公开(公告)号：US20220056435A1

公开(公告)日：2022-02-24

申请号：US17483032

申请日：2021-09-23

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jeremy AGRESTI ,  Samantha COOPER ,  George KARLIN-NEUMANN ,  Nick HEREDIA ,  Ronald LEBOFSKY

IPC: C12N15/10 ,  C12Q1/6853

Abstract: Methods, compositions, and kits are provided for nucleic acid analysis, including single cell analysis.

公开(公告)号：US11248260B2

公开(公告)日：2022-02-15

申请号：US16353865

申请日：2019-03-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Eli Hefner ,  Yann Jouvenot

IPC: C12Q1/686 ,  C12Q1/6818 ,  C12Q1/70 ,  C12Q1/6806

Abstract: Compositions, kits, and methods are provided for the normalization of a quantitative polymerase chain reaction (PCR) amplification. Also provided are compositions, kits, and methods for multiplexing qPCR amplification of two or more target nucleic acids in the same well.

公开(公告)号：US20220018838A1

公开(公告)日：2022-01-20

申请号：US17379193

申请日：2021-07-19

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： QIAN GAO ,  RAVI KAUL ,  SHUXIA ZHOU ,  ROGER P. WALKER

IPC: G01N33/569 ,  G01N21/64

Abstract: The present invention relates to the development of novel immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples. Novel multiplex and singleplex immunoassays for the detection of neutralizing antibodies and/or high avidity neutralizing antibodies to SARS-CoV-2 spike protein variants or fragments thereof and, optionally, one or more cytokine in patient samples are also provided.

公开(公告)号：US20220008928A1

公开(公告)日：2022-01-13

申请号：US17486804

申请日：2021-09-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Billy W. Colston, JR. ,  Benjamin J. Hindson ,  Kevin D. Ness ,  Donald A. Masquelier

IPC: B01L3/00 ,  B01F13/00 ,  B01L3/02 ,  B01L7/00 ,  G01N21/3563 ,  B01F3/08 ,  C12Q1/686 ,  G01N21/64 ,  B01F15/00 ,  B29C45/00 ,  G01N21/49

Abstract: Method of analysis. In the method, a microfluidic device defining a flow path extending from an inlet to an outlet may be selected. A sample-containing fluid may be introduced into the flow path via the inlet. Volumes of the sample-containing fluid may be isolated from one another on the flow path. A two-dimensional monolayer of the volumes may be imaged. The two-dimensional monolayer may be formed along the flow path between the inlet and the outlet.

公开(公告)号：US20210403989A1

公开(公告)日：2021-12-30

申请号：US17357618

申请日：2021-06-24

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ronald LEBOFSKY ,  Man CHENG

IPC: C12Q1/6834 ,  C12Q1/6869

Abstract: Barcoding composition and methods involving solid supports having sets of different oligonucleotides that can be decoded to the same identification sequence.

公开(公告)号：US20210389305A1

公开(公告)日：2021-12-16

申请号：US16900577

申请日：2020-06-12

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Shai NIMRI ,  Yochanan URI ,  Boaz RAN

IPC: G01N33/53 ,  B01L3/00 ,  G01N35/10 ,  G01N35/04 ,  G01N35/00 ,  G01N33/543

Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.

公开(公告)号：US20210387200A1

公开(公告)日：2021-12-16

申请号：US17343461

申请日：2021-06-09

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Garret BAUTISTA

IPC: B01L7/00

Abstract: A sample plate for a thermal cycler suitable for performing a polymerase chain reaction (PCR) procedure includes a base plate and a number of reaction vessels extending upward from the base plate. The sample plate further includes a vertical wall surrounding an outer perimeter defined by the reaction vessels. The vertical wall can be a continuation vertical wall, an intermittent vertical wall, or a perforated vertical wall. The intermittent vertical wall can include a plurality of wall portions, each of which plurality of wall portions is separated from other wall portions via a plurality of gaps.

公开(公告)号：US20210363574A1

公开(公告)日：2021-11-25

申请号：US17345834

申请日：2021-06-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Amy L. HIDDESSEN ,  Benjamin J. HINDSON

IPC: C12Q1/6848 ,  C12Q1/6844 ,  C12Q1/6816 ,  C12Q1/686

Abstract: System, including methods, apparatus, compositions, and kits, for making and using a stabilized emulsion. A method of generating a stabilized emulsion is provided. In the method, an aqueous phase may be provided. The aqueous phase may include an effective concentration of one or more skin-forming proteins. An emulsion may be formed. The emulsion may include droplets of a dispersed phase disposed in a continuous phase, with the aqueous phase being the continuous phase or the dispersed phase. The emulsion may be heated to create an interfacial skin between each droplet and the continuous phase, to transform the droplets into capsules.

公开(公告)号：US11175284B2

公开(公告)日：2021-11-16

申请号：US16193110

申请日：2018-11-16

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Clayton T. McKee

IPC: G01N33/53 ,  B01L3/00 ,  G01N33/558 ,  G01N33/543

Abstract: Lateral flow devices, methods and kits for performing lateral flow assays are provided.

公开(公告)号：US20210349105A1

公开(公告)日：2021-11-11

申请号：US17314376

申请日：2021-05-07

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： ROGER P. WALKER ,  HEIDI SCHOLZ

IPC: G01N33/68 ,  G01N33/569 ,  G01N33/533

Abstract: The present disclosure relates to the development of novel immunoassays for the detection of SARS-CoV-2 antigens and/or SARS-CoV-2 specific antibodies and, optionally, one or more cytokine in patient samples.