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公开(公告)号：US20090148344A1
公开(公告)日：2009-06-11
申请号：US12189082
申请日：2008-08-08
IPC分类号： G01N21/64
CPC分类号： A61K49/0019 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07D213/82 , C07F5/025 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , G01N33/542 , G01N33/543 , G01N33/582 , G01N33/66 , Y10T436/144444
摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
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公开(公告)号：US07470420B2
公开(公告)日：2008-12-30
申请号：US11296898
申请日：2005-12-07
CPC分类号： A61K49/0019 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07D213/82 , C07F5/025 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , G01N33/542 , G01N33/543 , G01N33/582 , G01N33/66 , Y10T436/144444
摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
摘要翻译： 本发明涉及一种改进的光学方法和光学感测装置，用于确定水性介质中体外和/或体内多羟基取代的有机分子的水平。 检测范围在约400和800nm之间。 特别地，在哺乳动物中实施感官设计以确定糖水平。 具体地说，在糖如果糖或葡萄糖的存在下，将染料与共轭含氮杂环芳族硼酸取代的双鎓化合物组合。 紫罗兰是优选的芳族共轭含氮硼酸取代的化合物。 该方法对于测定人的糖含量是有用的。
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公开(公告)号：US20080188722A1
公开(公告)日：2008-08-07
申请号：US11671880
申请日：2007-02-06
IPC分类号： A61B5/1455 , G01N21/64
CPC分类号： A61B5/14532 , A61B5/1451 , A61B5/14539 , A61B5/1459 , G01N33/66 , G01N33/84 , G01N2400/00
摘要： Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.
摘要翻译： 本发明的实施例涉及一种能够与单个指示器系统同时测量两种分析物的光学传感器。 在优选的实施方案中，传感器包括具有促进比例pH感测的酸和碱形式的荧光染料，其中染料进一步与葡萄糖结合部分相关联并且被配置为产生随葡萄糖浓度而变化的信号。
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公开(公告)号：US06627177B2
公开(公告)日：2003-09-30
申请号：US09731323
申请日：2000-12-05
IPC分类号： A61B1000
CPC分类号： G01N33/52
摘要： The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vivo in aqueous media. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.
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公开(公告)号：US4654100A
公开(公告)日：1987-03-31
申请号：US708199
申请日：1985-03-04
申请人： Larry D. Yats , Ritchie A. Wessling
发明人： Larry D. Yats , Ritchie A. Wessling
IPC分类号： C08K9/08 , C08J5/04 , C08J5/24 , C08K7/00 , C08L63/02 , C08L101/00 , D21H13/14 , D21H13/40 , D21H17/48 , D21H17/49 , D21H17/52 , B27N3/00 , B32B31/00 , C08K3/40 , D21D3/00
摘要： Processes for the preparation of random-fiber thermoset composite sheets by employing a latent curing agent thermoset resin formulation or a coreactant thermoset system such that uncured thermoset composite sheets are formed which can be subsequently formed and cured into articles of manufacture.
摘要翻译： 通过使用潜在性固化剂热固性树脂配制剂或共反应物热固性体系制备无规纤维热固性复合片材的方法，使得形成未固化的热固性复合片材，其随后可以形成并固化成制品。
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公开(公告)号：US3998776A
公开(公告)日：1976-12-21
申请号：US566865
申请日：1975-04-10
CPC分类号： C09D5/4407
摘要： An aqueous dispersion containing a water-insoluble, essentially electrically non-conductive, organic polymer as cation-active particles wherein a substantial portion of the cation-activity is provided by isothiouronium cations may be obtained by various methods including emulsion polymerization of hydrophobic monomers using an isothiouronium surfactant or by emulsion copolymerization of a monomer containing isothiouronium groups with hydrophobic monomers.
摘要翻译： 含有水不溶性，基本上不导电的有机聚合物作为阳离子活性颗粒，其中阳离子活性的相当大部分由异硫脲阳离子提供可以通过各种方法获得，包括使用疏水性单体的乳液聚合 异硫脲表面活性剂或通过含有异硫脲基团的单体与疏水性单体的乳液共聚合。
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公开(公告)号：US3965032A
公开(公告)日：1976-06-22
申请号：US351713
申请日：1973-04-16
IPC分类号： C08F2/00 , B01F17/00 , B01F17/24 , B01F17/34 , B01F17/52 , B01J13/00 , C08F2/24 , C08F8/00 , C08F20/00 , C08F20/34 , C08F15/02
CPC分类号： B01F17/0057 , B01J13/0004 , C08F2/24 , C08F8/44 , C08F2800/10 , C08F2800/20
摘要： This invention is directed to dispersions containing stabilizing amounts of certain substantially linear interpolymeric interfacially spreading polyelectrolytes composed of a mixture of nonionic hydrophobic units and ionic hydrophilic units where the nonionic units are randomly distributed in the backbone of the polyelectrolyte and where the polyelectrolyte is adsorbed at the surface of the disperse phase of the dispersion in a substantially flat configuration. The polyelectrolytes are further characterized by having an adsorption constant equal to or greater than 1 at the point where the surface of the disperse phase is saturated with the polyelectrolyte, the absorption constant being determined as the amount of polyelectrolyte in the disperse phase divided by the amount of polyelectrolyte in the continuous phase. These stabilized dispersions are particularly useful as coating compositions and for use in the preparation of microspheres and seed latexes.
摘要翻译： 本发明涉及含有稳定量的由非离子疏水单元和离子亲水单元的混合物组成的某些基本上直链的互聚物界面扩散聚电解质的分散体，其中非离子单元随机分布在聚电解质的主链中，并且其中聚电解质被吸附在 分散体的分散相的表面呈基本平坦的构型。 聚电解质进一步的特征在于在分散相的表面被聚电解质饱和的点处具有等于或大于1的吸附常数，吸收常数被确定为分散相中聚电解质的量除以量 的聚电解质在连续相中。 这些稳定的分散体特别可用作涂料组合物并用于制备微球和种子胶乳。
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58.发明授权Optical systems and methods for ratiometric measurement of blood glucose concentration 有权用于血糖浓度比例测量的光学系统和方法公开(公告)号：US08838195B2
公开(公告)日：2014-09-16
申请号：US12027158
申请日：2008-02-06
IPC分类号： A61B5/1455 , G01N21/64 , A61B5/1459 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/0071 , A61B5/14552 , A61B5/1459 , A61B5/7203 , G01N21/6428 , G01N21/645
摘要： Novel optical devices, methods and systems relating to the detection of glucose, and more particularly to real-time glucose monitoring, are disclosed herein. More particularly, various hardware and methodological means are disclosed for ratiometric correction of optical glucose measurements for artifacts of optical systems.
摘要翻译： 本文公开了与葡萄糖检测有关的新型光学器件，方法和系统，更具体地涉及实时葡萄糖监测。 更具体地，公开了用于光学系统的伪像的光学葡萄糖测量的比例校正的各种硬件和方法手段。
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公开(公告)号：US08178676B2
公开(公告)日：2012-05-15
申请号：US13069150
申请日：2011-03-22
申请人： Soya Gamsey , Ritchie A. Wessling
发明人： Soya Gamsey , Ritchie A. Wessling
CPC分类号： G01N33/523 , C07F5/025 , G01N2400/00
摘要： Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.
摘要翻译： 公开了用硼酸官能化的新型吡啶鎓盐及其制备方法。 当与荧光染料组合时，该化合物可用于检测多羟基取代的有机分子。
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60.发明授权Method for polymerizing a monomer solution within a cavity to generate a smooth polymer surface 有权在空腔内聚合单体溶液以产生光滑聚合物表面的方法公开(公告)号：US08110251B2
公开(公告)日：2012-02-07
申请号：US12026396
申请日：2008-02-05
IPC分类号： B05D3/10
CPC分类号： G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7786
摘要： In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.
摘要翻译： 在优选的实施方案中，本发明涉及在由多孔膜覆盖的空腔内聚合单体溶液以产生光滑聚合物表面的方法。 更具体地，该方法可用于提供具有光滑聚合物表面的医疗装置或传感器。
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