公开(公告)号：US20130209453A1

公开(公告)日：2013-08-15

申请号：US13642845

申请日：2011-04-22

申请人： Ronald Black ,  Jack Steven Jacobsen ,  Lioudmila Tchistiakova ,  Angela Widom ,  Davinder Gill ,  Lars Ekman ,  Ivan Lieberburg ,  Michael Grundman ,  James Callaway ,  Keith M. Gregg ,  Wagner Zago ,  Manuel J. Buttini

发明人： Ronald Black ,  Jack Steven Jacobsen ,  Lioudmila Tchistiakova ,  Angela Widom ,  Davinder Gill ,  Lars Ekman ,  Ivan Lieberburg ,  Michael Grundman ,  James Callaway ,  Keith M. Gregg ,  Wagner Zago ,  Manuel J. Buttini

IPC分类号： A61K39/395

CPC分类号： A61K39/3955 ,  A61K2039/505 ,  A61K2039/545 ,  A61K2039/55 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34

摘要： The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.

公开(公告)号：US08481692B2

公开(公告)日：2013-07-09

申请号：US13451631

申请日：2012-04-20

申请人： Maninder K. Sidhu ,  Annaliesa Sybil Anderson ,  Robert G. K. Donald ,  Kathrin Ute Jansen ,  Narender K. Kalyan ,  Justin Keith Moran ,  Mark E. Ruppen ,  Michael James Flint

发明人： Maninder K. Sidhu ,  Annaliesa Sybil Anderson ,  Robert G. K. Donald ,  Kathrin Ute Jansen ,  Narender K. Kalyan ,  Justin Keith Moran ,  Mark E. Ruppen ,  Michael James Flint

IPC分类号： A61K39/08 ,  C07K14/00

CPC分类号： C07K14/33 ,  A61K39/08 ,  C07K16/1282 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/1051 ,  C12N9/99 ,  C12N15/74

摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.

公开(公告)号：US20130143827A1

公开(公告)日：2013-06-06

申请号：US13751693

申请日：2013-01-28

申请人： Wyeth LLC

发明人： Li Shen ,  Kelly Keating ,  Oliver J. McConnell ,  William DeMaio ,  Appavu Chandrasekaran

IPC分类号： G01N33/53 ,  C07H19/24 ,  C07H17/00 ,  C07K16/44 ,  A61K31/70

CPC分类号： C07H19/24 ,  C07H17/00 ,  C07H17/02 ,  C07H19/02 ,  C07K16/44 ,  G01N33/94

摘要： A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.

公开(公告)号：US08430921B2

公开(公告)日：2013-04-30

申请号：US12454129

申请日：2009-05-13

申请人： Vincent York-Leung Wong ,  Marina Belkin ,  Chad Kamil Hickson ,  Leroy Glenn Owens, Jr.

发明人： Vincent York-Leung Wong ,  Marina Belkin ,  Chad Kamil Hickson ,  Leroy Glenn Owens, Jr.

IPC分类号： A61F7/08 ,  A61F7/00

CPC分类号： A61F7/0085 ,  A61F7/034 ,  A61F2007/0062 ,  A61F2007/0292 ,  A61M21/02

摘要： A portable moist heat delivery system comprising a water vapor generating portion comprising a water vapor source and a heat source; a water vapor-air regulating portion, said water vapor-air regulating portion comprising a water vapor-air mixing layer, and a water vapor-air distribution layer; said water vapor generating portion and said water vapor-air regulating portion being in fluid communication; and said water vapor-air regulating portion having a latent heat delivery surface disposed adjacent said water vapor-air regulating portion which delivers moist heat at a preselected temperature range wherein about 15% to about 95% of the moist heat is latent heat of condensation. Methods include delivering improved pain relief, blood flow, relaxation, and reduced cardiac workload.

公开(公告)号：US20130012702A1

公开(公告)日：2013-01-10

申请号：US13618090

申请日：2012-09-14

申请人： Bogdan Kazimierz Wilk ,  Arkadiy Zinoviy Rubezhov ,  Anthony Francis Hadfield ,  Jean Louise Helom

发明人： Bogdan Kazimierz Wilk ,  Arkadiy Zinoviy Rubezhov ,  Anthony Francis Hadfield ,  Jean Louise Helom

IPC分类号： C07D413/06 ,  C07D209/96 ,  C07D403/10 ,  C07D265/14

CPC分类号： C07D403/04 ,  C07D209/96 ,  C07D405/04 ,  C07D413/04

摘要： Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.

公开(公告)号：US20130011929A1

公开(公告)日：2013-01-10

申请号：US13546500

申请日：2012-07-11

申请人： Nataliya Bazhina ,  George Joseph Donato, III ,  Steven R. Fabian ,  John Lokhnauth ,  Sreenivasulu Megati ,  Charles Melucci ,  Christian Ofslager ,  Niketa Patel ,  Galen Radebaugh ,  Syed M. Shah ,  Jan Szeliga ,  Huyi Zhang ,  Tianmin Zhu

发明人： Nataliya Bazhina ,  George Joseph Donato, III ,  Steven R. Fabian ,  John Lokhnauth ,  Sreenivasulu Megati ,  Charles Melucci ,  Christian Ofslager ,  Niketa Patel ,  Galen Radebaugh ,  Syed M. Shah ,  Jan Szeliga ,  Huyi Zhang ,  Tianmin Zhu

IPC分类号： C07D221/28 ,  G01N30/02 ,  G01N33/00

CPC分类号： A61K31/485 ,  A61J1/05 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/08 ,  A61K9/20 ,  A61M5/178 ,  C07D471/08 ,  C07D489/08 ,  Y10T436/145555

摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.

公开(公告)号：US08350013B2

公开(公告)日：2013-01-08

申请号：US11899972

申请日：2007-09-07

申请人： Shujun Sun

发明人： Shujun Sun

IPC分类号： A61K39/395 ,  C07K1/22

CPC分类号： C07K1/22 ,  C07K1/16

摘要： The invention relates to methods for isolating a product and/or reducing turbidity and/or impurities from a load fluid comprising the product and one or more impurities by passing the load fluid through a medium, followed by at least one wash solution comprising arginine, and collecting the product using an elution solution. The invention further relates to a product prepared using a method as described herein.

摘要翻译： 本发明涉及通过使负载流体通过介质，然后是至少一种包含精氨酸的洗涤溶液和/或包含精氨酸的洗涤溶液和/或其中的至少一种洗涤溶液，从而分离产物和/或从包含产物和一种或多种杂质的负载流体中降低浊度和/ 使用洗脱液收集产品。 本发明还涉及使用本文所述的方法制备的产品。

公开(公告)号：US08343965B2

公开(公告)日：2013-01-01

申请号：US11412014

申请日：2006-04-26

申请人： Arwinder S. Nagi ,  Ramarao Chatlapalli ,  Shamim Hasan ,  Rolland W. Carson ,  Mohamed Ghorab

发明人： Arwinder S. Nagi ,  Ramarao Chatlapalli ,  Shamim Hasan ,  Rolland W. Carson ,  Mohamed Ghorab

IPC分类号： A61K31/535

CPC分类号： A61K31/575 ,  A61K9/145 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/536 ,  A61K45/00 ,  A61K45/06

摘要： Compositions, preferably pharmaceutical compositions, containing micronized tanaproget, or pharmaceutically acceptable salt thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, butylated hydroxyanisole, povidone, and magnesium stearate, are provided. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.

摘要翻译： 提供了包含微粉化的十八烷或其药学上可接受的盐，微晶纤维素，交联羧甲基纤维素钠，月桂基硫酸钠，丁基化羟基苯甲醚，聚维酮和硬脂酸镁的组合物，优选药物组合物。 该组合物可用于避孕和激素替代治疗以及治疗和/或预防子宫肌层肌瘤，良性前列腺肥大，良性和恶性肿瘤性疾病，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症，多囊卵巢综合征，以及癌和腺癌 垂体，子宫内膜，肾，卵巢，乳腺，结肠，前列腺和其他激素依赖性肿瘤，以及制备有用的药物。 额外的用途包括刺激食物摄入。

公开(公告)号：US08338456B2

公开(公告)日：2012-12-25

申请号：US12984043

申请日：2011-01-04

申请人： Christina Marie Coughlin ,  Jay Marshall Feingold ,  Daniel Stephen Johnston ,  Anna Berkenblit ,  Andrew Louis Strahs ,  Charles Michael Zacharchuk

发明人： Christina Marie Coughlin ,  Jay Marshall Feingold ,  Daniel Stephen Johnston ,  Anna Berkenblit ,  Andrew Louis Strahs ,  Charles Michael Zacharchuk

IPC分类号： A61K31/4709 ,  A61P35/00 ,  G01N1/30 ,  G01N33/53

CPC分类号： G01N33/57415

摘要： A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of PTEN null will be treated with a pan-ErbB tyrosine kinase inhibitor. A normalized PTEN protein expression score is obtained by comparing the tumor PTEN OD expression value with the non-malignant PTEN OD expression value.

摘要翻译： PTEN蛋白表达的定量测定的一个切入点，准确地识别两个PTEN基因的失活等位基因的肿瘤。 具有PTEN无效标准化PTEN评分的患者将用泛ErbB酪氨酸激酶抑制剂治疗。 通过比较肿瘤PTEN OD表达值与非恶性PTEN OD表达值获得标准化的PTEN蛋白表达评分。

公开(公告)号：US08338446B2

公开(公告)日：2012-12-25

申请号：US12594139

申请日：2008-03-28

申请人： Charles K. Melucci ,  John Lokhnauth

发明人： Charles K. Melucci ,  John Lokhnauth

IPC分类号： A61K31/4748 ,  C07D221/28

CPC分类号： C07D221/28 ,  C07D471/08

摘要： The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.

摘要翻译： 本发明提供式I化合物：其中X，R 1和R 2如本文所定义，及其组合物，其可用作外周μ阿片受体拮抗剂。