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51.发明公开公开(公告)号：US20230352543A1
公开(公告)日：2023-11-02
申请号：US18039668
申请日：2021-11-24
IPC分类号： H01L29/207 , H01L29/04 , H01L21/02
CPC分类号： H01L29/207 , H01L29/045 , H01L21/02395 , H01L21/02433
摘要： A semiconductor device comprising a substrate and an aluminium gallium arsenide-based semiconductor component, the substrate being monocrystalline, and the substrate having a gallium indium arsenide mixed crystal with the empirical formula GA(1-x)In(x)As, the indium content x being between 0.1 percent and 4 percent.
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公开(公告)号：US20230330258A1
公开(公告)日：2023-10-19
申请号：US18054018
申请日：2022-11-09
发明人： Christian HACKENBERGER , Marc-André KASPER , Philipp OCHTROP , Jahaziel JAHZERAH , Paul MACHUI , Dominik SCHUMACHER , Jonas HELMA-SMETS , Isabelle MAI
CPC分类号： A61K47/6889 , C07F9/30
摘要： The present invention relates to a conjugate having the formula (I):
wherein a receptor binding molecule (RBM) is connected with a drug moiety (D). The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.-
公开(公告)号：US20220363714A1
公开(公告)日：2022-11-17
申请号：US17853591
申请日：2022-06-29
摘要： The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
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公开(公告)号：US11161873B2
公开(公告)日：2021-11-02
申请号：US16328199
申请日：2017-09-01
发明人： Christian Hackenberger , Marc André Kasper , Maria Glanz , Tom Sauer , Dominik Schumacher , Jonas Helma-Smets , Heinrich Leonhardt , Andreas Stengl
摘要： Disclosed are novel conjugates and processes for the preparation thereof. A process tor the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).
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公开(公告)号：US20210332050A1
公开(公告)日：2021-10-28
申请号：US16975346
申请日：2019-02-26
发明人： Ronald Kühne , Hans-Günther Schmalz , Stephan Dohmen , Matthias Barone , Matthias Müller , Slim Chiha , Dominik Albat
IPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to chemical compounds which can be used in particular as structural mimetics of proline-rich peptides. The compounds of the present invention are capable of selectively inhibiting Ena/VASP-EVH1-mediated protein-protein interactions. The invention further relates to the use of these compounds as pharmaceutical agents and the use of the pharmaceutical agents for the treatment of tumor diseases.
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![Method for growing β phase of gallium oxide ([β]-Ga2O3) single crystals from the melt contained within a metal crucible](/abs-image/US/2021/06/08/US11028501B2/abs.jpg.150x150.jpg)
公开(公告)号：US11028501B2
公开(公告)日：2021-06-08
申请号：US15541764
申请日：2015-12-16
摘要： A method for growing beta phase of gallium oxide (β-Ga2O3) single crystals from the melt contained within a metal crucible surrounded by a thermal insulation and heated by a heater. A growth atmosphere provided into a growth furnace has a variable oxygen concentration or partial pressure in such a way that the oxygen concentration reaches a growth oxygen concentration value (C2, C2′, C2″) in the concentration range (SC) of 5-100 vol. % below the melting temperature (MT) of Ga2O3 or at the melting temperature (MT) or after complete melting of the Ga2O3 starting material adapted to minimize creation of metallic gallium amount and thus eutectic formation with the metal crucible. During the crystal growth step of the β-Ga2O3 single crystal from the melt at the growth temperature (GT) the growth oxygen concentration value (C2, C2′, C2″) is maintained within the oxygen concentration range (SC).
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公开(公告)号：US10833478B2
公开(公告)日：2020-11-10
申请号：US16327419
申请日：2017-08-21
发明人： Götz Erbert , Jörg Fricke , Andre Müller , Hans Wenzel , Bernd Sumpf , Katrin Paschke
摘要： The inventive waveguide structure comprises a first waveguide region having a constant first width adapted to guide electromagnetic waves mode sustainably along its longitudinal axis; a second waveguide region adapted to guide electromagnetic waves mode sustainably along its longitudinal axis, wherein the longitudinal axis of the first waveguide region and the longitudinal axis of the second waveguide region form a common longitudinal axis of the waveguide structure, wherein a first end face of the first waveguide region and a first end face of the second waveguide region are aligned with each other, the width of the first end face of the second waveguide region corresponding to the first width, and the width of the second waveguide region along its longitudinal axis widens from the first end face to a second end face to a second width greater than the first width.
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公开(公告)号：US10802116B2
公开(公告)日：2020-10-13
申请号：US16338405
申请日：2017-09-15
发明人： Armin Liero , Andreas Klehr , Thomas Hoffmann
摘要： The invention relates to an optical pulse generator comprising an active optical component adapted to emit optical radiation and electronic components of a means for electronically driving the optical component to excite the optical component to a pulsed emission of optical radiation, wherein the electronic components are arranged on a first side of a first submount, contact surfaces of the means for electronically driving are arranged on an opposite second side of the first submount, and the electronic components are connected to the contact surfaces of the means for electronically driving using electrically conductive vias in the first submount.
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59.发明申请公开(公告)号：US20200262847A1
公开(公告)日：2020-08-20
申请号：US16867835
申请日：2020-05-06
发明人： Michael BADER , Edgar SPECKER , Susann MATTHES , Anja SCHÜTZ , Keven MALLOW , Maik GROHMANN , Marc NAZARÉ
IPC分类号： C07D519/00
摘要： The invention relates to a xanthine derivative defined by chemical formula I or a salt thereof, its use as a medicament, especially for use in the treatment of serotonin-related diseases or disorders, and a pharmaceutical preparation comprising the xanthine derivative. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of serotonin and are effective in influencing the serotonin level in the body.
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60.发明授权公开(公告)号：US10690877B2
公开(公告)日：2020-06-23
申请号：US15500643
申请日：2015-07-24
摘要： The present invention relates to an to an optical device comprising a micro-optical system and a retainer, and to a method for producing an optical device. In the case of the device according to the invention, the micro-optical system (10) is fastened in such a way that the micro-optical system is oriented in relation to a surface (50) of the retainer (60). The device is characterized in that the retainer (60) has a round, tapered recess (40) and the micro-optical system (10) is fastened on a spherical cap (20) and the spherical cap (20) is fastened to the retainer (60), wherein the spherical cap (20) at least partially protrudes into the recess (40) and lies against a partial surface (30) of the recess (40) or an edge (41) in the recess (40), wherein the spherical cap (20) is fastened to the retainer (60) in the recess (40), but is not fastened where the spherical cap lies in contact. Because the spherical cap lies in contact, shrinking of a fasting means cannot cause a shift or rotation of the spherical cap and thus cannot cause a misadjustment.
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