公开(公告)号：US07205396B2

公开(公告)日：2007-04-17

申请号：US10508138

申请日：2002-08-15

申请人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

发明人： Isao Saito ,  Akimitsu Okamoto ,  Kazuo Tanaka

IPC分类号： C07H21/00 ,  C07H21/02 ,  C12Q1/68

CPC分类号： C07H21/04 ,  B82Y10/00 ,  C07H19/04 ,  C07H19/22 ,  C07H19/23 ,  H01L51/0072 ,  H01L51/0093

摘要： A nucleic acid base for hole transportation in DNAs which does not cause oxidative decomposition; and an artificial DNA molecule which can realize effective hole transportation in DNAs while maintaining the double spiral structure of the DNAs. Provided are: a nucleic acid which contains a benzodeazaadenine derivative base represented by the general formula (I): (wherein R1, R2, R3, R4, R5, and R6 each independently represents hydrogen, amino, mono (lower alkyl) amino, di (lower alkyl) amino, hydroxy, lower alkoxy, halogeno, cyano, mercapto, lower alkylthio, or aryl; and R7 and R8 each independently represents hydrogen or a group bonded to phosphoric acid); and a polynucleotide comprising the nucleic acid.

摘要翻译： DNA不会引起氧化分解的空穴传输核酸碱基; 以及能够在保持DNA的双螺旋结构的同时实现DNA中有效空穴传输的人造DNA分子。 提供：含有由通式（I）表示的苯并恶唑烷衍生物碱的核酸：

公开(公告)号：US06974668B1

公开(公告)日：2005-12-13

申请号：US09889379

申请日：2000-11-13

申请人： Hiroshi Sugiyama ,  Isao Saito ,  Hirokazu Iida

发明人： Hiroshi Sugiyama ,  Isao Saito ,  Hirokazu Iida

IPC分类号： C12N15/09 ,  A61K31/4178 ,  A61K31/70 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00 ,  C07D487/04 ,  C07H21/04 ,  C12M1/26 ,  C12Q1/02 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566

CPC分类号： G01N33/5011

摘要： A method for screening the effect of a segment A (chemical species A) on a substance (for example, a cell) containing DNA or RNA by using artificial chemical species. Namely, a method of detecting or identifying the function of a chemical species A on a substance containing DNA or RNA by using one or more chemical species represented by the following general formula (I) which are capable of recognizing a DNA base sequence; a kit therefor; and a plate to be used therein: B-L-A (I) wherein B represents a chemical structure containing an non-natural base capable of recognizing a DNA base sequence; A represents a chemical structure having an interaction with DNA; and L represents a linker whereby the chemical structures A and B can be linked together.

摘要翻译： 通过使用人造化学物质筛选片段A（化学物质A）对含有DNA或RNA的物质（例如细胞）的影响的方法。 即，通过使用能够识别DNA碱基序列的由以下通式（I）表示的一种或多种化学物质来检测或鉴定含有DNA或RNA的物质上的化学物质A的功能的方法; 一套工具; 和其中使用的板：B-L-A（I）其中B表示含有能够识别DNA碱基序列的非天然碱基的化学结构; A表示与DNA相互作用的化学结构; L表示连接物，化学结构A和B可以连接在一起。

公开(公告)号：US06857816B2

公开(公告)日：2005-02-22

申请号：US10067936

申请日：2002-02-08

申请人： Isao Saito ,  Koichi Kaneko ,  Yukitsugu Saba ,  Yasutsugu Kanamori ,  Hiroaki Neko

发明人： Isao Saito ,  Koichi Kaneko ,  Yukitsugu Saba ,  Yasutsugu Kanamori ,  Hiroaki Neko

IPC分类号： E02D3/039 ,  B62D55/00

CPC分类号： E02D3/039

摘要： A roller is equipped with a pair of crawlers. Each crawler includes a driving wheel detachably attached to a driving shaft. Each crawler also includes a set of driven wheels. Both sets of driven wheels are supported by a connecting member that is detachably attached on a bottom of a body. A roll, which is vibrated only in the perpendicular direction with respect to the ground surface, is attached to the body.

摘要翻译： 一个滚子配有一对履带。 每个履带包括可拆卸地附接到驱动轴的驱动轮。 每个履带还包括一组驱动轮。 两组从动轮由可拆卸地安装在车身底部的连接件支撑。 仅在相对于地面的垂直方向上振动的卷被附接到主体。

公开(公告)号：US06713633B1

公开(公告)日：2004-03-30

申请号：US09701264

申请日：2001-08-08

申请人： Hiroshi Sugiyama ,  Zhi-Fu Tao ,  Isao Saito

发明人： Hiroshi Sugiyama ,  Zhi-Fu Tao ,  Isao Saito

IPC分类号： A61K314164

CPC分类号： A61K31/407 ,  C07D487/04

摘要： Novel chemical species capable of simultaneously alkylating double-stranded DNA and cleaving the same; methods for alkylating and cleaving DNA by using these species; and anticancer agents with the use of these compounds. Compounds represented by the following general formula (I) which are capable of simultaneously alkylating double-stranded DNA and cleaving the same; a method for alkylating DNA and a method for cleaving double stranded DNA by using these compounds; and medicinal compositions with the use of these compounds: B—L—A(I) wherein B represents a chemical structure capable of recognizing the base sequence of DNA, for example, optionally substituted pyrrole-imidazole polyamide; A represents a chemical structure capable of binding to one base of DNA, for example, the alkylation moiety of duocarmycin A; and L represents a linker capable of binding the chemical structures A and B, for example, vinyl.

摘要翻译： 能够同时烷化双链DNA并切割相同的新型化学物质; 通过使用这些物质烷基化和切割DNA的方法; 和使用这些化合物的抗癌剂。 由以下通式（I）表示的化合物，其能够同时烷基化双链DNA并将其切割; 用于烷基化DNA的方法和通过使用这些化合物切割双链DNA的方法; 和使用这些化合物的药物组合物：B-L-A（I）其中B表示能够识别DNA碱基序列的化学结构，例如任选取代的吡咯 - 咪唑聚酰胺; A表示能够结合DNA的一个碱基的化学结构，例如二焦耳霉素A的烷基化部分; L表示能够结合化学结构A和B的接头，例如乙烯基。

公开(公告)号：US06593088B1

公开(公告)日：2003-07-15

申请号：US09830401

申请日：2001-06-28

申请人： Isao Saito ,  Kenzo Fujimoto ,  Shigeo Matsuda

发明人： Isao Saito ,  Kenzo Fujimoto ,  Shigeo Matsuda

IPC分类号： C12Q168

CPC分类号： C07H21/00 ,  C07H19/06

摘要： As a novel technique, which gives selective photoligation in high yield and enables ligated site-specific photocleavage, as well as free and reversible control of photoligation and photocleavage, a reversible photoligating nucleic acid of the following formula (1): is used to control photoligation and photocleavage to and from biofunctional polymers freely.

摘要翻译： 作为一种新技术，其以高产率提供选择性光连接并且能够进行连接位点特异性光切割，以及游离和可逆控制光切割和光切割，使用下式（1）的可逆光致核酸来控制光连接 并自由地从生物官能聚合物进行光切割。

公开(公告)号：US06497611B2

公开(公告)日：2002-12-24

申请号：US09767881

申请日：2001-01-24

申请人： Toshimichi Sakurada ,  Yasutoshi Fujita ,  Masao Yamaguchi ,  Kazuo Orii ,  Isao Saito

发明人： Toshimichi Sakurada ,  Yasutoshi Fujita ,  Masao Yamaguchi ,  Kazuo Orii ,  Isao Saito

IPC分类号： B24B4900

CPC分类号： B24B53/017 ,  B24B37/048 ,  G11B5/3103 ,  G11B5/3116 ,  G11B5/3163

摘要： Disclosed is a method of polishing a magnetic head slider whereby a by-processed step can be easily reduced. An air bearing surface of the magnetic head slider is polished with setting a bar that includes the magnetic head slider where a thin film magnetic head element is formed to reciprocate in a radius direction of a polishing plate, as well as rotating the polishing plate having a polishing surface. Polishing steps include a first polishing step of performing a height polish while rotating the polishing plate at a first velocity, and a second polishing step of performing a finishing polish while rotating the polishing plate at a second velocity sufficiently lower than the first velocity. The second velocity at the second polishing step is set so that an average linear velocity in the direction of the rotation of the polishing plate is equal to or lower than 0.032 m/s (preferably equal to or lower than 0.008 m/s). Consequently, the by-processed step that is generated on the air bearing surface of the magnetic head slider is reduced.

公开(公告)号：US06383239B1

公开(公告)日：2002-05-07

申请号：US09522115

申请日：2000-03-09

申请人： Yasuyuki Suzuki ,  Tomohiro Kaku ,  Isao Saito ,  Kazuya Orii ,  Yasutoshi Fujita ,  Masao Yamaguchi ,  Masahiro Sasaki

发明人： Yasuyuki Suzuki ,  Tomohiro Kaku ,  Isao Saito ,  Kazuya Orii ,  Yasutoshi Fujita ,  Masao Yamaguchi ,  Masahiro Sasaki

IPC分类号： C09K314

CPC分类号： C09G1/02 ,  C09K3/1472

摘要： The present invention relates to a free abrasive slurry composition which is advantageously used in uniform grinding of a composite material composed of a plurality of materials each having different hardness, without causing selective grinding. The free abrasive slurry composition contains abrasive particles, an anti-abrasion agent as an anti-selective grinding agent and a dispersion medium and the anti-abrasive agent is a compound containing one or both of sulfur and phosphorus or hydroxyl group(s) in the molecular chain.

摘要翻译： 本发明涉及一种自由磨料浆料组合物，其有利地用于均匀研磨由多种具有不同硬度的材料组成的复合材料，而不会引起选择性研磨。 游离研磨剂浆料组合物含有磨料颗粒，作为抗选择性研磨剂的抗磨剂和分散介质，抗磨剂是含有硫和磷或羟基中的一个或两个的化合物 分子链。

公开(公告)号：US5276560A

公开(公告)日：1994-01-04

申请号：US711891

申请日：1991-06-07

申请人： Isao Saito ,  Keitaro Yamashita

发明人： Isao Saito ,  Keitaro Yamashita

IPC分类号： G11B20/12 ,  G11B5/008 ,  G11B27/032 ,  G11B27/036 ,  G11B27/28 ,  G11B27/30 ,  H04N5/783 ,  H04N5/928 ,  H04N5/93 ,  G11B5/02

CPC分类号： H04N5/928 ,  G11B27/036 ,  G11B27/3027 ,  G11B5/0086 ,  H04N5/93 ,  G11B2220/90 ,  G11B27/032 ,  H04N5/783

摘要： A video tape recording apparatus includes a rotary magnetic head for scanning skewed recording tracks on a video tape, a device for recording a video signal in each of the recording tracks by the rotary magnetic head, a device for providing a first guard band area in each of the recording tracks next to the video signal recorded in the respective recording track, a device for recording a first audio signal next to the first guard band area by the rotary magnetic head, a device for providing a second guard band area next to the first audio signal in each of the recording tracks with the second guard band area having a length different from the length of the first guard band area, a device for recording a second audio signal next to the second guard band area by the rotary magnetic head, and a device for recording an index signal in a longer one of the first and second guard band areas by the rotary magnetic head.

摘要翻译： 录像带记录装置包括用于扫描录像带上的倾斜记录磁道的旋转磁头，用于通过旋转磁头在每个记录磁道中记录视频信号的装置，用于在每个记录磁道中提供第一保护带区域的装置 记录在相应记录磁道中的视频信号旁边的记录磁迹，用于通过旋转磁头记录第一保护带区域旁边的第一音频信号的装置，用于提供第二保护带区域的设备， 每个记录道中的音频信号，其中第二保护带区具有与第一保护带区的长度不同的长度;用于通过旋转磁头记录第二保护带区旁边的第二音频信号的装置，以及 用于通过旋转磁头在第一和第二保护带区域的较长的一个区域中记录索引信号的装置。

公开(公告)号：US5010188A

公开(公告)日：1991-04-23

申请号：US167152

申请日：1988-03-16

申请人： Hiroshi Yamauchi ,  Isao Sugiyama ,  Isao Saito ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Shigeto Negi

发明人： Hiroshi Yamauchi ,  Isao Sugiyama ,  Isao Saito ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Shigeto Negi

IPC分类号： C07D471/08 ,  C07D501/46

CPC分类号： C07D471/08

摘要： Described herein is a cephem derivative represented by the general formula: ##STR1## wherein n stands for 1 or 2, Y stands for CH or nitrogen atom, R.sub.1 represents a lower hydrocarbon group or a carboxyl-substituted, a carbamoyl-substituted, or a cyclopropyl-substituted lower alkyl group, and R.sub.2 denotes hydroxyl group, a lower alkyl group, a hydroxy-substituted lower alkyl group, or carbamoyl group. The derivative is useful as an antibacterial composition. Also described herein are processes for the production of the derivative, antibacterial composition, intermediate of the derivative and process for the production thereof.

公开(公告)号：US5008260A

公开(公告)日：1991-04-16

申请号：US167153

申请日：1988-03-16

申请人： Hiroshi Yamauchi ,  Isao Sugiyama ,  Isao Saito ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Shigeto Negi

发明人： Hiroshi Yamauchi ,  Isao Sugiyama ,  Isao Saito ,  Seiichiro Nomoto ,  Takashi Kamiya ,  Yoshimasa Machida ,  Shigeto Negi

IPC分类号： C07D471/08 ,  C07D501/46

CPC分类号： C07D471/08

摘要： Described herein is a cephem derivative represented by the general formula: ##STR1## wherein n stands for 1 or 2, Y stands for CH or nitrogen atom, R.sub.1 represents a lower hydrocarbon group or a carboxyl-substituted, a carbamoyl-substituted, or a cyclopropyl-substituted lower alkyl group, and R.sub.2 denotes hydroxyl group, a lower alkyl group, a hydroxy-substituted lower alkyl group, or carbamoyl group. The derivative is useful as an antibacterial agent. Also described herein are processes for the production of the derivative, antibacterial composition, intermediate of the derivative and process for the production thereof.