公开(公告)号：US20120008195A1

公开(公告)日：2012-01-12

申请号：US13177005

申请日：2011-07-06

申请人： Artur Hoegele ,  Christoph Hauger ,  Fenny Nauli

发明人： Artur Hoegele ,  Christoph Hauger ,  Fenny Nauli

IPC分类号： G02B21/02

CPC分类号： G02B21/025

摘要： Microscope system for acquiring a plurality of images, comprising: a zoom system which is configured to continuously vary a magnification of the microscope system over a magnification range of the microscope system, wherein the zoom system comprises two movable zoom components, which are arranged movably along a common optical axis of the microscope system; an aperture stop, which is configured such that a plurality of different observation beam paths of the microscope system are selectable, which traverse the zoom system; wherein the aperture stop, as seen along the optical axis, is arranged between the two movable zoom components; and wherein for all values of the magnification within the magnification range, the aperture stop is located within an aperture stop range which is measured along the optical axis and which surrounds a pupil position of the microscope system.

摘要翻译： 一种用于获取多个图像的显微镜系统，包括：变焦系统，被配置为在所述显微镜系统的放大范围内连续地改变所述显微镜系统的放大倍数，其中，所述变焦系统包括两个可移动的变焦分量， 显微镜系统的共同光轴; 孔径光阑被配置为使得可选择显微镜系统的多个不同的观察光束路径，其横越变焦系统; 其中，沿着所述光轴看到的所述孔径光阑布置在所述两个可移动变焦部件之间; 并且其中对于倍率范围内的所有放大倍率值，孔径光阑位于沿着光轴测量并围绕显微镜系统的光瞳位置的孔径光阑范围内。

公开(公告)号：US20110280810A1

公开(公告)日：2011-11-17

申请号：US13043120

申请日：2011-03-08

申请人： Christoph Hauger ,  Guido Hattendorf ,  Peter Maxwell Delaney ,  Robert F. Spetzler ,  Mark C. Preul ,  Jennifer Eschbacher ,  Peter Nakaji

发明人： Christoph Hauger ,  Guido Hattendorf ,  Peter Maxwell Delaney ,  Robert F. Spetzler ,  Mark C. Preul ,  Jennifer Eschbacher ,  Peter Nakaji

IPC分类号： A61K49/00 ,  A61B6/00

CPC分类号： A61B5/0068 ,  A61B1/00188 ,  A61B1/043 ,  A61B1/313 ,  A61B5/4064 ,  A61B90/20 ,  G02B21/0052

摘要： A method of detecting a brain tumor includes administering indocyanine green to a living body; exposing brain tissue in the living body; irradiating the exposed brain tissue with excitation light of indocyanine green; obtaining an image based on fluorescence of the excited indocyanine green in the brain tissue, wherein the image is obtained using an endomicroscope; and identifying portions of the brain tissue corresponding to the brain tumor based on the image.

摘要翻译： 检测脑肿瘤的方法包括向活体施用吲哚青绿; 暴露生物体内的脑组织; 用吲哚菁绿的激发光照射暴露的脑组织; 基于脑组织中激发的吲哚菁绿的荧光获得图像，其中使用内窥镜获得图像; 以及基于图像识别与脑肿瘤相对应的脑组织的部分。

公开(公告)号：US07924307B2

公开(公告)日：2011-04-12

申请号：US10918387

申请日：2004-08-16

申请人： Helge Jess ,  Ulrich Gold ,  Dieter Quendt ,  Christoph Hauger

发明人： Helge Jess ,  Ulrich Gold ,  Dieter Quendt ,  Christoph Hauger

IPC分类号： H04N13/00 ,  H04N13/02 ,  H04N7/18

CPC分类号： G02B21/0012 ,  G02B21/22 ,  G02B21/361 ,  G02B21/365 ,  G02B26/008 ,  G02B26/023 ,  H04N13/239 ,  H04N13/332

摘要： An optical viewing system (100) for viewing an object region has a display unit (105) which has a plurality of controllable display segments which make available color pulse sequences in order to generate a display image which is built up of a plurality of image points. The optical viewing system (100) includes a superposition unit (110) which superposes an image, which is made available by the display unit (105), onto the image of an object region (104). The optical viewing system has a camera unit (111, 113) to which the superposed image of display unit (105) and object region (104) is supplied. The camera unit (111, 113) has image sensors (112, 114) whose light sensitivity is adjustable as a function of time. The light sensitivity of the image sensors (112, 114) is matched to the color pulse sequence in such a manner that the image sensor (112, 114) can detect at least two light pulses of different color from the color pulse sequence from a display segment.

摘要翻译： 用于观看物体区域的光学观察系统（100）具有显示单元（105），该显示单元具有多个可控显示区段，该可显示区段提供可用的色彩脉冲序列，以便产生由多个图像点构成的显示图像 。 光学观察系统（100）包括将由显示单元（105）可用的图像叠加在对象区域（104）的图像上的叠加单元（110）。 光学观察系统具有显示单元（105）和对象区域（104）的叠加图像被提供到的相机单元（111,113）。 相机单元（111,113）具有其光敏度作为时间的函数可调的图像传感器（112,114）。 图像传感器（112,114）的光灵敏度与色彩脉冲序列匹配，使得图像传感器（112,114）可以从显示器的颜色脉冲序列中检测不同颜色的至少两个光脉冲 分割。

公开(公告)号：US07901080B2

公开(公告)日：2011-03-08

申请号：US12453349

申请日：2009-05-07

申请人： Christoph Hauger ,  Markus Seesselberg ,  Dieter Quendt

发明人： Christoph Hauger ,  Markus Seesselberg ,  Dieter Quendt

IPC分类号： A61B3/00 ,  G02B21/00

CPC分类号： G01B9/04 ,  A61B3/13 ,  A61B90/20 ,  A61B90/25

摘要： The invention is directed to an ophthalmologic surgical microscope system (100) for examining the eye of a patient. The ophthalmologic surgical microscope system includes a surgical microscope (101) as well as a carrier arrangement (102) wherein the surgical microscope (101) is accommodated so as to permit elevation adjustment in order to be able to adjust a work distance between the surgical microscope (101) and the eye of the patient. An ophthalmoscopic ancillary module (103) is connected to the surgical microscope and has an adjustable ophthalmoscopic magnifier system in order to adjust a distance between the ophthalmoscopic magnifier and the surgical microscope (101). The ophthalmologic surgical microscope system (100) has a sensor system for measuring the distance of the surgical microscope (101) from the patient eye. The sensor system is configured as an OCT-measuring device.

摘要翻译： 本发明涉及用于检查患者眼睛的眼科手术显微镜系统（100）。 眼科手术显微镜系统包括手术显微镜（101）以及载体装置（102），其中容纳手术显微镜（101）以允许高度调节，以便能够调节手术显微镜 （101）和患者的眼睛。 眼科辅助模块（103）连接到手术显微镜并且具有可调节的眼底放大镜系统，以便调整眼镜放大镜和手术显微镜（101）之间的距离。 眼科手术显微镜系统（100）具有用于测量手术显微镜（101）与患者眼睛的距离的传感器系统。 传感器系统配置为OCT测量装置。

公开(公告)号：US20100110538A1

公开(公告)日：2010-05-06

申请号：US12162601

申请日：2007-01-30

申请人： Joachim Steffen ,  Helge Jess ,  Christoph Hauger

发明人： Joachim Steffen ,  Helge Jess ,  Christoph Hauger

IPC分类号： G02B21/06 ,  G02B21/36

CPC分类号： G02B21/16 ,  G02B21/20 ,  G02B21/22

摘要： Disclosed is a microscope system (1) for sequential observation of different fluorescent dyes that are accumulated in a tissue located in an object plane (22). An illumination system (70) of the microscope system (1) for illuminating the object plane (22) with illumination radiation has at least two operating states. In one of the at least two operating states, the illumination radiation has a spectrum which includes an excitation band (A1) of a first fluorescent dye and, at the same time, is partly free from an excitation band (A2) of another fluorescent dye. An observation system (2) of the microscope system (1) for providing a first observation optical path (33) for optically imaging the object plane (22) has two different operating states as well. In one of the at least two operating states observation radiation guided in the first observation optical path (33) has a spectrum in sections of the first observation optical path which includes a first fluorescence band (F1) of the first fluorescent dye, while in at least one other operating state observation radiation guided in the first observation optical path (33) has a spectrum in at least some sections of the first observation optical path which is partly free from the first fluorescence band (F1) of the first fluorescent dye. The disclosed microscope system (1) further comprises a controller (3) which is configured to selectively switch the illumination system (70) as well as the observation system (2) into the first operating state, or to switch the illumination system (70) as well as the observation system (2) into the second operating state.

摘要翻译： 公开了用于顺序观察累积在位于物平面（22）内的组织中的不同荧光染料的显微镜系统（1）。 用照明辐射照射物平面（22）的显微镜系统（1）的照明系统（70）具有至少两个操作状态。 在所述至少两个操作状态中的一个中，所述照射辐射具有包括第一荧光染料的激发带（A1）的光谱，并且同时部分地不含另一荧光染料的激发带（A2） 。 用于提供用于对物平面（22）进行光学成像的第一观察光路（33）的显微镜系统（1）的观察系统（2）也具有两种不同的工作状态。 在所述至少两个操作状态中的一个中，在所述第一观察光路（33）中引导的观察辐射中的所述第一观察光路的具有所述第一荧光染料的第一荧光带（F1）的部分的光谱， 在第一观察光路（33）中引导的至少一个其他操作状态观察辐射在第一观察光路的至少部分没有第一荧光染料的第一荧光带（F1）的部分具有光谱。 所公开的显微镜系统（1）还包括控制器（3），其被配置为选择性地将照明系统（70）以及观察系统（2）切换到第一操作状态，或者切换照明系统（70） 以及观察系统（2）进入第二操作状态。

公开(公告)号：US20100044583A1

公开(公告)日：2010-02-25

申请号：US12506016

申请日：2009-07-20

申请人： Joachim Steffen ,  Christoph Hauger

发明人： Joachim Steffen ,  Christoph Hauger

IPC分类号： G01J1/58 ,  G02B5/22

CPC分类号： G01N21/6458 ,  A61B5/0059 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/6428 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G02B5/20 ,  G02B5/208 ,  G02B21/16

摘要： A filter set for observing fluorescent radiation in biological tissue includes at least one illumination filter and at least one observation filter. The at least one illumination filter is arrangeable in an illumination system of an optical system. The at least one least one observation filter is arrangeable in an imaging system of the optical system.

摘要翻译： 用于观察生物组织中的荧光辐射的滤光器组包括至少一个照明滤光器和至少一个观察滤光片。 所述至少一个照明滤光器可布置在光学系统的照明系统中。 所述至少一个至少一个观察滤波器可布置在所述光学系统的成像系统中。

公开(公告)号：US20090279052A1

公开(公告)日：2009-11-12

申请号：US12453349

申请日：2009-05-07

申请人： Christoph Hauger ,  Markus Seesselberg ,  Dieter Quendt

发明人： Christoph Hauger ,  Markus Seesselberg ,  Dieter Quendt

IPC分类号： A61B3/13 ,  A61B3/15

CPC分类号： G01B9/04 ,  A61B3/13 ,  A61B90/20 ,  A61B90/25

摘要： The invention is directed to an ophthalmologic surgical microscope system (100) for examining the eye of a patient. The ophthalmologic surgical microscope system includes a surgical microscope (101) as well as a carrier arrangement (102) wherein the surgical microscope (101) is accommodated so as to permit elevation adjustment in order to be able to adjust a work distance between the surgical microscope (101) and the eye of the patient. An ophthalmoscopic ancillary module (103) is connected to the surgical microscope and has an adjustable ophthalmoscopic magnifier system in order to adjust a distance between the ophthalmoscopic magnifier and the surgical microscope (101). The ophthalmologic surgical microscope system (100) has a sensor system for measuring the distance of the surgical microscope (101) from the patient eye. The sensor system is configured as an OCT-measuring device.

摘要翻译： 本发明涉及用于检查患者眼睛的眼科手术显微镜系统（100）。 眼科手术显微镜系统包括手术显微镜（101）以及载体装置（102），其中容纳手术显微镜（101）以允许高度调节，以便能够调节手术显微镜 （101）和患者的眼睛。 眼科辅助模块（103）连接到手术显微镜并且具有可调节的眼底放大镜系统，以便调整眼镜放大镜和手术显微镜（101）之间的距离。 眼科手术显微镜系统（100）具有用于测量手术显微镜（101）与患者眼睛的距离的传感器系统。 传感器系统配置为OCT测量装置。

公开(公告)号：US20090155735A1

公开(公告)日：2009-06-18

申请号：US12335579

申请日：2008-12-16

申请人： Christoph Hauger

发明人： Christoph Hauger

IPC分类号： A61C3/00

CPC分类号： A61B5/0088 ,  A61B5/6844 ,  A61B5/6886

摘要： A dental apparatus uses a white light interferometer (7) and has an emitter (31) for emitting measurement radiation toward a tooth, a receiver (31) for receiving measurement radiation reflected by the tooth, superposition equipment (21) for superposing reference radiation and reflected measurement radiation, and a detector (23) for detecting the superposed radiation and generating an interferometric signal representing the superposed radiation. The emitter (31) and receiver (31) are in the distal end (5) of a dental instrument (1) that can be brought close to the tooth. A control unit (13) causes the white light interferometer (7) to carry out depth scans of the tooth. An analyzer (9) receives the interferometric signal from the detector (23) and determines a distance to the pulp of the tooth from its surface. A warning device (11) is connected to the analyzer (9) and emits a signal when the distance reaches a predetermined minimum distance.

摘要翻译： 牙科设备使用白光干涉仪（7）并具有用于向牙齿发射测量辐射的发射器（31），用于接收由牙齿反射的测量辐射的接收器（31），用于叠加参考辐射的叠加设备（21） 以及用于检测叠加的辐射并产生表示叠加辐射的干涉信号的检测器（23）。 发射器（31）和接收器（31）位于可以靠近牙齿的牙科器具（1）的远端（5）中。 控制单元（13）使得白光干涉仪（7）对牙齿进行深度扫描。 分析器（9）从检测器（23）接收干涉信号，并从其表面确定与牙髓的距离。 警告装置（11）连接到分析器（9），并且当距离达到预定的最小距离时发出信号。

公开(公告)号：US20080304144A1

公开(公告)日：2008-12-11

申请号：US11984818

申请日：2007-11-21

申请人： Peter Reimer ,  Christoph Hauger ,  Alfons Abele ,  Markus Seesselberg

发明人： Peter Reimer ,  Christoph Hauger ,  Alfons Abele ,  Markus Seesselberg

IPC分类号： G02B21/22

CPC分类号： A61B5/0073 ,  A61B5/0066 ,  A61B90/20 ,  A61B90/36 ,  G02B21/0012

摘要： A surgical microscope (100) has viewing beams (109a, 109b) passing through a microscope imaging optic which includes a microscope main objective system (101) having a magnification system of variable magnification. The microscope imaging optic transposes a convergent viewing beam (109a, 109b) from the object region (114) into a parallel beam. The surgical microscope includes an OCT-system (120) for examining the object region (114). The OCT-system (120) makes available an OCT-scanning beam (190) which is guided through the microscope imaging optic.

摘要翻译： 手术显微镜（100）具有通过显微镜成像光学元件的观察光束（109a，109b），其包括具有可变放大倍数的放大系统的显微镜主要物镜系统（101）。 显微镜成像光学器件将会聚观察光束（109a，109b）从对象区域（114）转换成平行光束。 手术显微镜包括用于检查对象区域（114）的OCT系统（120）。 OCT系统（120）提供了OCT扫描光束（190），其被引导通过显微镜成像光学元件。

公开(公告)号：US07400409B2

公开(公告)日：2008-07-15

申请号：US10538587

申请日：2003-12-16

申请人： Christoph Hauger ,  Hans-Joachim Miesner ,  Ludwin Monz

发明人： Christoph Hauger ,  Hans-Joachim Miesner ,  Ludwin Monz

IPC分类号： G01B9/02

CPC分类号： G02B21/0004 ,  G01B9/02091 ,  G01B2290/65

摘要： A coherence microscope has a divider (3) that divides light emitted by a light source (1) into measurement light, which is supplied to and reflected by a specimen (13), and reference light. A superimposition device (25, 31) superimposes the measurement light reflected by the specimen (13) with the reference light. A short sensor array (41) detects the light resulting from the superimposition and permits a read-out rate of at least about 60 kHz. The superimposition device has an emission device (25, 31) for emitting the measurement light and the reference light arranged to effect extensive irradiation of the sensor array (41) with superimposed light. The ratio of distances covered by the measurement light and the reference light from the emission device (25, 31) to impingement points on the sensor array (41) varies in the portion of the sensor array (41) that is irradiated with superimposed light.

摘要翻译： 相干显微镜具有将由光源（1）发射的光分离成被供给到试样（13）并被反射的测量光和参考光的分割器（3）。 叠加装置（25,31）将由试样（13）反射的测量光与参考光重叠。 短传感器阵列（41）检测由叠加产生的光，并允许至少约60kHz的读出速率。 叠加装置具有用于发射测量光的发射装置（25,31）和布置成以叠加的光来广泛照射传感器阵列（41）的参考光。 测量光所覆盖的距离与来自发射装置（25,31）的参考光与传感器阵列（41）上的撞击点的比率在用叠加的光照射的传感器阵列（41）的部分中变化。