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公开(公告)号：US20090035352A1
公开(公告)日：2009-02-05
申请号：US12235978
申请日：2008-09-23
申请人： Janel Lanphere , Erin McKenna , Wendy Naimark , Marcia Buiser , Stephan Mangin
发明人： Janel Lanphere , Erin McKenna , Wendy Naimark , Marcia Buiser , Stephan Mangin
IPC分类号： A61F2/02
CPC分类号： A61L24/02 , A61B18/18 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K49/0452 , A61K51/1244 , A61L24/0015 , A61L24/0036 , A61L24/0089 , A61L2300/102 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2430/36
摘要： A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
摘要翻译： 药物递送颗粒包括具有主要大孔的储存区域和计量区域。 颗粒可以是高度球形的。
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公开(公告)号：US07951402B2
公开(公告)日：2011-05-31
申请号：US12235978
申请日：2008-09-23
申请人： Janel Lanphere , Erin McKenna , Wendy Naimark , Marcia Buiser , Stephan Mangin
发明人： Janel Lanphere , Erin McKenna , Wendy Naimark , Marcia Buiser , Stephan Mangin
CPC分类号： A61L24/02 , A61B18/18 , A61K9/14 , A61K9/1635 , A61K9/1652 , A61K49/0452 , A61K51/1244 , A61L24/0015 , A61L24/0036 , A61L24/0089 , A61L2300/102 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2430/36
摘要： A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
摘要翻译： 药物递送颗粒包括具有主要大孔的储存区域和计量区域。 颗粒可以是高度球形的。
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公开(公告)号：US07727555B2
公开(公告)日：2010-06-01
申请号：US11111511
申请日：2005-04-21
CPC分类号： B01J13/04 , A61K9/1694 , A61K41/00 , B01J2/02 , B01J2/18 , Y10T428/2984
摘要： Particles and related methods are disclosed. In some embodiments, a method of making particles can include forming a stream of a mixture including first and second materials, exposing the stream to a vibration, and treating the stream to form particles. The vibration can have, for example, a sinusoidal, triangular, and/or sawtooth waveform.
摘要翻译： 公开了颗粒和相关方法。 在一些实施方案中，制备颗粒的方法可以包括形成包含第一和第二材料的混合物流，将流暴露于振动，以及处理流以形成颗粒。 振动可以具有例如正弦，三角和/或锯齿波形。
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公开(公告)号：US20060199010A1
公开(公告)日：2006-09-07
申请号：US11111511
申请日：2005-04-21
申请人： Paul DiCarlo , Janel Lanphere , Thomas Casey , Marcia Buiser , Erin McKenna
发明人： Paul DiCarlo , Janel Lanphere , Thomas Casey , Marcia Buiser , Erin McKenna
CPC分类号： B01J13/04 , A61K9/1694 , A61K41/00 , B01J2/02 , B01J2/18 , Y10T428/2984
摘要： Particles and related methods are disclosed. In some embodiments, a method of making particles can include forming a stream of a mixture including first and second materials, exposing the stream to a vibration, and treating the stream to form particles. The vibration can have, for example, a sinusoidal, triangular, and/or sawtooth waveform.
摘要翻译： 公开了颗粒和相关方法。 在一些实施方案中，制备颗粒的方法可以包括形成包含第一和第二材料的混合物流，将流暴露于振动，以及处理流以形成颗粒。 振动可以具有例如正弦，三角和/或锯齿波形。
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公开(公告)号：US20070059375A1
公开(公告)日：2007-03-15
申请号：US11555413
申请日：2006-11-01
申请人： George Bourne , Marcia Buiser , Thomas Casey , Steve Keenan , Janel Lanphere , Jianmin Li , Erin McKenna , Zarouhi Minasian , Doreen Rao
发明人： George Bourne , Marcia Buiser , Thomas Casey , Steve Keenan , Janel Lanphere , Jianmin Li , Erin McKenna , Zarouhi Minasian , Doreen Rao
IPC分类号： A61K9/14
CPC分类号： A61F2/0036 , A61K9/1635 , A61K49/0452 , A61L24/001 , A61L24/0036 , A61L24/06 , A61L27/16 , A61L27/50 , A61L31/048 , A61L2430/36 , C08J3/12 , C08J3/24 , C08J2329/04 , C08L29/04
摘要： A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region substantially surrounding the interior having fewer relatively large pores than the interior region.
摘要翻译： 治疗组织的方法包括将基本上球形的聚合物颗粒置于组织中。 颗粒包括具有相对较大孔的内部区域，并且基本上围绕内部的第一区域具有比内部区域更少的相对较大的孔。
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公开(公告)号：US20050129775A1
公开(公告)日：2005-06-16
申请号：US10928452
申请日：2004-08-27
申请人： Janel Lanphere , Erin McKenna , Thomas Casey
发明人： Janel Lanphere , Erin McKenna , Thomas Casey
CPC分类号： A61K9/0009 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5036 , A61K9/5094 , A61K41/0028 , A61K41/0052
摘要： Ferromagnetic particles and methods are disclosed.
摘要翻译： 公开了铁磁颗粒和方法。
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公开(公告)号：US20050238870A1
公开(公告)日：2005-10-27
申请号：US10830195
申请日：2004-04-22
申请人： Marcia Buiser , Paul DiCarlo , Thomas Casey , Erin McKenna , Robert Rioux
发明人： Marcia Buiser , Paul DiCarlo , Thomas Casey , Erin McKenna , Robert Rioux
CPC分类号： A61K47/557 , Y10T428/25
摘要： Embolization, as well as related compositions and methods, are disclosed.
摘要翻译： 栓塞以及相关组合物和方法被公开。
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公开(公告)号：US20140005659A1
公开(公告)日：2014-01-02
申请号：US14014514
申请日：2013-08-30
申请人： Arnold E. Oyola , Erin McKenna
发明人： Arnold E. Oyola , Erin McKenna
CPC分类号： A61B18/18 , A61B17/0057 , A61B18/1492 , A61B2017/00641 , A61B2017/22067 , A61B2018/1472
摘要： A method of treating a patient is provided. The method comprises delivering an electrically conductive material within a vascular network, wherein the electrically conductive material embolizes in a region of the vascular network to form a vascular electrode array that assumes a geometry of the embolized region of the vascular network. The method may optionally comprise delivering a containment agent within the vascular network proximal to the delivered electrically conductive material to stabilize the vascular electrode array. The method further comprises applying electrical energy (e.g., radio frequency (RF) energy) to the vascular electrode array to therapeutically conduct electrical energy into a region of the targeted tissue adjacent the embolized region of the vascular network.
摘要翻译： 提供了一种治疗患者的方法。 该方法包括在血管网络内输送导电材料，其中导电材料栓塞在血管网络的区域中以形成假定血管网络的栓塞区域的几何形状的血管电极阵列。 该方法可以任选地包括在靠近所传送的导电材料的血管网内输送容纳剂，以稳定血管电极阵列。 该方法还包括向血管电极阵列施加电能（例如，射频（RF）能量）以将电能治疗地传导到与血管网络的栓塞区域相邻的目标组织的区域中。
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9.发明申请公开(公告)号：US20070167944A1
公开(公告)日：2007-07-19
申请号：US11564813
申请日：2006-11-29
申请人： Arnold E. Oyola , Erin McKenna
发明人： Arnold E. Oyola , Erin McKenna
IPC分类号： A61B18/18
CPC分类号： A61B18/18 , A61B17/0057 , A61B18/1492 , A61B2017/00641 , A61B2017/22067 , A61B2018/1472
摘要： A method of treating a patient is provided. The method comprises delivering an electrically conductive material within a vascular network, wherein the electrically conductive material embolizes in a region of the vascular network to form a vascular electrode array that assumes a geometry of the embolized region of the vascular network. The method may optionally comprise delivering a containment agent within the vascular network proximal to the delivered electrically conductive material to stabilize the vascular electrode array. The method further comprises applying electrical energy (e.g., radio frequency (RF) energy) to the vascular electrode array to therapeutically conduct electrical energy into a region of the targeted tissue adjacent the embolized region of the vascular network.
摘要翻译： 提供了一种治疗患者的方法。 该方法包括在血管网络内输送导电材料，其中导电材料栓塞在血管网络的区域中以形成假定血管网络的栓塞区域的几何形状的血管电极阵列。 该方法可以任选地包括在靠近所传送的导电材料的血管网内输送容纳剂，以稳定血管电极阵列。 该方法还包括向血管电极阵列施加电能（例如，射频（RF）能量）以将电能治疗地传导到与血管网络的栓塞区域相邻的靶组织的区域中。
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10.发明授权公开(公告)号：US08679111B2
公开(公告)日：2014-03-25
申请号：US14014514
申请日：2013-08-30
申请人： Arnold E. Oyola , Erin McKenna
发明人： Arnold E. Oyola , Erin McKenna
IPC分类号： A61B18/12
CPC分类号： A61B18/18 , A61B17/0057 , A61B18/1492 , A61B2017/00641 , A61B2017/22067 , A61B2018/1472
摘要： A method of treating a patient is provided. The method comprises delivering an electrically conductive material within a vascular network, wherein the electrically conductive material embolizes in a region of the vascular network to form a vascular electrode array that assumes a geometry of the embolized region of the vascular network. The method may optionally comprise delivering a containment agent within the vascular network proximal to the delivered electrically conductive material to stabilize the vascular electrode array. The method further comprises applying electrical energy (e.g., radio frequency (RF) energy) to the vascular electrode array to therapeutically conduct electrical energy into a region of the targeted tissue adjacent the embolized region of the vascular network.
摘要翻译： 提供了一种治疗患者的方法。 该方法包括在血管网络内输送导电材料，其中导电材料栓塞在血管网络的区域中以形成假定血管网络的栓塞区域的几何形状的血管电极阵列。 该方法可以任选地包括在靠近所传送的导电材料的血管网内输送容纳剂，以稳定血管电极阵列。 该方法还包括向血管电极阵列施加电能（例如，射频（RF）能量）以将电能治疗地传导到与血管网络的栓塞区域相邻的靶组织的区域中。
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