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310 条记录 (耗时 0.058 秒)

    Leukocyte regulatory factors 1 and 2
    51.
    发明申请
    Leukocyte regulatory factors 1 and 2 审中-公开
    白细胞调节因子1和2

    公开(公告)号：US20060063924A1

    公开(公告)日：2006-03-23

    申请号：US11272833

    申请日：2005-11-15

    申请人： Jian Ni ,  Jing-Shan Hu ,  Steven Ruben ,  Reiner Gentz

    发明人： Jian Ni ,  Jing-Shan Hu ,  Steven Ruben ,  Reiner Gentz

    IPC分类号： C07K14/475 ,  C07H21/02 ,  C12P21/06

    CPC分类号： C07K14/4702

    摘要： The present invention relates to novel LRF-1 and LRF-2 proteins which are related to the CRISP family and a protein called “Neutrophil Inhibitory Factor (NIF)” isolated from the canine hookworm (Ancylostoma caninum) that potently inhibits CD11/CD18-dependent neutrophil function. In particular, isolated nucleic acid molecules are provided encoding the human LRF-1 and LRF-2 proteins. LRF-1 and LRF-2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of LRF-1 or LRF-2 activity. Also provided are diagnostic methods for detecting immune system or other LRF-1- or LRF-2-related disorders and therapeutic methods for treating such disorders.

    摘要翻译： 本发明涉及与CRISP家族相关的新型LRF-1和LRF-2蛋白质，以及从犬钩虫（Ancylostoma caninum）中分离的称为“中性嗜中性粒细胞抑制因子（NIF）”的蛋白质，其有效抑制CD11 / CD18依赖性 中性粒细胞功能。 特别地，提供编码人LRF-1和LRF-2蛋白的分离的核酸分子。 还提供了LRF-1和LRF-2多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定LRF-1或LRF-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统或其他LRF-1或LRF-2相关疾病的诊断方法以及用于治疗这种疾病的治疗方法。

    Nucleic acids encoding tumor necrosis factor receptor 5
    54.
    发明授权
    Nucleic acids encoding tumor necrosis factor receptor 5 失效
    编码肿瘤坏死因子受体5的核酸

    公开(公告)号：US06261801B1

    公开(公告)日：2001-07-17

    申请号：US09006353

    申请日：1998-01-13

    申请人： Ying-Fei Wei ,  Reiner Gentz ,  Jian Ni ,  Steven M. Ruben

    发明人： Ying-Fei Wei ,  Reiner Gentz ,  Jian Ni ,  Steven M. Ruben

    IPC分类号： C12P2102

    CPC分类号： C07K14/70578 ,  A61K48/00

    摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5”, and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

    摘要翻译： 本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。 更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。 还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。 还提供了利用这种组合物的诊断和治疗方法。

    Polynucleotides encoding human G-protein coupled receptor GPRZ
    55.
    发明授权
    Polynucleotides encoding human G-protein coupled receptor GPRZ 失效
    编码人G蛋白偶联受体GPR2的多核苷酸

    公开(公告)号：US5998164A

    公开(公告)日：1999-12-07

    申请号：US467948

    申请日：1995-06-06

    申请人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/715 ,  C12N15/12 ,  C12N15/62

    CPC分类号： C07K14/7158 ,  C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： Human G-protein coupled receptor or polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体或多肽和编码此类多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    Ubiquitin conjugating enzymes 7,8 and 9
    56.
    发明授权
    Ubiquitin conjugating enzymes 7,8 and 9 失效
    泛素缀合酶7,8和9

    公开(公告)号：US5849286A

    公开(公告)日：1998-12-15

    申请号：US464604

    申请日：1995-06-05

    申请人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C12N9/00 ,  A61K38/51 ,  C12N9/10

    CPC分类号： C12N9/93 ,  C12Y603/02019 ,  A61K38/00

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

    摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。

    I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
    57.
    发明申请
    I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 审中-公开
    I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡

    公开(公告)号：US20060240036A1

    公开(公告)日：2006-10-26

    申请号：US11445311

    申请日：2006-06-02

    申请人： Jian Ni ,  Craig Rosen ,  Vishva Dixit ,  Reiner Gentz ,  Joseph Kenny

    发明人： Jian Ni ,  Craig Rosen ,  Vishva Dixit ,  Reiner Gentz ,  Joseph Kenny

    IPC分类号： A61K39/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N9/6475 ,  A61K38/00

    摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.

    摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。

    CD-44 like protein
    58.
    发明申请
    CD-44 like protein 审中-公开
    CD-44像蛋白质

    公开(公告)号：US20060142199A1

    公开(公告)日：2006-06-29

    申请号：US11359509

    申请日：2006-02-23

    申请人： Jian Ni ,  Reiner Gentz ,  Patrick Dillon

    发明人： Jian Ni ,  Reiner Gentz ,  Patrick Dillon

    IPC分类号： A61K38/17 ,  C07K14/74 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/70585 ,  A61K38/00 ,  C12N2799/026

    摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.

    摘要翻译： 本发明涉及一种新型的CD44样蛋白受体。 特别地，提供编码CD44样蛋白质的分离的核酸分子。 还提供CD44样多肽，以及用于鉴定能够增强或抑制CD44样蛋白介导的信号传导的激动剂和拮抗剂的筛选方法。 本发明还涉及用于治疗与由CD44样蛋白信号传导介导的过程相关的疾病的治疗方法。

    Tumor necrosis factor receptor-5
    59.
    发明授权
    Tumor necrosis factor receptor-5 失效
    肿瘤坏死因子受体-5

    公开(公告)号：US07049402B2

    公开(公告)日：2006-05-23

    申请号：US09826212

    申请日：2001-04-05

    申请人： Ying-Fei Wei ,  Reiner Gentz ,  Jian Ni ,  Steven M Ruben

    发明人： Ying-Fei Wei ,  Reiner Gentz ,  Jian Ni ,  Steven M Ruben

    IPC分类号： C07K14/00

    CPC分类号： C07K14/70578 ,  A61K48/00

    摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

    摘要翻译： 本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。 更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。 还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。 还提供了利用这种组合物的诊断和治疗方法。