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    Instrumentation for injection of therapeutic fluid into joints
    51.
    发明授权
    Instrumentation for injection of therapeutic fluid into joints 有权
    将治疗液注入关节的仪器

    公开(公告)号：US08083722B2

    公开(公告)日：2011-12-27

    申请号：US12605780

    申请日：2009-10-26

    申请人： William F. McKay

    发明人： William F. McKay

    IPC分类号： A61M5/00

    CPC分类号： A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00261 ,  A61B2018/00392 ,  A61M5/32 ,  A61M5/3298 ,  A61M2025/0085

    摘要： Described are novel medical delivery devices that can be used to effectively distribute a medical agent to multiple sites within a tissue volume without requiring the device to be repositioned, including for example to distribute the medical agent within the nucleus pulposus tissue of a spinal disc. Also described are medical delivery devices configured to simultaneously remove fluid from the tissue volume into which a medical agent is being delivered, thus avoiding or otherwise decreasing any pressure build-up and facilitating an effective, uniform delivery of the therapeutic agent.

    摘要翻译： 描述了可用于有效地将药剂分配到组织体积内的多个部位而不需要重新定位装置的新型医疗输送装置，包括例如将药剂分配在脊髓盘的髓核组织内。 还描述了被配置为同时从组织体积中去除流体的医疗输送装置，医药剂被递送到其中，从而避免或以其他方式减少任何压力积聚并促进治疗剂的有效且均匀的输送。

    Pressure/Vacuum Actuated Catheter Drug Delivery Probe
    52.
    发明申请
    Pressure/Vacuum Actuated Catheter Drug Delivery Probe 有权
    压力/真空驱动导管药物递送探针

    公开(公告)号：US20110270184A1

    公开(公告)日：2011-11-03

    申请号：US12912499

    申请日：2010-10-26

    申请人： Erhan H. Gunday ,  Lawrence J. Gerrans

    发明人： Erhan H. Gunday ,  Lawrence J. Gerrans

    IPC分类号： A61M5/00

    CPC分类号： A61M25/0084 ,  A61B18/1492 ,  A61B18/24 ,  A61M5/142 ,  A61M2005/1726 ,  A61M2025/0085

    摘要： A delivery probe for delivering a therapeutic agent to tissue is described including at least one delivery capsule for accommodating the agent, at least one delivery device in fluid communication with the capsule, an actuation mechanism for moving the capsule between an activated position and an inactivated position by providing at least one of a fluid and a vacuum, and a delivery mechanism for forcing the agent out of the capsule. A method of delivering a therapeutic agent to tissue is also described including providing a catheter with a delivery probe at a distal end, positioning the delivery probe next to the tissue, supplying fluid to an actuation chamber to position the probe into an activated position, supplying fluid to a delivery chamber to force the agent out of the probe, and establishing a vacuum in the actuation chamber to position the probe into an inactivated position.

    摘要翻译： 描述了用于将治疗剂递送到组织的递送探针，其包括用于容纳药剂的至少一个递送胶囊，与胶囊流体连通的至少一个递送装置，用于在激活位置和非活动位置之间移动胶囊的致动机构 通过提供流体和真空中的至少一个以及用于迫使药剂离开胶囊的输送机构。 还描述了将治疗剂递送到组织的方法，包括在远端提供具有输送探针的导管，将输送探针定位在组织旁边，将流体供应到致动室以将探针定位到激活位置， 流体输送到输送室以迫使试剂离开探针，以及在致动室中建立真空以将探针定位在非活动位置。

    CATHETER FOR INTRODUCTION OF MEDICATIONS TO THE TISSUES OF A HEART OR OTHER ORGAN
    54.
    发明申请
    CATHETER FOR INTRODUCTION OF MEDICATIONS TO THE TISSUES OF A HEART OR OTHER ORGAN 审中-公开
    用于介绍心脏或其他器官组织的药物导管

    公开(公告)号：US20100168713A1

    公开(公告)日：2010-07-01

    申请号：US12722931

    申请日：2010-03-12

    申请人： Tengiz Tkebuchava

    发明人： Tengiz Tkebuchava

    IPC分类号： A61M25/06

    CPC分类号： A61M25/0084 ,  A61B5/0215 ,  A61B5/4839 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M5/329 ,  A61M25/003 ,  A61M25/0071 ,  A61M2025/0002 ,  A61M2025/0037 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0096

    摘要： A positionable, direct-injection catheter that can access a specific region of the heart or other organ. The catheter is provided with one or two needle shafts, which may be located within respective sheaths that extend axially along the interior of the lumen of a main catheter shaft. Each needle shaft carries, at a distal end thereof a penetrable element or “needle” that is normally retracted within the distal tip of the main shaft during travel to the target organ, but is subsequently deployed by action of a handle-mounted trigger mechanism to extend the needles into the organ's wall. Each extended needle is curved to relative to the shaft's axis to enter the organ wall in a flattened trajectory that both reduces the chance of puncture through the wall and anchors the needles into the wall during injection (for reduced chance of pullout under pressure). A plurality of apertures which provide for more complete agent delivery rapidly, while maintaining a low delivery velocity to effect treatment delivery in as short a period of time as possible without the problems caused by high velocity delivery. The needles are typically arranged to exit the tip at contralateral orientations relative to each other.

    摘要翻译： 可定位的直接注射导管，可以进入心脏或其他器官的特定区域。 导管设置有一个或两个针轴，其可以位于沿着主导管轴的内腔的内部轴向延伸的相应护套内。 每个针轴在其远端处具有可穿透元件或“针”，该可穿透元件或“针”在行进到目标器官期间通常缩回到主轴的远侧末端内，但随后通过手柄安装的触发机构的动作来展开 将针伸入器官的墙壁。 每个延伸的针相对于轴的轴线弯曲，以平坦的轨迹进入器官壁，两者都减少了刺穿穿过壁的机会，并且在注射期间将针固定到壁中（为了减少在压力下拔出的可能性）。 多个孔可快速地提供更完整的药剂递送，同时保持较低的输送速度，以尽可能短的时间段内实现治疗输送，而不会引起由高速输送引起的问题。 针通常布置成相对于彼此以对侧取向离开尖端。

    Catheter for introduction of medications to the tissues of a heart or other organ
    55.
    发明授权
    Catheter for introduction of medications to the tissues of a heart or other organ 有权
    导管用于将药物引入心脏或其他器官的组织

    公开(公告)号：US07691086B2

    公开(公告)日：2010-04-06

    申请号：US11152398

    申请日：2005-06-14

    申请人： Tengiz Tkebuchava

    发明人： Tengiz Tkebuchava

    IPC分类号： A61M5/178 ,  A61M5/00 ,  A61M5/32

    CPC分类号： A61M25/0084 ,  A61B5/0215 ,  A61B5/4839 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M5/329 ,  A61M25/003 ,  A61M25/0071 ,  A61M2025/0002 ,  A61M2025/0037 ,  A61M2025/0085 ,  A61M2025/0086 ,  A61M2025/0096

    摘要： This invention overcomes the disadvantages of the prior art by providing a positionable, direct-injection catheters that can access a specific region of the heart or other organ. The catheter is provided with one or two needle shafts, which may be located within respective sheaths that extend axially along the interior of the lumen of a main catheter shaft. Each needle shaft carries, at a distal end thereof a penetrable element or “needle” that is normally retracted within the distal tip of the main shaft during travel to the target organ, but is subsequently deployed by action of a handle-mounted trigger mechanism to extend the needles into the organ's wall. Each extended needle is curved to relative to the shaft's axis to enter the organ wall in a flattened trajectory that both reduces the chance of puncture through the wall and anchors the needles into the wall during injection (for reduced chance of pullout under pressure). A plurality of apertures which provide for more complete agent delivery rapidly, while maintaining a low delivery velocity to effect treatment delivery in as short a period of time as possible without the problems caused by high velocity delivery. The needles are typically arranged to exit the tip at contralateral orientations relative to each other.

    摘要翻译： 本发明通过提供一种能够接近心脏或其他器官的特定区域的可定位的直接注射导管来克服现有技术的缺点。 导管设置有一个或两个针轴，其可以位于沿着主导管轴的内腔的内部轴向延伸的相应护套内。 每个针轴在其远端处具有可穿透元件或“针”，该可穿透元件或“针”在行进到目标器官期间通常缩回到主轴的远侧末端内，但随后通过手柄安装的触发机构的动作来展开 将针伸入器官的墙壁。 每个延伸的针相对于轴的轴线弯曲，以平坦的轨迹进入器官壁，两者都减少了刺穿穿过壁的机会，并且在注射期间将针固定到壁中（为了减少在压力下拔出的可能性）。 多个孔可快速地提供更完整的药剂递送，同时保持较低的输送速度，以尽可能短的时间段内实现治疗输送，而不会由高速输送引起的问题。 针通常布置成相对于彼此以对侧取向离开尖端。

    System and method for forming a non-ablative cardiac conduction block
    58.
    发明申请
    System and method for forming a non-ablative cardiac conduction block 失效
    用于形成非烧蚀性心脏传导阻滞的系统和方法

    公开(公告)号：US20040143238A1

    公开(公告)日：2004-07-22

    申请号：US10349323

    申请日：2003-01-21

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Randall J. Lee

    IPC分类号： A61M031/00

    CPC分类号： A61M25/0026 ,  A61B5/042 ,  A61B5/6852 ,  A61B17/00491 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/00323 ,  A61B2017/00495 ,  A61M25/0084 ,  A61M25/0147 ,  A61M2025/0085 ,  A61M2025/0089 ,  A61M2025/105 ,  A61M2025/1086

    摘要： A system forms a cardiac conduction block at a location in a heart of a patient without substantially ablating cardiac tissue. The system includes a delivery system coupled to a source of material that is substantially non-ablative with respect to cardiac tissue. The delivery system delivers the material to the location, and the material at the location forms a conduction block without ablating the cardiac cells there. The material may include living cells, such as for example skeletal myocytes, and/or may include a non-living matter such as biopolymers such as a fibrin glue agent, or collagen agents. An expandable member with needle assembly is used to deliver the material so as to form a non-ablative circumferential conduction block at a location where a pulmonary vein extends from an atrium.

    摘要翻译： 系统在患者的心脏中的位置处形成心脏传导阻滞，而基本上不消融心脏组织。 该系统包括耦合到相对于心脏组织基本上不消融的材料源的递送系统。 递送系统将材料递送到位置，并且位置处的材料形成传导阻滞，而不会在其处消融心脏细胞。 该材料可以包括活细胞，例如骨骼肌细胞，和/或可以包括诸如生物聚合物如纤维蛋白胶剂或胶原剂的非生物物质。 具有针组件的可扩张构件用于输送材料，以便在肺静脉从心房延伸的位置处形成非烧蚀性周缘传导阻滞。

    Tissue surface treatment apparatus and method
    59.
    发明申请
    Tissue surface treatment apparatus and method 有权
    组织表面处理装置及方法

    公开(公告)号：US20020120260A1

    公开(公告)日：2002-08-29

    申请号：US09797409

    申请日：2001-02-28

    发明人： David L. Morris ,  Steven A. Daniel ,  Daniel J. Balbierz

    IPC分类号： A61B018/18

    CPC分类号： A61M25/1002 ,  A61B18/1477 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/00029 ,  A61B2018/00291 ,  A61B2018/143 ,  A61B2018/1475 ,  A61M2025/0085

    摘要： A tissue surface treatment apparatus includes a housing having a proximal end, a distal including a tissue contacting surface and an interior defined by the housing. A handpiece is coupled to the housing. The tissue contact surface has a plurality of apertures. An energy delivery device including at least one electrode is positionable in the housing interior. The at least one electrode includes a tissue penetrating distal end in substantial alignment with an aperture of the plurality of aperture. The at least one electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy delivery device. The advancement device is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the at least one electrode from the housing interior into the target tissue site and completely withdrawal the at least one electrode into the housing interior. A cable is coupled to one of the housing or the energy delivery device. The cable is configured to be coupled to an energy source.

    摘要翻译： 组织表面处理装置包括具有近端，远端包括组织接触表面和由壳体限定的内部的壳体。 手机耦合到壳体。 组织接触表面具有多个孔。 包括至少一个电极的能量输送装置可定位在壳体内部。 所述至少一个电极包括与所述多个孔的孔基本对准的组织穿透远端。 所述至少一个电极构造成从所述壳体内部穿过所述孔并进入目标组织部位，以限定至少部分地由组织表面限定的消融体积。 进给装置连接到能量输送装置。 推进装置至少可部分地定位在壳体或手持件中的至少一个中。 推进装置被配置为将至少一个电极从壳体内部推进到目标组织部位，并且将至少一个电极完全撤回到壳体内部。 电缆连接到外壳或能量输送装置中的一个。 电缆被配置为耦合到能量源。

    Apparatus for delivering ablation fluid to treat lesions
    60.
    发明申请
    Apparatus for delivering ablation fluid to treat lesions 有权
    用于输送消融液以治疗病变的装置

    公开(公告)号：US20020120238A1

    公开(公告)日：2002-08-29

    申请号：US10074468

    申请日：2002-02-12

    申请人： Rex Medical

    发明人： James F. McGuckin JR. ,  Stephan A. DeFonzo

    IPC分类号： A61M005/00

    CPC分类号： A61B18/00 ,  A61B2017/00867 ,  A61B2090/3937 ,  A61M25/0068 ,  A61M2025/0085 ,  A61M2025/0096

    摘要： A surgical apparatus for delivering fluid to treat a lesion comprising a housing, an elongated member extending from the housing, and a plurality of tines positioned in the housing. Each of the tines has a lumen and at least one opening communicating with the lumen for delivering fluid to the lesion. An actuator is operatively associated with the tines and actuable to a first position to move the plurality of tines from a retracted position substantially within the elongated member to a first deployed position extending from the elongated member and actuable to a second position to move the plurality of tines from the first position to a second deployed position.

    摘要翻译： 一种用于输送流体以治疗包括外壳的损伤的外科手术装置，从所述壳体延伸的细长构件以及定位在所述壳体中的多个齿。 每个齿具有内腔和至少一个与内腔连通以将流体输送到病变的开口。 致动器可操作地与齿相关联并且可致动到第一位置，以将多个尖头从大致在细长构件内的缩回位置移动到从细长构件延伸并可致动到第二位置的第一展开位置，以移动多个 从第一位置到第二部署位置。