利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

138 条记录 (耗时 0.049 秒)

    Modulators of fatty acid amide hydrolase
    51.
    发明授权
    Modulators of fatty acid amide hydrolase 有权
    脂肪酸酰胺水解酶的调节剂

    公开(公告)号：US08940745B2

    公开(公告)日：2015-01-27

    申请号：US13695855

    申请日：2011-05-02

    申请人： John M. Keith ,  Jing Liu

    发明人： John M. Keith ,  Jing Liu

    IPC分类号： C07D405/12 ,  A61K31/496

    CPC分类号： C07D405/12

    摘要： 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is described, which is useful as a FAAH modulator. 4-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). A method of synthesizing 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide is also disclosed.

    摘要翻译： 描述了4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺，其可用作FAAH 调制器。 4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺可用于药物组合物和方法 治疗由脂肪酸酰胺水解酶（FAAH）活性（如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱和运动障碍（例如多发性硬化））介导的疾病状态，病症和状况。 还公开了合成4-（2,2-二氟 - 苯并[1,3]二氧杂环戊烯-5-基甲基） - 哌嗪-1-甲酸（4-氯 - 吡啶-3-基） - 酰胺的方法。

    Sirtuin activating compounds and processes for making the same
    52.
    发明授权
    Sirtuin activating compounds and processes for making the same 有权
    Sirtuin活化化合物及其制备方法

    公开(公告)号：US08841477B2

    公开(公告)日：2014-09-23

    申请号：US12503239

    申请日：2009-07-15

    申请人： Merritt B. Andrus ,  Jing Liu

    发明人： Merritt B. Andrus ,  Jing Liu

    IPC分类号： C07C69/88 ,  C07C67/29 ,  C07C69/017 ,  C07C67/287 ,  C07C67/293 ,  C07C67/08 ,  C07C67/14

    CPC分类号： C07C69/017 ,  C07C67/08 ,  C07C67/14 ,  C07C67/287 ,  C07C67/29 ,  C07C67/293 ,  Y02P20/55 ,  C07C69/716 ,  C07C69/63 ,  C07C69/18 ,  C07C69/16

    摘要： The present invention includes methods for preparing resveratrol, resveratrol esters and substituted and unsubstituted stilbenes of the formula given below; where each Y is —O or halogen, each Z is —O or halogen, each n and each m is independently the value of 0, 1, 2, 3, 4 or 5, each A and each B is independently selected from Pn, R or absent, each V and each W is independently selected from Pn, straight or branched alkyl of from 2 to 6 carbon atoms and cycloalkyl of from 3 to 8 carbon atoms, alkoxy, phenyl, benzyl or halogen, R is independently selected from the group comprising alkyl with at least one carbon atom, aryl and aralkyl, Pn is an alcohol protecting group and diastereoisomers of the foregoing. The compounds are made from a multi-step process including a N-heterocyclic carbene-type ligand coupling in the presence of a base with benzyol halide and styrene coupling partners. These compounds show increased stability for use in the food, cosmetic and pharmaceutical industries.

    摘要翻译： 本发明包括用于制备下列给出的式的白藜芦醇，白藜芦醇酯和取代和未取代的二苯乙烯的方法; 其中每个Y是-O或卤素，每个Z是-O或卤素，每个n和每个m独立地是0,1,2,3,4或5的值，每个A和每个B独立地选自Pn， R或不存在，每个V和每个W独立地选自Pn，2至6个碳原子的直链或支链烷基和3至8个碳原子的环烷基，烷氧基，苯基，苄基或卤素，R独立地选自 包含至少一个碳原子的烷基，芳基和芳烷基，Pn是上述的醇保护基和非对映异构体。 所述化合物由多步法制备，包括在碱存在下与苄氧基卤化物和苯乙烯偶联配偶体的N-杂环卡宾型配体偶联。 这些化合物在食品，化妆品和制药工业中显示出增加的稳定性。

    System for measuring fan rotational speed
    57.
    发明授权
    System for measuring fan rotational speed 失效
    风扇转速测量系统

    公开(公告)号：US08237393B2

    公开(公告)日：2012-08-07

    申请号：US12565773

    申请日：2009-09-24

    申请人： Ling-Yu Xie ,  Kun-Lung Wu ,  Sheng-Chung Huang ,  San-Yong Yang ,  Xin-Ping Zhang ,  Jing Liu

    发明人： Ling-Yu Xie ,  Kun-Lung Wu ,  Sheng-Chung Huang ,  San-Yong Yang ,  Xin-Ping Zhang ,  Jing Liu

    IPC分类号： G05B11/28

    CPC分类号： G01P3/48 ,  G01P3/486

    摘要： A system is used to measure a fan rotational speed. The system includes a main controller, a first socket coupled to the linear fan, a second socket connected to the main controller, and an optical fiber amplifier connected to the main controller. A PWM (pulse width module) fan is coupled to the second socket, the PWM fan sends a first rotational speed signal, which represent a rotation speed of the PWM fan, to the main controller via the second socket. The optical fiber amplifier is capable of radiating light on fan blades of the linear fan, and sensing light reflected by the fan blades to count a rotational speed of the linear fan, and generating a second rotational speed signal which represents a rotational speed of the linear fan. The optical fiber amplifier sends the second rotational speed signal to the main controller.

    摘要翻译： 系统用于测量风扇转速。 该系统包括主控制器，耦合到线性风扇的第一插座，连接到主控制器的第二插座和连接到主控制器的光纤放大器。 PWM（脉冲宽度模块）风扇耦合到第二个插座，PWM风扇通过第二个插座将一个表示PWM风扇的转速的第一转速信号发送到主控制器。 光纤放大器能够在线性风扇的风扇叶片上照射光，并且感测由风扇叶片反射的光以对线性风扇的转速进行计数，并产生代表线性风扇的转速的第二转速信号 风扇。 光纤放大器将第二转速信号发送到主控制器。

    Method and apparatus for handling disconnection between a media gateway and a media gateway controller
    58.
    发明授权
    Method and apparatus for handling disconnection between a media gateway and a media gateway controller 有权
    用于处理媒体网关和媒体网关控制器之间的断开的方法和装置

    公开(公告)号：US08195988B2

    公开(公告)日：2012-06-05

    申请号：US12734540

    申请日：2007-11-12

    申请人： Yu Xiao ,  Yangming Li ,  Jing Liu

    发明人： Yu Xiao ,  Yangming Li ,  Jing Liu

    IPC分类号： G06F11/00

    CPC分类号： H04L65/1043 ,  H04L65/103 ,  H04L67/2852 ,  H04L69/40

    摘要： The present invention relates to a method and apparatus in a Media Gateway (MG) for handling disconnection between the MG and a Media Gateway Controller (MGC). Multilevel requirements are fulfilled by setting different timeout periods for a disconnection timer. On the one hand, if the timeout period of the disconnection timer is not equal to zero, new events that occur during the disconnection are stored. Then, after the connection is recovered, the stored new events are reported to the MGC, so that the data and states in the MG can match those in the MGC after the connection recovery. On the other hand, if the timeout period of the disconnection timer is equal to zero, all active calls are immediately released.

    摘要翻译： 本发明涉及媒体网关（MG）中用于处理MG与媒体网关控制器（MGC）之间的断开连接的方法和装置。 通过为断开定时器设置不同的超时时间来满足多级要求。 一方面，如果断开定时器的超时时间不等于零，则存储断开期间发生的新事件。 然后，在恢复连接后，将存储的新事件报告给MGC，使得MG中的数据和状态可以在连接恢复后与MGC中的数据和状态相匹配。 另一方面，如果断开定时器的超时时间等于零，则立即释放所有活动呼叫。

    Method for Processing an Echo Amplitude Profile Generated by a Pulse-Echo Ranging System
    59.
    发明申请
    Method for Processing an Echo Amplitude Profile Generated by a Pulse-Echo Ranging System 有权
    用于处理由脉冲回波测距系统产生的回波振幅曲线的方法

    公开(公告)号：US20120092210A1

    公开(公告)日：2012-04-19

    申请号：US13276005

    申请日：2011-10-18

    申请人： Jing Liu

    发明人： Jing Liu

    IPC分类号： G01S13/08 ,  G01S15/08

    CPC分类号： G01S7/2921 ,  G01F23/284 ,  G01F23/296 ,  G01S7/2923 ,  G01S7/41 ,  G01S7/52004 ,  G01S7/527 ,  G01S13/88 ,  G01S15/88

    摘要： A method for considering an echo amplitude profile as a result of convoluting a single echo with a channel response sequence, wherein for multiple echo detection, an estimation task is broken into three major steps comprising estimating a channel response, recovering a full shape of a single echo, and iteratively updating the channel response and echo shape to increase their accuracy. The estimation of the channel response is treated as a single echo detection problem and includes estimating the strongest echo for its position and amplitude, removing an echo corresponding to this recovered channel from the echo amplitude profile, and repeating the preceding steps for the next strongest echo.

    摘要翻译： 一种考虑回波幅度曲线的方法，该方法是将单个回波与通道响应序列进行卷积，其中对于多重回波检测，将估计任务分为三个主要步骤，包括估计信道响应，恢复单个回波的完整形状 回波，并迭代更新通道响应和回波形状，以提高其精度。 信道响应的估计被视为单个回波检测问题，并且包括估计其位置和幅度的最强回波，从回波幅度分布中去除对应于该恢复信道的回波，并且针对下一个最强回波重复前述步骤 。