公开(公告)号：US10908157B2

公开(公告)日：2021-02-02

申请号：US15440191

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/58

Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.

公开(公告)号：US20200378966A1

公开(公告)日：2020-12-03

申请号：US16836245

申请日：2020-03-31

Applicant: Meso Scale Technologies, LLC

Inventor： Eli N. Glezer ,  Mikayla Higgins ,  John Kenten ,  George Sigal

IPC: G01N33/564

Abstract: The present invention relates to methods of diagnosing lupus in a patient, as well as methods of monitoring the progression of lupus and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20200209234A1

公开(公告)日：2020-07-02

申请号：US16815598

申请日：2020-03-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  C12Q1/6834 ,  C12Q1/6832 ,  C12Q1/6823 ,  G01N33/53

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.

公开(公告)号：US20200041525A1

公开(公告)日：2020-02-06

申请号：US16443005

申请日：2019-06-17

Applicant: Meso Scale Technologies, LLC.

Inventor： George Sigal

IPC: G01N33/68 ,  G01N33/576

Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.

公开(公告)号：US20180188269A1

公开(公告)日：2018-07-05

申请号：US15907369

申请日：2018-02-28

Applicant: Meso Scale Technologies, LLC.

Inventor： George Sigal

IPC: G01N33/68 ,  G01N33/576

CPC classification number: G01N33/6893 ,  G01N33/576 ,  G01N2800/085 ,  Y02A50/54

Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay kits used in connection with the diagnostic methods described herein.

公开(公告)号：US09891221B2

公开(公告)日：2018-02-13

申请号：US14319167

申请日：2014-06-30

Applicant: Meso Scale Technologies, LLC.

Inventor： Michael Tsionsky ,  Eli N. Glezer ,  Selen Stromgren ,  George Sigal ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC: C12Q1/68 ,  G01N31/00 ,  G01N33/573 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/58 ,  G01N21/76 ,  G01N33/53

CPC classification number: G01N33/573 ,  C12Q1/485 ,  G01N21/76 ,  G01N33/5306 ,  G01N33/54386 ,  G01N33/58 ,  G01N33/582 ,  G01N2333/91205 ,  G01N2458/30 ,  G01N2458/40 ,  Y10S435/967 ,  Y10S435/968 ,  Y10T436/10 ,  Y10T436/108331

Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

公开(公告)号：US20180029034A1

公开(公告)日：2018-02-01

申请号：US15784399

申请日：2017-10-16

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Sudeep Kumar ,  Pankaj Oberoi ,  George Sigal ,  Michael Tsionsky

IPC: B01L3/00 ,  G01N33/543 ,  C12Q1/68 ,  G01N33/68

CPC classification number: B01L3/50853 ,  B01L2300/021 ,  B01L2300/043 ,  B01L2300/0609 ,  B01L2300/0829 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/54306 ,  G01N33/54353 ,  G01N33/6845 ,  G01N2458/10 ,  C12Q2563/131

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20170370827A1

公开(公告)日：2017-12-28

申请号：US15587968

申请日：2017-05-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Jacob N. Wohlstadter ,  Eli Glezer ,  James Wilbur ,  George Sigal ,  Kent Johnson ,  Charles Clinton ,  Alan Kishbaugh ,  Bandele Jeffrey-Coker ,  Jeff D. Debad ,  Alan B. Fischer

IPC: G01N21/25 ,  B01L3/00 ,  G01N21/66 ,  G01N21/76 ,  B01L9/00 ,  G01N35/04 ,  G01N21/64

Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US20170312751A1

公开(公告)日：2017-11-02

申请号：US15646578

申请日：2017-07-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Stephen Higgins ,  Sandor Kovacs ,  Sudeep Kumar ,  Kenneth Page ,  Kristian Roth ,  George Sigal

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/68

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  C12Q1/686

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20160349253A1

公开(公告)日：2016-12-01

申请号：US15206656

申请日：2016-07-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Sudeep Kumar ,  George Sigal ,  Michael Tsionsky

IPC: G01N33/543 ,  C12Q1/68

CPC classification number: G01N33/54386 ,  C12Q1/6823 ,  C12Q1/6832 ,  C12Q1/6834 ,  G01N33/5306 ,  G01N2446/00 ,  G01N2458/30

Abstract: The invention relates to methods for conducting binding assays in an assay device that includes one or more storage and use zone. The storage zones of the assay device are configured to house one or more reagents used in an assay conducted in the use zone of the device.