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公开(公告)号：US09272098B2
公开(公告)日：2016-03-01
申请号：US13993534
申请日：2011-12-21
CPC分类号： A61M5/3257 , A61M5/20 , A61M5/2033 , A61M5/24 , A61M5/326 , A61M5/46 , A61M2205/581 , A61M2205/582
摘要： An auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel and a drive means releasably coupled to the plunger for advancing the syringe in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means is arranged to be decoupled from the plunger for advancing a needle shroud to a safe position (PS) to surround the injection needle after the injection. According to the invention, the drive means bears against a thrust collar arranged to be releasably coupled to the plunger through a ramped engagement of a first tongue and a first recess so as to rotate the thrust collar on translation in proximal direction (P). At least one longitudinal gap (G1, G2) is provided for guiding at a first and/or second protrusion of the thrust collar to prevent a rotation of the thrust collar. A circumferential gap (G3) is arranged to allow the thrust collar to rotate out of engagement to the plunger on removal of the auto-injector from the injection site.
摘要翻译： 用于给药液体药物（M）的自动注射器包括基本上圆柱形的壳体，其被布置成容纳预注射注射器，其具有注射针，柱塞和用于密封注射器筒的塞子和可释放地联接的驱动装置 到用于将注射器沿近端方向（P）推进的柱塞，用于针插入注射部位并将剂量的药物（M）移位到注射部位。 驱动装置被布置成与柱塞脱离，用于将针护罩推进到安全位置（PS）以在注射之后包围注射针。 根据本发明，驱动装置抵靠着被布置成通过第一舌片和第一凹部的倾斜接合可释放地联接到柱塞的止推套环，以便沿近端方向（P）平移来旋转止推环。 提供至少一个纵向间隙（G1，G2）用于在止推环的第一和/或第二突起处引导以防止止推环的旋转。 周向间隙（G3）布置成允许止推环在从注射部位移除自动注射器时旋转离开柱塞。
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公开(公告)号：US09205199B2
公开(公告)日：2015-12-08
申请号：US13580271
申请日：2011-02-16
CPC分类号： A61M5/3202 , A61M5/2033 , A61M5/315 , A61M5/326 , A61M5/46 , A61M5/482 , A61M5/484 , A61M2005/206 , A61M2005/208 , A61M2005/2086 , A61M2005/2418 , A61M2005/3103 , A61M2005/3152 , A61M2005/3247 , A61M2205/581 , A61M2205/583 , F16H25/20 , F16H25/2056
摘要： An auto-injector may be used to administer a dose of a liquid medicament (M). In some embodiments, a shroud is arranged inside a housing, the shroud slidable in longitudinal direction between at least a retracted position, in which a hollow injection needle is exposable and an advanced position, in which the needle is covered by the shroud. A protective needle shield is attachable to the needle in a manner to partially protrude beyond the proximal end of the shroud through the orifice with the needle in its advanced position. A syringe carrier is arranged inside the shroud and comprises at least one snap for locking it to the shroud in order to prevent relative axial motion. The snap is configured to automatically disengage upon removal of the protective needle shield to allow the syringe and needle to be retracted into the covered position under load of the syringe spring.
摘要翻译： 可以使用自动注射器来施用剂量的液体药物（M）。 在一些实施例中，护罩布置在壳体内部，护罩可以在至少缩回位置（其中空心注射针可暴露于其中）和前进位置之间在纵向方向上滑动，在该位置中针被护罩覆盖。 保护针护罩可以以针部分地突出超过护罩的近端通过孔口的方式附接到针上，其中针处于其前进位置。 注射器托架布置在护罩内部并且包括至少一个卡扣以将其锁定到护罩上，以防止相对的轴向运动。 卡扣被配置为在移除保护针护罩时自动脱离，以允许注射器和针在注射器弹簧的负载下缩回到覆盖位置。
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公开(公告)号：US08808250B2
公开(公告)日：2014-08-19
申请号：US13579928
申请日：2011-02-16
CPC分类号： A61M5/3232 , A61M5/2033 , A61M5/31583 , A61M5/3202 , A61M5/326 , A61M2005/206 , A61M2005/2073 , A61M2005/3152 , A61M2005/325
摘要： The invention relates to an auto-injector for administering a dose of a liquid medicament (M), comprising: an elongate outer casing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the outer casing having a distal end (D) and a proximal end (P) with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the outer casing, spring means capable of, upon activation: pushing the needle past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection, wherein the spring means is a torsion spring grounded at one end in the outer casing and at the other end in a first gear member rotatable about a longitudinal axis, wherein the first gear member, upon rotation, is arranged for translatively moving a second gear member toward the proximal end (P), the second gear member prevented from rotating and coupled to the stopper in order to push it towards the proximal end (P), wherein the first gear member is engaged with the activating means prior to manual operation in a manner to prevent rotation and disengaged from the activating means upon manual operation.
摘要翻译： 本发明涉及一种用于施用剂量的液体药物（M）的自动注射器，包括：细长外壳，布置成容纳具有中空针的注射器和用于密封注射器和移位药剂（M）的止动件， 所述外壳具有远端（D）和近端（P），所述近端具有旨在施加在注射部位上的孔，其中所述注射器相对于所述外壳可滑动地布置，所述弹簧装置能够在启动时： 将针推过近端（P），操作注射器以供给剂量的药剂（M），并且用针启动装置缩回注射器，该针启动装置被布置成在手动操作之前将弹簧装置锁定在加压状态，并且能够 在手动操作时释放用于注射的弹簧装置，其中弹簧装置是在外壳的一端接地的扭力弹簧，另一端处于可围绕纵向轴线旋转的第一齿轮构件，w 这里，第一齿轮构件在旋转时被布置用于朝向近端（P）平移地移动第二齿轮构件，防止第二齿轮构件旋转并联接到止动件，以将其推向近端（P） 其中，在手动操作之前，第一齿轮构件与激活装置接合，以防止在手动操作时旋转和从激活装置脱离的方式。
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公开(公告)号：US20130310759A1
公开(公告)日：2013-11-21
申请号：US13807268
申请日：2011-06-20
IPC分类号： A61M5/32
CPC分类号： A61M5/3221 , A61M5/2033 , A61M5/31511 , A61M5/326 , A61M5/46 , A61M2005/206 , A61M2005/208
摘要： The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end, operating the syringe to supply the dose of medicament, and retracting the syringe with the needle into the covered position after delivering the medicament, activating means arranged to lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection. The spring means is a single drive spring arranged to be grounded at a distal end in the housing for advancing the needle and for injecting the dose of medicament via a plunger and wherein the drive spring is arranged to have its ground in the housing switched to its proximal end for retracting the syringe. An interlock sleeve is telescoped in the proximal end of the housing, the interlock sleeve translatable in longitudinal direction between a proximal position and a distal position, wherein in its proximal position the interlock sleeve is arranged to be coupled to the syringe in the syringe's retracted position and wherein the interlock sleeve in its distal position is arranged to allow decoupling of the syringe.
摘要翻译： 本发明涉及一种用于给药液体药物的自动注射器，包括：细长壳体，布置成容纳具有中空针头的注射器和用于密封注射器并使药剂移位的塞子，壳体具有远端和 具有旨在施加在注射部位上的孔口的近端，其中所述注射器相对于所述壳体可滑动地布置;弹簧装置，其能够在启动时：将所述针从所述壳体内的覆盖位置推入到前进位置 并且经过近端，操作注射器以提供剂量的药物，并且在输送药物之后将针头注射到被覆盖的位置，激活装置被布置成在手动操作之前将弹簧装置锁定在加压状态 并且能够在手动操作时释放用于注射的弹簧装置。 弹簧装置是单个驱动弹簧，其布置成在壳体中的远端处接地，用于推进针头并且用于经由柱塞喷射剂量的药剂，并且其中驱动弹簧被布置成使得其壳体中的地面切换到其 近端用于缩回注射器。 互锁套筒在壳体的近端中伸缩，联锁套筒可以在近端位置和远端位置之间沿纵向方向平移，其中在其近端位置中，联锁套筒布置成在注射器的缩回位置联接到注射器 并且其中处于其远侧位置的所述互锁套筒布置成允许所述注射器解耦。
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公开(公告)号：US20130296796A1
公开(公告)日：2013-11-07
申请号：US13996145
申请日：2011-12-21
CPC分类号： A61M5/326 , A61M5/2033 , A61M5/24 , A61M5/46 , A61M2005/206 , A61M2005/208 , A61M2205/581 , A61M2205/582
摘要： The invention refers to an auto-injector for delivering a liquid medicament, comprising: an elongate housing arranged to contain a syringe with a hollow injection needle and a stopper, wherein the syringe is slidably arranged with respect to the housing, spring means capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position for insertion into the injection site, operating the syringe to inject the dose of medicament, and advancing a needle shroud over the needle for providing needle safety, activating means arranged to lock and release the spring means, wherein the spring means is a single drive spring in the shape of a compression spring grounded distally in the housing and proximally bearing against a thrust collar arranged to transmit load from the spring means via a plunger to the syringe and/or the stopper for needle insertion and injection, wherein the plunger is engageable to the thrust collar for joint axial translation, wherein the plunger is disengageable from the thrust collar on relative rotation so as to allow the thrust collar to be advanced further by the drive spring in order to engage the needle shroud for advancing it over the needle.
摘要翻译： 本发明涉及一种用于输送液体药物的自动注射器，包括：细长壳体，布置成容纳具有中空注射针头和塞子的注射器，其中所述注射器相对于所述壳体可滑动地布置， 激活时：将针从外壳内的覆盖位置推入到用于插入注射部位的前进位置，操作注射器以注射剂量的药物，并将针罩延伸到针上以提供针安全性，激活装置布置 以锁定和释放弹簧装置，其中弹簧装置是在壳体中向远侧接地的压缩弹簧的形状的单个驱动弹簧，并且向近侧支承着布置成将负载从弹簧装置经由柱塞传递到注射器的止推环 和/或用于针插入和注射的止动器，其中柱塞可接合到止推环用于关节轴向平移 其中所述柱塞在相对旋转时可与所述止推环脱开，从而允许所述推力环通过所述驱动弹簧进一步前进，以便与所述针罩接合以将其推进到所述针上。
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公开(公告)号：US20130296795A1
公开(公告)日：2013-11-07
申请号：US13807445
申请日：2011-06-22
CPC分类号： A61M5/2033 , A61M5/326 , A61M2005/2013 , A61M2005/206 , A61M2005/2086 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , Y10T74/18984
摘要： The invention refers to a shuttering mechanism for controlling translation of a longitudinally moveable component within an elongate housing, the shuttering mechanism comprising at least one set of castellations on the housing and at least one resilient arm associated with the longitudinally moveable component, the resilient arm having a dog resiliently biased towards the castellations so as to engage between or behind the castellations and block the translation, wherein a respective shutter arm is arranged alongside the set of castellations, the shutter arm having a number of consecutive ramped protrusions spaced from each other, wherein the castellations and the ramped protrusions have the same pitch, wherein a profiled surface is formed by the castellations and the ramped protrusions, wherein the shutter arm is moveable in longitudinal direction with respect to the set of castellations, wherein the shutter arm has at least one locking position with its ramped protrusions essentially in phase with the castellations thus allowing the dog of the resilient arm to catch between or behind the castellations and wherein the shutter arm has at least one unlocking position with its ramped protrusions out of phase with the castellations in such a manner that the ramped protrusions prevent the dog from engaging with the castellations or disengage them thus allowing translation of the longitudinally moveable component.
摘要翻译： 本发明涉及一种用于控制细长壳体内的纵向移动部件的平移的快门机构，所述遮蔽机构包括在所述壳体上的至少一组雉and和与所述纵向可移动部件相关联的至少一个弹性臂，所述弹性臂具有 一个朝向雉dog弹性地偏置的狗，以便在雉between之间或之后接合并阻挡平移，其中相应的襟翼臂被布置在cast the组旁边，快门臂具有彼此间隔开的多个连续的倾斜突起，其中 城堡和斜坡突起具有相同的间距，其中通过雉ations和倾斜的突起形成异形表面，其中，快门臂可相对于该组蓖体在纵向方向上移动，其中，快门臂具有至少一个 基本上具有斜坡突起的锁定位置 与雉房同相，从而允许弹性臂的狗抓住在蓖体之间或之后，并且其中快门臂具有至少一个解锁位置，其斜坡突起与雉房异相，使得倾斜的突起防止 狗与雉鸡接合或脱开，从而允许纵向可移动部件的平移。
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公开(公告)号：US20130274662A1
公开(公告)日：2013-10-17
申请号：US13993528
申请日：2011-12-21
CPC分类号： A61M5/2033 , A61M5/326 , A61M5/50 , A61M2005/206 , A61M2005/208
摘要： According to the invention, an auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (M), a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (P) towards a safe position (PS) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (PS) surrounds the injection needle after the injection has been carried out. The rotating collar engages the needle shroud in a manner that forces the rotating collar to rotate within the housing when the needle shroud is translated in the proximal direction (P).
摘要翻译： 根据本发明，用于给药液体药物（M）的自动注射器包括布置成容纳填充有药物（M）的预填充注射器的基本上圆柱形的壳体，针罩可相对于 所述壳体并适于搁置在接受注射的患者的皮肤上;布置在所述壳体内的可释放的驱动装置，所述可释放的驱动装置能够在松开时沿近端方向（P）朝向安全位置（PS）平移所述针罩， 以及可旋转地布置在所述壳体内的旋转轴环。 在进行注射后，安全位置（PS）的针罩围绕注射针头。 当针护罩沿近端方向（P）平移时，旋转套环以这样的方式接合针罩，即迫使旋转套环在壳体内旋转。
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公开(公告)号：US20130261558A1
公开(公告)日：2013-10-03
申请号：US13993534
申请日：2011-12-21
CPC分类号： A61M5/3257 , A61M5/20 , A61M5/2033 , A61M5/24 , A61M5/326 , A61M5/46 , A61M2205/581 , A61M2205/582
摘要： An auto-injector for administering a dose of a liquid medicament (M) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe with an injection needle, a plunger and a stopper for sealing a syringe barrel and a drive means releasably coupled to the plunger for advancing the syringe in the proximal direction (P) for needle insertion into an injection site and for displacing the dose of medicament (M) into the injection site. The drive means is arranged to be decoupled from the plunger for advancing a needle shroud to a safe position (PS) to surround the injection needle after the injection. According to the invention, the drive means bears against a thrust collar arranged to be releasably coupled to the plunger through a ramped engagement of a first tongue and a first recess so as to rotate the thrust collar on translation in proximal direction (P). At least one longitudinal gap (G1, G2) is provided for guiding at a first and/or second protrusion of the thrust collar to prevent a rotation of the thrust collar. A circumferential gap (G3) is arranged to allow the thrust collar to rotate out of engagement to the plunger on removal of the auto-injector from the injection site.
摘要翻译： 用于给药液体药物（M）的自动注射器包括基本上圆柱形的壳体，其被布置成容纳预注射注射器，其具有注射针，柱塞和用于密封注射器筒的塞子和可释放地联接的驱动装置 到用于将注射器沿近端方向（P）推进的柱塞，用于针插入注射部位并将剂量的药物（M）移位到注射部位。 驱动装置被布置成与柱塞脱离，用于将针护罩推进到安全位置（PS）以在注射之后包围注射针。 根据本发明，驱动装置抵靠着被布置成通过第一舌片和第一凹部的倾斜接合可释放地联接到柱塞的止推套环，以便沿近端方向（P）平移来旋转止推环。 提供至少一个纵向间隙（G1，G2）用于在止推环的第一和/或第二突起处引导以防止止推环的旋转。 周向间隙（G3）布置成允许止推环在从注射部位移除自动注射器时旋转离开柱塞。
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公开(公告)号：US20130204200A1
公开(公告)日：2013-08-08
申请号：US13880518
申请日：2011-10-25
申请人： Gareth Roberts , Chris Ward , Matthew Ekman
发明人： Gareth Roberts , Chris Ward , Matthew Ekman
IPC分类号： A61M5/32
CPC分类号： A61M5/3257 , A61M5/326 , A61M5/3272 , A61M2005/3267
摘要： According to the invention, a safety device for a pre-filled syringe comprises a hollow support body for retaining the pre-filled syringe therein, a hollow needle shield and a spring means made from a resilient plastics material. The needle shield is telescoped with the support body and the spring means biases the needle shield in a distal direction.
摘要翻译： 根据本发明，用于预填充注射器的安全装置包括用于将预填充的注射器保持在其中的中空支撑体，空心针护罩和由弹性塑料材料制成的弹簧装置。 针护罩用支撑体伸缩，弹簧装置沿远端方向偏压针罩。
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公开(公告)号：US20130172822A1
公开(公告)日：2013-07-04
申请号：US13579450
申请日：2011-02-16
IPC分类号： A61M5/32
CPC分类号： A61M5/3221 , A61M5/2033 , A61M5/3204 , A61M5/326 , A61M2005/206 , A61M2005/2073
摘要： The invention relates to an auto-injector (1) with a delay mechanism (36) for slowing down motion of a retraction sleeve (10) in axial direction of the auto-injector (1), the delay mechanism (36) comprising a circumferential outer wall (37) with a back collar (38) attached to a housing (2) of the auto-injector (1) and a circumferential inner wall (39) with a front collar (40) attached to the retraction sleeve (10) wherein a cavity is defined between the outer wall (37) and inner wall (39), the cavity sealed by the back collar (38) against the inner wall (39) and by the front collar (40) against the outer wall (37), the cavity filled with a viscous fluid, wherein at least one orifice is arranged in the delay mechanism (36) for allowing the viscous fluid to be pushed out as the volume of the cavity decreases due to axial motion of the component with respect to the housing. The retraction sleeve (10) is axially movably arranged in the housing (2) and serves for retracting the syringe (3) with the needle (4) into the covered position after delivering the medicament (M).
摘要翻译： 本发明涉及一种具有延迟机构（36）的自动注射器（1），用于在自动注射器（1）的轴向方向上减慢收缩套筒（10）的运动，延迟机构（36）包括周向 外壁（37），其具有附接到自动注射器（1）的壳体（2）的后环（38）和具有附接到缩回套筒（10）的前轴环（40）的周向内壁（39） 其中在所述外壁（37）和所述内壁（39）之间限定空腔，所述空腔被所述后环（38）密封抵靠所述内壁（39），并且所述前轴环（40）抵靠所述外壁（37） ），所述空腔填充有粘性流体，其中在所述延迟机构（36）中布置有至少一个孔口，用于当所述部件的轴向运动相对于所述腔体的轴向运动减小时，允许粘性流体被推出 住房。 缩回套筒（10）可轴向移动地布置在壳体（2）中，用于在输送药物（M）之后将注射器（3）用针（4）缩回到覆盖位置。
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