公开(公告)号：US06251516B1

公开(公告)日：2001-06-26

申请号：US09018596

申请日：1998-02-04

申请人： Robert F. Bonner ,  Lance A. Liotta ,  Michael Emmert-Buck ,  David B. Krizman ,  Rodrigo Chuaqui ,  W. Marston Linehan ,  Jeffry M. Trent ,  Seth R. Goldstein ,  Paul D. Smith ,  John I. Peterson

发明人： Robert F. Bonner ,  Lance A. Liotta ,  Michael Emmert-Buck ,  David B. Krizman ,  Rodrigo Chuaqui ,  W. Marston Linehan ,  Jeffry M. Trent ,  Seth R. Goldstein ,  Paul D. Smith ,  John I. Peterson

IPC分类号： B32B712

CPC分类号： G01N1/2813 ,  G01N1/04 ,  G01N1/08 ,  G01N1/2806 ,  G01N1/286 ,  G01N1/31 ,  G01N15/1468 ,  G01N33/50 ,  G01N2001/028 ,  G01N2001/2833 ,  G01N2001/284 ,  G01N2035/00237 ,  G02B21/32 ,  Y10T428/2813 ,  Y10T428/2839

摘要： A method of microdissection which involves forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes a selectively activatable adhesive layer which provides, for example, chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated, the transfer surface and tissue sample are separated. During separation, the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample, the zone of cells of interest may then be molecularly analyzed.

摘要翻译： 一种显微解剖的方法，其包括使用显微镜形成组织样本的细胞的图像场，从细胞的图像区鉴定至少一个感兴趣区域的至少一个感兴趣区域，所述细胞的至少一个区域包括不同类型的细胞， 并且从所述组织样品中提取所述感兴趣的细胞的至少一个区域。 通过使组织样品与可以选择性活化的转移表面接触使得其区域粘附到待提取的感兴趣的细胞区域来实现提取。 转移表面包括可选择性活化的粘合剂层，其提供例如化学或静电附着到组织样品的选定区域。 在转印表面被激活之后，转印表面和组织样品被分离。 在分离期间，感兴趣的细胞区保持粘附到转移表面，并因此与组织样品分离，然后可以分析分析感兴趣的细胞区域。

公开(公告)号：US5770545A

公开(公告)日：1998-06-23

申请号：US818541

申请日：1997-03-14

申请人： Lowell J. Lawrence ,  Terry L. Johnson ,  Stephan Kwiatkowski ,  Paul D. Smith

发明人： Lowell J. Lawrence ,  Terry L. Johnson ,  Stephan Kwiatkowski ,  Paul D. Smith

IPC分类号： A01N33/18 ,  C07C211/52 ,  C07C211/00

CPC分类号： C07C211/52 ,  A01N33/18

摘要： This invention relates to pendralin �2,6-dinitro-N-(1-ethylpropyl)-4-tert-butylaniline!, preemergence and postemergence herbicidal methods and herbicidal compositions employing pendralin.

摘要翻译： 本发明涉及彭达林[2,6-二硝基-N-（1-乙基丙基）-4-叔丁基苯胺]，芽前和芽后除草方法和采用潘达林的除草组合物。

公开(公告)号：US5519534A

公开(公告)日：1996-05-21

申请号：US248918

申请日：1994-05-25

申请人： Paul D. Smith ,  John Cole ,  Frank Harrington ,  Eric F. Bernstein

发明人： Paul D. Smith ,  John Cole ,  Frank Harrington ,  Eric F. Bernstein

IPC分类号： A61B18/22 ,  A61N5/06 ,  G02B5/02 ,  A61B17/36 ,  A61N5/00 ,  G01J1/04

CPC分类号： A61N5/062 ,  G02B5/02 ,  A61B2018/2261 ,  A61N2005/0644 ,  A61N2005/0666 ,  Y10S359/90

摘要： A irradiation attachment for an optical fiber which provides an output of light that has a highly uniform intensity. The device includes a hollow spherical shell having a diffusive reflective surface or target supported therein. Light is directed into the hollow spherical shell so that it reflects off the diffusive reflective surface or target. The reflected light is internally reflected off the inner surface of the hollow spherical shell several times before passing through an output aperture. As a result of the internal reflection within the hollow spherical shell, the light leaving the device has a highly uniform intensity. The device is particularly useful for photodynamic therapy.

摘要翻译： 用于光纤的照射附件，其提供具有高度均匀强度的光的输出。 该装置包括具有支撑在其中的漫射反射表面或靶的中空球壳。 光被引导到中空球壳中，使得其反射离开漫射反射表面或靶。 在通过输出孔之前，反射光在中空球壳的内表面内部被反射几次。 由于在空心球壳内的内部反射，离开设备的光具有高度均匀的强度。 该装置对光动力疗法特别有用。

公开(公告)号：US5435307A

公开(公告)日：1995-07-25

申请号：US676581

申请日：1991-03-29

申请人： Walter S. Friauf ,  Paul D. Smith ,  John W. Cole ,  Joseph F. Fessler ,  Roger E. Solomon ,  Eric F. Bernstein

发明人： Walter S. Friauf ,  Paul D. Smith ,  John W. Cole ,  Joseph F. Fessler ,  Roger E. Solomon ,  Eric F. Bernstein

IPC分类号： A61B5/00

CPC分类号： A61B5/0059

摘要： A method of optimizing photodynamic therapy in which retained concentrations of photosensitizers administered are measured on a real time basis by percutaneous measurements of fluorescence. A light weight hand held fluorometer is used to percutaneously measure fluorescence emitted by photosensitizers in a tissue situs that is subject to photodynamic therapy. The use of real time determinations of the concentration of photosensitizers allow optimization of illumination intensity and duration.

摘要翻译： 优化光动力疗法的方法，其中通过经皮测量荧光实时测量所施用的光敏剂的保留浓度。 使用轻量级的手持式荧光计经皮测量经受光动力学治疗的组织部位中的光敏剂发出的荧光。 使用光敏剂浓度的实时测定可以优化照明强度和持续时间。

公开(公告)号：US5210380A

公开(公告)日：1993-05-11

申请号：US741032

申请日：1991-08-06

申请人： Robert M. McDermott ,  Paul D. Smith ,  Scott McDermott

发明人： Robert M. McDermott ,  Paul D. Smith ,  Scott McDermott

IPC分类号： G01B7/00 ,  G01D5/12 ,  G06F3/033 ,  G06F3/041 ,  G06F3/046 ,  G06F3/047

CPC分类号： G06F3/046 ,  G06F3/041 ,  G06F3/047

摘要： Disclosed herein are position determining apparatus and conductor structures or grids therefor. The conductor structure for each axis includes a number of conductors which are run in a serpentine-type path each with uniform repeat increment. The repeat increment, which is the spacing or span between one run and the next of the same serpentine-type conductor, are uniform for each conductor (but may change from conductor to conductor) and is constrained by a maximum repeat increment, or a minimum repeat increment. In the preferred embodiments, there is at least a constraint on the maximum repeat increment to provide noise immunity. The conductors are arranged for each axis of the grid in a pattern such that signals obtained for that axis may be processed to provide binary numbers in a Gray-type code each unique to a small region of the active area in which the coil center is located. The small region for a given axis corresponds to the space between two immediately adjacent, active conductor portions for that axis, with a possible ambiguity of one space. Small regions in each axis define the coarse location of the coil center. Fine location within a region may be determined from the magnitudes of currents induced in selected runs preferably by interpolation.

摘要翻译： 这里公开了位置确定装置及其导体结构或网格。 每个轴的导体结构包括多个以蛇形式路径运行的导体，每个导体具有均匀的重复增量。 重复增量，即同一蛇形导体的一个行程和下一个之间的间距或跨度对于每个导体是均匀的（但可能从导体变为导体），并受到最大重复增量或最小值的约束 重复增量。 在优选实施例中，至少对最大重复增量具有约束以提供抗噪声性。 这些导体以格局布置成网格的每个轴线，使得为该轴获得的信号可以被处理以提供格雷型代码中的二进制数，每个二进制数字对于线圈中心所在的有效区域的小区域是唯一的 。 对于给定轴的小区域对应于用于该轴线的两个紧邻的有源导体部分之间的空间，具有一个空间的可能的模糊性。 每个轴的小区域定义线圈中心的粗略位置。 区域内的精细位置可以从优选地通过插值在所选择的行程中感应的电流的大小来确定。

公开(公告)号：US5137997A

公开(公告)日：1992-08-11

申请号：US829493

申请日：1992-02-03

申请人： Brian K. Conroy ,  Paul D. Smith

发明人： Brian K. Conroy ,  Paul D. Smith

IPC分类号： C08F10/00

CPC分类号： C08F10/00

摘要： Olefin polymerization catalysts, processes for preparing the catalysts and processes for producing polyolefins utilizing the catalysts are provided. The catalysts are basically comprised of a trialkylsilylamide-chromium complex adsorbed on an activated inorganic compound.

摘要翻译： 提供烯烃聚合催化剂，制备催化剂的方法和利用催化剂生产聚烯烃的方法。 催化剂基本上由吸附在活化的无机化合物上的三烷基甲硅烷基酰胺 - 铬络合物组成。

公开(公告)号：US5104841A

公开(公告)日：1992-04-14

申请号：US688974

申请日：1991-04-22

申请人： Brian K. Conroy ,  Paul D. Smith

发明人： Brian K. Conroy ,  Paul D. Smith

IPC分类号： C08F4/78 ,  C08F10/00

CPC分类号： C08F10/00

摘要： Olefin polymerization catalysts, processes for preparing the catalysts and processes for producing polyolefins utilizing the catalysts are provided. The catalysts are basically comprised of a trialkylsilylamide-chromium complex adsorbed on an activated inorganic refractory compound.

摘要翻译： 提供烯烃聚合催化剂，制备催化剂的方法和利用催化剂生产聚烯烃的方法。 催化剂基本上由吸附在活性无机耐候性化合物上的三烷基甲硅烷基酰胺 - 铬络合物组成。

公开(公告)号：US4579302A

公开(公告)日：1986-04-01

申请号：US587764

申请日：1984-03-09

申请人： William C. Schneider ,  Reginald B. Berka ,  Herbert C. Kavanaugh ,  Kornel Nagy ,  Richard C. Parish ,  John A. Schliesing ,  Paul D. Smith ,  Frederick J. Stebbins ,  Clarence J. Wesselski

发明人： William C. Schneider ,  Reginald B. Berka ,  Herbert C. Kavanaugh ,  Kornel Nagy ,  Richard C. Parish ,  John A. Schliesing ,  Paul D. Smith ,  Frederick J. Stebbins ,  Clarence J. Wesselski

IPC分类号： B64G99/00 ,  B64G1/10

CPC分类号： B64G9/00 ,  Y10S136/292

摘要： A triangular space station deployable in orbit. The framework is comprised of three trusses, formed of a pair of generally planar faces comprised of foldable struts which expand and lock into rigid structural engagement forming a repetition of equilateral triangles and non-folding diagonal struts interconnecting the two faces. The struts are joined together by node fittings. The framework can be packaged into a size and configuration which can be transported by a space shuttle orbiter in a single orbital flight and when deployed, provides large work/construction area and ample planar surface area for solar panels and thermal radiators. A plurality of modules are secured to the framework and then joined by tunnels to comprise an interconnected modular array disposed along the free edges of the framework. Thruster units for space station orientation and altitude maintenance are provided. The triangular space station provides a structurally stable unit having sufficiently high structural integrity and natural frequency for facilitating docking, satellite servicing and launch operations.

摘要翻译： 可在轨道上部署的三角形空间站。 该框架由三个桁架构成，由一对大体上平坦的面构成，该平面由可折叠的支柱膨胀并锁定成刚性结构接合，形成重复的等边三角形和互相连接两个面的非折叠对角支柱。 支柱通过节点配件连接在一起。 框架可以包装成一个尺寸和配置，可以在单轨道飞行中由航天飞机轨道运输，并且部署时，为太阳能电池板和散热器提供大的工作/建筑面积和宽的平面表面积。 多个模块被固定到框架上，然后由隧道连接以包括沿框架的自由边缘设置的互连的模块化阵列。 提供了用于空间站定向和高度维护的推进装置。 三角空间站提供了具有足够高的结构完整性和固有频率的结构稳定的单元，以便于对接，卫星维修和发射操作。

公开(公告)号：US08515093B2

公开(公告)日：2013-08-20

申请号：US12900322

申请日：2010-10-07

申请人： Sanjay M. Bhandari ,  Paul D. Smith ,  Jiang (Jennifer) Yu ,  Sheng-Yu Peng ,  Priscilla E. Escobar-Bowser

发明人： Sanjay M. Bhandari ,  Paul D. Smith ,  Jiang (Jennifer) Yu ,  Sheng-Yu Peng ,  Priscilla E. Escobar-Bowser

IPC分类号： H04R3/00 ,  H03G5/00

CPC分类号： H04R29/006 ,  H04R3/005 ,  H04R25/407

摘要： A system includes a plurality of inputs each configured to receive a filtered version of a source signal. The system extracts the energy information from each input signal and compares the energy information of a plurality of input signals. Alternatively, the system extracts energy information from a signal that is the difference of two input signals. Based on the energy information, the system determines at least one parameter that may be changed in at least one circuit in a plurality of circuits to minimize the differences in energy of the input signals or to minimize the energy of the difference signal. Parameters may include for example amplification, delay, and corner frequency values.The set of circuits may include microphone interface circuits. Merely by way of example, a system with microphone interface circuits may be included in a hearing enhancement device or in a hands-free earpiece.

摘要翻译： 系统包括多个输入，每个输入被配置为接收源信号的滤波版本。 该系统从每个输入信号中提取能量信息，并比较多个输入信号的能量信息。 或者，系统从作为两个输入信号的差的信号提取能量信息。 基于能量信息，系统确定可以在多个电路中的至少一个电路中改变的至少一个参数，以最小化输入信号的能量差异或最小化差分信号的能量。 参数可以包括例如放大，延迟和转角频率值。 该组电路可以包括麦克风接口电路。 仅举例来说，具有麦克风接口电路的系统可以包括在听力增强装置中或免提耳机中。

公开(公告)号：US20110083864A1

公开(公告)日：2011-04-14

申请号：US12721828

申请日：2010-03-11

申请人： Paul D. Smith ,  Robert G. Dunster ,  Paul Rennie ,  Beth A. Jones

发明人： Paul D. Smith ,  Robert G. Dunster ,  Paul Rennie ,  Beth A. Jones

IPC分类号： A62C37/00

CPC分类号： A62C37/48 ,  A62C3/07 ,  A62C35/68

摘要： A fire detection system includes a detection tube and a sensing device. The detection tube contains a sensing fluid having a first physical condition and a second physical condition. The sensing fluid is in the first physical condition below a temperature threshold, and is in the second physical condition above the temperature threshold. The sensing fluid is at least partially liquid in the first physical condition. The sensing device is movable to open in response to a transition of a portion of the sensing fluid from the first physical condition to the second physical condition.

摘要翻译： 火灾检测系统包括检测管和感测装置。 检测管包含具有第一物理条件和第二物理条件的检测流体。 感测流体处于低于温度阈值的第一物理状态，并且处于高于温度阈值的第二物理条件。 感测流体在第一物理条件下至少部分为液体。 响应于感测流体的一部分从第一物理状态到第二物理状态的转变，感测装置可移动以打开。