公开(公告)号：US07354568B1

公开(公告)日：2008-04-08

申请号：US09405046

申请日：1999-09-27

申请人： Thomas Meade ,  Scott Fraser ,  Russell Jacobs

发明人： Thomas Meade ,  Scott Fraser ,  Russell Jacobs

IPC分类号： A61B5/055

CPC分类号： A61K49/10 ,  A61K49/085

摘要： The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.

摘要翻译： 本发明涉及新型磁共振成像造影剂和检测生理信号或物质的方法。

公开(公告)号：US20060211016A1

公开(公告)日：2006-09-21

申请号：US11343462

申请日：2006-01-30

申请人： Jon Kayyem ,  Stephen O'Connor ,  Michael Gozin ,  Changjun Yu ,  Thomas Meade

发明人： Jon Kayyem ,  Stephen O'Connor ,  Michael Gozin ,  Changjun Yu ,  Thomas Meade

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： C07H21/02 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07H21/04 ,  C12Q1/6825

摘要： The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

公开(公告)号：US20050155104A1

公开(公告)日：2005-07-14

申请号：US11020848

申请日：2004-12-23

申请人： Patricia Apel-Birkhold ,  Timothy Hey ,  Robin Thompson ,  Thomas Meade ,  Ze Li ,  Sean Russell ,  Joel Sheets ,  Justin Lira ,  Kristin Fencil ,  Jon Mitchell

发明人： Patricia Apel-Birkhold ,  Timothy Hey ,  Robin Thompson ,  Thomas Meade ,  Ze Li ,  Sean Russell ,  Joel Sheets ,  Justin Lira ,  Kristin Fencil ,  Jon Mitchell

IPC分类号： A01H1/00 ,  A01H5/00 ,  A01N63/00 ,  A01N63/02 ,  C07H21/04 ,  C07K14/24 ,  C12N5/04 ,  C12N15/82

CPC分类号： C12N15/8286 ,  A01N63/00 ,  A01N63/02 ,  C07H21/04 ,  C07K14/24 ,  C12N15/8279 ,  Y02A40/162 ,  Y10S530/825

摘要： The subject invention relates to novel Xenorhabdus toxin complex (TC) proteins and genes that encode these proteins. More specifically, the subject invention relates to TC genes and proteins obtainable from Xenorhabdus bovienii strain ILM104.

摘要翻译： 本发明涉及新型异戊酰梭菌毒素复合物（TC）蛋白质和编码这些蛋白质的基因。 更具体地，本发明涉及从Xenorhabdus bovienii菌株ILM104获得的TC基因和蛋白质。

公开(公告)号：US5707605A

公开(公告)日：1998-01-13

申请号：US486968

申请日：1995-06-07

申请人： Thomas Meade ,  Scott Fraser ,  Russell Jacobs

发明人： Thomas Meade ,  Scott Fraser ,  Russell Jacobs

IPC分类号： A61K49/00 ,  A61K49/06 ,  A61K49/08 ,  G01N31/00 ,  G01N33/48

CPC分类号： A61K49/10 ,  A61K49/085 ,  A61K49/103 ,  A61K49/106

摘要： The invention relates to magnetic resonance imaging agents comprising a paramagnetic metal ion bound to a complex wherein said complex comprises a chelator and a blocking moiety convalently attached to said chelator which binds in at least a first coordination site of said metal ion and which is capable of interacting with a target substance such that the exchange of water in at least said first coordination site is increased.

摘要翻译： 本发明涉及包含与复合物结合的顺磁金属离子的磁共振成像剂，其中所述复合物包含螯合剂和与所述螯合剂共价连接的阻断部分，其结合至少所述金属离子的第一配位位点， 与目标物质相互作用，使得至少所述第一配位点中的水的交换增加。

公开(公告)号：US09617551B2

公开(公告)日：2017-04-11

申请号：US13812469

申请日：2011-07-29

申请人： Donald J. Merlo ,  Sean M. Russell ,  Diane M. Retallack ,  Aaron T. Woosley ,  Thomas Meade ,  Kenneth Narva

发明人： Donald J. Merlo ,  Sean M. Russell ,  Diane M. Retallack ,  Aaron T. Woosley ,  Thomas Meade ,  Kenneth Narva

IPC分类号： C12N15/82 ,  C12N15/74

CPC分类号： C12N15/8205 ,  C07K14/195 ,  C07K14/325 ,  C12N15/74 ,  C12N15/743 ,  C12N15/8274 ,  C12N15/8286 ,  Y02A40/162

摘要： Agrobacterium strains that harbor transformation-enhancing genes on a plasmid capable of replication independently of the Agrobacterium chromosome, the Ti plasmid, and plant transformation binary vectors, and uses for these Agrobacterium strains are provided. Additionally, Agrobacterium strains that are deficient in DNA recombination functions that result in instability or rearrangement of plant transformation binary vectors, and that harbor transformation-enhancing genes on a plasmid capable of replication independently of the Agrobacterium chromosome, the Ti plasmid, and plant transformation binary vectors, and uses for these strains, are also provided. Further included are Agrobacterium strains that harbor transformation-enhancing genes integrated into the Agrobacterium chromosome at a locus that does not interfere with or otherwise compromise the normal growth and plant transformation ability of the Agrobacterium cells, and uses for these Agrobacterium strains. Plants made using these Agrobacterium strains are also described.

公开(公告)号：US20080311096A1

公开(公告)日：2008-12-18

申请号：US12156515

申请日：2008-06-02

申请人： Bruce A. Lang ,  James W. Bing ,  Jonathan M. Babcock ,  Thomas Meade ,  Nicholas P. Storer ,  Blair David Siegfried ,  Elisen Jose Guedes Pereira

发明人： Bruce A. Lang ,  James W. Bing ,  Jonathan M. Babcock ,  Thomas Meade ,  Nicholas P. Storer ,  Blair David Siegfried ,  Elisen Jose Guedes Pereira

IPC分类号： A61K35/00 ,  A01H5/00 ,  A01P7/02

CPC分类号： A01N63/02 ,  C07K14/32 ,  C07K14/325 ,  C12N15/8286 ,  Y02A40/162

摘要： Compositions for controlling lepidopteran insects use Cry1Fa and Cry1Ab core toxin containing proteins in combination to delay or prevent development of resistance.

摘要翻译： 用于控制鳞翅目昆虫的组合物使用含有Cry1Fa和Cry1Ab核心毒素的蛋白质组合以延迟或预防抗性发展。

公开(公告)号：US20060088475A1

公开(公告)日：2006-04-27

申请号：US11125985

申请日：2005-05-10

申请人： Joseph Duimstra ,  Thomas Meade

发明人： Joseph Duimstra ,  Thomas Meade

IPC分类号： A61K49/10

CPC分类号： A61K49/085 ,  A61K47/555 ,  A61K49/10

摘要： The present invention relates to magnetic resonance imaging (MRI) contrast agent. In particular, the present invention provides MRI contrast agents that are sensitive to the enzyme beta-glucoronidase. The MRI contrast agents provide compositions and methods for non-invasive diagnostic imaging of tissues, including necrotic tumors.

摘要翻译： 本发明涉及磁共振成像（MRI）造影剂。 特别地，本发明提供对β-葡萄糖醛酸酶敏感的MRI造影剂。 MRI造影剂提供用于组织非侵入性诊断成像（包括坏死性肿瘤）的组合物和方法。

公开(公告)号：US20060073532A1

公开(公告)日：2006-04-06

申请号：US11283233

申请日：2005-11-18

申请人： Thomas Meade

发明人： Thomas Meade

IPC分类号： G01N33/53

CPC分类号： B82Y30/00 ,  B82Y5/00 ,  B82Y15/00 ,  G01N33/542 ,  G01N33/5438

摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.

公开(公告)号：US20050002866A1

公开(公告)日：2005-01-06

申请号：US10799550

申请日：2004-03-11

申请人： Thomas Meade ,  Scott Fraser

发明人： Thomas Meade ,  Scott Fraser

IPC分类号： A61K49/06 ,  A61K49/08 ,  A61K49/00

CPC分类号： A61K49/085 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  A61K49/122 ,  A61K49/128 ,  A61K49/14 ,  A61K49/146

摘要： The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.

摘要翻译： 本发明涉及新型磁共振成像造影剂和检测生理信号或物质的方法。

公开(公告)号：US06713045B1

公开(公告)日：2004-03-30

申请号：US09716178

申请日：2000-11-16

申请人： Thomas Meade ,  Scott Fraser ,  Russell Jacobs

发明人： Thomas Meade ,  Scott Fraser ,  Russell Jacobs

IPC分类号： A61B5055

CPC分类号： A61K49/085 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  A61K49/122 ,  A61K49/128 ,  A61K49/146

摘要： The invention relates to novel targeted magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.

摘要翻译： 本发明涉及新型靶向磁共振成像造影剂和检测生理信号或物质的方法。