公开(公告)号：US08262485B2

公开(公告)日：2012-09-11

申请号：US13231660

申请日：2011-09-13

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： F16D3/76

CPC分类号： F16F15/1245 ,  F16D3/68

摘要： A vibration damper (2) that is effective in the direction of rotation of a drive shaft and has a small radial extension. For this purpose, a first shaft part (6) is provided as a sleeve (8) and a second shaft part (7) is provided as an inner part extending axially into the sleeve (8). The two shaft parts (6, 7) engage via rotary drivers in complementary negative profiles (15, 16) of an interposed elastic damper part (10) in the direction of rotation. In addition to the negative profiles, the damper part may be provided with recesses (40) which modify its damping characteristics.

摘要翻译： 一种在驱动轴的旋转方向上有效并且具有小的径向延伸的减振器（2）。 为此，第一轴部（6）设置为套筒（8），第二轴部（7）设置为轴向延伸到套筒（8）中的内部。 两个轴部分（6,7）通过旋转驱动器沿着旋转方向与插入的弹性阻尼器部件（10）的互补的负型面（15,16）接合。 除了负型轮廓之外，阻尼器部分可以设置有改变其阻尼特性的凹部（40）。

公开(公告)号：US20120036943A1

公开(公告)日：2012-02-16

申请号：US12521213

申请日：2009-04-29

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01F1/34 ,  B23P11/00

CPC分类号： G01F25/0092 ,  A61M15/009 ,  A61M2209/02 ,  Y10T29/49826

摘要： For testing metered-dose-ejection devices, whether the ejected dose accords with a rated dose, the device (1) is sealingly applied (26) to a test compartment (24) and upon machine manipulation on the device (M, 5) a dose is ejected into the test compartment (24). Pressure difference established by such injection and with respect to a pre-established reference pressure (30) in the test compartment (24) is monitored by a pressure sensor (32). The output signal (o) of this sensor (32) is indicative of the extent of the addressed dose.

摘要翻译： 为了测试计量喷射装置，喷射的剂量是否符合额定剂量，装置（1）被密封地施加到测试室（24）上，并且在机器上操纵装置（M，5）a 剂量被喷射到测试室（24）中。 由压力传感器（32）监测通过这种注射和相对于测试室（24）中的预先建立的参考压力（30）建立的压力差。 该传感器（32）的输出信号（o）表示寻址的剂量的程度。

公开(公告)号：US07584650B2

公开(公告)日：2009-09-08

申请号：US11959925

申请日：2007-12-19

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/34 ,  G01M3/04

CPC分类号： G01M3/36

摘要： In a leak testing apparatus and a method for manufacturing unleaky closed containers having first and second flexible wall areas with different flexibility characteristics, a biasing member is moved toward and onto the first flexible area and a force detector monitors a biasing force at the second flexible area. A container is considered unleaky if a difference signal from force measuring signals at first and second points in time fulfills a test criteria. Sampling the biasing force monitored which results in the first force measuring signal includes determining maximum biasing force signal value which occurs during a time span up to and including the first point in time.

摘要翻译： 在泄漏测试装置和用于制造具有不同柔性特性的第一和第二柔性壁区域的不透明的封闭容器的方法中，偏置构件朝向和朝向第一柔性区域移动并且力检测器监测第二柔性区域 。 如果在第一和第二时间点的力测量信号的差分信号满足测试标准，则容器被认为是不透明的。 对所产生的第一力测量信号进行监测的偏压力的采样包括确定在直到并包括第一时间点的时间范围内发生的最大偏置力信号值。

公开(公告)号：US20080219965A1

公开(公告)日：2008-09-11

申请号：US11942220

申请日：2007-11-19

申请人： Allan Svendsen ,  Soren Flensted Lassen ,  Dirk Kostrewa ,  Luis Pasamontes ,  Martin Lehmann ,  Andrea Tomschy ,  Adolphus Van Loon ,  Kurt Vogel ,  Markus Wyss

发明人： Allan Svendsen ,  Soren Flensted Lassen ,  Dirk Kostrewa ,  Luis Pasamontes ,  Martin Lehmann ,  Andrea Tomschy ,  Adolphus Van Loon ,  Kurt Vogel ,  Markus Wyss

IPC分类号： A61K38/46 ,  C12N9/14

CPC分类号： C12N15/8257 ,  A23K10/14 ,  A23K20/189 ,  C12N9/16 ,  C12N15/8242 ,  C12N15/8243 ,  Y10S435/911 ,  Y10S435/916

摘要： The present invention relates to phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.

摘要翻译： 本发明涉及植酸酶变体，其制备和用途，当植酸酶变体在根据图1对齐时。 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。

公开(公告)号：US20080193998A1

公开(公告)日：2008-08-14

申请号：US11631542

申请日：2005-07-07

申请人： Sybille Ebert ,  Hans-Peter Hohnmann ,  Martin Lehmann ,  Nigel John Mouncey ,  Markus Wyss

发明人： Sybille Ebert ,  Hans-Peter Hohnmann ,  Martin Lehmann ,  Nigel John Mouncey ,  Markus Wyss

IPC分类号： C12N15/87 ,  C12N9/00 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C12P17/16

CPC分类号： C12N9/78

摘要： The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing riboflavin, a riboflavin precursor, FMN, FAD, or a derivative thereof.

摘要翻译： 本发明涉及显示增加的比活性的改良的GTP环化水解酶II酶和编码它们的多核苷酸。 本发明还涉及包含这些多核苷酸的载体和含有这些载体的宿主细胞。 本发明提供一种生产该修饰酶的方法和一种生产核黄素，核黄素前体，FMN，FAD或其衍生物的方法。

公开(公告)号：US20080016951A1

公开(公告)日：2008-01-24

申请号：US11828495

申请日：2007-07-26

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/04

CPC分类号： G01M3/04 ,  B65B3/04 ,  G01M3/22 ,  G01M3/226 ,  G01M3/3263 ,  G01M3/3281 ,  G01M3/329 ,  G08B21/20 ,  Y10T29/49771 ,  Y10T29/53022

摘要： For leak testing closed containers (9) which are filled with a filling product containing at least one liquid component the container is introduced in a test cavity (1) which is evacuated at least down to vapour pressure of that liquid component. The pressure in the surrounding of the container (9) and thus within test cavity (1) is monitored. Monitoring is performed by a vacuum pressure sensor (7), whereas lowering pressure surrounding the container (9) is performed by a vacuum pump (5). Leakage is detected by monitoring a pressure change in the surrounding of the container which is due to evaporation of liquid emerging from a leak and being evaporated in the low pressure surrounding.

摘要翻译： 对于密封容器（9）的泄漏测试，其中填充有包含至少一种液体组分的填充产品，容器被引入至少抽真空至该液体组分的蒸气压的测试空腔（1）中。 监测容器（9）周围并因此在测试腔（1）内的压力。 通过真空压力传感器（7）进行监视，而通过真空泵（5）执行围绕容器（9）的降低压力。 通过监测容器周围的压力变化来检测泄漏，这是由于泄漏出现的液体蒸发而在低压环境中蒸发。

公开(公告)号：US20070141685A1

公开(公告)日：2007-06-21

申请号：US10560726

申请日：2004-06-10

申请人： Renyuan Bai ,  Markus Huembelin ,  Martin Lehmann ,  Rual Lopez-Ulibarri ,  Markus Wyss

发明人： Renyuan Bai ,  Markus Huembelin ,  Martin Lehmann ,  Rual Lopez-Ulibarri ,  Markus Wyss

IPC分类号： C12P7/66 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12 ,  C12N1/21 ,  C12N15/74

CPC分类号： C12N9/1205

摘要： The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing isoprenoid compounds.

摘要翻译： 本发明涉及对反馈抑制不那么敏感的修饰的甲羟戊酸激酶以及编码它们的多核苷酸。 本发明还涉及包含这些多核苷酸的载体和含有这些载体的宿主细胞。 本发明提供了一种制备改性酶的方法和一种生产类异戊二烯化合物的方法。

公开(公告)号：US20070056355A1

公开(公告)日：2007-03-15

申请号：US11221803

申请日：2005-09-09

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/34

CPC分类号： G01M3/36

摘要： In a leak testing apparatus and a method for manufacturing unleaky closed containers having first and second flexible wall areas with different flexibility characteristics, a biasing member is moved toward and onto the first flexible area and a force detector monitors a biasing force at the second flexible area. A container is considered unleaky if a difference signal from force measuring signals at first and second points in time fulfills a test criteria. Sampling the biasing force monitored which results in the first force measuring signal includes determining maximum biasing force signal value which occurs during a time span up to and including the first point in time.

摘要翻译： 在泄漏测试装置和用于制造具有不同柔性特性的第一和第二柔性壁区域的不透明的封闭容器的方法中，偏置构件朝向和朝向第一柔性区域移动并且力检测器监测第二柔性区域 。 如果在第一和第二时间点的力测量信号的差分信号满足测试标准，则容器被认为是不透明的。 对所产生的第一力测量信号进行监测的偏压力的采样包括确定在直到并包括第一时间点的时间范围内发生的最大偏置力信号值。

公开(公告)号：US20060112759A1

公开(公告)日：2006-06-01

申请号：US11326381

申请日：2006-01-06

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/36

CPC分类号： G01M3/3281 ,  Y10T29/49771

摘要： A method and device for testing containers, the method calling for a difference in pressure to be generated between the pressure inside the container and the pressure immediately surrounding the container, the behavior of one of these pressures permitting the gas tightness of the container to be assessed. A pressure value is stored and subsequently compared with one of the pressures, the stored pressure value being stored electronically and compared with at least one value of the output signal from a pressure sensor. The container is housed in an enclosure which is connected to a pressure or suction line, and a pressure-value storage unit, a comparator unit and a pressure sensor are associated with the pressure or suction line.

公开(公告)号：US06514495B1

公开(公告)日：2003-02-04

申请号：US09273871

申请日：1999-03-22

申请人： Allan Svendsen ,  Søren Flensted Lassen ,  Dirk Kostrewa ,  Luis Pasamontes ,  Martin Lehmann ,  Andrea Tomschy ,  Adolphus Van Loon ,  Kurt Vogel ,  Markus Wyss

发明人： Allan Svendsen ,  Søren Flensted Lassen ,  Dirk Kostrewa ,  Luis Pasamontes ,  Martin Lehmann ,  Andrea Tomschy ,  Adolphus Van Loon ,  Kurt Vogel ,  Markus Wyss

IPC分类号： A61K3846

CPC分类号： C12N15/8257 ,  A23K10/14 ,  A23K20/189 ,  C12N9/16 ,  C12N15/8242 ,  C12N15/8243 ,  Y10S435/911 ,  Y10S435/916

摘要： Phytase variants, their preparation and uses, which phytase variants, when aligned according to FIG. 1, are amended as compared to a model phytase in at least one of a number of positions. Preferred model phytases are basidiomycete and ascomycete phytases, such as Peniophora phytase and Aspergillus phytases. Preferred phytase variants exhibits amended activity characteristics, such as improved specific activity and/or improved thermostability.

摘要翻译： 植酸酶变体，它们的制备和用途，当植酸酶变体根据图1对齐时， 与在多个位置中的至少一个中的模型植酸酶相比，修改了1。 优选的植酸酶类型是担子菌和子囊菌植酸酶，如Peniophora植酸酶和曲霉属植酸酶。 优选的植酸酶变体表现出修正的活性特征，例如提高的比活性和/或改善的热稳定性。