公开(公告)号：US06815706B2

公开(公告)日：2004-11-09

申请号：US10323139

申请日：2002-12-17

Applicant: Zhiyong Li ,  Yong Chen ,  Sean Xiao-An Zhang

Inventor： Zhiyong Li ,  Yong Chen ,  Sean Xiao-An Zhang

IPC: H01L2906

CPC classification number: H01L51/42 ,  H01L51/005 ,  H01L51/0071 ,  H01L51/0077 ,  H01L51/428 ,  Y02E10/549 ,  Y10S977/954

Abstract: An optical sensor is provided, comprising (a) a silicon nanowire of finite length having an electrical contact pad at each end thereof; and (b) a plurality of self-assembled molecules on a surface of the silicon nanowire, the molecules serving to modulate electrical conductivity of the silicon nanowire by either a reversible change in dipole moment of the molecules or by a reversible molecule-assisted electron/energy transfer from the molecules onto the silicon nanowire. Further, a method of making the optical sensor is provided. The concept of molecular self-assembly is applied in attaching functional molecules onto silicon nanowire surfaces, and the requirement of molecule modification (hydroxy group in molecules) is minimal from the point view of synthetic difficulty and compatibility. Self-assembly will produce well-ordered ultra-thin films with strong chemical bonding on a surface that cannot be easily achieved by other conventional methods.

Abstract translation: 提供了一种光学传感器，其包括（a）有限长度的硅纳米线，其每端具有电接触焊盘; 和（b）在硅纳米线的表面上的多个自组装分子，所述分子用于通过分子的偶极矩的可逆变化或通过可逆分子辅助电子/分子调制硅纳米线的导电性， 能量从分子转移到硅纳米线上。 此外，提供了制造光学传感器的方法。 分子自组装的概念应用于将功能分子附着在硅纳米线表面上，从合成难度和相容性的观点来看，分子修饰（分子中的羟基）的要求是最小的。 自组装将产生在表面上具有强化学键合的良好有序的超薄膜，其不能通过其它常规方法实现。

公开(公告)号：US09664560B2

公开(公告)日：2017-05-30

申请号：US14381009

申请日：2012-03-06

Applicant: R. Stanley Williams ,  Zhiyong Li

Inventor： R. Stanley Williams ,  Zhiyong Li

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65

CPC classification number: G01J3/0205 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/658 ,  G01N2201/06113 ,  G01N2201/068

Abstract: A double-grating surface-enhanced Raman spectrometer. The spectrometer includes a substrate; a plurality of nanofingers carried by the substrate, the nanofingers arranged to define a first optical grating; a light source oriented to project a beam of light toward the first optical grating; a second optical grating oriented to receive a beam of light scattered from the first optical grating; and a detector oriented to receive a beam of light scattered from the second optical grating.

公开(公告)号：US20160251405A1

公开(公告)日：2016-09-01

申请号：US15137606

申请日：2016-04-25

Applicant: Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

Inventor： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

IPC: C07K14/475

CPC classification number: A61K38/19 ,  A23L33/17 ,  A23V2002/00 ,  A61K38/22 ,  A61K39/00 ,  C07K14/475 ,  C07K14/52

Abstract: The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

Abstract translation: 本发明提供Metrnl蛋白在制备降血脂，降血糖药或膳食补充剂中的应用。 本发明还提供了制备具有Metrn1脂肪特异性过表达的小鼠的方法。

公开(公告)号：US09377409B2

公开(公告)日：2016-06-28

申请号：US13194556

申请日：2011-07-29

Applicant: Min Hu ,  Zhiyong Li ,  Fung Suong Ou ,  Ansoon Kim

Inventor： Min Hu ,  Zhiyong Li ,  Fung Suong Ou ,  Ansoon Kim

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  B82Y20/00

CPC classification number: G01N21/658 ,  B82Y20/00 ,  G01J3/0256 ,  G01J3/4412 ,  G01N2201/06113 ,  Y10S977/954 ,  Y10T29/49

Abstract: In a method of fabricating an apparatus for use in a sensing application, a plurality of nano-fingers are formed on a substrate and a Raman-active material nano-particle is formed on respective tips of the nano-fingers. In addition, the Raman-active material nano-particles on the tips of adjacent ones of the nano-fingers are caused to come into contact with the Raman-active material nano-particle on the tip of at least another one of the plurality of nano-fingers to form respective clusters and the clusters of Raman-active material nano-particles are transferred to a component layer from the plurality of nano-fingers while maintaining a spatial relationship between the contacting Raman-active material nano-particles.

Abstract translation: 在制造用于感测应用的装置的方法中，在衬底上形成多个纳米指，并且在纳米手指的各个尖端上形成拉曼活性材料纳米颗粒。 另外，使相邻的纳米指尖的拉曼活性物质纳米粒子与多个纳米尺寸中的至少另一个的前端的拉曼活性物质纳米粒子接触 - 形成相应的簇，并且拉曼活性材料纳米颗粒簇从多个纳米指转移到组分层，同时保持接触拉曼活性材料纳米颗粒之间的空间关系。

公开(公告)号：US08848183B2

公开(公告)日：2014-09-30

申请号：US13188941

申请日：2011-07-22

Applicant: Wei Yi ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li

Inventor： Wei Yi ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Zhiyong Li

IPC: G01N21/65 ,  B82Y20/00 ,  B82Y40/00 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  B82Y20/00 ,  B82Y40/00 ,  Y10T29/49826 ,  Y10T428/24893

Abstract: An apparatus includes a substrate and a plurality of nano-fingers attached at respective first ends to the substrate and freely movable along their lengths, in which a first set of the plurality of nano-fingers comprises a first physical characteristic, wherein a second set of the plurality of nano-fingers comprises a second physical characteristic, and wherein the first physical characteristic differs from the second physical characteristic.

Abstract translation: 一种装置包括：衬底和多个纳米指，其各自的第一端附接到衬底并且可沿其长度自由移动，其中多个纳米指的第一组包括第一物理特性，其中第二组 所述多个纳米指包含第二物理特性，并且其中所述第一物理特性与所述第二物理特性不同。

公开(公告)号：US20140198314A1

公开(公告)日：2014-07-17

申请号：US14239336

申请日：2011-10-18

Applicant: Zhiyong Li ,  Ansoon Kim

Inventor： Zhiyong Li ,  Ansoon Kim

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  G01N21/253 ,  G01N21/658

Abstract: A molecular sensing device includes a substrate; a well i) formed in a material that is positioned on a surface of the substrate or ii) formed in a surface of the substrate; a signal amplifying structure positioned in the wed; and an immersion fluid deposited into the well and surrounding the signal amplifying structure.

Abstract translation: 分子感测装置包括基板; 形成在位于基板的表面上的材料中，或ii）形成在基板的表面中的材料; 定位在所述信号放大结构中的信号放大结构; 以及沉积到井中并围绕信号放大结构的浸没流体。

公开(公告)号：US08687186B2

公开(公告)日：2014-04-01

申请号：US13383387

申请日：2009-07-30

Applicant: Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Jingjing Li ,  Huei Pei Kuo ,  David A. Fattal ,  Nobuhiko Kobayashi ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate having a surface and a plurality of tapered nanowires disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.

Abstract translation: 本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。 在一个实施例中，系统包括具有设置在表面上的表面和多个锥形纳米线的基板。 每个纳米线具有远离表面的锥形端。 该系统还包括设置在每个纳米线的锥形端附近的多个纳米颗粒。 当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

公开(公告)号：US20140086806A1

公开(公告)日：2014-03-27

申请号：US13881081

申请日：2010-10-28

Applicant: Zhiyong Li ,  Philip J. Kuekes

Inventor： Zhiyong Li ,  Philip J. Kuekes

IPC: B01J19/08

CPC classification number: B01J19/087 ,  B01J19/0046 ,  B01J2219/00495 ,  B01J2219/00641 ,  B01J2219/00716 ,  B82Y30/00 ,  C40B50/14 ,  C40B60/14 ,  H01L27/101 ,  H01L27/2463

Abstract: Systems and methods for synthesizing molecules on a substrate surface are disclosed. In one aspect, a molecule synthesizing system includes a crossbar array with a planar arrangement of crossbar junctions. Each crossbar junction is independently switchable between a high-resistance state and a low-resistance state. The system also includes a slab with a first surface and a second surface parallel to the first surface. The second surface is disposed on the crossbar array. A current applied to a crossbar junction in a high-resistance state creates an adjacent heated site on the first surface for attaching thermally reactive molecules for molecular synthesis.

Abstract translation: 公开了在衬底表面上合成分子的系统和方法。 在一个方面，分子合成系统包括具有交叉连接点的平面布置的交叉开关阵列。 每个交叉连接点可以在高电阻状态和低电阻状态之间独立切换。 该系统还包括具有平行于第一表面的第一表面和第二表面的板坯。 第二表面设置在横杆阵列上。 施加到高电阻状态的交叉连接处的电流在第一表面上产生相邻的加热部位，用于附加用于分子合成的热反应性分子。

公开(公告)号：US20140028995A1

公开(公告)日：2014-01-30

申请号：US13452218

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  R. Stanley Williams ,  Zhiyong Li

Inventor： Alexandre M. Bratkovski ,  R. Stanley Williams ,  Zhiyong Li

IPC: G01N21/01

CPC classification number: G01N21/01 ,  G01N21/648 ,  G01N21/658

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a flexible substrate, and an array of spaced apart sensing members formed on a surface of the flexible substrate. Each of the spaced apart sensing members includes a plurality of polygon assemblies. The polygon assemblies are arranged in a controlled pattern on the surface of the flexible substrate such that each of the plurality of polygon assemblies is a predetermined distance from each other of the plurality of polygon assemblies, and each of the plurality of polygon assemblies including collapsible signal amplifying structures controllably positioned in a predetermined geometric shape.

Abstract translation: 本文公开了集成传感器的示例。 集成传感器的示例包括柔性基板和形成在柔性基板的表面上的间隔开的感测部件阵列。 每个间隔开的感测构件包括多个多边形组件。 多边形组件以可控的图案布置在柔性基板的表面上，使得多个多边形组件中的每一个距离多个多边形组件中的彼此之间是预定距离，并且多个多边形组件中的每一个包括可折叠信号 放大结构可控地定位在预定的几何形状。

公开(公告)号：US20130330871A1

公开(公告)日：2013-12-12

申请号：US13494687

申请日：2012-06-12

Applicant: Bonna Newman ,  Venkatesan Murali ,  Zhiyong Li ,  Liang Chen

Inventor： Bonna Newman ,  Venkatesan Murali ,  Zhiyong Li ,  Liang Chen

IPC: H01L31/18

CPC classification number: H01L31/02363 ,  H01L31/02167 ,  H01L31/022425 ,  H01L31/0747 ,  H01L31/1892 ,  Y02E10/50

Abstract: A method for modifying the texture of a semiconductor material is provided. The method includes performing a first texture step comprising reactive ion etching to a first surface of semiconductor material. After the first texture step, the first surface of the semiconductor material has a random texture comprising a plurality of peaks and a plurality of valleys, and wherein at least fifty percent of the first surface has a peak-to-valley height of less than one micron and an average peak-to-peak distance of less than one micron. Additional texture steps comprising wet etch or RIE etching may be optionally applied.

Abstract translation: 提供了一种修改半导体材料纹理的方法。 该方法包括执行包括对半导体材料的第一表面的反应离子蚀刻的第一纹理步骤。 在第一纹理步骤之后，半导体材料的第一表面具有包括多个峰和多个谷的随机纹理，并且其中至少百分之五十的第一表面具有小于一个的峰谷高度 平均峰 - 峰距离小于1微米。 可以任选地应用包括湿蚀刻或RIE蚀刻的附加纹理步骤。