公开(公告)号：US09155497B1

公开(公告)日：2015-10-13

申请号：US13487933

申请日：2012-06-04

Applicant: John B. Plumley ,  Erin D. Milligan ,  Marek Osinski

Inventor： John B. Plumley ,  Erin D. Milligan ,  Marek Osinski

IPC: A61B5/1455 ,  G01N33/58 ,  A61B5/1459

CPC classification number: A61B5/1455 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/4058 ,  A61B5/6852 ,  A61B5/6877 ,  A61B2562/0233 ,  A61B2562/0285 ,  G01N33/588

Abstract: The invention provides a quantum dot (QD) modified optical fiber-based biosensor which characterizes matrix metalloproteinase (MMP) enzyme activity at pain signaling sites in the central nervous system (CNS) in vivo. Related systems and peptide biomarker screening methods are also provided.

Abstract translation: 本发明提供了一种量子点（QD）修饰的基于光纤的生物传感器，其特征在于体内中枢神经系统（CNS）的疼痛信号位点的基质金属蛋白酶（MMP）酶活性。 还提供了相关系统和肽生物标志物筛选方法。

公开(公告)号：US20150228985A1

公开(公告)日：2015-08-13

申请号：US14414132

申请日：2013-07-11

Applicant: STC.UNM

Inventor： Alexey Serov ,  Plamen B Atanassov

IPC: H01M4/90

CPC classification number: H01M4/9075 ,  B01J23/745 ,  B01J37/084 ,  C07D235/30 ,  C07D235/32 ,  H01M4/90 ,  H01M4/9041 ,  H01M2008/1095 ,  Y02E60/50

Abstract: A method of preparation of M-N—C catalytic material utilizing a sacrificial support approach and using inexpensive and readily available metal precursors and carbendazim (CBDZ) as the carbon source is described.

Abstract translation: 描述了使用牺牲支持方法并使用廉价且容易获得的金属前体和多菌灵（CBDZ）作为碳源制备M-N-C催化材料的方法。

公开(公告)号：US20150198617A1

公开(公告)日：2015-07-16

申请号：US14677053

申请日：2015-04-02

Applicant: Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

Inventor： Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/4703 ,  G01N2800/2871 ,  G01N2800/52

Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

Abstract translation: 提供了用于确定血脑屏障（BBB）损伤并治疗可能由于缺血事件而遭受BBB损伤的患者的方法和装置。 所述方法和装置涉及检测血液样品中裂解的闭合蛋白片段的存在。 根据一些实施方案，该方法进一步提供基于样品中闭合蛋白片段的浓度确定BBB损伤的程度。 在进一步的实施方案中，本公开提供用于检测血液样品中闭合蛋白片段的存在的试剂盒。

公开(公告)号：US09076813B1

公开(公告)日：2015-07-07

申请号：US14156176

申请日：2014-01-15

Applicant: Seung-Chang Lee ,  Steven Brueck ,  Daniel Feezell

Inventor： Seung-Chang Lee ,  Steven Brueck ,  Daniel Feezell

IPC: H01L21/336 ,  H01L29/66 ,  H01L21/28 ,  H01L29/78 ,  B82Y15/00

CPC classification number: H01L29/66742 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02241 ,  H01L21/02603 ,  H01L21/30612 ,  H01L21/30635 ,  H01L29/0669 ,  H01L29/0673 ,  H01L29/16 ,  H01L29/2003 ,  H01L29/401 ,  H01L29/42392 ,  H01L29/66469 ,  H01L29/775 ,  H01L29/7841 ,  H01L29/78696

Abstract: A method and structure for a semiconductor transistor, including various embodiments. In embodiments, a transistor channel can be formed between a semiconductor source and a semiconductor drain, wherein a transistor gate oxide completely surrounds the transistor channel and a transistor gate metal that completely surrounds the transistor gate oxide. Related fabrication processes are presented for similar device embodiments based on a Group III-V semiconductor material and silicon-on-insulator materials.

Abstract translation: 包括各种实施例的半导体晶体管的方法和结构。 在实施例中，可以在半导体源和半导体漏极之间形成晶体管沟道，其中晶体管栅极氧化物完全围绕晶体管沟道和完全围绕晶体管栅极氧化物的晶体管栅极金属。 针对基于III-V族半导体材料和绝缘体上硅材料的类似器件实施例提出了相关的制造工艺。

公开(公告)号：US09056111B1

公开(公告)日：2015-06-16

申请号：US13622651

申请日：2012-09-19

Applicant: STC.UNM ,  UNIVERSITY OF KANSAS

Inventor： Richard Smith Larson ,  Larry A. Sklar ,  Bruce S. Edwards ,  Juan Jacob Strouse ,  Irena Ivnitski-Steele ,  Hadya M. Khawaja ,  Jerec Warren Ricci ,  Jeffrey Aube ,  Jennifer Elizabeth Golden ,  Tuanli Yao ,  Warren S. Weiner ,  Chad E. Schroeder

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  A61K31/437 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/519 ,  A61K45/06

Abstract: The present invention provides pyrazolo[1,5-a]pyrimidine compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1. Compounds and compositions according to the present invention may be used to treat cancer, including drug resistant (DR) and multiple drug resistant (MDR) cancers.

Abstract translation: 本发明提供了抑制癌症相关转运蛋白的吡唑并[1,5-a]嘧啶化合物，通过施用这些化合物来治疗或预防与癌症相关的转运蛋白介导的疾病发作的方法，以及包含这些化合物的药物组合物 。 在一个实施方案中，本发明提供对ABCB1而言对ABCG2有选择性的吡唑并[1,5-a]嘧啶外排抑制剂。 根据本发明的化合物和组合物可用于治疗癌症，包括耐药性（DR）和多重耐药性（MDR）癌症。

公开(公告)号：US09054492B2

公开(公告)日：2015-06-09

申请号：US13998782

申请日：2013-12-05

Applicant: Marek A. Osinski ,  Gennady A. Smolyakov

Inventor： Marek A. Osinski ,  Gennady A. Smolyakov

IPC: H01S5/00 ,  H01S5/10 ,  H01S5/40 ,  H01S5/026 ,  H01S5/062 ,  H01S5/125 ,  H01S5/22 ,  H01S5/343

CPC classification number: H01S5/1071 ,  B82Y20/00 ,  H01S5/026 ,  H01S5/06213 ,  H01S5/1032 ,  H01S5/125 ,  H01S5/22 ,  H01S5/34306 ,  H01S5/4006

Abstract: The invention provides a semiconductor light-emitting device having a monolithically integrated master laser, such as a distributed-Bragg-reflector (DBR) master laser, and injection-locked ring slave laser with modulated photon lifetime for optical communication beyond 100 GHz.

Abstract translation: 本发明提供了具有单片集成主激光器的半导体发光器件，例如分布式布喇格反射器（DBR）主激光器，以及具有调制光子寿命的注入锁定环形从属激光器，用于超过100GHz的光通信。

公开(公告)号：US20150141957A1

公开(公告)日：2015-05-21

申请号：US14544032

申请日：2014-11-17

Applicant: STC.UNM

Inventor： Mark Hauswald

IPC: A61M5/142 ,  A61M5/168 ,  A61M5/315

CPC classification number: A61M5/14216 ,  A61M5/1422 ,  A61M5/16809 ,  A61M5/31535 ,  A61M5/31548 ,  A61M2202/048

Abstract: A mechanical infusion pump device for injecting medication into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger which is moved in a first direction against a mechanical biasing element by engagement with a manually operable, independently movable filling plunger to fill the syringe with fluid medication. The mechanical biasing element is provided for exerting bias on the syringe plunger in a second syringe-discharging direction to dispense medication from the syringe into the patient's IV when the filling plunger is released. Only a calibrated amount of medicine can be discharged to the patent's IV over time as determined by calibration of the biasing element and a metering element located between the syringe and the patient's IV for a given viscosity of the medication.

Abstract translation: 用于将药物注射到患者IV中的机械输液泵装置包括IV储存器和连接到IV储液器的注射器，并且具有注射器柱塞，该注射器柱塞通过与手动可操作的独立地接合而抵靠机械偏压元件沿第一方向移动 可移动的填充柱塞，用流体药物填充注射器。 提供了机械偏置元件，用于在第二注射器排出方向上在注射器柱塞上施加偏压，以在填充柱塞被释放时将药物从注射器分配到患者的IV中。 只有校准量的药物可以随着时间的推移排出到专利IV，如通过偏置元件的校准和位于注射器和患者IV之间的计量元件所确定的，用于给定的药物粘度。

公开(公告)号：US09030226B2

公开(公告)日：2015-05-12

申请号：US14076541

申请日：2013-11-11

Applicant: James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

Inventor： James Plusquellic ,  Dhruva J. Acharyya ,  Ryan L. Helinski

IPC: H04L9/08 ,  G06F21/73

CPC classification number: H04L9/0861 ,  G06F21/73 ,  G09C1/00 ,  H04L9/0866 ,  Y04S40/24 ,  Y10T29/49124

Abstract: A system and methods that generates a physical unclonable function (“PUF”) security key for an integrated circuit (“IC”) through use of equivalent resistance variations in the power distribution system (“PDS”) to mitigate the vulnerability of security keys to threats including cloning, misappropriation and unauthorized use.

Abstract translation: 通过使用配电系统（“PDS”）中的等效电阻变化，为集成电路（“IC”）生成物理不可克隆功能（“PUF”）安全密钥以减轻安全密钥的漏洞的系统和方法 威胁包括克隆，盗用和未经授权的使用。

公开(公告)号：US20150110720A1

公开(公告)日：2015-04-23

申请号：US14496605

申请日：2014-09-25

Applicant: ANATOLIY MARKIV ,  RAVI VENKATA DURVASULA ,  ANGRAY SINGH KANG

Inventor： ANATOLIY MARKIV ,  RAVI VENKATA DURVASULA ,  ANGRAY SINGH KANG

IPC: A61K49/00 ,  A61N5/06 ,  G01N33/53 ,  G01N33/58 ,  C07K14/00 ,  C07K16/18

CPC classification number: C12N15/62 ,  A61K49/0045 ,  A61K49/0058 ,  A61N5/062 ,  C07K14/001 ,  C07K16/18 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/60 ,  C12N15/63 ,  C12Q1/04 ,  G01N33/53 ,  G01N33/582

Abstract: Embodiments of the present invention provide for the facile generation of a stable recombinant fusion polypeptides with intrinsic fluorescent properties. The recombinant antibodies may be suitable for qualitative and/or quantitative immunofluorescence analysis. Generally, the fluorescent polypeptides include a fluorescent domain comprising a C-terminus and an N-terminus; a first antibody domain covalently linked to the C-terminus; and a second antibody domain covalently linked to the N-terminus.

Abstract translation: 本发明的实施方案提供了容易地产生具有固有荧光性质的稳定的重组融合多肽。 重组抗体可适用于定性和/或定量免疫荧光分析。 通常，荧光多肽包括包含C末端和N末端的荧光结构域; 与C末端共价连接的第一抗体结构域; 和与N末端共价连接的第二抗体结构域。

公开(公告)号：US08986651B2

公开(公告)日：2015-03-24

申请号：US13497738

申请日：2010-11-30

Applicant: Yubin Miao ,  Haixun Guo

Inventor： Yubin Miao ,  Haixun Guo

IPC: A61K51/00 ,  A61M36/14 ,  A61K51/08 ,  A61K38/00

CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K45/06 ,  A61K51/08 ,  A61K51/086 ,  A61K51/088 ,  C07K7/54

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及用于成像癌症的新型非侵入性诊断工具/化合物，特别是黑素瘤，包括体内转移性黑素瘤。 本发明化合物在癌细胞和组织中表现出增强的摄取，并且减少了肾中的肾摄取，证明了本发明化合物的有利的药代动力学。 根据本发明的化合物代表使用非侵入性分子成像技术在黑色素瘤的诊断和治疗中的进展，包括转移性黑素瘤。 本发明的新型探针也可用于开始黑色素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可以用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。