善诸如动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉吻合增殖等障碍 人工移植物，胆管阻塞，输尿管梗阻和/或肿瘤阻塞。