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    Methods of inhibiting proliferation or immunoglobulin production of B cells using human tumor necrosis factor receptor TR-17 polypeptides
    2.
    发明授权
    Methods of inhibiting proliferation or immunoglobulin production of B cells using human tumor necrosis factor receptor TR-17 polypeptides 有权
    使用人肿瘤坏死因子受体TR-17多肽抑制B细胞增殖或免疫球蛋白产生的方法

    公开(公告)号：US08518389B2

    公开(公告)日：2013-08-27

    申请号：US12336051

    申请日：2008-12-16

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K38/16

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。

    Antibodies That Specifically Bind to Chemokine Beta-4
    5.
    发明申请
    Antibodies That Specifically Bind to Chemokine Beta-4 审中-公开
    特异性结合趋化因子β-4的抗体

    公开(公告)号：US20110223178A1

    公开(公告)日：2011-09-15

    申请号：US13017658

    申请日：2011-01-31

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  C12N5/071 ,  C07K16/24 ,  C12N9/96 ,  A61P17/06 ,  A61P17/00 ,  A61P37/06

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-β4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-β4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-β4.

    摘要翻译： 本发明涉及与CK-和bgr特异性结合的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括癌症的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 ，牛皮癣，皮炎和炎性肠病。 本发明还涉及编码抗CK-bgr4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 ，牛皮癣，皮炎和炎症性肠病，包括向动物，优选人类施用有效量的一种或多种特异性结合CK-1的抗体或其片段或变体或相关分子。

    Tumor necrosis factor receptors 6α and 6β
    6.
    发明授权
    Tumor necrosis factor receptors 6α and 6β 失效
    肿瘤坏死因子受体6α和6＆bgr;

    公开(公告)号：US08003386B1

    公开(公告)日：2011-08-23

    申请号：US09006352

    申请日：1998-01-13

    申请人： Reiner Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    发明人： Reiner Gentz ,  Reinhard Ebner ,  Guo-Liang Yu ,  Steven M. Ruben ,  Jian Ni ,  Ping Feng

    IPC分类号： C12N15/28 ,  C12N15/09 ,  C12N15/06 ,  C12N15/12 ,  C12N5/10 ,  C12P21/00

    CPC分类号： C07K14/70578

    摘要： The present invention relates to novel Tumor Necorsis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α＆-6＆bgr的分离的核酸分子; 蛋白质。 TNFR-6α＆-6＆bgr; 还提供多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定TNFR-6α和-6β的激动剂和拮抗剂的筛选方法。 活动。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Human G-Protein Chemokine Receptor (CCR5) HDGNR10
    7.
    发明申请
    Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20110201030A1

    公开(公告)日：2011-08-18

    申请号：US13080424

    申请日：2011-04-05

    申请人： Yi Li ,  Steven M. Ruben

    发明人： Yi Li ,  Steven M. Ruben

    IPC分类号： G01N33/566 ,  C07K14/715 ,  C07K16/28

    CPC分类号： C07K14/7158 ,  A61K38/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了人G-蛋白趋化因子受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达有关的病症的方法。 还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。

    Antibodies to HSDEK49 polypeptides
    9.
    发明授权
    Antibodies to HSDEK49 polypeptides 失效
    HSDEK49多肽的抗体

    公开(公告)号：US07968689B2

    公开(公告)日：2011-06-28

    申请号：US12198817

    申请日：2008-08-26

    申请人： Craig A. Rosen ,  Steven M. Ruben ,  Paul A. Moore

    发明人： Craig A. Rosen ,  Steven M. Ruben ,  Paul A. Moore

    IPC分类号： C07K16/00

    CPC分类号： C07K16/2803

    摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

    摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

    Antibodies that specifically bind to chemokine β-4
    10.
    发明授权
    Antibodies that specifically bind to chemokine β-4 失效
    特异性结合趋化因子的抗体;

    公开(公告)号：US07943741B2

    公开(公告)日：2011-05-17

    申请号：US12123419

    申请日：2008-05-19

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K16/00

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.

    摘要翻译： 本发明涉及特异性结合CK-B4的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括癌症的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 ，牛皮癣，皮炎和炎性肠病。 本发明还涉及编码抗CK-B4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 牛皮癣，皮炎和炎性肠病，包括向动物，优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。