公开(公告)号：US07909775B2

公开(公告)日：2011-03-22

申请号：US11768641

申请日：2007-06-26

申请人： Don Alden ,  Dominique M. Freeman ,  Paul Lum

发明人： Don Alden ,  Dominique M. Freeman ,  Paul Lum

IPC分类号： A61B5/00

CPC分类号： B01L3/5027 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150809 ,  A61B5/150832 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/15142 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2400/0406

摘要： A method and apparatus (2) for obtaining a sample of blood. An embodiment includes of an apparatus (2) which integrates lancing (12), sample collection, and analysis. The presence of patients finger on the active sampling area can be sensed by monitoring the pressure applied by the finger on the device (2).

摘要翻译： 一种用于获得血液样本的方法和装置（2）。 实施例包括集成穿刺（12），样本收集和分析的装置（2）。 可以通过监测手指在装置（2）上施加的压力来感测患者手指在活动取样区域上的存在。

公开(公告)号：US07892183B2

公开(公告)日：2011-02-22

申请号：US10613517

申请日：2003-07-03

申请人： Dirk Boecker ,  Dominique M. Freeman ,  Don Alden

发明人： Dirk Boecker ,  Dominique M. Freeman ,  Don Alden

IPC分类号： A61B5/00 ,  A61B17/14 ,  A61B17/32 ,  B65D81/00

CPC分类号： A61B5/15146 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150183 ,  A61B5/150305 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/157

摘要： A body fluid sampling system is provided for use on a tissue site. In one embodiment, the system comprises a cartridge; a penetrating member driver; a plurality of penetrating members arranged in a radial configuration on the cartridge wherein sharpened distal tips of the penetrating members point radially outward; wherein an active one of the penetrating members may be operatively coupled to the penetrating member driver, the penetrating member driver moving the active one along a path out of a housing having a penetrating member exit, into the tissue site, stopping in the tissue site, and withdrawing out of the tissue site; and a plurality of analyte detecting members, wherein at least one of the analyte detecting members is positioned to receive fluid from a wound created by the active one of the penetrating members, wherein the detecting members are not pierced by the active one of the penetrating members.

公开(公告)号：US20110016691A1

公开(公告)日：2011-01-27

申请号：US12861514

申请日：2010-08-23

申请人： Don Alden ,  Travis Marsot

发明人： Don Alden ,  Travis Marsot

IPC分类号： B23P11/00

CPC分类号： A61B5/14532 ,  A61B5/1468 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15128 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/15176 ,  A61B5/157 ,  Y10T29/49764 ,  Y10T29/49771 ,  Y10T29/49826 ,  Y10T29/49885 ,  Y10T29/49904

摘要： An assembly is described that combines blood chemical analysis with lancing in a single multiple-test disposable cartridge. The penetrating members can be assembled and sterilized without damaging the analytical chemistry, and the functioning of the present radical disc cartridge mechanism is not substantially modified.

摘要翻译： 描述了将血液化学分析与单次多次测试的一次性药筒中的穿刺相结合的组件。 穿透构件可以组装和灭菌而不损坏分析化学物质，并且本质的盘式存储器机构的功能基本上不被改变。

公开(公告)号：US07875047B2

公开(公告)日：2011-01-25

申请号：US11627252

申请日：2007-01-25

申请人： Dominique Freeman ,  Don Alden ,  Dirk Boecker ,  Mike Cane ,  Matt Schumann ,  Mike Beadman

发明人： Dominique Freeman ,  Don Alden ,  Dirk Boecker ,  Mike Cane ,  Matt Schumann ,  Mike Beadman

IPC分类号： A61B17/14

CPC分类号： A61B5/1411 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150664 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150916 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/1513 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15161 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15182 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M37/0015

摘要： A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend outward from the cartridge to penetrate tissue. Each cavity has a longitudinal opening that provides access to an elongate portion of the penetrating member. A sterility barrier is coupled to the cartridge. The sterility barrier covers a plurality of the longitudinal openings. The sterility barrier is configured to be moved so that the elongate portion is accessed by the gripper without touching the barrier.

摘要翻译： 提供了一种与夹具一起使用的装置。 提供限定多个空腔的盒。 多个穿透构件至少部分地容纳在盒的空腔中。 穿透构件可滑动地移动以从筒向外延伸以穿透组织。 每个空腔具有纵向开口，其提供对穿透构件的细长部分的通路。 无菌屏障耦合到墨盒。 无菌屏障覆盖多个纵向开口。 无菌屏障被配置为移动，使得细长部分被夹持器接近而不接触屏障。

公开(公告)号：US07850622B2

公开(公告)日：2010-12-14

申请号：US11318242

申请日：2005-12-22

申请人： Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

发明人： Dominique Freeman ,  Dirk Boecker ,  Don Alden ,  Barry Dean Briggs ,  Jon Hewitt Leonard ,  Ray Freeman ,  George Gogue

IPC分类号： A61B5/00

CPC分类号： A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

摘要： A moving coil tissue penetration device includes a magnetic source that produces a magnetic field in a magnetically active region. A cylindrical coil is secured to a translation substrate and disposed at least partially within the magnetically active region. A sharpened member is configured to penetrate tissue and mechanically coupled to the translation substrate.

摘要翻译： 移动线圈组织穿透装置包括在磁性活性区域中产生磁场的磁源。 圆柱形线圈被固定到平移衬底并且至少部分地设置在磁性有效区域内。 锋利的构件构造成穿透组织并机械耦合到平移衬底。

公开(公告)号：US07850621B2

公开(公告)日：2010-12-14

申请号：US10559223

申请日：2004-06-07

申请人： Barry Dean Briggs ,  Travis Marsot ,  Jason Hegener ,  Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Matt Schumann ,  Mike Beadman

发明人： Barry Dean Briggs ,  Travis Marsot ,  Jason Hegener ,  Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Matt Schumann ,  Mike Beadman

IPC分类号： A61B5/00 ,  A61B17/32 ,  A61B17/14 ,  B65D81/00

CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150412 ,  A61B5/150755 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15161

摘要： A method of controlling a penetrating member is provided. The method comprises providing a lancing device comprising a penetrating member driver having a position sensor and a processor that can determine the relative position and velocity of the penetrating member based on measuring relative position of the penetrating member with respect to time; providing a predetermined velocity control trajectory based on a model of the driver and a model of tissue to be contacted. In some embodiments, a feedforward control to maintain penetrating member velocity along said trajectory.

摘要翻译： 提供了一种控制穿透构件的方法。 该方法包括提供穿刺装置，其包括具有位置传感器和处理器的穿透构件驱动器，所述穿透构件驱动器可以基于测量穿透构件相对于时间的相对位置来确定穿透构件的相对位置和速度; 基于驾驶员的模型和待接触的组织的模型提供预定的速度控制轨迹。 在一些实施例中，前馈控制器沿着所述轨迹保持穿透构件速度。

公开(公告)号：US20100274157A1

公开(公告)日：2010-10-28

申请号：US12797706

申请日：2010-06-10

申请人： Barry Dean Briggs ,  Travis Marsot ,  Jason Hegener ,  Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Matt Schumann ,  Mike Beadman

发明人： Barry Dean Briggs ,  Travis Marsot ,  Jason Hegener ,  Dominique M. Freeman ,  Dirk Boecker ,  Don Alden ,  Matt Schumann ,  Mike Beadman

IPC分类号： A61B5/151

CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150412 ,  A61B5/150755 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15161

摘要： A method of controlling a penetrating member is provided. The method comprises providing a lancing device comprising a penetrating member driver having a position sensor and a processor that can determine the relative position and velocity of the penetrating member based on measuring relative position of the penetrating member with respect to time; providing a predetermined velocity control trajectory based on a model of the driver and a model of tissue to be contacted. In some embodiments, a feedforward control to maintain penetrating member velocity along said trajectory.

公开(公告)号：US07749174B2

公开(公告)日：2010-07-06

申请号：US10363510

申请日：2002-06-12

申请人： Don Alden ,  Dominique M. Freeman ,  Paul Lum

发明人： Don Alden ,  Dominique M. Freeman ,  Paul Lum

IPC分类号： A61B5/00

CPC分类号： B01L3/5027 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150809 ,  A61B5/150832 ,  A61B5/15111 ,  A61B5/15117 ,  A61B5/15142 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  B01L2200/027 ,  B01L2200/143 ,  B01L2300/0816 ,  B01L2400/0406

摘要： A method and apparatus for obtaining a sample of blood. An embodiment consists of an apparatus which integrates lancing, sample collection, and analysis. The presence of patients finger on the active sampling area can be sensed by monitoring the pressure applied by the finger on the device.

摘要翻译： 一种获得血液样本的方法和装置。 一个实施例由一个整合穿刺，样本收集和分析的装置组成。 可以通过监测手指在装置上施加的压力来感测患者手指在活动取样区域上的存在。

公开(公告)号：US07699791B2

公开(公告)日：2010-04-20

申请号：US10363509

申请日：2002-06-12

申请人： Don Alden ,  Dominique M. Freeman ,  Paul Lum ,  Vladimir Drbal ,  Dirk Boecker ,  Edward D. Verdonk

发明人： Don Alden ,  Dominique M. Freeman ,  Paul Lum ,  Vladimir Drbal ,  Dirk Boecker ,  Edward D. Verdonk

IPC分类号： A61B5/00

CPC分类号： A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150099 ,  A61B5/150167 ,  A61B5/150427 ,  A61B5/150503

摘要： Blood samples can be collected without substantial contamination from ambient air, such that the blood sample may be analyzed accurately for gaseous components such as oxygen and carbon dioxide. An embodiment of the device has integrated actuation, lancing, and sample acquisition components, which in some embodiments are miniatuized and/or disposable.

摘要翻译： 可以收集血液样本而没有来自环境空气的实质污染，使得可以准确地分析血液样品用于气体组分如氧气和二氧化碳。 该装置的一个实施例具有集成的致动，采血和采样部件，其在一些实施例中是微型化和/或一次性的。

公开(公告)号：US07648469B2

公开(公告)日：2010-01-19

申请号：US12023615

申请日：2008-01-31

申请人： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

发明人： Dirk Boecker ,  Don Alden ,  Dominique M. Freeman

IPC分类号： A61B5/00 ,  A61B10/00 ,  B65D81/00 ,  A61B17/14 ,  A61B17/32

CPC分类号： G01N33/557 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905

摘要： These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. An analyte detecting member is positioned to receive fluid from a wound created by the penetrating member. The detection member is configured to determine a concentration of an analyte in the fluid using a sample of less than 1 μL of the fluid.

摘要翻译： 本发明的这些和其它目的是在包括电动驱动力发生器的组织部位上使用的体液取样系统中实现的。 穿透构件可操作地联接到力发生器。 力产生器将构件沿着路径移动离开具有穿透构件出口的壳体，进入组织部位，在组织部位停止，并从组织部位抽出。 分析物检测构件定位成从由穿透构件产生的伤口接收流体。 检测构件被配置为使用小于1μl流体的样品来确定流体中分析物的浓度。