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    Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases
    52.
    发明授权
    Diphenyl ether, diphenyl thioether and diphenyl methane phenol mannich bases 失效
    二苯基醚，二苯基硫醚和二苯甲烷苯酚甘露醇碱

    公开(公告)号：US4389416A

    公开(公告)日：1983-06-21

    申请号：US310164

    申请日：1981-10-09

    申请人： Jacob J. Plattner

    发明人： Jacob J. Plattner

    IPC分类号： C07C205/38 ,  A61K31/215 ,  C07C91/16 ,  C07C101/30 ,  C07C103/29

    CPC分类号： C07C205/38 ,  C07C255/00 ,  C07C323/00

    摘要： Described are compounds of the formula ##STR1## wherein R is hydrogen, loweralkyl, aminomethyl or halo; R.sub.1 is carboxy, carboxyloweralkyl, aminocarbonyl, hydroxymethyl, anilinomethyl, or aminomethyl; A is oxygen, CH.sub.2, Sulfur or a single bond; X is oxygen, CH.sub.2, sulfur or sulfoxide; and Y is hydrogen, loweralkyl or halo and may be the same or different, and pharmaceutically acceptable salts thereof.The compounds are effective as diuretic agents.

    摘要翻译： 描述的是下式的化合物：其中R是氢，低级烷基，氨基甲基或卤素; R1是羧基，羧基低级烷基，氨基羰基，羟甲基，苯胺基甲基或氨基甲基; A是氧，CH2，硫或单键; X是氧，CH 2，硫或亚砜; 和Y是氢，低级烷基或卤素，并且可以相同或不同，及其药学上可接受的盐。 这些化合物作为利尿剂是有效的。

    Enzymatic substrates
    53.
    发明授权
    Enzymatic substrates 失效
    酶底物

    公开(公告)号：US4161488A

    公开(公告)日：1979-07-17

    申请号：US934297

    申请日：1978-08-17

    申请人： Jacob J. Plattner ,  Houston F. Voss ,  Susan E. Magic

    发明人： Jacob J. Plattner ,  Houston F. Voss ,  Susan E. Magic

    IPC分类号： C12Q1/37 ,  C12Q1/56 ,  C07C153/11 ,  C07C101/00

    CPC分类号： C12Q1/56 ,  C12Q1/37

    摘要： The present invention encompasses the acid addition salts of a compound of the formula ##STR1## wherein R.sub.1 represents phenylsulfonyl, benzoyl, carbobenzoxy, and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, phenyl, or hydroxy substituted derivatives thereof; or alkanoyl having 2-12 carbon atoms; and R.sub.2 represents alkyl having 1-10 carbon atoms, or alkoxyalkyl having 2-6 carbon atoms, cycloalkyl having 5-7 carbon atoms, or benzyl and the halo, loweralkyl having 1-4 carbon atoms, loweralkoxy having 1-3 carbon atoms, hydroxy, carboxy, or phenyl substituted derivatives thereof.Compounds of the present invention are useful as analytical reagents. Enzymatic hydrolysis provides --S--R.sub.2 which can be further reacted with 5,5'-dithiobis (2-nitrobenzoic acid) to provide a colored product by which the enzyme concentration can be determined spectrophotometrically.

    摘要翻译： 本发明包括下式化合物的酸加成盐：其中R 1表示苯基磺酰基，苯甲酰基，苄氧羰基，卤素，具有1-4个碳原子的低级烷基，具有1-3个碳原子的低级烷氧基，苯基或羟基 取代衍生物; 或具有2-12个碳原子的烷酰基; R2表示具有1-10个碳原子的烷基或具有2-6个碳原子的烷氧基烷基，具有5-7个碳原子的环烷基，或苄基和卤素，具有1-4个碳原子的低级烷基，具有1-3个碳原子的低级烷氧基， 羟基，羧基或其苯基取代的衍生物。