中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

1257 records (took 0.156 seconds)

    Step-scan ion trap mass spectrometry for high speed proteomics
    641.
    发明授权
    Step-scan ion trap mass spectrometry for high speed proteomics 有权
    步进扫描离子阱质谱法用于高速蛋白质组学

    公开(公告)号：US08507846B2

    公开(公告)日：2013-08-13

    申请号：US13566352

    申请日：2012-08-03

    Applicant: Chung-Hsuan Chen ,  Jung-Lee Lin ,  Ming-Lee Chu

    Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Ming-Lee Chu

    IPC: B01D59/44 ,  H01J49/00

    CPC classification number: H01J49/4285 ,  H01J49/0031 ,  H01J49/424

    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.

    Abstract translation: 一种离子阱质谱仪和用于通过在带宽上以频率增量扫描驱动频率来获得离子质谱的方法，其中对于每个步骤，特定频率保持固定数量的完整循环，其中每个特定频率被改变 在下一步骤中连续地进入频率，并且其中每个步骤中的每个特定频率从相位零位置开始。

    OPTICAL MODULE AND MICROSCOPE
    642.
    发明申请
    OPTICAL MODULE AND MICROSCOPE 有权
    光学模块和显微镜

    公开(公告)号：US20130188249A1

    公开(公告)日：2013-07-25

    申请号：US13733421

    申请日：2013-01-03

    Applicant: ACADEMIA SINICA

    Inventor： En-Te HWU

    IPC: G02B21/28 ,  G02B7/02

    CPC classification number: G02B21/28 ,  G02B7/02 ,  G02B7/028 ,  G21K7/00 ,  H01J37/15

    Abstract: An optical module includes at least a carrying stage, at least an actuator unit and at least an optical assembly. The carrying stage has a first aperture. The actuator unit is disposed at one side of the carrying stage and has a second aperture. The optical assembly is connected with the actuator unit, and the actuator unit adjusts the position of the optical assembly. A radiated wave enters from one side of the optical module and passes through the first aperture, the second aperture and the optical assembly. A microscope with the optical module has compact size and is easily assembled and carried. The optical module and microscope can efficiently reduce the effect of ambient temperature variations so as to improve the measuring stability thereof.

    Abstract translation: 光学模块至少包括载物台，至少一个致动器单元和至少一个光学组件。 承载台具有第一孔。 致动器单元设置在承载台的一侧并且具有第二孔。 光学组件与致动器单元连接，致动器单元调节光学组件的位置。 辐射波从光学模块的一侧进入，并穿过第一孔，第二孔和光学组件。 具有光学模块的显微镜具有紧凑的尺寸并且易于组装和携带。 光学模块和显微镜可以有效地降低环境温度变化的影响，从而提高其测量的稳定性。

    MESOPOROUS SILICA NANOPARTICLE-MEDIATED DELIVERY OF DNA INTO ARABIDOPSIS ROOT
    643.
    发明申请
    MESOPOROUS SILICA NANOPARTICLE-MEDIATED DELIVERY OF DNA INTO ARABIDOPSIS ROOT 审中-公开
    将多糖二氧化硅纳米粒子介导的DNA转运到阿拉伯半球

    公开(公告)号：US20130185823A1

    公开(公告)日：2013-07-18

    申请号：US13742112

    申请日：2013-01-15

    Applicant: Academia Sinica

    Inventor： Lin Yun Kuang ,  Chia-An Huang ,  Yue-Le C. Hsing ,  Feng-Peng Chang ,  Yann Hung ,  Chung-Yuan Mou

    IPC: C12N15/82

    CPC classification number: C12N15/8202 ,  C12N15/8207 ,  C12N15/87

    Abstract: Transient gene expression is a powerful tool for plant genomics studies. Recently, the use of nanomaterials has drawn great interest. Delivery with mesoporous silica nanoparticles (MSNs) has many advantages. We used surface-functionalized MSNs to deliver and express foreign DNA in Arabidopsis thaliana root cells without the aid of particle bombardment. Gene expression was detected in the epidermis layer and in the more inner cortex and endodermis root tissues. This method is superior to the conventional gene-gun method to deliver DNA, which delivers the gene to the epidermis layer only. Less DNA is needed for the MSN method. Our system is the first use of nanoparticles to deliver DNA to plants with good efficiency and without external aids. MSNs, with multifunctionality and the capability of cargo delivery to plant cells as we demonstrated, provide a versatile system for biomolecule delivery, organelle targeting, and even agriculture, such as improved nutrient uptake.

    Abstract translation: 瞬时基因表达是植物基因组学研究的有力工具。 最近，纳米材料的使用引起了极大的兴趣。 带有介孔二氧化硅纳米粒子（MSN）的交付具有许多优点。 我们使用表面官能化的MSN在拟南芥根系细胞中传递和表达外源DNA，而无需粒子轰击。 在表层和内皮层和内皮根组织中检测到基因表达。 这种方法优于传统的基因枪方法来传递DNA，仅将基因转运到表皮层。 MSN方法需要较少的DNA。 我们的系统是第一次使用纳米粒子将DNA提供给植物，效率高，无需外部助剂。 MSNs具有多功能性和货物运送到植物细胞的能力，如我们所展示的，为生物分子递送，细胞器靶向甚至农业提供了多功能系统，如改善营养摄取。

    Anti-CεmX antibodies capable of binding to human mIgE on B lymphocytes
    646.
    发明授权
    Anti-CεmX antibodies capable of binding to human mIgE on B lymphocytes 有权
    能够与B淋巴细胞上的人mIgE结合的抗CepsilonmX抗体

    公开(公告)号：US08460664B2

    公开(公告)日：2013-06-11

    申请号：US13203483

    申请日：2010-02-25

    Applicant: Tsewen Chang ,  Jiun-bo Chen ,  Pheidias C Wu ,  Alfur F Hung

    Inventor： Tsewen Chang ,  Jiun-bo Chen ,  Pheidias C Wu ,  Alfur F Hung

    IPC: A61K39/395

    CPC classification number: C07K16/2803 ,  A61K39/39566 ,  C07K16/4291 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  Y10S424/805 ,  Y10S424/81 ,  Y10S530/862 ,  Y10S530/868

    Abstract: The invention pertains to the generation and utility of antibodies that can bind effectively to CεmX domain on membrane-bound IgE (mIgE) expressed on the surface of human B lymphocytes. The CεmX domain of 52 amino acid residues, located between the CH4 domain and the C-terminal membrane-anchor peptide on human membrane-bound epsilon chain, had been suggested as an antigenic site for immunological targeting of B cells expressing mIgE. Previous reported monoclonal antibodies, including a20, which bind to RADWPGPP (SEQ ID NO:1) peptide at the C-terminal of CεmX, have now been found to bind poorly to mIgE on human B cells. We have discovered that only monoclonal antibodies specific for certain segments, such as GLAGGSAQSQRAPDRVL (SEQ ID NO:2) and HSGQQQGLPRAAGGSVPHPR (SEQ ID NO:3), of CεmX can bind effectively to mIgE on human B cells and hence have the utility for targeting those B cells for the treatment of diseases mediated by IgE.

    Abstract translation: 本发明涉及可在人B淋巴细胞表面表达的膜结合IgE（mIgE）上有效结合CepsilonmX结构域的抗体的产生和应用。 已经建议位于人膜结合的ε链上的CH4结构域和C末端膜锚定肽之间的52个氨基酸残基的Cepsilonm结构域作为用于免疫靶向表达mIgE的B细胞的抗原位点。 现在已经发现，先前报道的包含与CepsilonmX C末端的RADWPGPP（SEQ ID NO：1）肽结合的α20的单克隆抗体在人B细胞上与mIgE结合不良。 我们已经发现，只有对于某些片段特异性的单克隆抗体，如GLEGGSAQSQRAPDRVL（SEQ ID NO：2）和HSGQQQGLPRAAGGSVPHPR（SEQ ID NO：3）），可以有效地结合人B细胞上的mIgE，因此具有靶向 用于治疗由IgE介导的疾病的那些B细胞。

    Plant tubby-like proteins
    648.
    发明授权
    Plant tubby-like proteins 有权
    植物卵巢样蛋白

    公开(公告)号：US08410337B2

    公开(公告)日：2013-04-02

    申请号：US12372231

    申请日：2009-02-17

    Applicant: Jei-Fu Shaw ,  Chia-ping Lai ,  Po-Hong Chen

    Inventor： Jei-Fu Shaw ,  Chia-ping Lai ,  Po-Hong Chen

    IPC: A01H5/00 ,  C12N5/14 ,  C12N15/82

    CPC classification number: C12N15/8261 ,  C07K14/415 ,  C12N15/8271 ,  Y02A40/146

    Abstract: An isolated polypeptide containing an amino acid sequence at least 70% identical to a Tubby-like protein (SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11), and an isolated nucleic acid encoding the polypeptide. Disclosed is an isolated nucleic acid that, under stringent conditions, hybridizes to a probe containing one of SEQ ID NOs:1-11; or its complementary sequence. Also disclosed are (1) a transformed cell or a transgenic plant containing such a nucleic acid and (2) a transformed cell or a transgenic plant having a reduced level(s) of one or more of the Tubby-like proteins. Also within the scope of the invention are methods for making the transformed cells or transgenic plants.

    Abstract translation: 一种分离的多肽，其含有与Tubby样蛋白质（SEQ ID NO：1,2,3,4,5,6,7,8,9,10或11）至少70％相同的氨基酸序列，以及 分离的编码多肽的核酸。 公开了一种分离的核酸，其在严格条件下与含有SEQ ID NO：1-11之一的探针杂交; 或其互补序列。 还公开了（1）含有这种核酸的转化细胞或转基因植物和（2）具有降低的一种或多种类似蛋白质的水平的转化细胞或转基因植物。 在本发明的范围内也是用于制备转化细胞或转基因植物的方法。

    STEP-SCAN ION TRAP MASS SPECTROMETRY FOR HIGH SPEED PROTEOMICS
    650.
    发明申请
    STEP-SCAN ION TRAP MASS SPECTROMETRY FOR HIGH SPEED PROTEOMICS 有权
    用于高速度保护的步进扫描质谱分析

    公开(公告)号：US20130032709A1

    公开(公告)日：2013-02-07

    申请号：US13566352

    申请日：2012-08-03

    Applicant: Chung-Hsuan CHEN ,  Jung-Lee LIN ,  Ming-Lee CHU

    Inventor： Chung-Hsuan CHEN ,  Jung-Lee LIN ,  Ming-Lee CHU

    IPC: H01J49/34 ,  H01J49/36 ,  H01J49/26

    CPC classification number: H01J49/4285 ,  H01J49/0031 ,  H01J49/424

    Abstract: An ion trap mass spectrometer and methods for obtaining a mass spectrum of ions by step scanning the driving frequency in frequency increments over a bandwidth, wherein for each step a specific frequency is held for a fixed number of complete cycles, wherein each specific frequency is changed continuously to the frequency in the next step, and wherein each specific frequency in each step starts at phase zero position.

    Abstract translation: 一种离子阱质谱仪和用于通过在带宽上以频率增量扫描驱动频率来获得离子质谱的方法，其中对于每个步骤，特定频率保持固定数量的完整循环，其中每个特定频率被改变 在下一步骤中连续地进入频率，并且其中每个步骤中的每个特定频率从相位零位置开始。

Patent Agency Ranking