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公开(公告)号：US11567005B2
公开(公告)日：2023-01-31
申请号：US15767838
申请日：2016-10-12
Applicant: CYTIVA SWEDEN AB
Inventor： Ewa Pol
IPC: G01N21/552 , G01N21/27 , G01N33/68
Abstract: A method for determining instrument-dependent parameters of a surface plasmon resonance, SPR, biosensor system, and using those instrument-dependent parameters to measure the concentration of an analyte is provided herein. Also disclosed are methods of monitoring surface binding interactions of the analyte using the instrument-dependent parameters.
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公开(公告)号：US20220403318A1
公开(公告)日：2022-12-22
申请号：US17763860
申请日：2020-10-01
Applicant: Cytiva Sweden AB
Inventor： Shivakumar Selvaraj , Bineesh Kandoth , Sahebagouda Alagur , Nagaraj Raghavendra Rao , Thomas Falkman
Abstract: The present subject matter discloses a bioreactor apparatus. The bioreactor apparatus comprises a bioreactor vessel configured to culture cells. The bioreactor apparatus furthermore comprises a sensor configured to measure Dissolved Oxygen (DO) in the bioreactor vessel. The DO measurements comprise a plurality of DO values recorded at, at least, a plurality of time instances during operation of the bioreactor apparatus. The bioreactor apparatus furthermore comprises a controller configured to obtain the DO measurements. The controller furthermore is to determine, in real-time or approximately real-time, an oxygen mass transfer co-efficient (kLa) associated with the operation of the bioreactor apparatus. Furthermore, the controller is configured to control, in real-time or approximately real-time, at least one cell culture parameter associated with the operation of the bioreactor apparatus based on the kLa.
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公开(公告)号：US20220283062A1
公开(公告)日：2022-09-08
申请号：US17826924
申请日：2022-05-27
Applicant: Cytiva Sweden AB
Inventor： Enrique Napoleon Carredano , Elenor Strandberg
Abstract: The present invention relates to the preparation of liquid mixtures, and more particularly to the preparation of a liquid mixture, such as a buffer, wherein the conductivity of the liquid mixture is measured and the pH indirectly determined if the buffer concentration is known. Another object of the present invention is to provide a method of preparing a liquid mixture with a predetermined pH value by using conductivity as feedback control parameter.
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公开(公告)号：US20220275798A1
公开(公告)日：2022-09-01
申请号：US17634455
申请日：2020-06-24
Applicant: Cytiva Sweden AB
Inventor： Klaus Gebauer , Andreas Lundin , Andreas Marcstrom , David Gronowitz , Bjorn Johansson , Mats Nilsson , Bjorn Olovsson
Abstract: A diapharagm pump for a bioprocess system comprises a pump head (1; 101; 201; 301) comprising: a common inlet (3); a common outlet (5); a plurality of pump cavities (7) each including at least one cooperating pair of one-way valves, the at least one pair of one-way valves including an inlet valve (9) and an outlet valve (11), wherein the respective inlet valves (9) are in fluid communication with the common inlet (3) and the respective outlet valves (11) are in fluid communication with the common outlet (5) and wherein a centre of the outlet valve (11) for each pump cavity is positionable above a centre of the inlet valve (9) for the same pump cavity when the diaphragm pump is oriented for use to inhibit trapped gas; and a plurality of moveable diaphragms (13) each respectively provided in a respective of said pump cavities (7) for varying a volume of the pump cavities. The system further comprises a pump drive (31) which is configured to transfer a motion to the diaphragms (13) of the pump head (1; 101; 201) for accomplishing a fluid displacement from the common inlet (3) to the common outlet (5) of the pump head (1; 101; 201; 301) as a result of said varying of the volume of the pump cavities (7).
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公开(公告)号：US20220275317A1
公开(公告)日：2022-09-01
申请号：US17763135
申请日：2020-09-30
Applicant: Cytiva Sweden AB
Inventor： Klas Marteleur , Andreas Marcstrom , Mats Olsson , Klaus Gebauer
Abstract: Disclosed is a bioprocess system (1) comprising a flow path (3; 3a, 3) comprising: a plurality of inlets (7); at least one bio-processing device inlet connection (9a) and at least one bioprocessing device outlet connection (9b); a plurality of outlets (11); and flow path parts (5a′, 5b′, 5c′, 5d′, 5e′) of at least some active components (5a, 5b, 5c, 5d, 5e) comprised in the bioprocess system; and active parts (5a″, 5b″, 5c″, 5d″, 5e″) of said active components (5a, 5b, 5c, 5d, 5e). The flow path (3; 3a, 3b) of the bioprocess system is positioned centrally within the bioprocess system (1) and in a vertical orientation, whereby the active parts (5a″, 5b″, 5c″, 5d″, 5e″) are positioned around the flow path (3; 3a, 3b) being accessible from outside the bioprocess system (1) and each in connection with a corresponding flow path part (5a′, 5b′, 5c′, 5d′, 5e′) of an active component (5a, 5b, 5c, 5d, 5e).
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Patent Agency Ranking
66.发明申请公开(公告)号：US20220259532A1
公开(公告)日：2022-08-18
申请号：US17618352
申请日：2020-06-23
Applicant: Cytiva Sweden AB
Inventor： Magnus Raberg , Tobias Soderman , Andreas Borgstrom , Helena Ohrvik
Abstract: The present invention relates to a computer implemented method performed by a controller (C) configured to control a bioprocess comprised in a bioreactor (BR), the method comprising obtaining (410) measurement results by performing spectroscopy of a bioprocessing fluid (FL) comprised in the bioreactor (BR), generating bioprocessing parameters using the measurement results, one or more bioprocessing target parameters and one or more trained models, and, controlling the bioprocess using the generated bioprocessing parameters. The method wherein the one or more trained models are neural networks, wherein the measurement results comprise a spectrum, wherein the spectrum is split to a number N parts used to calculate N average values, wherein the N average values and the corresponding values of bioprocessing parameters are used § as features in the neural network.
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公开(公告)号：US20220184527A1
公开(公告)日：2022-06-16
申请号：US17686157
申请日：2022-03-03
Applicant: Cytiva Sweden AB
Inventor： Johan Avallin , Klaus Gebauer
Abstract: A method and a system and a container system for transferring separation resin from at least one first container (3; 3′; 3a, 3b; 3a′, 3b′, 3c′, 3d′) to a second container (5; 5′), wherein said first container is a deformable, single-use separation resin storage container, said method comprising the steps of:
preparing (S1) the at least one first container by providing a deformable, single-use container comprising an outlet port (4′) with a predefined volume of separation resin in a storage solution;
fluidizing (S3) the separation resin in the at least one first container to provide a resin slurry, said fluidizing being performed by mechanical interaction to the first container from an outside of the first container to provide a deformation of said first container;
fluidically connecting (S5) the outlet port (4′) of the at least one first container to an inlet port (103) of the second container;
transferring (S7) separation resin from the at least one first container to the second container by generating a pressure difference between an interior of the second container and an interior of the first container where the pressure is lower in the second container.-
公开(公告)号：US20220175992A1
公开(公告)日：2022-06-09
申请号：US17437097
申请日：2020-03-23
Applicant: Cytiva Sweden AB
Inventor： Johan Avallin , Anna Gronberg , Anders Nilsson , Henrik Ingvarsson , Linda Persson , Magnus Asplund , Reinhard Braaz
Abstract: The invention discloses a method for sanitization of a bioprocess chro matography column, comprising the steps of: a) providing a bioprocess chromatogra phy column with a packed bed of separation resin particles and a movable adapter, b) with the adapter in contact with the packed bed, conveying a sanitization fluid through the packed bed to a column outlet; c) raising the adapter to provide a gap between the packed bed and the adapter, d) lowering the adapter to close the gap; and e) conveying an equilibration liquid through the packed bed to a column outlet.
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公开(公告)号：US20220128523A1
公开(公告)日：2022-04-28
申请号：US17430915
申请日：2020-02-24
Applicant: Cytiva Sweden AB
Inventor： Lars Mattsson , Ioana Erlandsson , Therese Westman , Enrique Carredano , Jenny Dunker
Abstract: The present invention relates to a computer-implemented method for controlling preparation of a liquid mixture comprising an acid and its conjugate base or a base and its conjugate acid. The method comprises obtaining (S11) a composition for the liquid mixture to be prepared and determining (S12) a plurality of settings for controlling a preparation of the liquid mixture in one or more automated processes. The plurality of settings are provided (S13) to one or more control systems of the one or more automated processes. The present invention also relates to a buffer tool configured to perform the computer-implemented method, a buffer management system comprising the buffer tool, and a computer readable storage medium (25), having stored thereon a computer program which, when executed in a buffer tool, causes execution of the computer-implemented method.
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公开(公告)号：US20220127557A1
公开(公告)日：2022-04-28
申请号：US17435436
申请日：2020-03-25
Applicant: Cytiva Sweden AB
Inventor： Andreas Castan , Ricardo A. Medronho , Leda Castilho , Iona Walter Bettinardi
Abstract: A bioreactor system for culturing cells, comprising: —at least one bioreactor (3); and —at least one hydrocyclone (5a; 5b; 5c; 5d, 5d′; 5e) comprising: —a cell culture inlet (7) which is connected to a cell culture outlet (9) of the bioreactor (3) via a pump (11), whereby a cell culture from the bioreactor can be transferred to the hydrocyclone (5a: 5b; 5c; 5d, 5d′; 5e) when a cell culture is provided in the bioreactor, —a hydrocyclone separation part (13) into which cell culture can be introduced from the cell culture inlet (7), —a top outlet (15) through which a part of the cell culture with decreased cell concentration can be transferred after separation in the hydrocyclone separation pan (13); and —a bottom outlet (17) through which a pan of the cell culture with increased cell concentration can be transferred after separation in the hydrocyclone separation part (13), wherein said bottom outlet (17) of the hydrocyclone (5a; 5b; 5c; 5d, 5d′; 5e) is provided in a position such that when the bioreactor system is used for culturing cells the bottom outlet (17) is in connection with a headspace (21) of the bioreactor (3) and wherein said bottom outlet (17) is provided such that the bottom outlet (17) has a free space around it such that a cell culture transferred out form the bottom outlet (17) is allowed to freely discharge around the bottom outlet.
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