摘要:
A semiconductor memory device comprises a bottom electrode of a capacitor connected to a source region of a semiconductor substrate through a contact plug formed in a portion of a through-hole. The remaining portion of the through-hole has a side-wall film, on which a portion of the bottom electrode film is disposed. The two-level structure of the through-hole improves the step coverage of the side-wall film and avoids over-etching of the silicon substrate.
摘要:
An indole derivative of the formula: ##STR1## wherein R.sub.1 is lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower alkylaminosulfonyl, etc., R.sub.2 is hydrogen, halogen, lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, etc., R.sub.3 is hydrogen or lower alkyl, R.sub.4 is halogen or trifluoromethyl, R.sub.5 is lower alkyl, or a salt thereof, these compounds being potent .beta..sub.3 -adrenergic receptor-stimulating agent with excellent adrenoceptor selectivity, and being useful in the prophylaxis or treatment of obesity or diabetes mellitus.
摘要:
A method for producing an optically active 3-hydroxy-hexanoic acid represented by formula (1) and the enantimer by asymmetrically hydrolyzing a racemic ester of 3-hydroxyhexanoic acid in the presence of a lipase derived from porcine pancreas. ##STR1##
摘要:
The present invention provides a method for producing optically active 3-substituted-2-norbornanones which are useful as starting materials for several kinds of physiologically active materials, and to their intermediates, optically active 2-hydroxy-2-norbornanecarboxylic acid and to a method for producing these intermediates.
摘要:
Optically active cyclopentenols are here disclosed which are represented by the formula (I) ##STR1## (wherein R is a hydrogen atom or an acyl group having 2 to 15 carbon atoms, and the sign * denotes a chiral carbon atom).The optically active cyclopentenols can be prepared by a process which comprises the step of carrying out a transesterification between (.+-.)-cyclopentenol represented by the formula (IV) ##STR2## and triglyceride or vinyl ester by the use of esterase to obtain an optically active cyclopentenol represented by the formula (II) ##STR3## and an optically active cyclopentenol derivative represented by the formula (III) ##STR4## (wherein R' is an acyl group having 2 to 15 carbon atoms, and the sign * denotes a chiral carbon atom) which is a derivative of the enantiomer of the cyclopentenol (II); or alternatively, by another process which comprises the step of hydrolysis or alcoholysis of an optically active cyclopentenol derivative represented by the formula (III) ##STR5## (wherein R' is an acyl group having 2 to 15 carbon atoms, and the sign * denotes a chiral carbon atom) to obtain an optically active cyclopentenol represented by the formula (II) ##STR6## having the same absolute configuration as in the aforesaid derivative.
摘要:
The invention provides a method for producing an optically active hydroxy lactone which comprises reacting under substantially anhydrous conditions and in the presence of an enzyme an ester and a racemic compound represented by the general formula (I): ##STR1## wherein n is 0 or 1, any one of R.sup.1 and R.sup.2 is a hydroxy group, and R.sup.2 =R.sup.3 =H or R.sup.2 =R.sup.3 =CH.sub.3 when R.sup.1 is the hydroxy group, and R.sup.1 =R.sup.3 =H when R.sup.2 is the hydroxy group, to effect a transesterification reaction, and resolving to an optically active alcohol which has R- or S-configuration and the ester of the symmetric alcohol.
摘要:
The present invention provides a process for producing optically active compounds by a biochemical method in which specific compounds having hydroxyl groups are reacted with esters in the presence of hydrolases. The compounds have the following general formula: ##STR1## wherein X is selected from halogen atoms and a cyano group. Y is selected from the group constituting substituted phenyl groups, halogen atoms, cyano, trifluoromethyl and amino groups and alkylamino and alkyloxycarbonyl groups in which alkyl groups have 1-20 carbon atoms. R is an alkylene group having 1-20 carbon atoms and n is 0 or 1.
摘要:
The invention provides a metal salt of a crosslinked cellulose derivative represented by the following formula (I), wherein the degree of substitution of the hydroxyl group of glucose unit of the crosslinked cellulose derivative by a functional group a is 1 or more. R—O-A (I) {In the formula (I), R represents a crosslinked cellulose residue and A represents a functional group a having cation-exchange ability.}
摘要:
The present invention provides a compound selected from sulfated cellulose and salts thereof which can be used as an active ingredient for a cutaneous external preparation produced intending to prevent, soften, improve or cure atopic cutaneous symptoms and the like and which are excellent in a hydrolytic resistance, and dermatitis therapeutic agents and cosmetics using the same.
摘要:
(S)-4-Amino-5-chloro-2-methoxy-N-[1-[1-(2-tetrahydrofuryl-carbonyl) -4-piperidinylmethyl]-4-piperidinyl]benzamide of the following formula (I): or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, and a process for preparing the same, a pharmaceutical composition containing the same, and intermediate therefor. The compound of the present invention is useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent, which shows a potent affinity for 5-HT4 receptor, and shows few effects on the heart, and further shows few side effects on the central nervous system based on the dopamine D2 receptor.