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    METHOD OF ACNE TREATMENT BY CONCOMITANT TOPICAL ADMINISTRATION OF BENZOYL PEROXIDE AND TRETINOIN
    61.
    发明申请
    METHOD OF ACNE TREATMENT BY CONCOMITANT TOPICAL ADMINISTRATION OF BENZOYL PEROXIDE AND TRETINOIN 审中-公开

    公开(公告)号：US20190015369A1

    公开(公告)日：2019-01-17

    申请号：US15978146

    申请日：2018-05-13

    Applicant: SOL-GEL TECHNOLOGIES LTD.

    Inventor： Moshe Arkin ,  Stephen Cherkez ,  Ofer Toledano

    IPC: A61K31/203 ,  A61K47/14 ,  A61K9/50 ,  A61K31/327 ,  A61K9/00

    Abstract: The present disclosure relates to methods of treatment of acne in a patient in need thereof, comprising the concomitant once daily topical administration of from about 20 w/w to about 10% w/w of solid particulate benzoyl peroxide (BPO) and from about 0.01% w/w to about 0.1% w/w of solid particulate all trans retinoic acid (ATRA) for a period of up to 3 months, wherein the side-effects of the two actives are medically acceptable and wherein the therapeutic effect of BPO and ATRA is superior to the effect of each active administered alone. The concomitant administration may be carried out by once daily administration to a patient in need thereof of a single composition or of a first composition comprising BPO and a second composition comprising ATRA from a dual chamber dispenser or from two separate dispensers, mixed before applying on the skin of a patient in need thereof for up to 2 weeks, up to 1 month, preferably up to 2 months and more preferably up to 3 months.

    COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING A PEROXIDE AND RETINOID
    66.
    发明申请
    COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING A PEROXIDE AND RETINOID 审中-公开
    用于包含过氧化物和再生物的局部应用的组合物

    公开(公告)号：US20100047357A1

    公开(公告)日：2010-02-25

    申请号：US12525329

    申请日：2008-02-03

    Applicant: Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Haim Bar-Simantov ,  Leora Shapiro ,  Raed Abu-Reziq

    Inventor： Ofer Toledano ,  Hanan Sertchook ,  Natalia Loboda ,  Haim Bar-Simantov ,  Leora Shapiro ,  Raed Abu-Reziq

    IPC: A61K9/14 ,  A61K31/327 ,  A61K31/202 ,  A61K31/192 ,  A61K31/4436 ,  A61P17/00 ,  A61P17/06 ,  A61P17/10

    CPC classification number: A61K9/0014 ,  A61K9/28 ,  A61K47/34

    Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.

    Abstract translation: 本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质， 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。

    METHOD FOR LONG-TERM TREATMENT OF ROSACEA
    69.
    发明申请
    METHOD FOR LONG-TERM TREATMENT OF ROSACEA 有权

    公开(公告)号：US20220362204A1

    公开(公告)日：2022-11-17

    申请号：US17869210

    申请日：2022-07-20

    Applicant: Sol-Gel Technologies Ltd.

    Inventor： Ofer TOLEDANO ,  Ofra LEVY-HACHAM ,  Ori NOV ,  Vered RAM

    IPC: A61K31/327 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61P17/00 ,  A61K9/50 ,  A61K9/10

    Abstract: A regimen for the long-term therapeutic treatment of rosacea. The regimen includes topically applying to the skin of a subject in need of said treatment a pharmaceutical composition. The pharmaceutical composition includes about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient. The benzoyl peroxide is the only active ingredient in said pharmaceutical composition, and the pharmaceutical composition is applied once daily for a period of up to about 40 weeks to about 52 weeks, to achieve, in a group of such subjects, a success rate of about 75% to about 85%.

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