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104 条记录 (耗时 0.029 秒)

    Method of making bone particles
    52.
    发明授权
    Method of making bone particles 有权
    制造骨颗粒的方法

    公开(公告)号：US08323700B2

    公开(公告)日：2012-12-04

    申请号：US10509585

    申请日：2003-03-31

    申请人： John W. Morris ,  Kenneth C. Petersen ,  Lawrence A. Shimp ,  Mark P. Daugherty

    发明人： John W. Morris ,  Kenneth C. Petersen ,  Lawrence A. Shimp ,  Mark P. Daugherty

    IPC分类号： A61K35/32 ,  A61F2/28

    CPC分类号： A61L27/3683 ,  A01N1/00 ,  A61F2/4644 ,  A61F2002/2835 ,  A61F2002/4645 ,  A61F2002/4649 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02 ,  A61L2430/40

    摘要： The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.

    摘要翻译： 本发明涉及一种用于制造各种尺寸的骨的骨颗粒的方法和用于该方法的工件形成和保持装置。 工件形成装置包括底座和附接到基座表面的底座。 还提供了一种用于形成固化骨和固定介质的装置，其包括工件形成装置和包围基架的可拆卸的成形构件。 将骨浸入这种工件形成装置内的固定介质中，固化介质被固化以形成骨和固定介质的固化块，然后细分以提供与固定介质相关联的骨颗粒。 可以任选地除去固定介质以留下适合用于矫形应用的骨颗粒，包括植入物。

    Methods for Collagen Processing and Products Using Processed Collagen
    55.
    发明申请
    Methods for Collagen Processing and Products Using Processed Collagen 有权
    胶原加工方法和使用加工胶原产品

    公开(公告)号：US20080195202A1

    公开(公告)日：2008-08-14

    申请号：US11673972

    申请日：2007-02-12

    申请人： Nels J. Lauritzen ,  Lawrence A. Shimp

    发明人： Nels J. Lauritzen ,  Lawrence A. Shimp

    IPC分类号： A61F2/02

    CPC分类号： A61L27/54 ,  A61L15/325 ,  A61L27/24 ,  A61L27/34 ,  A61L2300/00

    摘要： Purifying human derived collagen from human tissue includes treating harvested human tissue with an enzyme to form a collagen product, deactivating the enzyme with a non-alkaline enzyme deactivation solution, and collecting the collagen product resulting from the enzyme treatment, where the collected collagen product includes a preserved amount of its natural collagen constituents. Various medical implants can be formed using the isolated, enzymatically-treated human derived collagen having an amount of its natural collagen constituents preserved, and may include implantable sponges, patches, tubes, structural supports and coatings, and which may be used for repair, barrier, support and/or stabilization purposes.

    摘要翻译： 从人体组织中纯化人源胶原蛋白包括用酶处理收获的人体组织以形成胶原产物，用非碱性酶失活溶液使酶失活，以及收集由酶处理产生的胶原产物，其中所收集的胶原产品包括 保留量的天然胶原成分。 可以使用分离的，经酶处理的人源胶原蛋白形成各种医学植入物，其具有保存的天然胶原蛋白成分的量，并且可以包括可植入的海绵，贴剂，管，结构载体和涂层，并且其可用于修复，屏障 ，支持和/或稳定目的。

    Vertebral augmentation composition and method
    56.
    发明授权
    Vertebral augmentation composition and method 有权
    椎体增大组成及方法

    公开(公告)号：US07399739B2

    公开(公告)日：2008-07-15

    申请号：US10399423

    申请日：2001-10-23

    申请人： Lawrence A. Shimp

    发明人： Lawrence A. Shimp

    IPC分类号： A61K38/00 ,  A61K9/14 ,  A61K35/32 ,  A61K33/42 ,  A61F2/02

    CPC分类号： A61B17/7095 ,  A61B17/7097 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/426 ,  A61L2300/64 ,  A61L2400/06 ,  A61L2430/38

    摘要： A flowable vertebral augmentation composition for the treatment and repair of a vertebral body defect, e.g., an osteoporotic condition, contains biocompatible, optionally osteoconductive, support elements that are resistant to deformation or fracture under the normal physiologic loads to which the repair site is subject, the support elements being incorporable into the repair site, at least one osteoinductive susbtance and an amount of biocompatible carrier sufficient to render the augmentation composition flowable, the carrier having the capacity to be cleared from the repair site.

    摘要翻译： 用于治疗和修复椎体缺损（例如骨质疏松症）的可流动的脊椎增大组合物包含生物相容性，任选的骨传导性支持元件，其在修复部位受到的正常生理负荷下耐变形或断裂， 所述支撑元件可以并入所述修复部位，至少一种骨诱导性和一定量的生物相容性载体足以使所述增加组合物流动，所述载体具有从所述修复部位清除的能力。

    Process and composition for curing meat
    59.
    发明授权
    Process and composition for curing meat 失效
    治疗肉类的方法和组成

    公开(公告)号：US4781934A

    公开(公告)日：1988-11-01

    申请号：US864235

    申请日：1986-05-19

    申请人： Lawrence A. Shimp ,  Raimond Pals

    发明人： Lawrence A. Shimp ,  Raimond Pals

    IPC分类号： A23B4/02 ,  A23B4/023

    CPC分类号： A23B4/02 ,  A23B4/0235

    摘要： Pork and other meat products are cured with pickling solutions from which nitrite is effectively exhausted during curing, thereby avoiding nitrosoamine formation, by buffering the solutions at the requisite acid pH with an alkali metal (M) glassy phosphate of the formula M(PO.sub.2 OM).sub.n OM having an M/P mole ratio of 1.188/1 to 1.250/1 and an average chain length (n) of about 8-11.

    摘要翻译： 通过在固化期间亚硝酸盐被有效地排出的酸洗溶液来固化猪肉和其他肉类产品，从而通过用式M（PO 2 OM）nOM的碱金属（M）的磷酸玻璃将溶液缓冲至必要的酸性pH，从而避免亚硝基磺酸盐的形成 M / P摩尔比为1.188 / 1至1.250 / 1，平均链长（n）约为8-11。

    Process for making sodium tripolyphosphate
    60.
    发明授权
    Process for making sodium tripolyphosphate 失效
    制备三聚磷酸钠的方法

    公开(公告)号：US4536377A

    公开(公告)日：1985-08-20

    申请号：US639280

    申请日：1984-08-08

    申请人： Lawrence A. Shimp

    发明人： Lawrence A. Shimp

    IPC分类号： C01B25/41 ,  C01B25/30

    CPC分类号： C01B25/412

    摘要： A one step spray drying process for making high assay sodium tripolyphosphate having a high concentration of form I material by spray drying an aqueous sodium orthophosphate feed liquor having an Na.sub.2 O:P.sub.2 O.sub.5 ratio of 1.60 to 1.70 at a temperature between 250.degree. and 420.degree. C. for up to one minute to produce sodium tripolyphosphate and cooling the product to 150.degree. C. or below in twenty minutes or less.

    摘要翻译： 一步喷雾干燥工艺，用于通过在250°至420℃的温度下喷雾干燥Na2O:P2O5比为1.60-1.70的正磷酸钠水溶液，制备具有高浓度I型材料的高分辨三聚磷酸钠。 长达一分钟以生产三聚磷酸钠，并在二十分钟或更短时间内将产物冷却至150℃或更低。