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公开(公告)号：US06232295B1
公开(公告)日：2001-05-15
申请号：US08321552
申请日：1994-10-12
IPC分类号： A61K4800
CPC分类号： A61K49/146 , A61K47/645 , A61K49/085 , Y10S977/808 , Y10S977/927 , Y10S977/93
摘要： A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.
摘要翻译： 描述了能够特异性结合并进入目标细胞的递送载体，为细胞的磁共振成像（MRI）递送许多顺磁离子。 递送载体包含具有与具有净负电荷的另一个聚合物分子络合的净正电荷的聚合物分子。 细胞靶向部分和MRI造影剂连接到一个或两个聚合物分子。 在一个实施方案中，具有净负电荷的聚合物分子是核酸。 因此，递送载体可以用于其中用于基因治疗的核酸和用于MRI对比的药剂共同转运到特定细胞的临床方案，允许对核酸递送进行医学成像监测。
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公开(公告)号：US6096273A
公开(公告)日：2000-08-01
申请号：US743798
申请日：1996-11-05
CPC分类号： C07H21/00 , C12Q1/6825
摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
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公开(公告)号：US5780234A
公开(公告)日：1998-07-14
申请号：US709263
申请日：1996-09-06
IPC分类号： C12N15/09 , C07H21/00 , C07H23/00 , C12Q1/68 , G01N33/566 , C07H21/02 , C07H21/04 , C12Q1/70
CPC分类号： C07H23/00 , C07H21/00 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827
摘要： The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
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公开(公告)号：US08580231B2
公开(公告)日：2013-11-12
申请号：US13551344
申请日：2012-07-17
CPC分类号： A61K49/106 , A61K31/57 , A61K49/085 , A61K49/10 , A61K49/126 , A61K49/14 , C01F17/00 , C07J1/0003 , G01R33/5601
摘要： The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
摘要翻译： 本发明涉及用磁共振造影剂成像的组合物和方法。 特别地，本发明提供了用于选择性成像的靶向造影剂。
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公开(公告)号：US08383356B2
公开(公告)日：2013-02-26
申请号：US13366068
申请日：2012-02-03
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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公开(公告)号：US08337813B2
公开(公告)日：2012-12-25
申请号：US12210829
申请日：2008-09-15
申请人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
IPC分类号： A61B5/055
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译： 本发明一般涉及多模式磁共振成像（MRI）造影剂。 特别地，本发明提供了构造成操纵周围水质子旋转的纵向（T1）和横向（T2）弛豫时间的MRI造影剂。
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公开(公告)号：US08114661B2
公开(公告)日：2012-02-14
申请号：US12773382
申请日：2010-05-04
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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公开(公告)号：US20110177008A1
公开(公告)日：2011-07-21
申请号：US13008576
申请日：2011-01-18
申请人： Lisa M. Manus , Daniel J. Mastarone , Dean Ho , Thomas J. Meade
发明人： Lisa M. Manus , Daniel J. Mastarone , Dean Ho , Thomas J. Meade
CPC分类号： A61K49/1881
摘要： The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.
摘要翻译： 本发明提供了用于合成顺磁性金属离子和纳米金刚石的共轭物的组合物和方法及其用途。 特别地，本发明提供顺磁金属 - 纳米金刚石缀合物的合成和使用这种组合物作为分子成像探针的方法。
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公开(公告)号：US07713711B2
公开(公告)日：2010-05-11
申请号：US11981735
申请日：2007-10-30
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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60.发明申请公开(公告)号：US20100029909A1
公开(公告)日：2010-02-04
申请号：US12471731
申请日：2009-05-26
IPC分类号： C07K14/575 , C07K14/435 , G01R33/48
CPC分类号： A61K49/10 , A61K49/085
摘要： The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
摘要翻译： 本发明涉及用磁共振造影剂成像的组合物和方法。 特别地，本发明提供了用于选择性成像的靶向造影剂。
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