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公开(公告)号:US20130079346A1
公开(公告)日:2013-03-28
申请号:US13603602
申请日:2012-09-05
申请人: Paul Gillespie
发明人: Paul Gillespie
IPC分类号: A61K31/426 , A61K31/496 , A61K31/506 , C07D417/10 , A61K31/4439 , C07D417/04 , C07D277/30 , A61K31/427 , A61K31/5377 , A61K31/454
CPC分类号: C07D277/34 , C07D277/38 , C07D417/04 , C07D417/08 , C07D417/12
摘要: There are disclosed are compounds of the formula: wherein R1 and R2 are as disclosed herein, which are eIF4E inhibitors useful in the treatment of cancers. Also disclosed are compositions comprising the compounds, as well as methods of treating cancer using the compounds.
摘要翻译: 已经公开了下式的化合物:其中R1和R2如本文所公开的,其是可用于治疗癌症的eIF4E抑制剂。 还公开了包含该化合物的组合物,以及使用该化合物治疗癌症的方法。
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公开(公告)号:US08314250B2
公开(公告)日:2012-11-20
申请号:US12905120
申请日:2010-10-15
申请人: Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
发明人: Kevin W. Anderson , Paul Gillespie , Nicholas J. S. Huby , Norman Kong , John L. Roberts , Pamela L. Rossman , Sung-Sau So
IPC分类号: C07D285/01 , C07D417/06 , A61K31/425 , A61K31/4535 , A61K31/4523
CPC分类号: C07D275/06
摘要: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.
摘要翻译: 本发明涉及具有细胞毒活性的根据式1的化合物。 该化合物可用于治疗癌症。
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公开(公告)号:US20120238569A1
公开(公告)日:2012-09-20
申请号:US13399106
申请日:2012-02-17
IPC分类号: A61K31/5377 , C07D417/12 , C07D417/14 , C07D409/12 , C07D409/14 , A61P11/06 , A61K31/427 , A61K31/381 , A61K31/416 , A61K31/506 , A61K31/497 , A61P11/00 , C07D277/56 , A61K31/426
CPC分类号: C07D277/20 , C07D333/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of inflammatory diseases and disorders such as, for example, asthma and COPD.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗炎性疾病和病症,例如哮喘和COPD。
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公开(公告)号:US08268870B2
公开(公告)日:2012-09-18
申请号:US13324650
申请日:2011-12-13
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun
IPC分类号: A61K31/4439 , C07D401/12
CPC分类号: C07D231/56 , C07D401/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
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公开(公告)号:US08138208B2
公开(公告)日:2012-03-20
申请号:US12497807
申请日:2009-07-06
申请人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
发明人: Li Chen , Fariborz Firooznia , Paul Gillespie , Yun He , Tai-An Lin , Sung-Sau So , HongYing Yun , Zhenshan Zhang
IPC分类号: A61K31/4439 , A61K31/416 , C07D231/54 , C07D401/02
CPC分类号: C07D231/56 , C07D401/12 , C07D413/12
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中Q,W,X,R 1 -R 5和n在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂,可用于治疗与该受体相关的疾病和病症如哮喘。
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公开(公告)号:US08124629B2
公开(公告)日:2012-02-28
申请号:US12614478
申请日:2009-11-09
申请人: Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
发明人: Fariborz Firooznia , Paul Gillespie , Tai-An Lin , Eric Mertz , Achyutharao Sidduri , Sung-Sau So , Jenny Tan , Kshitij Chhabilbhai Thakkar
IPC分类号: A61K31/44 , A61K31/192 , C07D211/54 , C07C63/64
CPC分类号: C07D295/26 , C07C57/58 , C07C59/68 , C07C69/76 , C07C255/57 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/62 , C07D231/12 , C07D239/26 , C07D257/04 , C07D317/70
摘要: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐和酯,其中X,Q和R 1 -R 6在详细描述和权利要求书中定义。 此外,本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂或部分激动剂,可用于治疗与该受体相关的疾病和病症,例如哮喘。
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公开(公告)号:US07842825B2
公开(公告)日:2010-11-30
申请号:US12138459
申请日:2008-06-13
IPC分类号: C07D319/00
CPC分类号: C07D213/79 , C07C65/24 , C07D277/56 , C07D307/68 , C07D333/40 , C07D405/06
摘要: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
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公开(公告)号:US20100005735A1
公开(公告)日:2010-01-14
申请号:US12498643
申请日:2009-07-07
申请人: Paul Gillespie , Jianhua Zhang
发明人: Paul Gillespie , Jianhua Zhang
IPC分类号: E04C3/30
摘要: A telescoping shoring post having an inner tube having a plurality of projections spaced longitudinally thereon, longitudinally adjacent projections forming a groove there between to create a plurality of grooves on the inner tube; a hollow outer tube, the outer tube dimensions to allow the inner tube to slide therein; a load plate, the load plate having a collar adapted to affix the load plate to the outer tube and tongues projecting from the load plate, the tongues adapted to project over a hollow portion of the outer tube when the load plate is affixed to the outer tube, wherein the inner tube can slide within the outer tube to a gross adjustment extension length and wherein the tongues on the load plate are adapted to engage the grooves on the inner tube.
摘要翻译: 一种伸缩式支柱,其具有内管,所述内管具有在其上纵向隔开的多个突起,纵向相邻的突起在其间形成凹槽,以在内管上形成多个凹槽; 一个中空的外管,外管尺寸允许内管在其中滑动; 负载板,该负载板具有适于将负载板固定到外管的凸缘和从负载板突出的舌片,所述舌片适于在所述负载板固定到所述外壳上时突出到所述外管的中空部分上 管,其中内管可以在外管内滑动到大的调整延伸长度,并且其中装载板上的舌片适于接合内管上的凹槽。
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公开(公告)号:US07581709B2
公开(公告)日:2009-09-01
申请号:US10495530
申请日:2003-12-17
申请人: Paul Gillespie , Charles Wood
发明人: Paul Gillespie , Charles Wood
CPC分类号: E04G11/38 , E04G11/48 , E04G11/486 , E04G17/18 , E04G25/066 , E04G2009/025 , Y10T403/59 , Y10T403/591
摘要: A system of interconnecting structural components for supporting and forming suspended concrete slabs that allow removal of form panels without disturbing the slab support posts (shores). Additional features of the system accommodate changes in suspended slab thickness, horizontal slab dimensions that are not multiples of the basic component dimensions, slab edge cantilevered form panels, attachment to walls and remote manipulation of form panels from the floor below using an erection staff. The primary system components are panels, support posts, telescopic beams, adjustable hanger connections, wall hangers, wall beams, raking shore assemblies and erection/stripping staffs. Form panels are directly supported by the shores without the use of an intermediate member (usually a beam) that is common practice in the concrete forming industry. The system reduces the number of required components that in turn reduces the capital cost to the user and improves his labor efficiency and quality of the concrete surface.
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公开(公告)号:US07530545B2
公开(公告)日:2009-05-12
申请号:US11893873
申请日:2007-08-16
申请人: Paul Gillespie , Charles Wood
发明人: Paul Gillespie , Charles Wood
IPC分类号: E04G25/00
CPC分类号: E04G11/38 , E04G11/48 , E04G11/486 , E04G17/18 , E04G25/066 , E04G2009/025 , Y10T403/59 , Y10T403/591
摘要: A system of interconnecting structural components for supporting and forming suspended concrete slabs that allow removal of form panels without disturbing the slab support posts (shores). Additional features of the system accommodate changes in suspended slab thickness, horizontal slab dimensions that are not multiples of the basic component dimensions, slab edge cantilevered form panels, attachment to walls and remote manipulation of form panels from the floor below using an erection staff. The primary system components are panels, support posts, telescopic beams, adjustable hanger connections, wall hangers, wall beams, raking shore assemblies and erection/stripping staffs. Form panels are directly supported by the shores without the use of an intermediate member (usually a beam) that is common practice in the concrete forming industry. The system reduces the number of required components that in turn reduces the capital cost to the user and improves his labor efficiency and quality of the concrete surface.
摘要翻译: 互连用于支撑和形成悬挂混凝土板的结构部件的系统,其允许在不干扰板支撑柱(海岸)的情况下移除模板。 该系统的附加功能适应悬挂板坯厚度的变化,水平板尺寸不是基本部件尺寸的倍数,板坯边缘悬臂板,墙壁附件和使用安装人员从下面的地板远程操作板形板。 主要系统组件是面板,支撑柱,伸缩梁,可调节的衣架连接,壁挂架,墙梁,耙岸组件和安装/拆卸人员。 在不使用在混凝土成形工业中常见的中间构件(通常为梁)的情况下,板形板直接由岸边支撑。 该系统减少了所需组件的数量,从而降低了用户的资本成本,提高了他的劳动效率和混凝土表面的质量。
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