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公开(公告)号:US20150118223A9
公开(公告)日:2015-04-30
申请号:US13642845
申请日:2011-04-22
申请人: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini , Gene G. Kinney
发明人: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini , Gene G. Kinney
IPC分类号: A61K39/395
CPC分类号: A61K39/3955 , A61K2039/505 , A61K2039/545 , A61K2039/55 , C07K16/18 , C07K2317/24 , C07K2317/34
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
摘要翻译: 本发明提供了阿尔茨海默病和类似疾病的免疫治疗方法,其中通过测量tau的水平来监测施用的状态。
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公开(公告)号:US20130209453A1
公开(公告)日:2013-08-15
申请号:US13642845
申请日:2011-04-22
申请人: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini
发明人: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini
IPC分类号: A61K39/395
CPC分类号: A61K39/3955 , A61K2039/505 , A61K2039/545 , A61K2039/55 , C07K16/18 , C07K2317/24 , C07K2317/34
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
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公开(公告)号:US09272030B2
公开(公告)日:2016-03-01
申请号:US13642845
申请日:2011-04-22
申请人: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini , Gene G. Kinney
发明人: Ronald Black , Jack Steven Jacobsen , Lioudmila Tchistiakova , Angela Widom , Davinder Gill , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Wagner Zago , Manuel J. Buttini , Gene G. Kinney
IPC分类号: C07K16/18 , A61K39/00 , A61K39/395
CPC分类号: A61K39/3955 , A61K2039/505 , A61K2039/545 , A61K2039/55 , C07K16/18 , C07K2317/24 , C07K2317/34
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered is monitored by measuring levels of tau.
摘要翻译: 本发明提供了阿尔茨海默病和类似疾病的免疫治疗方法,其中通过测量tau的水平来监测施用的状态。
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公开(公告)号:US09644025B2
公开(公告)日:2017-05-09
申请号:US12738396
申请日:2008-10-17
申请人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
发明人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
IPC分类号: A61K39/395 , C07K16/18 , C07K16/28 , G06Q99/00 , A61K39/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G06Q99/00
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
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公开(公告)号:US20120070379A1
公开(公告)日:2012-03-22
申请号:US13231903
申请日:2011-09-13
申请人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
发明人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
IPC分类号: A61K39/395 , G06Q90/00 , A61K39/00 , A61K49/00 , A61P25/28
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G06Q99/00
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
摘要翻译: 本发明提供了阿尔茨海默病和类似疾病的免疫治疗方法,其中给予患者的方案取决于患者的ApoE基因型。
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公开(公告)号:US20100266505A1
公开(公告)日:2010-10-21
申请号:US12738396
申请日:2008-10-17
申请人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
发明人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
IPC分类号: A61K49/06 , A61K39/395
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G06Q99/00
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
摘要翻译: 本发明提供了阿尔茨海默病和类似疾病的免疫治疗方法,其中给予患者的方案取决于患者的ApoE基因型。
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公开(公告)号:US20090155256A1
公开(公告)日:2009-06-18
申请号:US12253929
申请日:2008-10-17
申请人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
发明人: Ronald Black , Lars Ekman , Ivan Lieberburg , Michael Grundman , James Callaway , Keith M. Gregg , Jack Steven Jacobsen , Davinder Gill , Lioudmila Tchistiakova , Angela Widom
IPC分类号: A61K39/395 , C07K16/00 , C07H21/00 , A61P25/28
CPC分类号: C07K16/18 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/77 , G06Q99/00
摘要: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
摘要翻译: 本发明提供了阿尔茨海默病和类似疾病的免疫治疗方法,其中给予患者的方案取决于患者的ApoE基因型。
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公开(公告)号:US20060073148A1
公开(公告)日:2006-04-06
申请号:US11155843
申请日:2005-06-17
申请人: Lioudmila Tchistiakova , Marion Kasaian , Debra Donaldson , Xiang-Yang Tan , Davinder Gill , Macy Jin , Bruce Jacobson , Samuel Goldman , John Knopf , Angela Widom
发明人: Lioudmila Tchistiakova , Marion Kasaian , Debra Donaldson , Xiang-Yang Tan , Davinder Gill , Macy Jin , Bruce Jacobson , Samuel Goldman , John Knopf , Angela Widom
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N5/06
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要: Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
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公开(公告)号:US20120064600A1
公开(公告)日:2012-03-15
申请号:US13208162
申请日:2011-08-11
申请人: Erwin R. BOGHAERT , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil R. Sreekumar
发明人: Erwin R. BOGHAERT , Nitin K. Damle , Philip Ross Hamann , Kiran Khandke , Arthur Kunz , Kimberly A. Marquette , Lioudmila Tchistiakova , Davinder Gill , Kodangattil R. Sreekumar
CPC分类号: C07K16/28 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/77 , C07K2317/92
摘要: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
摘要翻译: 抗5T4抗体,抗5T4抗体/药物偶联物,以及制备和使用该抗体的方法。
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公开(公告)号:US07501121B2
公开(公告)日:2009-03-10
申请号:US11155843
申请日:2005-06-17
申请人: Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人: Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号: A61K39/395 , C07K16/24
CPC分类号: C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要: Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译: 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂(例如抗体及其片段)。
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