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公开(公告)号：US20230133910A1
公开(公告)日：2023-05-04
申请号：US17907055
申请日：2021-03-29
Inventor： Yi YANG , Xianjun CHEN , Xin XIE , Ni SU
IPC: C12Q1/6876 , C12Q1/6816
Abstract: The present disclosure relates to an aptamer nucleic acid molecule, a complex containing the aptamer and fluorophore small molecules, a method for detecting intrecellular or extracellular RNA, DNA or other target molecules, as well as a kit containing the aptamer. The aptamer of the present disclosure can specifically bind to fluorophore small molecules, and can significantly improve their fluorescence intensity under light excitation at suitable wavelength.
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公开(公告)号：US20230097553A1
公开(公告)日：2023-03-30
申请号：US17904587
申请日：2021-02-09
Inventor： Honglin LI , Ke XU , Zhenjiang ZHAO
IPC: A61K31/42 , A61K31/277 , A61P31/18 , A61P31/16
Abstract: An application of a compound represented by formula I or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating RNA virus infection.
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公开(公告)号：US20230086554A1
公开(公告)日：2023-03-23
申请号：US17630356
申请日：2021-04-28
Inventor： Shuai Gu , Lei Xing , Jianguo Yu
Abstract: The disclosure provides a precursor solution, a perovskite solar cell and a preparation method thereof. The solute of the precursor solution includes a metal halide, the solvent of the precursor solution is an organic solvent, and the precursor solution contains nanobubbles, which have a diameter not more than 1000 nm, and the zeta potential of the precursor solution does not exceed −20 mV. The method of preparing the precursor solution includes: (1) preparing an organic solvent containing nanobubbles; (2) dissolving a solute in the organic solvent containing nanobubbles. The precursor solution of the disclosure has a very low zeta potential, and the nanobubbles can exist stably in the organic solvent(s) for up to one month. When comparing with traditional methods for preparing the precursor solution of the perovskite cells, the method for preparing the precursor solution of the disclosure can effectively improve the stability, reproducibility and solubility of the metal halide in the organic solvent(s).
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公开(公告)号：US20230056311A1
公开(公告)日：2023-02-23
申请号：US17611992
申请日：2020-05-15
Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
Inventor： Lixin ZHANG , Weishan WANG , Shanshan LI , Zilong LI , Gaoyi TAN , Jingyu ZHANG
Abstract: A method for improving the production of Streptomyces polyketide compounds is provided. The method greatly improves the capability of the Streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in Streptomyces during the stationary phase. A method for switching the primary metabolism of Streptomyces to the secondary metabolism, Streptomyces producing polyketide compounds, and use thereof are also provided.
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公开(公告)号：US20220324067A1
公开(公告)日：2022-10-13
申请号：US17764136
申请日：2020-05-20
Inventor： Xiancheng ZHANG , Kaiming ZHANG , Shulei YAO , Shuang LIU , Feng CHENG , Shantung TU
IPC: B23P9/02
Abstract: Provided is a bilateral ultrasonic rolling processing track coordination method for a blade surface, the method comprising: step S1, performing layering processing on a blade to acquire a contour curve of “A”-shaped and “n”-shaped blade edges of a blade model at different heights; step S2: determining the endpoints of a blade processing track; and step S3: planning the thickness and the rotation angle of the blade, comprising: step S31, solving a main direction angle αmain of the contour curve; step S32, solving the thickness d of the blade; step S33, solving a rotation angle required by blade processing when the blade edge is “A”-shaped; and step S34, solving the rotation angle required by blade processing when the blade edge is “n”-shaped. According to the method, blade deformation generated by an ultrasonic rolling force is reduced, the processing efficiency is improved, and the blade processing precision is also improved.
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Patent Agency Ranking
公开(公告)号：US11345900B2
公开(公告)日：2022-05-31
申请号：US17294424
申请日：2019-11-26
Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
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公开(公告)号：US11306095B2
公开(公告)日：2022-04-19
申请号：US15577518
申请日：2016-05-30
Inventor： Honglin Li , Yufang Xu , Zhenjiang Zhao , Wei Zhou , Yuqiong Xu , Deheng Sun , Xia Wang , Zhuo Chen
IPC: C07D487/04 , A61P35/00 , A61P35/02 , A61K31/519 , C07D475/00
Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
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公开(公告)号：US11291200B2
公开(公告)日：2022-04-05
申请号：US16347429
申请日：2017-11-22
Inventor： Meijin Guo , Jiarui Li , Zejian Wang , Yuxia Chen , Yingping Zhuang
Abstract: The present disclosure relates to the application of a viable cell monitor to the cryopreservation of plant cells. The viable cell monitor is, for the first time, used in a method for rapidly evaluating the effect of cell freezing-preservation. The effect of a cryoprotectant on cell preservation is evaluated through the change in the capacitance of viable cells before and after cell freezing and resuscitation. Viable cell electrodes can provide a quick and accurate characterization of viable cell concentrations. Combining the viable cell capacitance with the detection result of 2,3,4-triphenyl tetrazolium chloride (TTC), a rapid and quantitative evaluation of the effect of a freezing method on cell preservation can be achieved, thus overcoming the low effectiveness and non-quantification of previous cell preservation methods. Compared with traditional methods, the method of the present disclosure can improve the comprehensive score of cell cryopreservation by 5 times or more.
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公开(公告)号：US20220057194A1
公开(公告)日：2022-02-24
申请号：US17312543
申请日：2019-03-28
Inventor： Xiancheng Zhang , Shuang Liu , Shulei Yao , Xumin Zhu , Kaiming Zhang , Yixin Liu , Yunfei Jia , Shantung Tu
Abstract: The present application provides an on-machine point cloud detection and compensation method for processing complex surfaces, which comprises: step S1, installing a detecting and scanning actuator on an ultrasonic rolling machine tool; step S2, installing a processed workpiece on the chuck which is scanned by the detecting and scanning actuator to obtain the point cloud data of the workpiece in a coordinate system of detecting and scanning actuator, which is converted into the point cloud data of the workpiece in a coordinate system of machine tool; step S3, processing the point cloud data of the workpiece in the coordinate system of machine tool; step S4, obtaining and compensating the shape error feature of the workpiece according to theoretical design data of the processed workpiece and processed point cloud data of the workpiece in the coordinate system of machine tool. The accuracy and efficiency of complex surface strengthening is improved in the present application.
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公开(公告)号：US20220002684A1
公开(公告)日：2022-01-06
申请号：US17294424
申请日：2019-11-26
Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. , EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: A monooxygenase having an amino acid sequence obtained by mutation of the amino acid sequence shown in SEQ ID NO:2 is disclosed. The use of the monooxygenase of the present invention in production of chiral sulfoxide-based drugs has advantages including mild reaction conditions, environmental friendliness, high yield, high optical purity of products, less peroxide products, and the like, and therefore the monooxygenase in the present invention has a good industrial application prospect in the production of proton pump inhibitors for the treatment of gastric ulcers.
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