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51.发明申请Highly Water Permeable Hollow Fiber Membrane Type Blood Purifier and Process for Manufacturing the Same 审中-公开高透水中空纤维膜型血液净化器及其制造方法公开(公告)号：US20080000830A1
公开(公告)日：2008-01-03
申请号：US11573339
申请日：2005-08-08
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Noriko Monden , Shinya Koyama , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Noriko Monden , Shinya Koyama , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： B01D69/02 , A61L2/081 , A61L2/186 , A61L2202/24 , B01D67/009 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2323/12 , B01D2323/30 , B01D2323/34 , B01D2325/02 , B01D2325/022 , B01D2325/20
摘要： The present invention relates to a highly water-permeable hollow fiber membrane type blood purifier which comprises hydrophobic polymer hollow fiber membranes each containing a hydrophilic polymer, wherein the hollow fiber membrane has a hydrophilic polymer content of 25 to 50 mass % and a ratio of hole areas of 8 to 25% at its outer surface, and has a thickness non-uniformity degree of 0.6 or more, a thickness of 10 to 60 μm and a burst pressure of 0.5 to 2 MPa, and which is characterized in that the blood purifier has a water permeability of 150 to 2,000 ml/m2/hr/mmHg, and in that said blood purifier is exposed to radioactive rays on conditions that the oxygen concentration of an ambient atmosphere around the hollow fiber membranes is from 0.001% inclusive to 0.1% inclusive, and that the moisture content of the hollow fiber membrane to its weight is from 0.2 mass % inclusive to 7 mass % inclusive. The present invention also relates to a process for manufacturing the same-blood purifier.
摘要翻译： 本发明涉及一种高透水性中空纤维膜型血液净化器，其包含各自含有亲水性聚合物的疏水性聚合物中空纤维膜，其中，中空纤维膜的亲水性聚合物含量为25〜50质量％，孔的比例 其外表面的面积为8〜25％，厚度不均匀度为0.6以上，厚度为10〜60μm，爆破压力为0.5〜2MPa，其特征在于，所述血液净化器 具有150-2,000ml / m 2 / hr / mmHg的透水性，并且在中空纤维膜周围环境气氛的氧气浓度的条件下将所述血液净化器暴露于放射线 为0.001〜0.1％，中空纤维膜的水分含量为0.2质量％以上7质量％以下。 本发明还涉及同一血液净化器的制造方法。
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公开(公告)号：US20060148979A1
公开(公告)日：2006-07-06
申请号：US10546362
申请日：2004-10-12
申请人： Makio Mori , Takayuki Fukutomi , Takashi Shirokawa , Tomoaki Sugiyama , Shinya Takeda , Toshiaki Masuda , Yoshiaki Shirakabe
发明人： Makio Mori , Takayuki Fukutomi , Takashi Shirokawa , Tomoaki Sugiyama , Shinya Takeda , Toshiaki Masuda , Yoshiaki Shirakabe
IPC分类号： C08L9/00
CPC分类号： C08J9/32 , B60C1/00 , B60C15/06 , B60C17/00 , C08J2321/00 , C08L21/00 , C08L33/02 , C08L33/18 , C08L2666/04
摘要： A rubber composition containing 100 parts by weight of a diene-based rubber and 0.5 to 25 parts by weight of a heat expandable microcapsule composed of a thermoplastic resin particle having a substance enclosed therein, capable of vaporizing or expanding due to heat to thereby generate a gas, wherein a shell of the heat expandable microcapsule comprises a thermoplastic resin obtained by polymerization from, as a main component of a monomer, a nitrile-based monomer (I), a monomer (II) having an unsaturated double bond and carboxyl group in the molecule thereof, a monomer (III) having two or more polymerizable double bonds and, optionally, a copolymerizable monomer (IV) for adjusting the expansion characteristics, and a pneumatic tire using the same, whereby the tire weight is decreased and the ice traction thereof is improved.
摘要翻译： 一种橡胶组合物，其含有100重量份的二烯系橡胶和0.5〜25重量份的热塑性树脂颗粒，所述热塑性树脂颗粒由其内包含的物质组成，所述热塑性树脂颗粒能够由于热而蒸发或膨胀，从而产生 气体，其中，所述热膨胀性微胶囊的壳包含由作为单体的主要成分的腈系单体（I），具有不饱和双键和羧基的单体（II）聚合得到的热塑性树脂 其分子，具有两个或多个可聚合双键的单体（III）和任选的用于调节膨胀特性的可共聚单体（IV），以及使用该单体的充气轮胎，由此轮胎重量降低，并且冰牵引力 改善了。
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公开(公告)号：US20060065565A1
公开(公告)日：2006-03-30
申请号：US10534491
申请日：2003-10-30
申请人： Toshiaki Masuda , Hiroshi Fukushima , Hiroshi Todo
发明人： Toshiaki Masuda , Hiroshi Fukushima , Hiroshi Todo
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , B65D81/3266 , B65D2203/00 , B65D2203/12
摘要： A plural-chamber container capable of indicating whether or not a peelable partition wall is peeled and hence a medical professional can quickly become aware of a state of communication among respective chambers when using the plural-chamber container, wherein the plural-chamber container formed of a synthetic resin film and a plurality of chambers compartmentalized by a peelable partition wall formed by thermally welding part of the opposed films, characterized in that a means capable of indicating the peeling of the partition wall is provided on a surface of the plural-channel container.
摘要翻译： 能够指示可剥离隔壁是否剥离的多室容器，因此医疗专业人员在使用多室容器时可以迅速地意识到各室之间的连通状态，其中，多室容器由 合成树脂膜和由通过热焊接相对膜的一部分而形成的可剥离隔壁隔开的多个室，其特征在于，在所述多通道容器的表面上设置有能够指示所述分隔壁剥离的装置 。
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54.发明授权公开(公告)号：US06429294B1
公开(公告)日：2002-08-06
申请号：US09334893
申请日：1999-06-17
IPC分类号： A61M114
CPC分类号： A61M1/287 , A61M1/1696 , A61M1/284
摘要： A peritoneal dialysis fluid used for a continuous recirculating peritoneal dialysis wherein the peritoneal dialysis fluid is infused into a peritoneal cavity of a patient and then, typically on a continuous process basis a portion of the dialysis fluid is sequentially drained from the cavity, cleansed through an extracorpreal dialyzer, and reinfused into the cavity. The dialysis fluid contains as an osmotic agent a substance which does not substantially permeate through pores of hollow fiber membrane of an extracorporeal dialyzer, preferably an osmotic agent having a molecular weight of about 20,000 to about 100,000. The supplemented amount of the osmotic agent is reduced or not needed during the dialysis.
摘要翻译： 用于连续循环腹膜透析的腹膜透析液，其中将腹膜透析液注入患者的腹膜腔，然后通常在连续过程的基础上将部分透析液从腔中顺次排出，通过 体外透析液，并重新灌注到腔内。 透析液含有作为渗透剂的物质，其基本上不渗透通过体外透析器的中空纤维膜的孔隙，优选分子量为约20,000至约100,000的渗透剂。 透析期间补充量的渗透剂减少或不需要。
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55.发明授权公开(公告)号：US10759175B2
公开(公告)日：2020-09-01
申请号：US16278937
申请日：2019-02-19
申请人： Toshiaki Masuda , Tsutoh Aoyama , Takahiko Kuroda , Masaki Kato
发明人： Toshiaki Masuda , Tsutoh Aoyama , Takahiko Kuroda , Masaki Kato
摘要： A liquid discharge head includes a plurality of nozzles to discharge a liquid, a plurality of pressure chambers communicating with the plurality of nozzles, respectively, a plurality of individual supply channels communicating with the plurality of pressure chambers, respectively, a plurality of common-supply branch channels each having a side face and a bottom face and communicating with two or more of the plurality of individual supply channels, respectively, and a common-supply main channel communicating with the plurality of common-supply branch channels. The plurality of common-supply branch channels includes a curved portion on a corner between the side face and the bottom face of each of the plurality of common-supply branch channels along a direction of liquid flow in the plurality of common-supply branch channels.
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公开(公告)号：US09969161B2
公开(公告)日：2018-05-15
申请号：US15447266
申请日：2017-03-02
IPC分类号： B41J2/14 , H01L41/18 , B41J2/16 , H01L41/187
CPC分类号： B41J2/14233 , B41J2/14201 , B41J2/1607 , B41J2/161 , B41J2/1628 , B41J2/1631 , B41J2/164 , B41J2/1642 , B41J2/1645 , B41J2/1646 , B41J2002/14258 , B41J2202/03 , C04B2235/00 , C04B2235/3232 , H01L41/18 , H01L41/1875 , H01L41/1876
摘要： An electromechanical transducer element includes a first electrode, a second electrode, and a piezoelectric material. The piezoelectric material is disposed between the first electrode and the second electrode and deformable with a voltage applied in accordance with a drive signal. The piezoelectric material is made of a composite oxide having a perovskite structure preferentially oriented in at least one of a (100) plane and a (001) plane. A drop in diffraction intensity is included in a rocking curve corresponding to at least one of a (200) plane and a (002) plane measured at a position of 2θ where the diffraction intensity is largest at a peak of diffraction intensity corresponding to the (200) plane out of peaks of diffraction intensity measured by an X-ray diffraction θ-2θ method.
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57.发明授权公开(公告)号：US07837042B2
公开(公告)日：2010-11-23
申请号：US11573333
申请日：2005-08-09
申请人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Hideyuki Yokota , Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： B01D63/021 , A61M2209/06 , B01D65/022 , B01D65/10 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/08 , B01D71/68 , B01D2313/23 , B01D2321/346 , B01D2323/34 , B01D2325/022 , Y10T428/249958
摘要： The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.
摘要翻译： 本发明涉及一种包含聚砜型选择性渗透性中空纤维膜的中空纤维膜组件，其包含聚砜基树脂和亲水性聚合物作为主要成分，其中（A）亲水性聚合物在内表面最上层中的含量 的中空纤维膜的至少比膜的内表面的邻近层中的亲水性聚合物的含量大至少1.1倍，（B）亲水性聚合物在外表面的最上层中的含量 中空纤维膜比膜的内表面的最上层中的亲水性聚合物的含量大至少1.1倍。 中空纤维膜组件暴露于放射线，条件是中空纤维膜周围的环境气氛的氧浓度为0.001〜0.1％，中空纤维膜的水分含量为 0.2〜7质量％。
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公开(公告)号：US20080087599A1
公开(公告)日：2008-04-17
申请号：US11577235
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/169 , A61L2/087 , A61L2202/22 , A61M1/168 , A61M1/1682 , B01D61/28 , B01D63/02 , B01D65/022 , B01D67/0097 , B01D2321/28 , B01D2321/34
摘要： The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package.The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.
摘要翻译： 本发明提供了一种对血液净化器进行灭菌的方法，该方法有效地减少归因于选择性渗透性分离膜的劣化的血液净化器的提取物的量随着放射线或电子射线暴露期间和之后的时间而变化 ，哪种方法在用于血液渗透治疗时安全性高度可靠。 本发明还提供一种血液净化器包装。 本发明涉及一种用于对通过将相同的血液净化器暴露于放射线和/或电子射线的基本干燥的选择性渗透性分离膜作为主要成分的血液净化器进行灭菌的方法，该方法是 其特征在于，将血液净化器与除氧剂和保湿剂一起密封在包装袋中，或与能够释放水分的除氧剂一起密封，然后通过上述曝光在这样的密封状态下灭菌。
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公开(公告)号：US20080067122A1
公开(公告)日：2008-03-20
申请号：US11577209
申请日：2005-10-13
申请人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
发明人： Kimihiro Mabuchi , Noriko Monden , Noriaki Kato , Yuuki Hatakeyama , Takashi Sunohara , Toshiaki Masuda
CPC分类号： A61M1/168 , A61L2/087 , A61L2202/22 , A61M1/16 , A61M1/1682 , A61M1/169 , A61M2209/06 , B01D65/022 , B01D67/0011 , B01D67/0097 , B01D69/08 , B01D71/68 , B01D2321/34 , B01D2323/34 , B01D2325/36 , B01D2325/38
摘要： The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.
摘要翻译： 本发明提供了一种血液净化器，其显示从其选择性渗透性分离膜中提取的过氧化氢的量减少，因此在其半胱氨酸用途的安全性方面是高度可靠的。 本发明涉及一种血液净化器，其包括选择性渗透性分离膜作为主要成分，其特征在于，经过3个月以上从血液净化器除去的选择性渗透性分离膜中提取的过氧化氢的量已经过去 由于通过暴露于放射线和/或电子射线对血液净化器的灭菌不大于10ppm。
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公开(公告)号：US07293646B2
公开(公告)日：2007-11-13
申请号：US10534491
申请日：2003-10-30
申请人： Toshiaki Masuda , Hiroshi Fukushima , Hiroshi Todo
发明人： Toshiaki Masuda , Hiroshi Fukushima , Hiroshi Todo
IPC分类号： B65D25/08
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/2024 , B65D81/3266 , B65D2203/00 , B65D2203/12
摘要： A plural-chamber container capable of indicating whether or not a peelable partition wall is peeled and hence a medical professional can quickly become aware of a state of communication among respective chambers when using the plural-chamber container, wherein the plural-chamber container formed of a synthetic resin film and a plurality of chambers compartmentalized by a peelable partition wall formed by thermally welding part of the opposed films, characterized in that a means capable of indicating the peeling of the partition wall is provided on a surface of the plural-channel container.
摘要翻译： 能够指示可剥离隔壁是否剥离的多室容器，因此医疗专业人员在使用多室容器时可以迅速地意识到各室之间的连通状态，其中，多室容器由 合成树脂膜和由通过热焊接相对膜的一部分而形成的可剥离隔壁隔开的多个室，其特征在于，在所述多通道容器的表面上设置有能够指示所述分隔壁剥离的装置 。
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