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76 条记录 (耗时 0.04 秒)

    Nucleic acids encoding tumor necrosis factor receptor 5
    52.
    发明授权
    Nucleic acids encoding tumor necrosis factor receptor 5 失效
    编码肿瘤坏死因子受体5的核酸

    公开(公告)号：US06261801B1

    公开(公告)日：2001-07-17

    申请号：US09006353

    申请日：1998-01-13

    申请人： Ying-Fei Wei ,  Reiner Gentz ,  Jian Ni ,  Steven M. Ruben

    发明人： Ying-Fei Wei ,  Reiner Gentz ,  Jian Ni ,  Steven M. Ruben

    IPC分类号： C12P2102

    CPC分类号： C07K14/70578 ,  A61K48/00

    摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5”, and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

    摘要翻译： 本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。 更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。 还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。 还提供了利用这种组合物的诊断和治疗方法。

    Polynucleotides encoding human G-protein coupled receptor GPRZ
    53.
    发明授权
    Polynucleotides encoding human G-protein coupled receptor GPRZ 失效
    编码人G蛋白偶联受体GPR2的多核苷酸

    公开(公告)号：US5998164A

    公开(公告)日：1999-12-07

    申请号：US467948

    申请日：1995-06-06

    申请人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/715 ,  C12N15/12 ,  C12N15/62

    CPC分类号： C07K14/7158 ,  C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： Human G-protein coupled receptor or polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体或多肽和编码此类多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    Ubiquitin conjugating enzymes 7,8 and 9
    54.
    发明授权
    Ubiquitin conjugating enzymes 7,8 and 9 失效
    泛素缀合酶7,8和9

    公开(公告)号：US5849286A

    公开(公告)日：1998-12-15

    申请号：US464604

    申请日：1995-06-05

    申请人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C12N9/00 ,  A61K38/51 ,  C12N9/10

    CPC分类号： C12N9/93 ,  C12Y603/02019 ,  A61K38/00

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

    摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。

    Polynucleotides encoding human G-protein coupled receptor GPR1
    57.
    发明授权
    Polynucleotides encoding human G-protein coupled receptor GPR1 失效
    编码人G蛋白偶联受体GPR1的多核苷酸

    公开(公告)号：US6090575A

    公开(公告)日：2000-07-18

    申请号：US467947

    申请日：1995-06-06

    申请人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    发明人： Yi Li ,  Liang Cao ,  Jian Ni ,  Reiner Gentz ,  Carol J. Bult ,  Granger G. Sutton, III ,  Craig A. Rosen

    IPC分类号： A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12N5/10 ,  C12N15/62

    CPC分类号： C07K14/705 ,  A61K48/00

    摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

    摘要翻译： 公开了人G-蛋白偶联受体多肽和编码此类多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白偶联受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白偶联受体核酸序列中的突变和受体的可溶形式的改变水平的诊断方法。

    Ubiquitin conjugating enzymes 8 and 9
    58.
    发明授权
    Ubiquitin conjugating enzymes 8 and 9 失效
    泛素缀合酶8和9

    公开(公告)号：US5968797A

    公开(公告)日：1999-10-19

    申请号：US903396

    申请日：1997-07-22

    申请人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K16/40 ,  C12N9/00 ,  C12N9/10 ,  C07H21/04 ,  C12N15/00

    CPC分类号： C12N9/93 ,  C07K16/40 ,  A61K38/00

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

    摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。

    Ubiquitin conjugating enzymes 8 and 9
    59.
    发明授权
    Ubiquitin conjugating enzymes 8 and 9 失效
    泛素缀合酶8和9

    公开(公告)号：US5650313A

    公开(公告)日：1997-07-22

    申请号：US464342

    申请日：1995-06-05

    申请人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    发明人： Jian Ni ,  Reiner Gentz ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K16/40 ,  C12N9/00 ,  C12N9/10 ,  C07H21/04 ,  C12N1/20 ,  C12P21/06

    CPC分类号： C12N9/93 ,  C07K16/40 ,  A61K38/00

    摘要： Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.

    摘要翻译： 公开了人类UCE 7，UCE 8和UCE 9多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来治疗恶性细胞增殖的方法。 还公开了抗这种多肽的拮抗剂及其作为治疗性阿尔茨海默氏病，萎缩性骨骼肌，非洲猪瘟病毒和凋亡性细胞死亡的治疗剂的用途。 还公开了用于检测与UCE 7,8和9核酸序列中的突变相关的疾病的诊断测定以及由这些序列编码的多肽的浓度。