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63 条记录 (耗时 0.057 秒)

    Pyrazolyl amino imidazolines as antihypertensive agents
    51.
    发明授权
    Pyrazolyl amino imidazolines as antihypertensive agents 失效
    吡唑基氨基咪唑啉作为抗高血压药

    公开(公告)号：US4234594A

    公开(公告)日：1980-11-18

    申请号：US36884

    申请日：1979-05-07

    申请人： Martin Winn ,  Carl W. Nordeen ,  David L. Arendsen

    发明人： Martin Winn ,  Carl W. Nordeen ,  David L. Arendsen

    IPC分类号： C07D231/38 ,  C07D231/40 ,  A61K31/40 ,  A61K31/415 ,  A61K31/435 ,  A61K31/47

    CPC分类号： C07D231/38 ,  C07D231/40

    摘要： Described is a method of treating hypertensive by administering to mammalian patients compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, loweralkyl, lowercycloalkyl, aralkyl, aryl, pyridyl, isoquinolyl, phthalazinyl, or aryl substituted by one or more hydrogen, halo, loweralkyl, lowercycloalkyl, haloloweralkyl, haloloweralkyl, aminosulfonyl, nitro, hydroxy, alkoxy, carboxy, alkoxycarbonyl, cycloalkoxy carbonyl, aminocarbonyl, diloweralkylaminocarbonyl or ##STR2## wherein n is 4 or 5.R.sub.3 is hydrogen, halogen, loweralkyl or aryl, andR.sub.4 is hydrogen, acyl, amino or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof.

    摘要翻译： 描述了通过向哺乳动物患者施用式IMA的化合物治疗高血压的方法，其中R 1和R 2是氢，低级烷基，低级环烷基，芳烷基，芳基，吡啶基，异喹啉基，酞嗪基或被一个或多个氢取代的芳基，卤素 低级烷基，低级环烷基，卤代低级烷基，卤代低级烷基，氨基磺酰基，硝基，羟基，烷氧基，羧基，烷氧羰基，环烷氧基羰基，氨基羰基，二低级烷基氨基羰基或其中n为4或5.R 3为氢，卤素，低级烷基或芳基， 是氢，酰基，氨基或低级烷基，及其药学上可接受的酸加成盐。

    5,6-Dimethoxy-2-heterocyclic benzimidazoles
    52.
    发明授权
    5,6-Dimethoxy-2-heterocyclic benzimidazoles 失效
    5,6-二甲氧基-2-杂环苯并咪唑

    公开(公告)号：US4088765A

    公开(公告)日：1978-05-09

    申请号：US746656

    申请日：1976-12-02

    申请人： Martin Winn ,  Jaroslav Kyncl

    发明人： Martin Winn ,  Jaroslav Kyncl

    IPC分类号： C07D401/04 ,  A61K31/445 ,  A61K31/47

    CPC分类号： C07D401/04

    摘要： Described are the compounds 5,6-dimethoxy-2-(4-benzyl-1-piperidino) benzimidazole and 5,6-dimethoxy-2 (6,7-dimethoxy-1,2,3,4-tetrahydro 2-isoquinolinyl benzimidazole and pharmaceutically acceptable acid addition salts thereof. The compounds are useful as antihypertensive agents.

    摘要翻译： 描述了5,6-二甲氧基-2-（4-苄基-1-哌啶子基）苯并咪唑和5,6-二甲氧基-2（6,7-二甲氧基-1,2,3,4-四氢-2-异喹啉基苯并咪唑） 这些化合物可用作抗高血压剂。

    Alkylphenyl benzopyranopyridines
    53.
    发明授权
    Alkylphenyl benzopyranopyridines 失效
    烷基苯基苯并吡喃并吡啶

    公开(公告)号：US3932432A

    公开(公告)日：1976-01-13

    申请号：US442032

    申请日：1974-02-13

    申请人： Martin Winn

    发明人： Martin Winn

    IPC分类号： A61K31/435 ,  A61P25/04 ,  A61P25/20 ,  C07C37/055 ,  C07C43/205 ,  C07D491/04 ,  C07D491/052 ,  C07D213/30

    CPC分类号： C07D491/04 ,  C07C37/055 ,  C07C43/2055

    摘要： Alkylphenyl benzopyranopyridines represented by the formula ##SPC1##Where R.sub.1 is hydrogen, loweralkyl, loweralkanoyl, cycloalkylloweralkyl, cycloalkylloweralkanoyl, loweralkenyl, loweralkynyl, haloloweralkenyl, phenylloweralkyl, phenylloweralkenyl or phenylloweralkynyl; R.sub.2 is loweralkyl; R.sub.3 is hydrogen; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R.sub.4 and R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.

    摘要翻译： 由下式表示的烷基苯基苯并吡喃并吡啶R1为氢，低级烷基，低级烷酰基，环烷基低级烷基，环烷基低级烷酰基，低级烯基，低级炔基，卤代低级烯基，苯基低级烷基，苯基低级烯基或苯基低级炔基。 R2是低级烷基; R3是氢; Y是具有1至10个碳原子的直链或支链亚烷基; 并且每个R 4和R 5和R 6是由氢，卤素，三氟甲基或低级烷基组成的组中相同或不同的成员; 及其药学上可接受的盐。

    Antihypertensive agents
    58.
    发明授权
    Antihypertensive agents 失效
    抗高血压药

    公开(公告)号：US4112097A

    公开(公告)日：1978-09-05

    申请号：US760895

    申请日：1977-01-21

    申请人： Martin Winn ,  Jaroslav Kyncl ,  Daniel Ambrose Dunnigan ,  Peter Hadley Jones

    发明人： Martin Winn ,  Jaroslav Kyncl ,  Daniel Ambrose Dunnigan ,  Peter Hadley Jones

    IPC分类号： C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08

    CPC分类号： C07D309/08

    摘要： Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

    摘要翻译： 描述了选自2 [4（四氢-2-呋喃基） - 哌嗪基] -4-氨基-6,7-二甲氧基喹唑啉和2- [4（四氢吡喃-2-羰基） - 哌嗪基] -4的抗高血压药 - 氨基-6,7-二甲氧基喹唑啉及其药学上可接受的酸加成盐。 这些化合物是高度水溶性的，并且可以以时间释放形式以及肠胃外给药，包括静脉内给药。

    Heterocyclic esters of alkylphenyl benzopyranopyridines
    60.
    发明授权
    Heterocyclic esters of alkylphenyl benzopyranopyridines 失效
    烷基苯基苯并吡喃并吡啶的杂环酯

    公开(公告)号：US4081449A

    公开(公告)日：1978-03-28

    申请号：US348367

    申请日：1973-04-05

    申请人： Martin Winn

    发明人： Martin Winn

    IPC分类号： C07D471/04 ,  C07D491/052 ,  C07D491/04

    CPC分类号： C07D471/04

    摘要： Heterocyclic esters of alkylphenyl benzopyranopyridines represented by the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl, loweralkanoyl, cycloalkylloweralkyl, cycloalkylloweralkanoyl, loweralkenyl, loweralkynyl, haloloweralkenyl, phenylloweralkyl, phenylloweralkenyl or phenylloweralkynyl; R.sub.2 is loweralkyl; R.sub.3 is ##STR2## WHEREIN X is a straight or branched chain alkylene group having from one to eight carbon atoms, a is an integer from 1 to 4, b is an integer from 1 to 4 and Z is CH.sub.2, O, S or NR.sub.7, with R.sub.7 being hydrogen or loweralkyl, with the limitation that when X is O, S or NR.sub.7, the sum of a and b is 3 or 4; and R.sub.8 is hydrogen or loweralkyl; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R.sub.4 and R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable acid addition salts thereof.

    摘要翻译： 由下式表示的烷基苯基苯并吡喃并吡啶的杂环酯其中R 1是氢，低级烷基，低级烷酰基，环烷基低级烷基，环烷基低级烷酰基，低级烯基，低级炔基，卤代烯基，苯基低级烷基，苯基低级烯基或苯基低级炔基。 R2是低级烷基; R3是，其中X是具有1至8个碳原子的直链或支链亚烷基，a是1至4的整数，b是1至4的整数，Z是CH 2，O，S或NR 7 其中R 7为氢或低级烷基，限制在X为O，S或NR 7时，a和b之和为3或4; R8是氢或低级烷基; Y是具有1至10个碳原子的直链或支链亚烷基; 并且每个R 4和R 5和R 6是由氢，卤素，三氟甲基或低级烷基组成的组中相同或不同的成员; 及其药学上可接受的酸加成盐。