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    Peptide imaging agents
    52.
    发明授权
    Peptide imaging agents 有权
    肽成像剂

    公开(公告)号：US08529874B2

    公开(公告)日：2013-09-10

    申请号：US12600265

    申请日：2008-05-16

    申请人： Edvin Wilhelm Johannesen ,  Alan Cuthbertson

    发明人： Edvin Wilhelm Johannesen ,  Alan Cuthbertson

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B8/00

    CPC分类号： A61K49/0056 ,  A61B5/0071 ,  A61B5/4842 ,  A61K49/0032

    摘要： The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).

    摘要翻译： 本发明涉及适用于体内光学成像的标记的cMet结合肽。 肽用适于在红色至近红外区域成像的光学报告基团标记。 还公开了药物组合物和试剂盒，以及体内成像方法，特别是用于检测，分期，诊断，监测疾病进展或监测结肠直肠癌（CRC）的治疗。

    Peptide-based compounds
    54.
    发明授权
    Peptide-based compounds 失效

    公开(公告)号：US07737252B2

    公开(公告)日：2010-06-15

    申请号：US10395500

    申请日：2003-03-24

    申请人： Alan Cuthbertson

    发明人： Alan Cuthbertson

    IPC分类号： C07K7/64

    CPC分类号： C07K14/70546 ,  A61K51/082 ,  C07K7/06

    摘要： This invention relates to new peptide-based compounds and their use in therapeutically effective treatments as well as for diagnostic imaging techniques. More specifically the invention relates to the use of such peptide-based compounds used as targeting vectors that bind to receptors associated with angiogenesis, in particular the αvβ3 integrin receptor. Such contrast agents may thus be used for diagnosis of for example malignant diseases, heart diseases, inflammation-related diseases, rheumatoid arthritis and Kaposi's sarcoma. Moreover such compounds may also be used in therapeutic treatment of these diseases.

    CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY CONSISTING OF A CYCLIC OLIGOAMID CORE OF 3 TO 4 IDENTICIAL MONOMER UNITS WITH 3 TO 4 PARAMAGNETIC CHELATE SIDE CHAINS
    55.
    发明申请
    CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY CONSISTING OF A CYCLIC OLIGOAMID CORE OF 3 TO 4 IDENTICIAL MONOMER UNITS WITH 3 TO 4 PARAMAGNETIC CHELATE SIDE CHAINS 审中-公开
    具有3至4个参考火焰侧链的3至4个标识单体的环状共轭成像和光谱法的对比剂

    公开(公告)号：US20090110640A1

    公开(公告)日：2009-04-30

    申请号：US12294263

    申请日：2006-12-01

    申请人： Oskar Axelsson ,  Alan Cuthbertson ,  Andreas Meijer

    发明人： Oskar Axelsson ,  Alan Cuthbertson ,  Andreas Meijer

    IPC分类号： A61K49/06 ,  C08G69/02 ,  A61K49/00

    CPC分类号： C07D487/22 ,  C07D471/22 ,  C07D498/22

    摘要： The present invention relates to: Compounds of formula (I) consisting of a cyclic polymer core A and groups -L-X attached to said core A-(L-X)n (I) wherein A denotes a cyclic polymer which is comprised of 3 or 4 identical monomers which are connected by amide bonds; L may be present or not and if present is that same or different and denotes a linker moiety, X is the same or different and denotes a chelator; and n denotes an integer of 3 or 4; Compound of formula (II) consisting of a cyclic polymer core A and groups -L-X′ attached to said core A-(L-X′)n (H) wherein A denotes a cyclic polymer which is comprised of 3 or 4 identical monomers which are connected by amide bonds; L may be present or not and if present is that same or different and denotes a linker moiety, X is the same or different and denotes a paramagnetic chelate consisting of a chelator X and a paramagnetic metal ion M; and n denotes an integer of 3 or 4; And compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and magnetic resonance spectroscopy (MRS).

    摘要翻译： 本发明涉及：由环状聚合物芯A和与所述核A-（LX）n（I）连接的基团-LX组成的式（I）化合物，其中A表示由3或4个相同的环状聚合物组成的环状聚合物 通过酰胺键连接的单体; L可以存在或不存在，如果存在相同或不同，并且表示连接体部分，X相同或不同，表示螯合剂; n表示3或4的整数; 式（II）的化合物由环状聚合物核心A和与所述核 - （L-X'）n（H）连接的基团-LX'组成，其中A表示由3或4个相同的单体组成的环状聚合物， 通过酰胺键连接; L可以存在或不存在，如果存在相同或不同，并且表示连接体部分，X相同或不同，表示由螯合剂X和顺磁性金属离子M组成的顺磁性螯合物; n表示3或4的整数; 以及包含式（II）化合物及其作为磁共振（MR）成像（MRI）和磁共振光谱学（MRS）中的造影剂的用途的组合物。

    Radiolabelled Insulin
    56.
    发明申请
    Radiolabelled Insulin 审中-公开
    放射性标记胰岛素

    公开(公告)号：US20080213174A1

    公开(公告)日：2008-09-04

    申请号：US11575158

    申请日：2005-09-13

    申请人： Matthias Eberhard Glaser ,  Frank Brady ,  Sajinder Kaur Luthra ,  Alan Cuthbertson ,  Hege Karlsen

    发明人： Matthias Eberhard Glaser ,  Frank Brady ,  Sajinder Kaur Luthra ,  Alan Cuthbertson ,  Hege Karlsen

    IPC分类号： A61K51/08 ,  C07K14/62

    CPC分类号： A61K51/088

    摘要： The invention relates to in vivo imaging agents, specifically radiolabelled insulin derivatives of formula (III); wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—, and is preferably —CO—NH—, —NH— or —O—; Y is H, alkyl or aryl substituents; R* is a radiolabel moiety suitable for detection by SPECT or PET; and methods for preparing the same as well as their use in in vivo imaging methods.

    摘要翻译： 本发明涉及体内成像剂，特别是式（III）的放射性标记的胰岛素衍生物; 其中X是-CO-NH-，-NH-，-O-，-NHCONH-或-NHCSNH-，优选为-CO-NH-，-NH-或-O-; Y是H，烷基或芳基取代基; R *是适于通过SPECT或PET检测的放射性标记部分; 及其制备方法以及它们在体内成像方法中的应用。

    Method for fabricating conducting plates for a high-Q MIM capacitor
    58.
    发明申请
    Method for fabricating conducting plates for a high-Q MIM capacitor 有权
    制造高Q MIM电容器导电板的方法

    公开(公告)号：US20080089007A1

    公开(公告)日：2008-04-17

    申请号：US11549052

    申请日：2006-10-12

    申请人： Isaiah O. Oladeji ,  Alan Cuthbertson

    发明人： Isaiah O. Oladeji ,  Alan Cuthbertson

    IPC分类号： H01G4/008 ,  H01L21/64

    CPC分类号： H01L27/0805 ,  H01L21/76838 ,  H01L28/75

    摘要： A method of forming one or more capacitors on or in a substrate and a capacitor structure resulting therefrom is disclosed. The method includes forming a trench in the substrate, lining the trench with a first copper-barrier layer, and substantially filling the trench with a first copper layer. The first copper layer is substantially chemically isolated from the substrate by the first copper-barrier layer. A second copper-barrier layer is formed over the first copper layer and a first dielectric layer is formed over the second copper-barrier layer. The dielectric layer is substantially chemically isolated from the first copper layer by the second copper-barrier layer. A third copper-barrier layer is formed over the dielectric layer and a second copper layer is formed over the third copper-barrier layer. The second copper layer is formed in a non-damascene process.

    摘要翻译： 公开了一种在衬底上或衬底中形成一个或多个电容器的方法以及由此产生的电容器结构。 该方法包括在衬底中形成沟槽，用第一铜阻挡层衬套沟槽，并用第一铜层基本上填充沟槽。 第一铜层通过第一铜阻挡层与衬底基本上化学隔离。 在第一铜层上形成第二铜阻挡层，在第二铜阻挡层上形成第一电介质层。 电介质层通过第二铜阻挡层与第一铜层基本上化学隔离。 在电介质层上形成第三铜阻挡层，在第三铜阻挡层上形成第二铜层。 第二铜层以非镶嵌工艺形成。

    Method of high-density plasma boron-containing silicate glass film deposition
    59.
    发明授权
    Method of high-density plasma boron-containing silicate glass film deposition 失效
    高密度等离子体含硼硅酸盐玻璃膜沉积方法

    公开(公告)号：US06500771B1

    公开(公告)日：2002-12-31

    申请号：US09494635

    申请日：2000-01-31

    申请人： Vladislav Vassiliev ,  John Leonard Sudijono ,  Alan Cuthbertson

    发明人： Vladislav Vassiliev ,  John Leonard Sudijono ,  Alan Cuthbertson

    IPC分类号： H01L2131

    CPC分类号： H01L21/02129 ,  C23C16/045 ,  C23C16/401 ,  H01L21/022 ,  H01L21/02211 ,  H01L21/02274 ,  H01L21/02304 ,  H01L21/02362 ,  H01L21/31625

    摘要： A method for fabricating a boron-contained silicate glass layers, such as borosilicate and borophosphosilicate glass films at low temperature using High Density Plasma CVD with silane derivatives as a source of silicon, boron and phosphorus compounds as a doping compounds, oxygen is described. RF plasma with certain plasma density is maintained throughout the entire deposition step in reactor chamber. Key feature of the invention's process is a flow capability of boron-contained silicate glass materials which provide a film with good film integrity and void-free gap-fill within the steps of device structures after low temperature thermal budget anneal conditions.

    摘要翻译： 描述了使用硅烷衍生物作为硅源，硼和磷化合物作为掺杂化合物的氧的高密度等离子体CVD制备含硼硅酸盐玻璃层例如硼硅酸盐和硼磷硅酸盐玻璃膜的方法，例如硼硅酸盐和硼磷硅酸盐玻璃膜。 在反应器室中的整个沉积步骤中保持具有一定等离子体密度的RF等离子体。 本发明方法的主要特征是含硼硅酸盐玻璃材料的流动能力，其在低温热预热退火条件之后在器件结构的步骤中提供具有良好膜完整性和无空隙间隙填充的膜。