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51.发明申请MICROCHIP RESERVOIR DEVICES USING WIRELESS TRANSMISSION OF POWER AND DATA 审中-公开使用无线传输功率和数据的MICROCHIP储存设备公开(公告)号：US20080172043A1
公开(公告)日：2008-07-17
申请号：US11747598
申请日：2007-05-11
申请人： Norman F. Sheppard , John T. Santini , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： Norman F. Sheppard , John T. Santini , Stephen J. Herman , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M5/00
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042
摘要： Devices and methods are provided for wirelessly powering and/or communicating with implanted medical devices used for the controlled exposure and release of reservoir contents, such as drugs or sensors. The device may include a substrate having a plurality of reservoirs containing reservoir contents for release or exposure; and a rechargeable or on-demand power source comprising a local component which can wirelessly receive power from a remote transmitter wherein the received power can be used, directly or following transduction, to activate the release or exposure of the reservoir contents.
摘要翻译： 提供了用于与用于受控地暴露和释放储存器内容物（例如药物或传感器）的植入式医疗装置的无线供电和/或通信的装置和方法。 该装置可以包括具有多个储存器的基板，该储存器包含用于释放或暴露的储存器内容物; 以及可充电或点播电源，其包括本地组件，其可以从远程发射机无线地接收电力，其中可以直接或继续使用所接收的功率来激活所述储存器内容物的释放或暴露。
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公开(公告)号：US06875208B2
公开(公告)日：2005-04-05
申请号：US10159550
申请日：2002-05-31
申请人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Nolan T. Flynn , Scott A. Uhland , Zouhair Sbiaa , John M. Maloney
发明人： John T. Santini, Jr. , Michael J. Cima , Norman F. Sheppard, Jr. , Nolan T. Flynn , Scott A. Uhland , Zouhair Sbiaa , John M. Maloney
CPC分类号： A61K9/0097 , A61K9/0009 , Y10T137/8242
摘要： Microchip devices and methods of manufacture thereof are provided to increase the uniformity and reliability of active exposure and release of microchip reservoir contents. In one embodiment, the microchip device for the controlled release or exposure of molecules or secondary devices comprises: (1) a substrate having a plurality of reservoirs; (2) reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs; (3) reservoir caps positioned on the reservoirs over the reservoir contents; (4) electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and (5) a current distribution means, a stress induction means, or both, operably engaged with or integrated into the reservoir cap, to enhance reservoir cap disintegration.
摘要翻译： Microchip的器件及其制造方法被提供以增加微芯片储存器内容物的主动曝光和释放的均匀性和可靠性。 在一个实施例中，用于分子或次要装置的受控释放或暴露的微芯片装置包括：（1）具有多个储存器的基板; （2）位于储层中的包含分子，次要装置或二者的储层内容物; （3）位于油藏内的油藏内的储层盖; （4）电活化装置，用于使贮存器盖分解以开始在所选择的储存器中暴露或释放储存器内容物; 和（5）电流分配装置，应力感应装置或两者，可操作地与储存器盖接合或集成到储存器盖中，以增强储存器盖分解。
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公开(公告)号：US06852526B2
公开(公告)日：2005-02-08
申请号：US10282505
申请日：2002-10-28
申请人： Michael J. Cima , Hongming Chen , J. Richard Gyory
发明人： Michael J. Cima , Hongming Chen , J. Richard Gyory
CPC分类号： G01N33/5088 , B01L3/50255 , G01N13/00 , G01N33/5008 , G01N33/5044 , G01N2500/00
摘要： The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a surface of the second member. Each sample surface is substantially the same size as each opening. The transdermal assay apparatus also includes a magnetic clamp configured to clamp a tissue specimen between the sample surface and the opening. The magnetic clamp preferably includes a magnet having a strength that is selected based on the clamping force required between the first member and the second member. The invention also provides a method for using a transdermal assay apparatus.
摘要翻译： 透皮测定装置包括第一，第二和第三构件。 第一构件具有一个或多个样品表面，每个样品表面被配置为在其上接收样品。 第二构件限定一个或多个储存器，每个储存器在第二构件的表面上具有开口。 每个样品表面的大小与每个开口大致相同。 透皮测定装置还包括构造成在样品表面和开口之间夹持组织样本的磁性夹具。 磁夹具优选地包括具有基于第一构件和第二构件之间所需的夹紧力选择的强度的磁体。 本发明还提供了一种使用透皮测定装置的方法。
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54.发明授权Microchip devices for delivery of molecules and methods of fabrication thereof 有权用于递送分子的Microchip器件及其制造方法公开(公告)号：US06808522B2
公开(公告)日：2004-10-26
申请号：US09727858
申请日：2000-12-01
IPC分类号： A16K922
CPC分类号： A61K9/0097 , A61K9/0009 , A61K9/0024 , Y10T436/25
摘要： Methods of manufacturing microchip devices are provided for controlled release of molecules, such as drugs. Methods include compression molding and casting, alone or in combination with microfabrication techniques. In preferred embodiments, devices are made by (1) filling a die with a polymer powder; (2) compressing the powder to form a polymer preform; (3) thermal compression molding the preform to form a substrate in a mold having a plurality of protrusions that form reservoirs in the substrate; and (4) filling the reservoirs with a release system comprising the molecules to be released. Alternatively, ceramic devices are formed by casting the substrate from a ceramic powder or a slurry using a mold having protrusions that form reservoirs in the substrate. Control over the release rate and time of the molecules from the reservoirs of the microchip device is provided by incorporating release systems and/or reservoir caps.
摘要翻译： 提供制造微芯片器件的方法用于控制释放诸如药物之类的分子。 方法包括压塑和铸造，单独或与微细加工技术组合。 在优选实施例中，装置通过（1）用聚合物粉末填充模具制成; （2）压缩粉末以形成聚合物预成型体; （3）热压缩成型预成型件以在具有在基板中形成储存器的多个突起的模具中形成基板; 和（4）用包含要释放的分子的释放系统填充储存器。 或者，通过使用具有在基板中形成储存器的突起的模具从陶瓷粉末或浆料浇铸基材来形成陶瓷装置。 通过结合释放系统和/或储存器盖来控制来自微芯片装置的储存器的分子的释放速率和时间。
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公开(公告)号：US06686207B2
公开(公告)日：2004-02-03
申请号：US09976835
申请日：2001-10-12
IPC分类号： G01N100
CPC分类号： G01N35/10 , B01D17/04 , B01D17/06 , B01D21/0009 , B01J2219/00274 , B01J2219/00315 , B01J2219/00387 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00745 , B01J2219/00747 , B01J2219/00756 , B01L3/5085 , B03C5/026 , B03C5/028 , C40B30/08 , C40B40/10 , C40B40/14 , C40B40/18 , C40B60/14 , G01N2035/00188 , G01N2035/00237 , Y10T436/25 , Y10T436/25375
摘要： Micron scale dielectric items are manipulated by methods and apparatus taking advantage of spatially non-uniform field. Such fields give rise to a force on dielectric items, directing them generally toward regions of more concentrated field. The electrode may be elongated, either unitary, with a generally planar counter electrode, or dual, such as parallel pins, loops or plates. If dual, particles are generally attracted to regions of high field concentration, including tips, edges and spaces between electrode conductors. Items can be granular, threadlike, or sheets, and microelectronic parts and other shapes. Items can also be collected directly into a recess of a pharmaceutical material delivery microchip, with a conductive membrane of the microchip acting as a manipulating electrode. Items are attracted without regard to their surface charge, or the polarity of the field, which can be AC or DC. Charging, or knowing the charge of items to be manipulated is not necessary. The amount of material collected can be precisely controlled by varying parameters of collection, such as distance between the electrode and the items, distance between dual conductors, size (diameter, length) of the conductors, any dielectric sheathing thereof, and voltage. Elongated electrodes can be used to manipulate items into and from recesses, such as wells of microtitre trays, microchips, and semiconductor chips. Several recesses can be used to calibrate an array of collecting and depositing electrodes and deposits. Items can be removed from fluids, such as aerosol dispersions, and an air cleaner is also disclosed. Dielectrophoretic forces are exploited. Techniques and apparatus for depositing such items include charged targets and targets with electrodes designed to create a non-uniform field.
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公开(公告)号：US06537256B2
公开(公告)日：2003-03-25
申请号：US10195338
申请日：2002-07-15
申请人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： John T. Santini, Jr. , Charles E. Hutchinson , Scott A. Uhland , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M500
CPC分类号： A61K9/0097 , A23L2/52 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61K9/0009 , A61L31/14 , A61L31/16 , A61L2300/416 , A61M5/1407 , A61M15/0031 , A61M15/0045 , A61M15/005 , A61M15/008 , A61M15/0083 , A61M15/009 , A61M2205/8225
摘要： Apparatus and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparatus include microchip devices which have reservoirs containing the molecules for release. The apparatus and methods provide for active or passive controlled release of the molecules. Embodiments include systems for release of fragrance molecules and beverage additives.
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57.发明授权公开(公告)号：US06514518B2
公开(公告)日：2003-02-04
申请号：US09932245
申请日：2001-08-17
IPC分类号： A61F214
CPC分类号： A61K9/0024 , A61F2/02 , A61F2/28 , A61F2/3094 , A61F2002/009 , A61F2002/30032 , A61F2002/30062 , A61F2002/3028 , A61F2002/30677 , A61F2002/30932 , A61F2002/30962 , A61F2210/0004 , A61F2230/0063 , A61F2240/001 , A61F2250/003 , A61F2250/0067 , A61K9/0051 , A61K9/14 , A61K9/1647 , A61K9/1694 , A61K9/20 , A61K9/2086 , A61K9/2095 , B29C64/00 , B29C64/165 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
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公开(公告)号：US6123861A
公开(公告)日：2000-09-26
申请号：US22322
申请日：1998-02-11
CPC分类号： A61K9/0009 , A61K9/0097 , A61M2205/0244 , A61M37/00
摘要： Fabrication methods are provided for microchips that control both the rate and time of release of multiple chemical substances and allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate. Reservoirs are etched into the substrate using either chemical (wet) etching or plasma (dry) etching techniques well known in the field of microfabrication. Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. A release system, which includes the molecules to be delivered, is inserted into the reservoirs by injection, inkjet printing, or spin coating methods. Exemplary release systems include polymers and polymeric matrices, non-polymeric matrices, and other excipients or diluents. The physical properties of the release system control the rate of release of the molecules. The reservoirs can contain multiple drugs or other molecules in variable dosages. The filled reservoirs can be capped with materials that passively disintegrate, materials that allow the molecules to diffuse passively out of the reservoir over time, or materials that disintegrate upon application of an electric potential. Release from an active device can be controlled by a preprogrammed microprocessor, remote control, or by biosensors.
摘要翻译： 为微芯片提供制造方法，其控制多种化学物质的释放速率和时间，并允许以连续或脉动方式释放多种分子。 在所有优选的实施方案中，将待递送的药物或其它分子和周围流体不可渗透的材料用作基底。 使用在微细加工领域中众所周知的化学（湿）蚀刻或等离子（干）蚀刻技术将储层蚀刻到基底中。 使用这些技术，可以在单个微芯片上制造数百到数千个储层。 包括待输送分子的释放系统通过注射，喷墨印刷或旋涂方法插入储存器中。 示例性的释放系统包括聚合物和聚合物基质，非聚合物基质和其它赋形剂或稀释剂。 释放系统的物理性质控制分子的释放速率。 储层可以含有多种药物或其他可变剂量的分子。 填充的储层可以用被动分解的材料封盖，允许分子随时间被动地扩散出储层的材料，或在施加电势时分解的材料。 从有源设备释放可以由预编程的微处理器，遥控器或生物传感器控制。
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公开(公告)号：US5797898A
公开(公告)日：1998-08-25
申请号：US675375
申请日：1996-07-02
CPC分类号： A61K9/0009 , A61K9/0097 , A61M2205/0244 , A61M37/00
摘要： Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or other molecules to be delivered and the surrounding fluids is used as the substrate. Reservoirs are etched into the substrate using either chemical (wet) etching or ion beam (dry) etching techniques well known in the field of microfabrication. Hundreds to thousands of reservoirs can be fabricated on a single microchip using these techniques. The molecules to be delivered are inserted into the reservoirs by injection or spin coating methods in their pure form or in a release system. Exemplary release systems include polymers and polymeric matrices, non-polymeric matrices, and other excipients or diluents. The physical properties of the release system control the rate of release of the molecules. The reservoirs can contain multiple drugs or other molecules in variable dosages. The filled reservoirs can be capped with materials that either degrade or allow the molecules to diffuse passively out of the reservoir over time or materials that oxidize and dissolve upon application of an electric potential. Release from an active device can be controlled by a preprogrammed microprocessor, remote control, or by biosensors.
摘要翻译： 提供微芯片，其控制多种化学物质的释放速率和时间，并且允许以连续或脉动方式释放多种分子。 在所有优选的实施方案中，将待递送的药物或其它分子和周围流体不可渗透的材料用作基底。 使用在微细加工领域熟知的化学（湿）蚀刻或离子束（干）蚀刻技术将储层蚀刻到基底中。 使用这些技术，可以在单个微芯片上制造数百到数千个储层。 通过注射或旋涂方法将要输送的分子以纯形式或释放系统插入储存器中。 示例性的释放系统包括聚合物和聚合物基质，非聚合物基质和其它赋形剂或稀释剂。 释放系统的物理性质控制分子的释放速率。 储层可以含有多种药物或其他可变剂量的分子。 填充的储存器可以被降解的材料封盖，或允许分子随时间被动地扩散到储存器中，或者在施加电势时氧化和溶解的材料。 从有源设备释放可以由预编程的微处理器，遥控器或生物传感器控制。
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公开(公告)号：US10806383B2
公开(公告)日：2020-10-20
申请号：US13643707
申请日：2011-05-04
摘要： A sensor is provided for measuring a dissolved oxygen concentration in vivo when implanted at a tissue site and in ex vivo applications. The sensor includes an article comprising a sensing medium retained within the implantable article by an oxygen-permeable material. The sensing medium comprises an MR contrast agent for oxygen. The sensor is configured to indicate the dissolved oxygen concentration of a fluid, e.g., in vivo at the tissue site, when subjected to an MR-based method.
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