摘要:
Display device based on layer break up or layer displacement having at least two different states, in which one of the fluids (5) e.g oil in a first state adjoins at least a first support plate (3) and in the second state the other fluid (6) at least partly adjoins the first support plate. In one embodiment a picture element corresponds to a substantially closed space and in the first state the other fluid layer substantially completely adjoins both support plates and is divided in two sub-layers. This makes it possible on the one hand to use lower voltages to make displacement occur. On the other hand this opens the opportunity to color displays.
摘要:
The invention relates to a sensor device for detecting a target in a sample suspected of comprising the target, which device is suitable for use in an assay such as a sandwich assay. The invention further relates to a method for detecting a target in a sample. The device comprises a sensor surface, which is functionalised with one moiety of a strong binding couple, which moiety preferably shows little or no cross reactivity with the target molecule.
摘要:
In a 2D/3D display, a switchable lenticular array having foci which can be switched in a continuous way between first focal strength and a second focal strength is provided. The switchable lenticular array comprises fluid cylindrical lens portions, while the foci can be controlled by electrowetting.
摘要:
Switching between 2D and 3D visualization is achieved by an optical-index matching fluid (9) which can be brought between a lenticular sheet (6, 7) and a top plate (10). The fluid may contain two immiscible fluids while switching is based on (re)distribution of the fluids due to electrostatic forces.
摘要:
Pixels of a display device include a reservoir containing two immiscible fluids. Switching of a pixel state is based on redistribution of the fluids within the reservoir due to electrostatic forced applied onto electrodes, and a potential applied to one of the fluids which is electrically conducting.
摘要:
The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.
摘要:
The invention relates to a method and a sensor device (100) for the detection of clusters (C) of magnetic particles (MP) in a sample volume (111), particularly of clusters (C) consisting of two magnetic particles (MP) with different binding sites that are bound to a target molecule in a sandwich configuration. Output light (L2) originating from an interaction of input light (L1) with clusters (C) of magnetic particles (MP) is detected. Moreover, the magnetic particles (MP, C) are actuated by a magnetic actuation field (B), wherein said actuation is at least once interrupted by a pause. In this way a high output signal can be achieved that properly reflects the amount of specifically bound clusters (C).
摘要:
The invention relates to a method and an apparatus (100) for the enrichment of magnetic particles (1) in a sample fluid. The sample fluid is provided in a sample cartridge (2) between a first pole (111) and a second pole (112) of an actuator magnet (110). A minimal magnetic flux as well as a minimal magnetic gradient are then established inside the sample fluid, wherein their values depend on the particular magnetic particles (1) and the sample fluid under consideration. In a preferred embodiment, the first pole (111) has a single tip (T).
摘要:
The present invention relates to a coating for preventing non-specific binding of molecules to a surface layer comprising an affinity molecule, said coating comprises single layer comprising non-affine spacer molecules forming a mesh; or a shell structure, wherein said shell structure comprises a first layer comprising one or more affinity molecules and further a second layer, which is coupled to the first layer, and wherein said first and second layer comprise non-affine spacer molecules forming a mesh. The present invention further relates to a particle, a flat structure or a matrix comprising such a coating. In a further aspect the present invention relates to the use of the coating, coated particle, coated flat structure or coated matrix for detection and/or purification of a specific target biomolecule from a sample and/or determination of the concentration of the specific target biomolecule. The present invention further relates to an assay for the detection of specific target biomolecules from a sample and/or determination of the concentration of specific target biomolecules comprising the use of such coating, coated particle, coated flat structure or coated matrix, in particular coated nanoparticles.
摘要:
The invention relates to a method and a sensor device (100) for the detection of clusters (C) of magnetic particles (MP) in a sample volume (111), particularly of clusters (C) consisting of two magnetic particles (MP) with different binding sites that are bound to a target molecule in a sandwich configuration. Output light (L2) originating from an interaction of input light (L1) with clusters (C) of magnetic particles (MP) is detected. Moreover, the magnetic particles (MP, C) are actuated by a magnetic actuation field (B), wherein said actuation is at least once interrupted by a pause. In this way a high output signal can be achieved that properly reflects the amount of specifically bound clusters (C).