公开(公告)号：US07787962B2

公开(公告)日：2010-08-31

申请号：US11946453

申请日：2007-11-28

申请人： Yougandh Chitre ,  Cheuk Tang

发明人： Yougandh Chitre ,  Cheuk Tang

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/05 ,  A61N1/057

摘要： An implantable electrical medical lead for a pulse generator includes a distal electrode, a connector for electrical connection with the pulse generator, an electrical conductor within the lead extending between the connector and the distal electrode, and an insulating sheath of flexible resilient material normally covering the electrical conductor having self sealing properties to re-insulate the electrical conductor in the event a rupture of the sheath should occur which exposes the electrical conductor. The insulating sheath includes an outer insulative layer, an inner insulative layer, and an intermediate plasticized layer to seal any occurring rupture in the insulating sheath and re-insulate the electrical conductor which has been exposed.

摘要翻译： 用于脉冲发生器的可植入电气医疗引线包括远端电极，用于与脉冲发生器电连接的连接器，在连接器和远端电极之间延伸的引线内的电导体，以及柔性弹性材料的绝缘护套，通常覆盖 电导体具有自密封特性，以在出现电导体破裂的情况下重新绝缘电导体。 绝缘护套包括外绝缘层，内绝缘层和中间增塑层，用于密封绝缘护套中的任何发生的断裂，并重新绝缘已暴露的电导体。

公开(公告)号：US07403823B1

公开(公告)日：2008-07-22

申请号：US11205865

申请日：2005-08-16

申请人： Mark W. Kroll ,  John R. Helland ,  Yougandh Chitre ,  Michael Yang

发明人： Mark W. Kroll ,  John R. Helland ,  Yougandh Chitre ,  Michael Yang

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/0563 ,  A61N2001/0585

摘要： An implantable lead assembly for a body implantable medical system adapted to transmit electrical signals between a proximal end portion of the lead assembly and a distal end portion of the lead assembly to thereby stimulate selected body tissue includes an elongated insulative sheath of flexible resilient material having at least one longitudinally extending lumen, an electrical conductor received within the lumen of the insulative sheath and extending between a proximal end and a distal end, and at least one elongated super plastic element slidably received within the lumen of the insulative sheath, the super plastic element being bendable to configure the lead assembly to negotiate tortuous turns in the vasculature of the body. An electrical connector is coupled to the proximal end of the conductor for releasable attachment to a stimulating pulse generator and an electrode is coupled to the distal end of the conductor.

摘要翻译： 一种用于身体可植入医疗系统的可植入引线组件，其适于在引线组件的近端部分和引线组件的远端部分之间传输电信号，从而刺激所选择的身体组织，包括柔性弹性材料的细长绝缘护套， 至少一个纵向延伸的内腔，电导体，其容纳在绝缘护套的内腔内并在近端和远端之间延伸;以及至少一个细长超塑料元件，其可滑动地容纳在绝缘护套的内腔内，超塑料元件 可以弯曲以配置导线组件来协商身体脉管系统中的曲折转弯。 电连接器耦合到导体的近端，用于可释放地附接到刺激脉冲发生器，并且电极耦合到导体的远端。

公开(公告)号：US07363091B1

公开(公告)日：2008-04-22

申请号：US10732332

申请日：2003-12-09

申请人： Cole H. Chen ,  Phong D. Doan ,  Yougandh Chitre ,  John R. Helland

发明人： Cole H. Chen ,  Phong D. Doan ,  Yougandh Chitre ,  John R. Helland

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A drug-eluting endocardial lead and method of manufacture. The silicone elastomer of the present invention is ideally suited to a manufacturing environment due to its extended pot life and decreased curing time. A preferred silicone elastomer is comprised of a multi-part mixture having at least a base portion and a curing portion. Additionally, since curing does not begin until the base and curing portions are combined, the mixing can be physically undertaken closer to the location of the endocardial lead and the curing “clock” does not start until the mixing occurs and external heat is applied. Since the silicone elastomer formed by base and curing components have improved the pot life and curing characteristics, the mixture is suitable for mixing with a steroid and then dispensing into an endocardial lead tip thus eliminating current design limitations imposed by current art while concomitantly minimizing manufacturing costs.

摘要翻译： 药物洗脱心内膜铅及其制造方法。 本发明的有机硅弹性体由于其使用寿命延长并且固化时间缩短而理想地适用于制造环境。 优选的有机硅弹性体由至少具有基部分和固化部分的多部分混合物组成。 此外，由于固化直到基部和固化部分组合才开始固化，所以混合可以在物理上更接近于心内膜的位置，并且固化“钟”不会开始，直到混合发生并且外部加热。 由于由碱和固化组分形成的硅氧烷弹性体已经改善了适用期和固化特性，所以该混合物适用于与类固醇混合，然后分配到心内膜引导末端，从而消除了当前技术所施加的当前设计限制，同时最小化制造成本 。

公开(公告)号：US07181290B2

公开(公告)日：2007-02-20

申请号：US10800372

申请日：2004-03-12

申请人： Yougandh Chitre ,  David E. Kistler

发明人： Yougandh Chitre ,  David E. Kistler

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N2001/0585

摘要： To implant a lead system for an implantable cardiac stimulation device, a guide wire is slidably introduced into a longitudinally extending internal passage of an elongated stylet. In turn, the combined stylet and guide wire are slidably introduced into the longitudinally extending lumen of an elongated tubular lead body of flexible resilient insulative material having a thrusting region near its distal end. With the distal end of the stylet in engagement with the thrusting region of the lead, the stylet together with the lead and guide wire are advanced until the lead should encounter a tortuous turn in the vasculature of the body. At this point, the guide wire is advanced through the stylet and into the vasculature until the distal end of the guide wire arrives at a chosen location. The stylet then re-continues its advance together with the lead until the lead reaches the desired implant location.

摘要翻译： 为了植入用于可植入心脏刺激装置的引导系统，引导线可滑动地引入到细长探针的纵向延伸的内部通道中。 反过来，组合的探针和引导线可滑动地引入柔性弹性绝缘材料的细长管状引线本体的纵向延伸的内腔中，其具有在其远端附近的推压区域。 当探针的远端与引线的推进区域接合时，探针与引导线和引导线一起前进，直到引线应该在身体的脉管系统中遇到曲折的转弯。 此时，引导线通过探针并进入脉管系统，直到引导线的远端到达所选择的位置。 探针然后重新继续前进，直到引线达到所需的植入位置。

公开(公告)号：US07174220B1

公开(公告)日：2007-02-06

申请号：US10802462

申请日：2004-03-16

申请人： Yougandh Chitre ,  John R. Helland

发明人： Yougandh Chitre ,  John R. Helland

IPC分类号： A61N1/00

CPC分类号： A61N1/056

摘要： An implantable cardiac stimulation lead system for use with an implantable stimulation device includes at least a pair of conductors, braided together and extending between proximal and distal ends and co-extruded with flexible resilient insulation material. Each conductor may be a multi-strand cable composed of MP35N or DFT and have its outer peripheral surfaces coated with insulative material. An electrical connector is coupled to the proximal end of the lead system for connection with a stimulation device and includes terminals electrically connected to the conductors. The proximal connector is thereby electrically coupled to a distal tip electrode and to at least one electrode proximally spaced from the distal tip electrode. The lead system may include an elongated tubular lead body of flexible resilient insulative material having a longitudinally extending lumen for receiving a stylet for aid in implanting the lead system. Alternatively, an introducer sheath may be employed for implantation.

摘要翻译： 用于可植入刺激装置的可植入心脏刺激引导系统包括至少一对导体，编织在一起并且在近端和远端之间延伸并与柔性弹性绝缘材料共挤出。 每个导体可以是由MP35N或DFT组成的多股电缆，其外周表面涂有绝缘材料。 电连接器耦合到引导系统的近端以与刺激装置连接，并且包括电连接到导体的端子。 近端连接器由此电耦合到远端尖端电极和至少一个与远侧末端电极间隔开的电极。 引导系统可以包括柔性弹性绝缘材料的细长管状引线体，其具有纵向延伸的内腔，用于接收探针以便于植入引导系统。 或者，可以使用导引鞘来进行植入。

公开(公告)号：US07058454B1

公开(公告)日：2006-06-06

申请号：US10232866

申请日：2002-08-30

申请人： Yougandh Chitre ,  John R. Helland

发明人： Yougandh Chitre ,  John R. Helland

IPC分类号： A61N1/05

CPC分类号： A61N1/0565

摘要： A lead assembly for a body implantable medical system adapted to transmit electrical signals between proximal and distal end portions of the lead assembly to thereby stimulate selected body tissue includes an electrical conductor, an insulative sheath composed of silicone or polyurethane covering the conductor, an electrical connector coupled to the proximal end of the conductor for releasable attachment to a stimulating pulse generator and a distal electrode coupled to the distal end of the conductor. The distal electrode has an outer surface generally coaxial with the lead assembly and facing transversely of the longitudinal axis of the lead assembly and generally parallel to the selected body tissue intended for stimulation. The outer surface of the distal electrode is composed of a biocompatible metallic alloy and includes a layer of a material that exhibits low polarization and thereby enhances the electrical efficacy of the electrode.

摘要翻译： 一种用于身体可植入医疗系统的引线组件，其适于在引线组件的近端部分和远端部分之间传输电信号从而刺激所选择的身体组织，包括电导体，由覆盖导体的硅树脂或聚氨酯组成的绝缘护套，电连接器 耦合到导体的近端，用于可释放地附接到刺激脉冲发生器和耦合到导体的远端的远端电极。 远端电极具有与引线组件大致同轴并且横向于导线组件的纵向轴线的外表面，并且大致平行于用于刺激的所选择的身体组织。 远端电极的外表面由生物相容的金属合金构成，并且包括显示低偏振的材料层，从而提高电极的电功效。

公开(公告)号：US06792318B2

公开(公告)日：2004-09-14

申请号：US10172193

申请日：2002-06-13

申请人： Yougandh Chitre ,  Kerwyn Schimke

发明人： Yougandh Chitre ,  Kerwyn Schimke

IPC分类号： A61N100

CPC分类号： A61N1/0563 ,  A61N1/057

摘要： An implantable cardiac stimulation lead system for use with an implantable stimulation device includes an elongated lead with a conductor extending between distal and proximal ends. A tubular insulating sheath overlies the conductor and has an outer peripheral surface of revolution defined by a radius originating at the longitudinal axis. A tip electrode at the distal end of the lead is attached to the conductor. A proximal connector is in electrical continuity with the stimulation device and coupled to the tip electrode. The insulating sheath is formed with a passive fixation feature formed into the outer peripheral surface for encouraging tissue ingrowth to facilitate stability of the tip electrode when the lead system is implanted. No portion of the passive fixation feature extends radially from the longitudinal axis by a distance greater than the radius of the tubular insulating sheath.

摘要翻译： 用于可植入刺激装置的可植入心脏刺激引导系统包括具有在远端和近端之间延伸的导体的细长引线。 管状绝缘护套覆盖在导体上，并具有由纵向轴线起源的半径限定的旋转外周面。 引线前端的尖端电极连接在导体上。 近端连接器与刺激装置电连接并且连接到尖端电极。 绝缘护套形成有形成在外周表面中的被动固定特征，用于在植入引线系统时促进组织向内生长以促进尖端电极的稳定性。 被动固定特征的任何部分从纵向轴线径向延伸的距离大于管状绝缘护套的半径。

公开(公告)号：US06430447B1

公开(公告)日：2002-08-06

申请号：US09707706

申请日：2000-11-07

申请人： Yougandh Chitre ,  Phong Doan

发明人： Yougandh Chitre ,  Phong Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable stimulating electrode for directly contacting the endocardium of a human heart exhibits low polarization values of less than about 0.3 mV and is intended for use with an implantable lead having an electrical connector coupled to the proximal end of a conductor for releasable attachment to a stimulating pulse generator. The electrode is comprised of a metallic substrate having an initially exposed outer surface substantially covered with a first inner layer of titanium nitride and a second outer layer of platinum black. The first inner layer of titanium nitride has a thickness of less than about 15 microns and the second outer layer of platinum black overlying the layer of titanium nitride, similarly, has a thickness of less than about 15 microns. The invention includes a method of making the implantable stimulating electrode.

摘要翻译： 用于直接接触人心内膜的可植入刺激电极显示小于约0.3mV的低偏振值，并且旨在用于具有耦合到导体的近端的电连接器的可植入导线，用于可释放地附接到刺激 脉冲发生器。 电极由具有初始暴露的外表面的金属基底构成，其基本上覆盖有第一内层氮化钛和第二外层铂黑。 氮化钛的第一内层具有小于约15微米的厚度，并且类似地覆盖在氮化钛层上的第二外层铂黑的厚度小于约15微米。 本发明包括制造可植入刺激电极的方法。

公开(公告)号：US06198973B1

公开(公告)日：2001-03-06

申请号：US09320405

申请日：1999-05-26

申请人： Phong Doan ,  Lisa Caffee ,  Yougandh Chitre

发明人： Phong Doan ,  Lisa Caffee ,  Yougandh Chitre

IPC分类号： A61N104

CPC分类号： A61N1/0568

摘要： An electrode assembly for a body implantable lead comprises a longitudinally extending dispenser housing having an internal cavity with opposed longitudinally extending openings for storing a drug to be dispensed. A tip electrode integral and axially aligned with the dispenser housing has a face adapted for positioning adjacent the desired body site, a transverse channel formed into and transversely across its face, and an orifice extending between the channel and the internal cavity for elution of the drug to the desired body site. A weld sleeve integral and axially aligned with the dispenser housing distant from the tip electrode has an outer peripheral surface for engageably receiving one end of an elongated electrical conductor, and a collar spaced from the dispenser housing. The electrical conductor is welded to the collar to obtain a welded connection for electrical continuity between the tip electrode and the electrical conductor. An insulative sheath of resilient material is fittingly received on the outer peripheral surface of the dispenser housing overlying the longitudinally extending openings and the welded connection between the electrical conductor and the weld sleeve. Insulative tubing is received on the coiled conductor includes a skirt member distant from the tip electrode and coaxial with the insulative tubing and biased radially into engagement with the outer peripheral surface of the insulative tubing. A plurality of fixation tines are integral with, and extend radially outwardly from, the insulative sheath at a plurality of circumferentially spaced locations.

摘要翻译： 用于身体可植入引线的电极组件包括纵向延伸的分配器壳体，其具有内部空腔，具有相对的纵向延伸的开口，用于储存待分配的药物。 与分配器壳体一体并且轴向对齐的尖端电极具有适于邻近所需体部位置定位的面，形成在其表面上并横向横过其表面的横向通道，以及在通道和内腔之间延伸以用于药物洗脱的孔 到所需的身体部位。 与远离尖端电极的分配器壳体一体并且轴向对齐的焊接套筒具有用于可接合地接纳细长电导体的一端的外周面和与分配器壳体间隔开的套环。 电导体焊接到套环以获得用于尖端电极和电导体之间的导电性的焊接连接。 弹性材料的绝缘护套适当地容纳在分配器壳体的外周表面上，覆盖纵向延伸的开口以及电导体和焊接套管之间的焊接连接。 绝缘管被接收在线圈导体上，包括远离尖端电极并与绝缘管同轴并且径向偏压地与绝缘管的外周表面接合的裙部构件。 在多个周向间隔开的位置处，多个固定齿与绝缘护套成一体并且从其径向向外延伸。

公开(公告)号：US20120209349A1

公开(公告)日：2012-08-16

申请号：US13447050

申请日：2012-04-13

申请人： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

发明人： Konstantinos Alataris ,  Andre B. Walker ,  Jon Parker ,  Yougandh Chitre ,  Sangsoo Wesley Park ,  James R. Thacker

IPC分类号： A61N1/34

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/06 ,  A61N1/36021 ,  A61N1/3605 ,  A61N1/36157 ,  A61N1/36164 ,  A61N1/36167 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36182 ,  A61N1/37235 ,  A61N1/37241 ,  A61N1/37247 ,  A61N1/37264 ,  A61N1/3787

摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications.