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    Methods for directly injecting plug forming materials from a catheter
    53.
    发明申请
    Methods for directly injecting plug forming materials from a catheter 失效
    从导管直接注射栓塞形成材料的方法

    公开(公告)号：US20070106259A1

    公开(公告)日：2007-05-10

    申请号：US11636638

    申请日：2006-12-11

    申请人： Samuel Epstein ,  Wendy Naimark ,  Tim Mickley

    发明人： Samuel Epstein ,  Wendy Naimark ,  Tim Mickley

    IPC分类号： A61M5/178 ,  A61M25/00 ,  A61M31/00 ,  A61M5/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/3419 ,  A61B2017/3488 ,  A61B2018/00392 ,  A61M2025/0089

    摘要： The present invention relates to the direct delivery of therapeutic to a target tissue. In one embodiment a method for direct injection of plug forming material into a body tissue is provided. The method may comprise providing a catheter including a injection tube having a first channel, a second channel and a piercing tip. The first and second channels can be in fluid communication with a pressure source and a plug forming material. The injection tube may be slidably positioned in a pressure apron and moved from a first position to a second position so that the piercing tip extends beyond the tissue-mating surface in the second position to deliver the plug forming material.

    摘要翻译： 本发明涉及将治疗剂直接递送到靶组织。 在一个实施例中，提供了一种用于将栓塞形成材料直接注射到身体组织中的方法。 该方法可以包括提供包括具有第一通道，第二通道和穿刺尖端的注射管的导管。 第一和第二通道可以与压力源和塞子形成材料流体连通。 注射管可以可滑动地定位在压力皮圈中并从第一位置移动到第二位置，使得穿刺尖端在第二位置延伸超过组织配合表面以递送栓塞形成材料。

    Energetically-controlled delivery of biologically active material from an implanted medical device
    54.
    发明申请
    Energetically-controlled delivery of biologically active material from an implanted medical device 有权
    从植入式医疗装置对生物活性材料进行能量控制递送

    公开(公告)号：US20070010871A1

    公开(公告)日：2007-01-11

    申请号：US11514618

    申请日：2006-09-01

    申请人： Mark Hamm ,  Louis Barbato ,  Robert Crowley ,  Wendy Naimark ,  Hatal Patel

    发明人： Mark Hamm ,  Louis Barbato ,  Robert Crowley ,  Wendy Naimark ,  Hatal Patel

    IPC分类号： A61F2/06

    CPC分类号： A61K31/335 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18 ,  A61L2420/08

    摘要： A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer comprising a biologically active material and optionally a polymeric material is disposed on the surface of the medical device. A second coating layer comprising magnetic particles and a polymeric material is disposed on the first coating layer. The second coating layer, which is substantially free of a biologically active material, protects the biologically active material prior to delivery. The system includes the medical device and a source of energy, such as an electromagnetic or mechanical vibrational energy. When the patient is exposed to the energy source, the magnetic particles move out of the second coating layer and create channels therein through which the biologically active material can be released.

    摘要翻译： 能够向体腔患者提供生物活性物质的按需递送的医疗装置和系统以及制造这种医疗装置的方法。 包含生物活性材料和任选的聚合材料的第一涂层设置在医疗装置的表面上。 包含磁性颗粒和聚合物材料的第二涂层设置在第一涂层上。 基本上不含生物活性物质的第二涂层在输送之前保护生物活性物质。 该系统包括医疗装置和能量源，例如电磁或机械振动能量。 当患者暴露于能量源时，磁性颗粒从第二涂层移出并在其中产生通道，通过该通道释放生物活性物质。

    Processes for producing polymer coatings for release of therapeutic agent
    55.
    发明授权
    Processes for producing polymer coatings for release of therapeutic agent 有权
    用于制备用于释放治疗剂的聚合物涂层的方法

    公开(公告)号：US06923996B2

    公开(公告)日：2005-08-02

    申请号：US10430165

    申请日：2003-05-06

    申请人： Samuel J. Epstein ,  Wendy Naimark

    发明人： Samuel J. Epstein ,  Wendy Naimark

    IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00

    CPC分类号： B05D3/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/64

    摘要： A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

    摘要翻译： 提供了含有治疗剂的医疗装置的方法。 该方法包括：（a）在医疗器械表面上提供包含交联剂的反应层; 和（b）随后在反应层上施加包含聚合物和治疗剂的含聚合物的层。 交联剂与聚合物相互作用以形成包含治疗剂的交联聚合物区域。 医疗装置的实例包括可植入或可插入的医疗装置，例如导管，球囊，脑动脉瘤填充线圈，动静脉分流器和支架。

    Medical device with drug delivery member
    56.
    发明授权
    Medical device with drug delivery member 失效
    医疗器械配药

    公开(公告)号：US08740844B2

    公开(公告)日：2014-06-03

    申请号：US10645653

    申请日：2003-08-20

    申请人： Toby Freyman ,  Timothy J. Mickley ,  Maria J. Palasis ,  Wendy Naimark

    发明人： Toby Freyman ,  Timothy J. Mickley ,  Maria J. Palasis ,  Wendy Naimark

    IPC分类号： A61M31/00 ,  A61M29/02

    CPC分类号： A61M29/02 ,  A61M25/1029 ,  A61M2025/0057 ,  A61M2025/105

    摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。

    Processes for producing polymer coatings through surface polymerization
    58.
    发明授权
    Processes for producing polymer coatings through surface polymerization 失效
    通过表面聚合生产聚合物涂层的方法

    公开(公告)号：US07931932B2

    公开(公告)日：2011-04-26

    申请号：US12070275

    申请日：2008-02-14

    申请人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    发明人： Robert A. Herrmann ,  Frederick H. Strickler ,  Wendy Naimark ,  Peter L. Dayton

    IPC分类号： B05D3/06 ,  C08F2/46 ,  C08F295/00 ,  A61F2/06

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/606

    摘要： A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.

    摘要翻译： 具有治疗剂释放聚合物涂层的医疗装置。 该医疗装置由一种方法提供，该方法包括：（a）将至少一种反应性物质附着到医疗器械表面上，该反应性物质在单体存在下导致链增长聚合; （b）使反应性物质与至少一种单体物质接触，从而在医疗装置的表面上形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。 治疗剂可以在形成聚合物涂层期间或在形成聚合物涂层之后引入。 至少一种反应性物质可以包括例如自由基物质，碳负离子物质，碳阳离子物质，齐格勒 - 纳塔聚合配合物，茂金属络合物和/或原子转移自由基聚合引发剂。 或者，医疗装置由包括以下步骤的方法提供：（a）在医疗器械表面固定最少一种聚合催化剂，该聚合催化剂在单体存在下导致聚合; （b）使医疗器械表面与至少一种单体物质接触，从而在医疗装置的表面形成聚合物涂层; 和（c）在聚合物涂层内提供至少一种治疗剂。

    Energetically-controlled delivery of biologically active material from an implanted medical device
    59.
    发明授权
    Energetically-controlled delivery of biologically active material from an implanted medical device 有权
    从植入式医疗装置对生物活性材料进行能量控制递送

    公开(公告)号：US07585320B2

    公开(公告)日：2009-09-08

    申请号：US11514618

    申请日：2006-09-01

    申请人： Mark A Hamm ,  Louis J Barbato ,  Robert J Crowley ,  Wendy Naimark ,  Hatal Patel

    发明人： Mark A Hamm ,  Louis J Barbato ,  Robert J Crowley ,  Wendy Naimark ,  Hatal Patel

    IPC分类号： A61F2/06 ,  A61F2/00

    CPC分类号： A61K31/335 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L31/18 ,  A61L2420/08

    摘要： A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer comprising a biologically active material and optionally a polymeric material is disposed on the surface of the medical device. A second coating layer comprising magnetic particles and a polymeric material is disposed on the first coating layer. The second coating layer, which is substantially free of a biologically active material, protects the biologically active material prior to delivery. The system includes the medical device and a source of energy, such as an electromagnetic or mechanical vibrational energy. When the patient is exposed to the energy source, the magnetic particles move out of the second coating layer and create channels therein through which the biologically active material can be released.

    摘要翻译： 能够向体腔患者提供生物活性物质的按需递送的医疗装置和系统以及制造这种医疗装置的方法。 包含生物活性材料和任选的聚合材料的第一涂层设置在医疗装置的表面上。 包含磁性颗粒和聚合物材料的第二涂层设置在第一涂层上。 基本上不含生物活性物质的第二涂层在输送之前保护生物活性物质。 该系统包括医疗装置和能量源，例如电磁或机械振动能量。 当患者暴露于能量源时，磁性颗粒从第二涂层移出并在其中产生通道，通过该通道释放生物活性材料。

    Processes for producing polymer coatings for release of therapeutic agent
    60.
    发明授权
    Processes for producing polymer coatings for release of therapeutic agent 有权
    用于制备用于释放治疗剂的聚合物涂层的方法

    公开(公告)号：US07390525B2

    公开(公告)日：2008-06-24

    申请号：US11033918

    申请日：2005-01-12

    申请人： Samuel J. Epstein ,  Wendy Naimark

    发明人： Samuel J. Epstein ,  Wendy Naimark

    IPC分类号： B05D3/00

    CPC分类号： B05D3/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/64

    摘要： A method for furnishing a therapeutic-agent-containing medical device is provided. The method comprises: (a) providing a reactive layer comprising a cross-linking agent on a medical device surface; and (b) subsequently applying a polymer-containing layer, which comprises a polymer and a therapeutic agent, over the reactive layer. The cross-linking agent interacts with the polymer to form a cross-linked polymeric region that comprises the therapeutic agent. Moreover, in certain embodiments, the polymer-containing layer does not comprise the cross-linking agent at the time the polymer-containing layer is applied over the reactive layer. Examples of medical devices include implantable or insertable medical devices, for example, catheters, balloon, cerebral aneurysm filler coils, arterio-venous shunts and stents.

    摘要翻译： 提供了含有治疗剂的医疗装置的方法。 该方法包括：（a）在医疗器械表面上提供包含交联剂的反应层; 和（b）随后在反应层上施加包含聚合物和治疗剂的含聚合物的层。 交联剂与聚合物相互作用以形成包含治疗剂的交联聚合物区域。 此外，在某些实施方案中，含聚合物的层在反应层上施加聚合物层时，不包含交联剂。 医疗装置的实例包括可植入或可插入的医疗装置，例如导管，球囊，脑动脉瘤填充线圈，动静脉分流器和支架。