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51.发明授权Methods of diagnosing tumors using the G-protein coupled receptor (GPCR), RAI-3 有权使用G蛋白偶联受体（GPCR），RAI-3诊断肿瘤的方法公开(公告)号：US07517652B2
公开(公告)日：2009-04-14
申请号：US11809905
申请日：2007-05-31
申请人： Gena S. Whitney , Gregory Opiteck , Leah Ann Garulacan , Chandra S. Ramanathan , Murray McKinnon , John N. Feder
发明人： Gena S. Whitney , Gregory Opiteck , Leah Ann Garulacan , Chandra S. Ramanathan , Murray McKinnon , John N. Feder
CPC分类号： C12Q1/6886 , C07K14/705 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5023 , G01N33/5041 , G01N33/5044 , G01N33/5091 , G01N33/566 , G01N33/574 , G01N33/6884 , G01N33/74 , G01N2333/726 , G01N2500/00 , G01N2800/122
摘要： The present invention describes a G-protein coupled receptor (GPCR) family member newly identified as being modified, e.g., phosphorylated, and associated with tyrosine phosphorylated activation complexes, following exposure of cells to smoke from tobacco burning substances, namely, cigarette smoke. This GPCR protein is RAI-3, which was first found to be phosphorylated in cells treated with cigarette smoke and to be associated with other proteins activated in cigarette smoke treated cells by virtue of the present invention. Because cigarette smoke is considered to be a major causative factor of chronic obstructive pulmonary disease (COPD) and disorders and conditions related thereto, the RAI-3 protein is newly provided as a cellular drug target for screening, discovering, and identifying modulators for the treatment and/or prevention of COPD and its related disorders and conditions, such as emphysema and chronic bronchitis. In accordance with the present invention RAI-3 modulators, e.g., agonists and antagonists, can be used as therapeutics in the treatment of COPD and numerous other diseases and disorders that are associated with regulation of NF-κB and/or its associated or interacting signaling molecules. This invention further provides SNPs of RAI-3, e.g., for determining COPD association in individuals.
摘要翻译： 本发明描述了在将烟草暴露于烟草燃烧物质（即香烟烟雾）之后，新鉴定为被修饰，例如磷酸化并与酪氨酸磷酸化活化复合物相关的G-蛋白偶联受体（GPCR）家族成员。 该GPCR蛋白是RAI-3，其首先被发现在用香烟烟雾处理的细胞中被磷酸化并且与通过本发明在香烟烟雾处理的细胞中活化的其它蛋白质相关联。 由于香烟烟雾被认为是慢性阻塞性肺疾病（COPD）的主要致病因素及与之相关的病症和病症，所以RAI-3蛋白质作为筛选，发现和鉴定调节剂治疗的细胞药物靶点被新提供 和/或预防COPD及其相关疾病和病症如肺气肿和慢性支气管炎。 根据本发明，RAI-3调节剂（例如激动剂和拮抗剂）可用作治疗COPD和许多与调节NF-κB和/或其相关或相互作用的信号相关的其它疾病和病症 分子。 本发明还提供RAI-3的SNP，例如用于确定个体中的COPD关联。
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52.发明授权公开(公告)号：US07344860B2
公开(公告)日：2008-03-18
申请号：US10817607
申请日：2004-04-02
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HBMYP2X7v polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HBMYP2X7v多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HBMYP2X7v多肽应用于与这些多肽相关的各种疾病和/或病症的诊断，治疗和/或预防的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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53.发明授权Human leucine-rich repeat-containing proteins specifically expressed in the nervous system 有权在神经系统中特异表达的人类富含亮氨酸的重复含蛋白质公开(公告)号：US07141381B2
公开(公告)日：2006-11-28
申请号：US10424233
申请日：2003-04-25
CPC分类号： C07K14/47 , A61K38/00 , G01N2333/4709
摘要： The present invention describes two newly discovered Human Leucine Rich Repeat (LRR)-containing proteins, HLRRNS-2 and HLRRNS-3, and their encoding polynucleotides. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotides and/or polypeptides of the present invention. In addition, methods involving the new HLRR-containing proteins HLRRNS-2 and HLRRNS-3, or modulators thereof, for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
摘要翻译： 本发明描述了两种新发现的含有人类亮氨酸重复序列（LRR）的蛋白质，HLRRNS-2和HLRRNS-3及其编码多核苷酸。 还描述了与本发明的多核苷酸和/或多肽相关的表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 此外，涉及用于治疗，诊断，预防和筛选与异常细胞生长，神经系统疾病和与该疾病相关的疾病或病症相关疾病的新的含有HLRR的蛋白质HLRRNS-2和HLRRNS-3或其调节剂的方法 大脑被说明。
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54.发明授权Methods of diagnosing renal tumors by determining the expression level of RNA encoding the HGPRBMY18 polypeptide 有权通过确定编码HGPRBMY18多肽的RNA的表达水平来诊断肾肿瘤的方法公开(公告)号：US07115375B2
公开(公告)日：2006-10-03
申请号：US10768878
申请日：2004-01-30
CPC分类号： C07K14/72 , A61K38/00 , C07K14/705 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158
摘要： The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, kidney, and prostate are illustrated.
摘要翻译： 本发明描述了新发现的人G-蛋白偶联受体及其编码多核苷酸。 还描述了与本发明的多核苷酸和/或多肽相关的表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。 此外，还示出了用于治疗，诊断，预防和筛选与异常细胞生长，内分泌状况，神经病症以及与垂体腺，结肠癌，乳腺癌，肺癌，肾癌和前列腺癌相关的疾病或病症的疾病的方法。
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55.发明授权Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74 有权编码HM74的新型人G蛋白偶联受体变体的多核苷酸HGPRBMY74公开(公告)号：US07094572B2
公开(公告)日：2006-08-22
申请号：US10800249
申请日：2004-03-12
IPC分类号： C12N15/12
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HGPRBMY74多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY74多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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56.发明授权Human leucine-rich repeat containing protein expressed predominately in small intestine, HLRRSI1 有权人类富含亮氨酸的重复含有蛋白主要表达于小肠，HLRRSI1公开(公告)号：US06858407B2
公开(公告)日：2005-02-22
申请号：US10029347
申请日：2001-12-20
IPC分类号： A61K38/00 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/04 , A61P9/10 , A61P31/18 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/68 , C12P21/06 , C07H21/04
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/705 , C12Q1/6883 , G01N33/5011 , G01N33/502 , G01N33/5044 , G01N33/505 , G01N33/5052 , G01N33/5058 , G01N33/5064 , G01N33/5076 , G01N33/5091 , G01N33/68 , G01N33/6842
摘要： The present invention provides novel polynucleotides encoding HLRRSI1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLRRSI1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly gastrointestinal diseases and/or disorders. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供了编码HLRRSI1多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HLRRSI1多肽应用于诊断，治疗和/或预防与这些多肽，特别是胃肠道疾病和/或病症有关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US5753438A
公开(公告)日：1998-05-19
申请号：US436074
申请日：1995-05-08
申请人： Dennis T. Drayna , John N. Feder , Andreas Gnirke , Bruce E. Kimmel , Winston J. Thomas , Roger K. Wolff
发明人： Dennis T. Drayna , John N. Feder , Andreas Gnirke , Bruce E. Kimmel , Winston J. Thomas , Roger K. Wolff
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
摘要翻译： 公开了在普通遗传性血色素沉着病（HH）基因中存在突变的新遗传标记。 标记的多重性允许定义在其基因组DNA中含有该突变的载体和纯合子的基因型特征。
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公开(公告)号：US5705343A
公开(公告)日：1998-01-06
申请号：US599252
申请日：1996-02-09
申请人： Dennis T. Drayna , John N. Feder , Andreas Gnirke , Bruce E. Kimmel , Winston J. Thomas , Roger K. Wolff
发明人： Dennis T. Drayna , John N. Feder , Andreas Gnirke , Bruce E. Kimmel , Winston J. Thomas , Roger K. Wolff
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： New genetic markers for the presence of a mutation in the common hereditary hemochromatosis (HH) gene are disclosed. The multiplicity of markers permits definition of genotypes characteristic of carriers and homozygotes containing this mutation in their genomic DNA.
摘要翻译： 公开了在普通遗传性血色素沉着病（HH）基因中存在突变的新遗传标记。 标记的多重性允许定义在其基因组DNA中含有该突变的载体和纯合子的特征性基因型。
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公开(公告)号：US08257927B2
公开(公告)日：2012-09-04
申请号：US13178445
申请日：2011-07-07
申请人： Winston J. Thomas , Dennis T. Drayna , John N. Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger K. Wolff
发明人： Winston J. Thomas , Dennis T. Drayna , John N. Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger K. Wolff
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/70539 , C12Q1/6883
摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
摘要翻译： 本发明一般涉及导致疾病遗传性血色素沉着症（HH）的基因及其突变。 更具体地，本发明涉及对应于正常和突变HH基因的DNA序列的鉴定，分离和克隆，以及它们的转录物和基因产物的表征。 本发明还涉及用于筛选HH纯合子的方法等，还涉及HH诊断，产前筛查和诊断以及HH疾病的治疗，包括基因治疗剂，基于蛋白质和基于抗体的治疗剂和小分子治疗剂。
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60.发明申请POLYNUCLEOTIDE ENCODING A NOVEL HUMAN P2X7 SPLICE VARIANT, HBMYP2X7V 有权多核苷酸编码一种新型人P2X7 SPLICE变体，HBMYP2X7V公开(公告)号：US20120035350A1
公开(公告)日：2012-02-09
申请号：US11899162
申请日：2007-09-04
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HBMYP2X7v polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译： 本发明提供编码HBMYP2X7v多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HBMYP2X7v多肽应用于与这些多肽相关的各种疾病和/或病症的诊断，治疗和/或预防的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。
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