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公开(公告)号：US09286615B2
公开(公告)日：2016-03-15
申请号：US13199047
申请日：2011-08-16
申请人： Roderick A. Hyde , Jordin T. Kare , Wayne R. Kindsvogel , Royce A. Levien , Erez Lieberman , Mark A. Malamud , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
发明人： Roderick A. Hyde , Jordin T. Kare , Wayne R. Kindsvogel , Royce A. Levien , Erez Lieberman , Mark A. Malamud , Nathan P. Myhrvold , Elizabeth A. Sweeney , Clarence T. Tegreene , Charles Whitmer , Lowell L. Wood, Jr.
CPC分类号： G06Q30/02 , A61B5/4833 , G06F19/3456
摘要： Embodiments disclosed herein relate to methods, devices, and computer systems thereof for visibly or non-visibly indicating a subject has received a medical treatment. In certain embodiments, a subject receives an information mark in conjunction with a medical treatment. In certain embodiments, the information mark includes unique information relating to the subject. In certain embodiments, devices, computer systems, and methods relate to reading an information mark on a subject, and optionally determining if further medical treatment of the subject is warranted. In certain embodiments, receipt of an information mark entitles a subject to a reward.
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52.发明授权Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen 有权包括重组B淋巴细胞细胞系的组合物和方法，包括外源掺入的表达外源性膜免疫球蛋白的第一抗原反应性的核酸，并且包括表达内源性分泌的免疫球蛋白的反应性的第二抗原的内源基因公开(公告)号：US09175072B2
公开(公告)日：2015-11-03
申请号：US13374351
申请日：2011-12-22
IPC分类号： C12N5/10 , A61K38/00 , C12N5/00 , C07K16/18 , A61K39/00 , C12N5/0781 , C07K16/00 , C07K16/10 , C07K16/12 , C07K16/30 , C07K16/44 , G01N33/68
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , A61K2039/5156 , C07K16/00 , C07K16/1018 , C07K16/109 , C07K16/1271 , C07K16/3069 , C07K16/44 , C07K2317/14 , C07K2317/76 , C12N5/0635 , C12N2510/00 , G01N33/6854
摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.
摘要翻译： 本文公开了在分离的B淋巴细胞系中产生一种或多种免疫球蛋白的组合物和方法。 分离的细胞系包括能够表达至少一种外源掺入的膜免疫球蛋白的分离的B淋巴细胞系，其对第一抗原具有反应性，并且至少一种内源分泌的免疫球蛋白可与第二抗原反应。
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53.发明申请Systems, Devices, Methods, and Compositions Including Ferromagnetic Structures 审中-公开包括铁磁结构的系统，设备，方法和组成公开(公告)号：US20130038330A1
公开(公告)日：2013-02-14
申请号：US13570038
申请日：2012-08-08
CPC分类号： A61K49/1818
摘要： Magnetic resonance systems, devices, methods, and compositions are provided. A nuclear magnetic resonance imaging composition includes, but is not limited to, a plurality of ferromagnetic microstructures configured to generate a time-invariant magnetic field within at least a portion of one or more internal surface-defined voids. In an embodiment, at least one of the plurality of ferromagnetic microstructures includes one or more targeting moieties attached thereof.
摘要翻译： 提供了磁共振系统，装置，方法和组合物。 核磁共振成像组合物包括但不限于多个铁磁微结构，其被配置为在一个或多个内表面限定的空隙的至少一部分内产生时不变的磁场。 在一个实施方案中，所述多个铁磁微结构中的至少一个包括与其连接的一个或多个靶向部分。
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公开(公告)号：US20120020938A1
公开(公告)日：2012-01-26
申请号：US12804647
申请日：2010-07-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
CPC分类号： A61K35/15 , A61K35/17 , A61K35/28 , A61K35/407 , A61K2035/122
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
摘要翻译： 本公开涉及涉及用于将至少一种治疗剂递送至生物组织或受试者的生物细胞的组合物，方法，系统，计算机实施的方法及其计算机程序产品。
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公开(公告)号：US20120020885A1
公开(公告)日：2012-01-26
申请号：US12806338
申请日：2010-08-09
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Wayne R. Kindsvogel , Eric C. Leuthardt , Stephen L. Malaska , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： A61K49/00 , A61P35/00 , A61P35/02 , A61P37/06 , C12N5/00 , A61K35/12 , A61P31/00 , A61P9/10 , A61P3/10 , A61P1/12 , A61P17/02 , A61P3/04 , C12Q1/02 , A61P1/02
CPC分类号： A61K38/18 , A61K35/28 , A61K35/30 , A61K35/407 , A61K35/545 , A61K38/19 , A61K38/20 , A61K38/2066 , A61K38/21 , C12N2510/00
摘要： The present disclosure relates to compositions, methods, systems, computer-implemented methods, and computer program products thereof that relate to biological cells for delivery of at least one therapeutic agent to a biological tissue or subject.
摘要翻译： 本公开涉及涉及用于将至少一种治疗剂递送至生物组织或受试者的生物细胞的组合物，方法，系统，计算机实施的方法及其计算机程序产品。
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56.发明授权Systems, devices, methods, and compositions including functionalized ferromagnetic structures 有权包括官能化铁磁结构的系统，装置，方法和组合物公开(公告)号：US08058872B2
公开(公告)日：2011-11-15
申请号：US12455298
申请日：2009-05-29
IPC分类号： G01V3/00
CPC分类号： G01R33/383 , A61K49/1866 , B82Y5/00 , G01R33/465 , G01R33/48 , G01R33/5601
摘要： Magnetic resonance systems, devices, methods, and compositions are provided. A nuclear magnetic resonance imaging composition includes, but is not limited to, a plurality of functionalized ferromagnetic microstructures configured to generate a time-invariant magnetic field within at least a portion of one or more internal surface-defined voids.
摘要翻译： 提供了磁共振系统，装置，方法和组合物。 核磁共振成像组合物包括但不限于多个功能化的铁磁微结构，其被配置为在一个或多个内表面限定的空隙的至少一部分内产生时不变的磁场。
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公开(公告)号：US20110070154A1
公开(公告)日：2011-03-24
申请号：US12806007
申请日：2010-08-03
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Wayne R. Kindsvogel , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Wayne R. Kindsvogel , Gary L. McKnight , Elizabeth A. Sweeney , Lowell L. Wood, JR.
IPC分类号： A61K39/00 , A61K9/127 , A61K39/395 , A61K51/04 , A61K49/00 , C12N5/10 , A61P37/04 , A61P37/08 , A61P37/00 , B82Y5/00
CPC分类号： A61K35/18 , A61K39/00 , A61K41/0071 , A61K47/6901 , A61K49/0002 , A61K2039/515 , A61K2039/5154 , A61K2039/5156 , A61K2039/55516 , A61K2039/55555 , A61K2039/605 , C12N5/0006 , C12N5/0641
摘要： The present disclosure relates to various embodiments associated with artificial cells, particularly artificial antigen presenting cells, methods of making the same, methods of administering the same, computer systems relating thereto, computer-implemented methods relating thereto, and associated computer program products.
摘要翻译： 本公开涉及与人造细胞，特别是人造抗原呈递细胞相关的各种实施方案，其制备方法，其施用方法，与其相关的计算机系统，与其相关的计算机实现的方法和相关联的计算机程序产品。
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58.发明申请Systems, devices, methods, and compositions including targeted ferromagnetic structures 有权包括目标铁磁结构的系统，装置，方法和组合物公开(公告)号：US20100301855A1
公开(公告)日：2010-12-02
申请号：US12455297
申请日：2009-05-29
IPC分类号： G01R33/48
CPC分类号： G01R33/383 , G01R33/465 , G01R33/48 , G01R33/5601
摘要： Magnetic resonance systems, devices, methods, and compositions are provided. A nuclear magnetic resonance imaging composition includes, but is not limited to, a plurality of target-selective ferromagnetic microstructures configured to generate a time-invariant magnetic field within at least a portion of one or more internal surface-defined voids.
摘要翻译： 提供了磁共振系统，装置，方法和组合物。 核磁共振成像组合物包括但不限于多个目标选择性铁磁微结构，其被配置为在一个或多个内表面限定的空隙的至少一部分内产生时不变的磁场。
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公开(公告)号：US20090087404A1
公开(公告)日：2009-04-02
申请号：US12250911
申请日：2008-10-14
申请人： Wayne R. Kindsvogel , Steven D. Hughes , Richard D. Holly , Christopher H. Clegg , Donald C. Foster , Rebecca A. Johnson , Mark D. Heipel , Pallavur V. Sivakumar
发明人： Wayne R. Kindsvogel , Steven D. Hughes , Richard D. Holly , Christopher H. Clegg , Donald C. Foster , Rebecca A. Johnson , Mark D. Heipel , Pallavur V. Sivakumar
CPC分类号： C07K16/32 , A61K38/20 , A61K39/395 , A61K39/39558 , C07K16/2818 , C07K16/2896 , C07K2317/732 , A61K2300/00
摘要： Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.
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公开(公告)号：US6018026A
公开(公告)日：2000-01-25
申请号：US980400
申请日：1997-11-26
IPC分类号： C07K1/00 , C07K14/49 , C07K14/705 , C07K14/71 , C07K14/72 , C07K16/46 , C07K19/00 , C12N15/09 , C12N15/62 , C12N15/81 , C12P21/04
CPC分类号： C07K14/71 , C07K14/72 , C07K2317/52 , C07K2317/56 , C07K2319/30
摘要： Methods for producing secreted receptor analogs and biologically active peptide dimers are disclosed. The methods for producing secreted receptor analogs and biologically active peptide dimers utilize a DNA sequence encoding a receptor analog or a peptide requiring dimerization for biological activity joined to a dimerizing protein. The receptor analog includes a ligand-binding domain. Polypeptides comprising essentially the extracellular domain of a human PDGF receptor fused to dimerizing proteins, the portion being capable of binding human PDGF or an isoform thereof, are also disclosed. The polypeptides may be used within methods for determining the presence of and for purifying human PDGF or isoforms thereof.
摘要翻译： 公开了生产分泌的受体类似物和生物活性肽二聚体的方法。 用于产生分泌的受体类似物和生物活性肽二聚体的方法利用编码受体类似物的DNA序列或需要二聚化的肽连接到二聚化蛋白的生物活性。 受体类似物包括配体结合结构域。 还公开了包含与二聚化蛋白融合的人PDGF受体的基本上胞外结构域的多肽，该部分能够结合人PDGF或其同种型。 多肽可以用于确定人PDGF或其同种型的存在和用于纯化人PDGF或其同种型的方法。
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