公开(公告)号：US20060294347A1

公开(公告)日：2006-12-28

申请号：US11134687

申请日：2005-05-19

Applicant: Xiang Zou ,  Hong Wang ,  Scott Rodgers ,  Darrell Boggs ,  Bryant Bigbee ,  Shivanandan Kaushik ,  Anil Aggarwal ,  Ittai Anati ,  Doron Orenstein ,  Per Hammarlund ,  John Shen ,  Larry Smith ,  James Crossland ,  Chris Newburn

Inventor： Xiang Zou ,  Hong Wang ,  Scott Rodgers ,  Darrell Boggs ,  Bryant Bigbee ,  Shivanandan Kaushik ,  Anil Aggarwal ,  Ittai Anati ,  Doron Orenstein ,  Per Hammarlund ,  John Shen ,  Larry Smith ,  James Crossland ,  Chris Newburn

IPC: G06F9/44

CPC classification number: G06F9/3851 ,  G06F9/30087 ,  G06F9/3009 ,  G06F9/4843 ,  G06F11/3409 ,  G06F11/348 ,  G06F2201/86 ,  G06F2201/88 ,  G06F2201/885

Abstract: Method, apparatus, and system for a programmable event driven yield mechanism that may activate other threads. The yield mechanism may allow triggering of a service thread that may execute currently with a main thread upon occurrence of an architecturally-defined condition. The service thread may be activated, in response to the condition, with limited intervention of an operating system. In one embodiment, an apparatus includes execution resources to execute a plurality of instructions and a monitor to detect an architecturally-defined condition. The apparatus may include an event handler to handle a yield event generated when the architecturally-defined condition has been detected. An architectural mechanism, including processor instructions and channel registers, may be utilized to allow user-level code to enable the yield event mechanism. Other embodiments are also described and claimed.

Abstract translation: 用于可激活其他线程的可编程事件驱动产量机制的方法，装置和系统。 收益机制可以允许在出现体系结构定义的条件时触发可以执行当前与主线程的服务线程。 响应于条件，可以在操作系统的有限干预下激活服务线程。 在一个实施例中，装置包括执行多个指令的执行资源和监视器以检测体系结构定义的条件。 该装置可以包括事件处理程序，用于处理当检测到体系结构定义的条件时产生的产出事件。 可以使用包括处理器指令和通道寄存器在内的架构机制来允许用户级代码来实现产出事件机制。 还描述和要求保护其他实施例。

公开(公告)号：US20060014926A1

公开(公告)日：2006-01-19

申请号：US10530253

申请日：2003-10-02

Applicant: Maria Cassetti ,  Larry Smith ,  Jeffrey Pullen ,  Susan McElhiney

Inventor： Maria Cassetti ,  Larry Smith ,  Jeffrey Pullen ,  Susan McElhiney

IPC: A61K39/12 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  A61K38/00

CPC classification number: A61K39/0011 ,  A61K38/162 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/585 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/20022 ,  C12N2710/20032 ,  C12N2710/20034 ,  C12N2710/24143 ,  C12N2770/36143

Abstract: The present invention provides immunogenic and pharmaceutical compositions for the treatment and prevention of human papillomavirus (HPV)-associated cancers and in particular, cervical cancer. In particular, this invention relates to fusion proteins, and the nucleic acids encoding these fusion proteins, used to generate immune responses against HPV. Specifically, this invention provides for fusions of HPV E6 and E7 in which the E6 and/or E7 contains one or more mutations. These mutations abrogate the transformation activity of these oncogenic proteins and, thus, confer safety to the E6/E7 fusions. In addition, these fusions maintain or increase the immunogenic efficacy of E6 and E7. Any gene or protein delivery method can be used to deliver or package the immunogenic compositions of the present invention.

Abstract translation: 本发明提供用于治疗和预防人乳头状瘤病毒（HPV）相关癌症，特别是宫颈癌的免疫原性和药物组合物。 特别地，本发明涉及融合蛋白和编码这些融合蛋白的核酸，用于产生针对HPV的免疫应答。 具体地，本发明提供了HPV E6和E7的融合体，其中E6和/或E7含有一个或多个突变。 这些突变消除了这些致癌蛋白的转化活性，从而赋予了E6 / E7融合的安全性。 此外，这些融合保持或增加E6和E7的免疫原性功效。 任何基因或蛋白质递送方法可用于递送或包装本发明的免疫原性组合物。

公开(公告)号：US20050214295A1

公开(公告)日：2005-09-29

申请号：US11058728

申请日：2005-02-15

Applicant: Sudhir Paul ,  Gennady Gololobov ,  Larry Smith

Inventor： Sudhir Paul ,  Gennady Gololobov ,  Larry Smith

IPC: A61K39/00 ,  A61K38/00 ,  A61K39/395 ,  A61P5/14 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P19/04 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  C07K7/04 ,  C07K16/00 ,  C07K16/10 ,  C07K16/32 ,  C12N9/00 ,  C12N9/64

CPC classification number: C07K16/1063 ,  A61K2039/505 ,  C07K16/32 ,  C07K2317/34 ,  C12N9/0002

Abstract: Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders.

Abstract translation: 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激与特定医学病症有关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。

公开(公告)号：USD497142S1

公开(公告)日：2004-10-12

申请号：US29196403

申请日：2003-12-30

Applicant: Larry Smith

Designer： Larry Smith