公开(公告)号：US11040111B2

公开(公告)日：2021-06-22

申请号：US16111242

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Steven R Roffler ,  Tian-Lu Cheng ,  Chien-Han Kao ,  Bing-Mae Chen ,  Yu-Cheng Su ,  Hsin-Yi Tung ,  Kuo-Hsiang Chuang

IPC: C07K16/00 ,  A61K47/68 ,  C07K16/44 ,  C07K16/32 ,  C07K16/30 ,  C07K16/28 ,  A61K49/00 ,  A61K47/69 ,  A61K39/395 ,  A61K47/60 ,  A61K39/00

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US20210154319A9

公开(公告)日：2021-05-27

申请号：US16111242

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： STEVEN R ROFFLER ,  TIAN-LU CHENG ,  CHIEN-HAN KAO ,  BING-MAE CHEN ,  YU-CHENG SU ,  HSIN-YI TUNG ,  Kuo-Hsiang Chuang

IPC: A61K47/68 ,  C07K16/32 ,  A61K49/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/44

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US20210150148A1

公开(公告)日：2021-05-20

申请号：US17099867

申请日：2020-11-17

Applicant: ACADEMIA SINICA

Inventor： WEN-LIAN HSU

IPC: G06F40/30 ,  G06F40/295 ,  G06F40/263 ,  G06F40/284 ,  G06F40/253 ,  G06F40/58

Abstract: A natural language processing method, comprising: receiving multiple input words; and reducing the multiple words into one or more subject word data structures according to sets stored in a database, wherein one of the subject word data structures includes a first input word and a second input words among the input words, wherein one of the sets includes a compatible relation between the first input word and the second input word, wherein the compatible relation between the first input word and the second word includes a compatible property for denoting an intensity representing occurrences of the first input word and the second word in a training corpus.

公开(公告)号：US10998175B2

公开(公告)日：2021-05-04

申请号：US16686203

申请日：2019-11-17

Applicant: Academia Sinica

Inventor： Abdil Ozdemir ,  Jung-Lee Lin ,  Chung-Hsuan Chen

IPC: H01J49/00 ,  H01J49/16 ,  H01J49/06

Abstract: Disclosed herein is a device for characterizing a biological sample or an airborne sample. According to embodiments of the present disclosure, the device comprises an electrospray source, a mass analyzer, a charge detector, and optionally, an ion guide. The present device is useful in analyzing the particle population in the biological or airborne sample based on the mass to charge (m/z) ratio and the charge (z) of each particle. Also disclosed herein are the methods of making a diagnosis of cancer by use of the present device, and methods of determining the mass distribution of particles in an airborne sample.

公开(公告)号：US20210123927A1

公开(公告)日：2021-04-29

申请号：US17084125

申请日：2020-10-29

Applicant: National Defense Medical Center ,  Academia Sinica

Inventor： Ann CHEN ,  Shuk-Man KA ,  Shih-Hsiung WU

IPC: G01N33/68

Abstract: The present invention provides a lectin from Crenomytilus grayanus or Mytilus trossulus as diagnostic reagents for IgA nephropathy. The present invention also provides a diagnostic kit for detecting Galactose-deficient IgA1 (Gd-IgA1), comprising RussiaSea-001 (also called as CGL) isolated from Crenomytilus grayanus or RussiaSea-002 (also called as MTL) isolated from Mytilus trossulus. The present invention further provides a method for detecting Gd-IgA1 using RussiaSea-001 or RussiaSea-002

公开(公告)号：US20210101939A1

公开(公告)日：2021-04-08

申请号：US16932372

申请日：2020-07-17

Applicant: Academia Sinica

Inventor： Chiaho Shih ,  Heng-Li Chen ,  Pei-Yi Su

IPC: C07K14/005 ,  A01N37/46 ,  A01N63/00 ,  C07K7/08 ,  A61P31/04

Abstract: An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

公开(公告)号：US10941130B2

公开(公告)日：2021-03-09

申请号：US16362172

申请日：2019-03-22

Applicant: ACADEMIA SINICA

Inventor： Po-Wen Chung ,  Prasenjit Bhaumik ,  Hao-Ju Chou

IPC: C07D307/46 ,  B01J8/06 ,  B01D3/10 ,  C01D15/10

Abstract: This invention relates to a novel molten salt system in chemical transformation of saccharides and a method as well as an apparatus for multi carbon production by the molten salt system. It is found that an eutectic molten salt composition is advantageous for multi-carbon productions through chemical transformation under mild conditions. This invention further provides a method and an apparatus for preparing 5-hydroxymethylfurfural (HMF) and HMF-derived chemicals from saccharides by the said molten salt system.

公开(公告)号：US20210063587A1

公开(公告)日：2021-03-04

申请号：US16557268

申请日：2019-08-30

Applicant: NATIONAL SYNCHROTRON RADIATION RESEARCH CENTER ,  ACADEMIA SINICA

Inventor： BING-MING CHENG ,  HSIAO-CHI LU ,  JEN-IU LO ,  HUAN-CHENG CHANG

IPC: G01T1/202 ,  G01J1/42 ,  H01L31/09 ,  H01L31/0232 ,  G01J1/58

Abstract: The present disclosure provides a fluorescent nitrogen-vacancy diamond (FNVD) having a plurality of nitrogen-vacancy centers with a concentration about 1 ppm to 10,000 ppm. The FNVD as built-in fluorophores exhibit a nearly constant emission profile over 540 nm to 850 nm upon excitation by vacuum ultraviolet (VUV), extreme ultraviolet (EUV) and X-rays for the energy larger than 6.2 eV. Applying the FNVD sensor can measure VUV/EUV/X-rays as a sensing sheet, manufacturing method and uses thereof, sensor and lithography apparatus. The superb photostability and broad applicability of FNVDs offer a promising solution for the long-standing problem of lacking robust and reliable detectors for VUV, EUV, and X-rays.

公开(公告)号：US20210030825A1

公开(公告)日：2021-02-04

申请号：US16963992

申请日：2018-05-29

Applicant: ACADEMIA SINICA

Inventor： LIE-FEN SHYUR ,  MARIA KARMELLA APAYA ,  MENG-TING CHANG

IPC: A61K36/28 ,  A61P35/04 ,  A61K31/704 ,  A61K31/7032 ,  A61K31/045

Abstract: A method for treating breast cancer and/or treating breast cancer metastasis in a subject in need of such treatment including administering to said subject an effective amount of Crassocephalum rabens extract and optionally a pharmaceutically acceptable carrier or excipient.

公开(公告)号：US20210025009A1

公开(公告)日：2021-01-28

申请号：US16940284

申请日：2020-07-27

Applicant: TAIPEI MEDICAL UNIVERSITY ,  Academia Sinica

Inventor： Yueh-Lin WU ,  Hsi-Hsien CHEN ,  Heng LIN ,  Ji-Yen CHENG ,  Pei-Kuen WEI

IPC: C12Q1/6886 ,  C12Q1/686

Abstract: The present invention pertains to detection of a tumor in a urinary organ using microRNA(s). MiR-200c-5p, miR-214-3p, miR-21-5p, miR-21-3p, miR-210-3p and/or miR-200b-3p can be used as biomarkers of tumors in a urinary organ to detect a tumor in or predict a prognosis of a tumor in a urinary organ.