Process for the treatment of aspartame
    54.
    发明授权
    Process for the treatment of aspartame 失效
    阿斯巴甜治疗的过程

    公开(公告)号:US5587178A

    公开(公告)日:1996-12-24

    申请号:US351579

    申请日:1994-12-07

    IPC分类号: A23L27/30 A61K9/20

    CPC分类号: A23L27/32 Y10S514/951

    摘要: The invention relates to a process for the treatment of dried aspartame characterized in that, in a first separation step, particles smaller than 50 .mu.m are removed, with the aid of a stream of air, from aspartame having a particle size distribution with which more than 5 wt. % of the aspartame has a particle size of less than 20 .mu.m and more than 10 wt. % of the aspartame has a particle size of more than 400 .mu.m, and that in a second separation step the product resulting from the first step is subjected to a screening step using a screen that separates at a value between 150 and 250 .mu.m, after which the fraction of the smaller particles thus obtained is recovered as a first product and the fraction of the larger particles is recovered as a second product or is optionally subjected to a further separation step using a screen that separates at a value between 400 and 1000 .mu.m, the fraction of smaller particles thus obtained being recovered as the second product. Aspartame having a particle size distribution in which at least 94% of the particles are larger than 20 .mu.m and smaller than 250 .mu.m appears to present exceptionally good properties as regards processability and dissolution rate.

    摘要翻译: 本发明涉及一种用于处理干燥的阿斯巴甜的方法,其特征在于,在第一分离步骤中,借助于空气流从具有粒度分布的阿斯巴甜中除去小于50μm的颗粒, 超过5wt。 %的阿斯巴甜具有小于20μm的粒度和大于10wt。 %的天冬甜素具有大于400μm的粒度,并且在第二分离步骤中,使用分离在150-250μm之间的筛子对由第一步产生的产物进行筛选步骤, 之后将如此获得的较小颗粒的份数作为第一产物回收,并且较大颗粒的份数作为第二产物回收,或者任选地使用分离为400至1000之间的筛网进一步分离步骤 如此获得的较小颗粒的分数作为第二产物回收。 具有至少94%的颗粒大于20μm且小于250μm的粒度分布的天冬甜素在加工性和溶解速率方面表现出非常好的性能。

    Method of preparing granules of dipeptide
    55.
    发明授权
    Method of preparing granules of dipeptide 失效
    制备二肽颗粒的方法

    公开(公告)号:US5358186A

    公开(公告)日:1994-10-25

    申请号:US112981

    申请日:1993-08-30

    CPC分类号: A23L27/32 A23P10/25

    摘要: In producing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a particle size of falling within a determined particle size range by compaction granulation, formation of fine powdery .alpha.-APM is prevented by breaking the compacted .alpha.-APM so that the one-pass yield of the granules is elevated and the sieving efficiency is elevated. In a method of preparing granules of .alpha.-L-aspartyl-L-phenylalanine methyl ester by compaction granulation of the ester singly or along with a vehicle of not more than the same amount of the ester, after the compaction or after having roughly broken the compacted material, the material is broken down so as to pass through a screen or perforated plate having pores with a diameter falling within the range of from 1 mm to 10 mm and then further broken and classified.

    摘要翻译: 在通过压实造粒生产粒径处于确定的粒度范围内的α-L-天冬氨酰基-L-苯丙氨酸甲酯的颗粒中,通过打破压实的α-APM来防止细粉末α-APM的形成, 颗粒的单程产率提高,筛分效率提高。 在制备α-L-天冬氨酰基-L-苯丙氨酸甲酯的颗粒的方法中,通过单独压制酯化或与不超过相同量的酯的载体一起制成颗粒,在压实之后或在大致破裂之后 将材料分解,通过具有直径在1mm至10mm范围内的孔的筛网或多孔板,然后进一步破碎分级。

    Microencapsulated high intensity sweetening agents having prolonged
sweetness release and methods for preparing same
    57.
    发明授权
    Microencapsulated high intensity sweetening agents having prolonged sweetness release and methods for preparing same 失效
    具有延长甜度释放的微胶囊化高强度甜味剂及其制备方法

    公开(公告)号:US5108763A

    公开(公告)日:1992-04-28

    申请号:US679865

    申请日:1991-04-03

    摘要: The present invention is a directed at a sweetening agent delivery system having prolonged sweetness release prepared by a method which comprises the steps of (A) providing the following ingredients in percentages by weight of the sweetening agent delivery system (a) a solution of a high intensity sweetening agent, wherein the sweetening agent is present in an amount from about 0.01% to about 60%, (b) polyvinyl acetate present in an amount from about 40% to about 93% and having a molecular weight in the range from about 2,000 to about 100,000, (c) a plasticizing agent present in an amount from about 0.1% to about 20%, (d) a waxy material having a melting point from about 30.degree. C. to about 120.degree. C. present in an amount from about 0.5% to about 40%, and (e) an emulsifying agent present in an amount from about 0.1% to about 20%, (B) melting and blending the polyvinyl acetate with the plasticizing agent to form a uniform mixture, (C) admixing the solution of high intensity sweetening agent with the melted mixture from step (B) and evaporating the solvent to form a uniform mixture, (D) admixing the waxy material and the emulsifying agent with the mixture from step (C) to form a uniform mixture, (E) cooling and blending the mixture from step (D), and (F) granulating the mixture from step (E).

    摘要翻译: 本发明涉及一种具有延长的甜味释放的甜味剂递送系统,其通过包括以下步骤的方法制备,所述方法包括以下步骤:(A)以甜味剂递送系统的重量百分比提供以下成分(a)高 强度甜味剂,其中甜味剂的存在量为约0.01%至约60%,(b)聚乙酸乙烯酯的存在量为约40%至约93%,分子量为约2,000 至约100,000,(c)以约0.1%至约20%的量存在的增塑剂,(d)熔点为约30℃至约120℃的蜡质材料,其量为 约0.5%至约40%,和(e)以约0.1%至约20%的量存在的乳化剂,(B)将聚乙酸乙烯酯与增塑剂熔融并共混以形成均匀的混合物,(C) 混合高强度甜味剂的溶液 与步骤(B)的熔融混合物蒸发并蒸发溶剂以形成均匀的混合物,(D)将蜡质材料和乳化剂与来自步骤(C)的混合物混合以形成均匀的混合物,(E)冷却和 混合来自步骤(D)的混合物,和(F)将来自步骤(E)的混合物制粒。