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    Accelerated precomputation of reduced deformable models
    51.
    发明授权
    Accelerated precomputation of reduced deformable models 有权

    公开(公告)号：US10474927B2

    公开(公告)日：2019-11-12

    申请号：US15757261

    申请日：2016-09-02

    Applicant: STC.UNM ,  Yin Yang

    Inventor： Yin Yang

    IPC: G06K9/62 ,  G06T13/20 ,  G06T17/20 ,  G06F17/16

    Abstract: Technologies are disclosed for precomputation of reduced deformable models. In such precomputation, a Krylov subspace iteration may be used to construct a series of inertia modes for an input mesh. The inertia modes may be condensed into a mode matrix. A set of cubature points may be sampled from the input mesh, and cubature weights of the set of cubature points may be calculated for each of the inertia modes in the mode matrix. A training dataset may be generated by iteratively adding training samples to the training dataset until a training error metric converges, wherein each training sample is generated from an inertia mode in the mode matrix and corresponding cubature weights. The reduced deformable model may be generated, including inertia modes in the training dataset and corresponding cubature weights.

    PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES
    53.
    发明申请
    PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES 审中-公开
    肽类显示的方法和方法及RNA病毒类病毒颗粒的选择

    公开(公告)号：US20160354459A1

    公开(公告)日：2016-12-08

    申请号：US15176396

    申请日：2016-06-08

    Applicant: STC. UNM

    Inventor： David S. Peabody ,  Bryce Chackerian

    IPC: A61K39/12 ,  C12N7/00

    CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

    Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one—on average—to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.

    Abstract translation: 本发明涉及一种用于控制病毒样颗粒（VLPs），特别是包括MS2 VLP的肽显示效价的系统和方法。 在该方法中，可以从单个RNA产生大量野生型和低量的单链二聚体外壳蛋白。 通过提供允许从单个RNA产生大量野生型和少量单链二聚体包被蛋白质的系统，允许轻度调整VLP上的显示剂价位水平，特别是 MS2 VLPS在广泛的范围内，从一个平均至少一个到每个粒子多达九十个。 这有助于免疫原和疫苗的生产，包括显示低效价的VLP。 公开了可用于病毒样颗粒表达的核酸构建物，其由通过插入异源肽修饰的MS2的外壳多肽组成，其中异源肽显示在病毒样颗粒上并包裹MS2nRNA。 还公开了核酸构建体，其可用于由通过插入异源肽修饰的PP7的外壳多肽组成的病毒样颗粒的表达，其中异源肽显示在病毒样颗粒上并包裹PP7 mRNA。

    SYSTEMS AND METHODS FOR ANALYZING STABILITY USING METAL RESISTANCE VARIATIONS
    54.
    发明申请
    SYSTEMS AND METHODS FOR ANALYZING STABILITY USING METAL RESISTANCE VARIATIONS 审中-公开
    使用金属电阻变化分析稳定性的系统和方法

    公开(公告)号：US20160188296A1

    公开(公告)日：2016-06-30

    申请号：US14907423

    申请日：2014-08-28

    Applicant: STC. UNM

    Inventor： James Plusquellic

    IPC: G06F7/58

    CPC classification number: G06F7/588 ,  G06F2207/58 ,  G09C1/00 ,  H04L9/002 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/26 ,  Y04S40/24

    Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

    Abstract translation: 本公开描述了用于分析由物理不可克隆功能（PUF）产生的位串的统计质量的技术。 PUF利用集成电路的电网线的电阻变化。 分析了串串的温度和电压稳定性。 本公开还描述了将电压降转换成数字代码，其中转换对于简单和差异的侧向信道攻击具有弹性。

    SOLID COMPOSITIONS FOR PHARMACEUTICAL USE
    57.
    发明申请
    SOLID COMPOSITIONS FOR PHARMACEUTICAL USE 审中-公开
    用于药物使用的固体组合物

    公开(公告)号：US20140141094A1

    公开(公告)日：2014-05-22

    申请号：US14113653

    申请日：2012-04-25

    Applicant: Hugh Smyth ,  Ibrahim M. El-Sherbiny

    Inventor： Hugh Smyth ,  Ibrahim M. El-Sherbiny

    IPC: A61K47/48

    CPC classification number: A61K47/48923 ,  A61K9/0075 ,  A61K9/5161 ,  A61K31/496

    Abstract: The invention relates to solid compositions that may be suitable for administering a therapeutic agent to a subject. The invention also relates to methods of making such solid compositions. The invention further relates to methods of treating a disease, condition, or disorder by administering to a subject such solid compositions.

    Abstract translation: 本发明涉及可适用于给受试者施用治疗剂的固体组合物。 本发明还涉及制备这种固体组合物的方法。 本发明还涉及通过向受试者施用这种固体组合物来治疗疾病，病症或病症的方法。

    Method of making magnetic iron nitride nanoparticles
    58.
    发明申请
    Method of making magnetic iron nitride nanoparticles 有权
    制备磁性氮化铁纳米颗粒的方法

    公开(公告)号：US20140079621A1

    公开(公告)日：2014-03-20

    申请号：US13987912

    申请日：2013-09-16

    Applicant: Leisha M. Armijo

    Inventor： Leisha M. Armijo

    IPC: H01F1/01

    CPC classification number: H01F1/01 ,  H01F1/0045 ,  H01F1/065

    Abstract: Magnetic iron nitride nanoparticles, such as Fe16N2 nanoparticles, are made by subjecting iron nanoparticles synthesized from iron oxide or iron carbonyl precursor to a solid-gas reaction with a nitrogen-containing gas.

    Abstract translation: 通过使由铁氧化物或羰基铁前体合成的铁纳米颗粒与含氮气体进行固体气体反应来制备磁性氮化铁纳米颗粒，例如Fe 16 N 2纳米颗粒。

    APPARATUS AND TECHNIQUES OF NON-INVASIVE ANALYSIS
    59.
    发明申请
    APPARATUS AND TECHNIQUES OF NON-INVASIVE ANALYSIS 审中-公开
    非入侵分析的设备和技术

    公开(公告)号：US20130023773A1

    公开(公告)日：2013-01-24

    申请号：US13639818

    申请日：2011-04-07

    Applicant: Sanjay Krishna ,  Sanchita Krishna

    Inventor： Sanjay Krishna ,  Sanchita Krishna

    IPC: A61B6/00

    CPC classification number: A61B5/01 ,  A61B5/0077 ,  A61B5/444

    Abstract: Apparatus and methods, which comprise examination of an abnormality on a subject using a temperature stimulus applied to the subject, provide a non-invasive analysis technique. In an embodiment, a non-invasive infrared imaging technique can be used to observe the temporal response of a lesion to temperature stimuli to form a basis for evaluating the abnormality. A technique including applying temperature stimuli and detecting responses to the applied temperature stimuli provide a non-invasive technique that can be used to identify an abnormality on a subject and/or characteristics of the abnormality. In an embodiment, a non-invasive transient infrared imaging technique can be used to observe the temporal response of a lesion to temperature stimuli to form a basis for determining characteristics correlated to the lesion. Additional apparatus, systems, and methods are disclosed.

    Abstract translation: 包括使用应用于受试者的温度刺激对受试者的异常进行检查的装置和方法提供非侵入性分析技术。 在一个实施例中，可以使用非侵入性红外成像技术来观察病变对温度刺激的时间反应，以形成用于评估异常的基础。 包括对所施加的温度刺激应用温度刺激和检测反应的技术提供了可用于识别受试者的异常和/或异常特征的非侵入性技术。 在一个实施例中，可以使用非侵入性瞬时红外成像技术来观察病变对温度刺激的时间反应，以形成用于确定与病变相关的特征的基础。 公开了附加装置，系统和方法。

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