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公开(公告)号：US08076636B2
公开(公告)日：2011-12-13
申请号：US12373341
申请日：2007-07-12
申请人： Kevin Giles
发明人： Kevin Giles
CPC分类号： H01J49/0481 , G01N27/622 , H01J49/004 , H01J49/062
摘要： A mass spectrometer is disclosed comprising a first chamber (10) and a second chamber (5). The second chamber (5) is located downstream of the first chamber 10 and an inter-chamber aperture (12) is provided between the two chambers (5,10). An ion guide (13) is located in the first chamber (10) and an ion mobility spectrometer (6) is located in the second chamber (5). Helium gas is provided to the first chamber (10). As ions are accelerated towards the ion mobility spectrometer 6 from a relatively low pressure region they pass initially into the first chamber (10). The helium gas provided in the first chamber (10) minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide (13) and are subsequently transmitted to the ion mobility spectrometer (6) located in the second chamber (5).
摘要翻译： 公开了一种质谱仪，其包括第一室（10）和第二室（5）。 第二室（5）位于第一室10的下游，并且在两个室（5,10）之间设置室间孔（12）。 离子导向器（13）位于第一室（10）中，离子迁移谱仪（6）位于第二室（5）中。 氦气被提供到第一室（10）。 当离子从相对低的压力区域向离子迁移谱仪6加速时，它们首先进入第一腔室（10）。 设置在第一室（10）中的氦气最小化离子碎片和离子鉴别效应，因为离子被加速到相对高的压力区域。 然后离子由离子引导件（13）传输，随后被传递到位于第二室（5）中的离子迁移谱仪（6）。
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公开(公告)号：US20100065733A1
公开(公告)日：2010-03-18
申请号：US12306162
申请日：2007-06-25
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (6) arranged upstream of a collision or fragmentation cell (8). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (6). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (6) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (8). During the time that the potential of the ion mobility spectrometer or separator (6) is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator (6) such as an ion source (1), ion guide (2), quadrupole mass filter (3), optional second collision or fragmentation cell (4) and an ion trapping device (5) are kept constant.
摘要翻译： 公开了一种质谱仪，其包括设置在碰撞或分裂单元（8）的上游的离子迁移谱仪或分离器（6）。 根据离子迁移谱仪或分离器（6）内的离子迁移率分离离子。 离子离子迁移谱仪或分离器（6）离子的动能随着时间的推移基本线性地增加，以优化离子进入碰撞或破碎电池（8）时的碎裂能。 在离子迁移谱仪或分离器（6）的电位变化的时间内，离子迁移谱仪或分离器（6）上游离子光学部件的离子源（1），离子导向器 2），四极质量过滤器（3），任选的第二碰撞或碎裂单元（4）和离子捕获装置（5）保持恒定。
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公开(公告)号：US20090173880A1
公开(公告)日：2009-07-09
申请号：US11720520
申请日：2005-12-02
CPC分类号： H01J49/065
摘要： An ion guide (7a) is disclosed comprising one or more layers of intermediate planar, plate or mesh electrodes (2). A first array of first electrodes (8a-8e) is provided on an upper surface and a second array of second electrodes (9a-9e) is arranged on a lower surface. An ion guiding region is formed within the ion guide (7a). One or more transient DC voltages or potentials are preferably applied to the first and second array of second electrodes (8a-8e, 9a-9e) in order to urge, propel, force or accelerate ions through or along the ion guide (7a).
摘要翻译： 公开了一种离子导向器（7a），其包括一层或多层中间平面，板状或网状电极（2）。 第一电极阵列（8a-8e）设置在上表面上，第二电极阵列（9a-9e）布置在下表面上。 离子引导区域形成在离子导向器（7a）内。 优选地将一个或多个瞬态DC电压或电位施加到第一和第二第二电极阵列（8a-8e，9a-9e），以促使，推动，强迫或加速离子通过或沿着离子导向器（7a）。
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公开(公告)号：US07205538B2
公开(公告)日：2007-04-17
申请号：US11472278
申请日：2006-06-22
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
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公开(公告)号：US07095013B2
公开(公告)日：2006-08-22
申请号：US10448057
申请日：2003-05-30
IPC分类号： H01J49/40
CPC分类号： H01J49/065
摘要： A mass spectrometer is disclosed having an ion guide which receives ions from either a pulsed ion source or an ion trap, or a continuous ion source. The ion guide emits packets of ions. The pulses of ions emitted from the ion guide may be synchronised with another device such as an ion detector, an orthogonal acceleration Time of Flight mass analyser, an ion trap or a mass filter.
摘要翻译： 公开了一种质谱仪，其具有从脉冲离子源或离子阱或连续离子源接收离子的离子导向器。 离子导向器发出离子束。 从离子导向器发射的离子的脉冲可以与诸如离子检测器，正交加速时间飞行质量分析器，离子阱或质量过滤器的另一装置同步。
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公开(公告)号：US07071467B2
公开(公告)日：2006-07-04
申请号：US10633702
申请日：2003-08-05
IPC分类号： H01J49/40
CPC分类号： H01J49/4225
摘要： A mass spectrometer is disclosed comprising an ion trap wherein ions which have been temporally separated according to their mass to charge ratio or ion mobility enter the ion trap. Once at least some of the ions have entered the ion trap, a plurality of ion trapping regions are created along the length of the ion trap in order to fractionate the ions. Alternatively, the ions may be received within one or more axial trapping regions which are translated along the ion trap with a velocity which is progressively reduced to zero.
摘要翻译： 公开了一种质谱仪，其包括离子阱，其中根据其质荷比或离子迁移率暂时分离的离子进入离子阱。 一旦至少一些离子已经进入离子阱，沿着离子阱的长度产生多个离子捕获区域，以分离离子。 或者，离子可以被接收在一个或多个沿着离子阱平移的轴向捕获区域中，其速度逐渐减小到零。
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公开(公告)号：US06977371B2
公开(公告)日：2005-12-20
申请号：US10457515
申请日：2003-06-10
申请人： Robert Harold Bateman , Kevin Giles
发明人： Robert Harold Bateman , Kevin Giles
CPC分类号： H01J49/065 , H01J49/005
摘要： A mass spectrometer is disclosed having a gas collision cell. An AC or RF ion guide comprising a plurality of ring electrodes which preferably have the same internal diameter is provided within the gas collision cell. The ion guide extends upstream and/or downstream of the gas collision cell so that ions may be continuously radially confined as they pass from a vacuum chamber maintained at a relatively low pressure, through an inlet differential pumping aperture to the gas collision cell, through the gas collision cell and then out of the gas collision cell through an outlet differential pumping aperture.
摘要翻译： 公开了一种具有气体碰撞池的质谱仪。 包含多个优选具有相同内径的环形电极的AC或RF离子导向器设置在气体碰撞室内。 离子导向件在气体碰撞室的上游和/或下游延伸，使得离子可以在维持在相对较低的压力的真空室中通过入口差动泵送孔通过气体碰撞室，从而连续地径向地限制，通过 气体碰撞池，然后通过出口差分泵浦孔径离开气体碰撞池。
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公开(公告)号：US06903331B2
公开(公告)日：2005-06-07
申请号：US10178854
申请日：2002-06-25
CPC分类号： H01J49/062
摘要： An ion tunnel ion trap comprises a plurality of electrodes having apertures. The ion tunnel ion trap is preferably coupled to a time of flight mass analyser.
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公开(公告)号：US06791078B2
公开(公告)日：2004-09-14
申请号：US10603824
申请日：2003-06-26
IPC分类号： H01J4940
CPC分类号： G01N27/622
摘要： A mass spectrometer comprising an ion mobility separator for separating ions according to their ion mobility is disclosed. The ion mobility separator comprises a plurality of electrodes and one or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain ion mobility are separated from other ions having different ion mobilities.
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公开(公告)号：US09293314B2
公开(公告)日：2016-03-22
申请号：US14130428
申请日：2012-07-06
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analyzing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analyzing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analyzing the third ions.
摘要翻译： 公开了一种自动重复执行多个操作循环的质谱法，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将第一离子暴露于第一光离解装置以形成多个第二离子并质量分析第二离子; 和（iii）将第一离子暴露于第一光解离装置以形成多个第二离子，使第二离子碎裂以形成多个第三离子并大量分析第三离子。
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